DONALD YM contact LEUNG

Summary

Affiliation: National Jewish Medical and Research Center
Country: USA

Publications

  1. pmc High constitutive glucocorticoid receptor beta in human neutrophils enables them to reduce their spontaneous rate of cell death in response to corticosteroids
    I Strickland
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, Denver, Colorado 80206, USA
    J Exp Med 193:585-93. 2001
  2. pmc Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta
    D Y Leung
    Division of Allergy Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Exp Med 186:1567-74. 1997
  3. ncbi request reprint New concepts in the pathogenesis of atopic dermatitis
    Donald Y M Leung
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, Denver, CO, USA
    Curr Opin Immunol 15:634-8. 2003
  4. ncbi request reprint Infection in atopic dermatitis
    Donald Y M Leung
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Curr Opin Pediatr 15:399-404. 2003
  5. pmc New insights into atopic dermatitis
    Donald Y M Leung
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    J Clin Invest 113:651-7. 2004
  6. ncbi request reprint Atopic dermatitis
    Donald Y M Leung
    Division of Pediatric Allergy and Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Lancet 361:151-60. 2003
  7. ncbi request reprint Pathogenesis of atopic dermatitis
    D Y Leung
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 104:S99-108. 1999
  8. ncbi request reprint Molecular basis of allergic diseases
    D Y Leung
    Division of Pediatric Allergy and Immunology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Mol Genet Metab 63:157-67. 1998
  9. ncbi request reprint Report of the Topical Calcineurin Inhibitor Task Force of the American College of Allergy, Asthma and Immunology and the American Academy of Allergy, Asthma and Immunology
    Luz Fonacier
    Winthrop University Hospital, Mineola, MN, USA
    J Allergy Clin Immunol 115:1249-53. 2005
  10. ncbi request reprint Advances in atopic dermatitis
    Liang Shiou Ou
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chang Gung Med J 28:1-8. 2005

Research Grants

  1. THE ROLE OF BACTERIAL TOXINS IN HUMAN SKIN DISEASE
    Donald Leung; Fiscal Year: 2009
  2. MECHANISMS OF STEROID RESISTANT ASTHMA
    Donald Leung; Fiscal Year: 2007
  3. THE ROLE OF BACTERIAL TOXINS IN HUMAN SKIN DISEASE
    Donald Leung; Fiscal Year: 2007
  4. MECHANISMS OF STEROID RESISTANT ASTHMA
    Donald Leung; Fiscal Year: 2009
  5. THE ROLE OF BACTERIAL TOXINS IN HUMAN SKIN DISEASE
    Donald Leung; Fiscal Year: 2004
  6. The Role of bacterial toxins in human skin disease.
    DONALD YM contact LEUNG; Fiscal Year: 2010
  7. ROLE OF BACTERIAL TOXINS IN HUMAN SKIN DISEASES
    Donald Leung; Fiscal Year: 1993
  8. ROLE OF BACTERIAL TOXINS IN HUMAN SKIN DISEASE
    Donald Leung; Fiscal Year: 1999
  9. IMMUNOMODULATION OF VACCINIA-INDUCED ANTIMICROBIAL PEPT*
    Donald Leung; Fiscal Year: 2005
  10. MECHANISMS OF STEROID RESISTANT ASTHMA
    DONALD YM LEUNG; Fiscal Year: 2010

Detail Information

Publications66

  1. pmc High constitutive glucocorticoid receptor beta in human neutrophils enables them to reduce their spontaneous rate of cell death in response to corticosteroids
    I Strickland
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, Denver, Colorado 80206, USA
    J Exp Med 193:585-93. 2001
    ..Moreover, upregulation of this GR by proinflammatory cytokines such as IL-8 further enhances their survival in the presence of glucocorticoids during inflammation...
  2. pmc Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta
    D Y Leung
    Division of Allergy Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Exp Med 186:1567-74. 1997
    ..We conclude that increased expression of GCR-beta is cytokine inducible and may account for GC insensitivity in this common inflammatory condition...
  3. ncbi request reprint New concepts in the pathogenesis of atopic dermatitis
    Donald Y M Leung
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, Denver, CO, USA
    Curr Opin Immunol 15:634-8. 2003
    ..An increased prevalence of atopic dermatitis has generated increased interest and research into each of these areas, and new treatment strategies are being developed based upon an increased understanding of these issues...
  4. ncbi request reprint Infection in atopic dermatitis
    Donald Y M Leung
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Curr Opin Pediatr 15:399-404. 2003
    ..This skin disease is often triggered by bacterial, fungal, or viral skin infections. The mechanisms resulting in this increased propensity for skin infections have been an area of active investigation...
  5. pmc New insights into atopic dermatitis
    Donald Y M Leung
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    J Clin Invest 113:651-7. 2004
    ..This review summarizes recent progress in our understanding of the pathophysiology of atopic dermatitis and the implications for new management strategies...
  6. ncbi request reprint Atopic dermatitis
    Donald Y M Leung
    Division of Pediatric Allergy and Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Lancet 361:151-60. 2003
    ..New management approaches have evolved from advances in our understanding of the pathobiology of this common skin disorder...
  7. ncbi request reprint Pathogenesis of atopic dermatitis
    D Y Leung
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 104:S99-108. 1999
    ....
  8. ncbi request reprint Molecular basis of allergic diseases
    D Y Leung
    Division of Pediatric Allergy and Immunology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Mol Genet Metab 63:157-67. 1998
    ..The identification of key cells and molecules involved in the initiation and maintenance of allergic inflammation is likely to become an important target in the treatment of this common group of illnesses...
  9. ncbi request reprint Report of the Topical Calcineurin Inhibitor Task Force of the American College of Allergy, Asthma and Immunology and the American Academy of Allergy, Asthma and Immunology
    Luz Fonacier
    Winthrop University Hospital, Mineola, MN, USA
    J Allergy Clin Immunol 115:1249-53. 2005
  10. ncbi request reprint Advances in atopic dermatitis
    Liang Shiou Ou
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chang Gung Med J 28:1-8. 2005
    ..The introduction of a new class of topical anti-inflammatory medications, topical calcineurin inhibitors, has significantly increased our treatment options and led to the rethinking of potential management approaches in AD...
  11. ncbi request reprint Racial differences in T-lymphocyte response to glucocorticoids
    Monica J Federico
    National Jewish Medical and Research Center, 1400 Jackson St J316, Denver, CO 80206, USA
    Chest 127:571-8. 2005
    ..Asthma morbidity and mortality is increased in blacks...
  12. ncbi request reprint Disease management of atopic dermatitis: an updated practice parameter. Joint Task Force on Practice Parameters
    Donald Y M Leung
    Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, Colorado, USA
    Ann Allergy Asthma Immunol 93:S1-21. 2004
  13. ncbi request reprint Effect of pimecrolimus cream 1% on skin condition and sleep disturbance in children with atopic dermatitis
    Harvey L Leo
    J Allergy Clin Immunol 114:691-3. 2004
  14. pmc Cytokine modulation of atopic dermatitis filaggrin skin expression
    Michael D Howell
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 120:150-5. 2007
    ..Atopic dermatitis (AD) is a chronic inflammatory skin disease that is characterized by a defective skin barrier function. Recent studies have reported mutations of the skin barrier gene encoding filaggrin in a subset of patients with AD...
  15. ncbi request reprint Sleep disorders in patients with asthma, atopic dermatitis, and allergic rhinitis
    Bruce G Bender
    J Allergy Clin Immunol 116:1200-1. 2005
  16. pmc Increased glucocorticoid receptor beta alters steroid response in glucocorticoid-insensitive asthma
    Elena Goleva
    Department of Pediatrics, National Jewish Medical Research Center, 1400 Jackson Street, Room K926i, Denver, CO 80206, USA
    Am J Respir Crit Care Med 173:607-16. 2006
    ..Glucocorticoids (GCs) are highly effective in the treatment of asthma. However, some individuals have GC-insensitive asthma...
  17. doi request reprint Corticosteroid-resistant asthma is associated with classical antimicrobial activation of airway macrophages
    Elena Goleva
    Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 122:550-9.e3. 2008
    ..The cause of corticosteroid-resistant (CR) asthma is unknown...
  18. ncbi request reprint Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, Davos
    J Allergy Clin Immunol 118:152-69. 2006
    ..The consensus report is part of the PRACTALL initiative, which is endorsed by both academies...
  19. ncbi request reprint Atopic dermatitis
    Mark Boguniewicz
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Allergy Clin Immunol 118:40-3. 2006
  20. ncbi request reprint Immune dysregulation in atopic dermatitis
    Peck Y Ong
    National Jewish Medical and Research Center, Department of Pediatrics, Room K926i, 1400 Jackson Street, Denver, Colorado 80206, USA
    Curr Allergy Asthma Rep 6:384-9. 2006
    ..Understanding these pathomechanisms may improve our current therapies for atopic dermatitis...
  21. ncbi request reprint Role of bacterial superantigens in atopic dermatitis : implications for future therapeutic strategies
    Ivan D Cardona
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Am J Clin Dermatol 7:273-9. 2006
    ....
  22. ncbi request reprint Cytokines and chemokines orchestrate atopic skin inflammation
    Bernhard Homey
    Department of Dermatology, Heinrich Heine University, Moorenstrasse 5, Dusseldorf 40225, Germany
    J Allergy Clin Immunol 118:178-89. 2006
    ..In this review we summarize advances in our understanding of the complex interdependent network of members of the rapidly growing protein superfamilies of cytokines and chemokines that lead to the development of AD...
  23. ncbi request reprint IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis
    Janine Bilsborough
    Department of Autoimmunity and Inflammation, ZymoGenetics, Inc, Seattle, WA 98102, USA
    J Allergy Clin Immunol 117:418-25. 2006
    ..IL-31 is a newly discovered T-cell cytokine that, when overexpressed in mice, results in pruritus and skin dermatitis resembling human atopic dermatitis (AD)...
  24. ncbi request reprint 10. Atopic dermatitis
    Mark Boguniewicz
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Rm J310, Denver, CO 80206, USA
    J Allergy Clin Immunol 117:S475-80. 2006
    ..New treatment approaches include use of topical steroids as maintenance therapy and use of topical calcineurin inhibitors for early intervention with topical steroids used as rescue therapy...
  25. ncbi request reprint T regulatory cells in atopic dermatitis and subversion of their activity by superantigens
    Liang Shiou Ou
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Allergy Clin Immunol 113:756-63. 2004
    ..CD4+CD25+ T regulatory (Treg) cells are thought to play an important role in controlling inflammatory responses...
  26. ncbi request reprint Divergent expression and function of glucocorticoid receptor beta in human monocytes and T cells
    Ling Bo Li
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Room K926i, Denver, CO 80206, USA
    J Leukoc Biol 79:818-27. 2006
    ..Our data suggest that GCRbeta contributes to variation in the GC responses of monocytes versus T cells...
  27. ncbi request reprint Endogenous antimicrobial peptides and skin infections in atopic dermatitis
    Peck Y Ong
    Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    N Engl J Med 347:1151-60. 2002
    ..We compared the levels of expression of LL-37 and human beta-defensin 2 (HBD-2) in inflamed skin from patients with atopic dermatitis and from those with psoriasis...
  28. ncbi request reprint Decreased IL-15 may contribute to elevated IgE and acute inflammation in atopic dermatitis
    Peck Y Ong
    Division of Allergy and Immunology, Department of Pediatrics, The National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 168:505-10. 2002
    ..In addition, IL-15 was found to suppress IgE synthesis (p < 0.01) by the PBMC of AD patients. These data support the concept that reduced IL-15 expression may contribute to the pathogenesis of AD...
  29. pmc Body mass and glucocorticoid response in asthma
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, J 220 Denver, CO 80206, USA
    Am J Respir Crit Care Med 178:682-7. 2008
    ..Obesity may alter glucocorticoid response in asthma...
  30. ncbi request reprint Adrenomedullin is highly expressed in blood monocytes associated with acute Kawasaki disease: a microarray gene expression study
    Ichiro Nomura
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Pediatr Res 57:49-55. 2005
    ..Our current study suggests that ADM-expressing monocytes that infiltrate the coronary vascular wall may be the cause of coronary dilation in the acute phase of KD...
  31. ncbi request reprint Atopic dermatitis and asthma: parallels in the evolution of treatment
    Lawrence F Eichenfield
    Pediatric and Adolescent Dermatology, Children s Hospital, San Diego, CA 92123, USA
    Pediatrics 111:608-16. 2003
    ....
  32. ncbi request reprint Advances in allergic skin diseases
    Donald Y M Leung
    Division of Pediatric Allergy and Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 111:S805-12. 2003
    ..The introduction of a new class of topical anti-inflammatory medications, topical calcineurin inhibitors, has significantly increased our treatment options and led to a rethinking of potential management approaches in atopic dermatitis...
  33. ncbi request reprint Actigraphy assessment of sleep disturbance in patients with atopic dermatitis: an objective life quality measure
    Bruce G Bender
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, Denver, Colo 80206, USA
    J Allergy Clin Immunol 111:598-602. 2003
    ....
  34. doi request reprint Disease severity, scratching, and sleep quality in patients with atopic dermatitis
    Bruce G Bender
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Am Acad Dermatol 58:415-20. 2008
    ..The relationship between sleep quality and disease severity in patients with atopic dermatitis has not been clearly defined...
  35. pmc Airway remodeling and lack of bronchodilator response in steroid-resistant asthma
    Elena Goleva
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 802060, USA
    J Allergy Clin Immunol 120:1065-72. 2007
    ..Steroid-resistant (SR) asthma is characterized by airway inflammation that fails to resolve despite treatment with corticosteroids, raising concerns that resistance to steroid therapy in asthma could lead to airway remodeling...
  36. ncbi request reprint Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes
    Ichiro Nomura
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 171:3262-9. 2003
    ..These observations could explain the increased susceptibility of AD skin to microorganisms, and suggest a new fundamental rule that may explain the mechanism for frequent infection in other Th2 cytokine-mediated diseases...
  37. ncbi request reprint Preface to atopic dermatitis intervention to control the atopic march
    Donald Y M Leung
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Allergy Clin Immunol 112:S117. 2003
  38. ncbi request reprint Immune mechanisms leading to atopic dermatitis
    Natalija Novak
    Department of Dermatology, University of Bonn, Bonn, Germany
    J Allergy Clin Immunol 112:S128-39. 2003
    ..The current review will examine recent advances that have been made in our understanding of the genetic and pathophysiologic prerequisites that form the basis of this common recalcitrant skin disorder...
  39. ncbi request reprint The black box warning for topical calcineurin inhibitors: looking outside the box
    Luz Fonacier
    Winthrop University Hospital, State University of New York, Stony Brook School of Medicine, New York, USA
    Ann Allergy Asthma Immunol 97:117-20. 2006
  40. ncbi request reprint Risk assessment in anaphylaxis: current and future approaches
    F Estelle R Simons
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada, and Department of Respiratory Medicine, Brighton General Hospital, Belfast, UK
    J Allergy Clin Immunol 120:S2-24. 2007
    ....
  41. pmc ATF2 impairs glucocorticoid receptor-mediated transactivation in human CD8+ T cells
    Ling Bo Li
    Divisions of Pediatric Allergy and Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Blood 110:1570-7. 2007
    ..The data indicate refractory steroid-induced transactivation but similar steroid-induced transrepression of CD8(+) cells compared with CD4(+) cells caused by decreased levels of the histone acetyltransferase ATF2...
  42. ncbi request reprint The role of allergens in asthma
    Thomas Platts-Mills
    Asthma and Allergic Diseases Center, University of Virginia, Charlottesville, USA
    Am Fam Physician 76:675-80. 2007
    ..Information on sensitization can be used to educate patients about the role of allergens in their symptoms, to provide avoidance advice, or to design immunotherapy...
  43. pmc Superantigen profile of Staphylococcus aureus isolates from patients with steroid-resistant atopic dermatitis
    Patrick M Schlievert
    Department of Microbiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Clin Infect Dis 46:1562-7. 2008
    ..T cells activated in vitro by superantigens become steroid resistant. The objective was to assess the superantigen profiles of S. aureus isolates from patients with steroid-resistant atopic dermatitis...
  44. ncbi request reprint Risk factors of atopic dermatitis patients for eczema herpeticum
    Wenming M Peng
    J Invest Dermatol 127:1261-3. 2007
  45. doi request reprint Th2 cytokines act on S100/A11 to downregulate keratinocyte differentiation
    Michael D Howell
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Invest Dermatol 128:2248-58. 2008
    ..S100/A11 and p21 gene expression was also found to be significantly lower in acute and chronic AD skin. This study demonstrates an important role for S100/A11 and p21 in regulating skin barrier integrity and the innate immune response...
  46. pmc Macrophage inflammatory protein 3alpha deficiency in atopic dermatitis skin and role in innate immune response to vaccinia virus
    Byung Eui Kim
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 119:457-63. 2007
    ..Macrophage inflammatory protein 3alpha (MIP-3alpha) is a C-C chemokine expressed by keratinocytes that exhibits antimicrobial activity against bacteria and fungi; however, its role in antiviral innate immunity is unknown...
  47. pmc Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6
    Byung Eui Kim
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Clin Immunol 126:332-7. 2008
    ..This study suggests that Th2 cytokines inhibit expression of LOR and IVL through a STAT-6 dependent mechanism...
  48. ncbi request reprint Mechanism of HBD-3 deficiency in atopic dermatitis
    Michael D Howell
    Division of Allergy and Immunology, Department of Pediatrics, The National Jewish Medical and Research Center, Room K926, 1400 Jackson Street, Denver, CO 80206, USA
    Clin Immunol 121:332-8. 2006
    ..These studies suggest that neutralizing the Th2 cytokine milieu in AD skin may augment the innate immune response against bacterial and viral pathogens...
  49. ncbi request reprint Safety of topical calcineurin inhibitors in atopic dermatitis: evaluation of the evidence
    Jonathan M Spergel
    Curr Allergy Asthma Rep 6:270-4. 2006
    ..To date, studies from clinical trials, systemic absorption, and post-marketing surveillance show no evidence for this systemic immunosuppression or increased risk for any malignancy...
  50. ncbi request reprint Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects
    Scott H Sicherer
    The Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 118:170-7. 2006
    ..Progress in our understanding of the immunology of atopic dermatitis and autoimmune urticaria has also been made. These observations will likely contribute toward optimizing management of these common allergic disorders...
  51. ncbi request reprint A role for STAT5 in the pathogenesis of IL-2-induced glucocorticoid resistance
    Elena Goleva
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Immunol 169:5934-40. 2002
    ..This study demonstrates a novel role for STAT5 in IL-2-induced steroid insensitivity...
  52. ncbi request reprint The chemokine receptor CCR6 identifies interferon-gamma expressing T cells and is decreased in atopic dermatitis as compared with psoriasis
    Peck Y Ong
    J Invest Dermatol 119:1463-4. 2002
  53. ncbi request reprint Effect of anti-IgE therapy in patients with peanut allergy
    Donald Y M Leung
    National Jewish Medical and Research Center, Denver, USA
    N Engl J Med 348:986-93. 2003
    ..TNX-901 is a humanized IgG1 monoclonal antibody against IgE that recognizes and masks an epitope in the CH3 region of IgE responsible for binding to the high-affinity Fc(epsilon) receptor on mast cells and basophils...
  54. pmc Characterization of Staphylococcus aureus enterotoxin L
    Paul M Orwin
    Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Infect Immun 71:2916-9. 2003
    ..T cells bearing the T-cell receptor beta chain variable regions 5.1, 5.2, 6.7, 16, and 22 were significantly stimulated by recombinant SEL...
  55. ncbi request reprint Polarized in vivo expression of IL-11 and IL-17 between acute and chronic skin lesions
    Masao Toda
    Meakins Christie Laboratories, McGill University, Montreal, Canada
    J Allergy Clin Immunol 111:875-81. 2003
    ..Several remodeling-associated cytokines, including transforming growth factor (TGF) beta1, IL-11, and IL-17, have been shown to be increased in allergic diseases, including asthma...
  56. ncbi request reprint Progress in peanut allergy research: are we closer to a cure?
    Donald Y M Leung
    J Allergy Clin Immunol 112:12-4. 2003
  57. ncbi request reprint Distinct patterns of gene expression in the skin lesions of atopic dermatitis and psoriasis: a gene microarray analysis
    Ichiro Nomura
    Department Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 112:1195-202. 2003
    ..DNA microarray studies allow the simultaneous comparison of thousands of messenger RNAs that may identify the disease-specific pattern of tissue inflammatory responses...
  58. ncbi request reprint Microbial superantigens induce glucocorticoid receptor beta and steroid resistance in a nasal explant model
    Samer Fakhri
    Department of Otolaryngology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Laryngoscope 114:887-92. 2004
    ..To study the role of superantigen (SAg) in inducing glucocorticoid (GC) receptor beta and steroid resistance in an explant model of nasal tissue...
  59. ncbi request reprint CD56+ cells induce steroid resistance in B cells exposed to IL-15
    Qing Xu
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 172:7110-5. 2004
    ..This study demonstrates that B cells develop steroid resistance in the presence of CD56(+) cells after IL-15 stimulation. Furthermore, IL-15 and IL-4 have the capacity to induce B cell insensitivity to steroids...
  60. ncbi request reprint Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insect stings
    Scott H Sicherer
    Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 114:118-24. 2004
    ..Lastly, there are new recommendations for patients with convincing insect sting reaction histories but negative skin test responses to venom...
  61. ncbi request reprint Differential control of TH1 versus TH2 cell responses by the combination of low-dose steroids with beta2-adrenergic agonists
    Elena Goleva
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO, 80206, USA
    J Allergy Clin Immunol 114:183-91. 2004
    ..Combination treatment with steroids and long-acting beta2-agonists provides greater asthma control than simply increasing the dose of steroids...
  62. pmc Characterization of two novel pyrogenic toxin superantigens made by an acute rheumatic fever clone of Streptococcus pyogenes associated with multiple disease outbreaks
    Laura M Smoot
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Infect Immun 70:7095-104. 2002
    ..The data demonstrate that SpeL and SpeM are pyrogenic toxin superantigens and suggest that they may participate in the host-pathogen interactions in some ARF patients...
  63. ncbi request reprint New approaches for the treatment of anaphylaxis
    Donald Y M Leung
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Novartis Found Symp 257:248-60; discussion 260-4, 276-85. 2004
    ..These studies suggest that treatment of patients with anti-IgE therapy may represent an effective long-term approach for management of food-induced anaphylaxis...
  64. ncbi request reprint Staphylococcal enterotoxin B inhibits regulatory T cells by inducing glucocorticoid-induced TNF receptor-related protein ligand on monocytes
    Ivan D Cardona
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 117:688-95. 2006
    ..Superantigens inhibit naturally occurring CD4+CD25+ regulatory T-cell (nTreg) activity, yet the mechanism for this is unknown...
  65. ncbi request reprint Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus
    Michael D Howell
    Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    Immunity 24:341-8. 2006
    ..The current study demonstrates that Th2 cytokines enhance VV replication in AD skin by subverting the innate immune response against VV in a STAT-6-dependent manner...
  66. ncbi request reprint Atopic dermatitis
    Peck Y Ong
    National Jewish Medical and Research Center, Denver, Colorado, USA
    Clin Allergy Immunol 16:355-79. 2002

Research Grants27

  1. THE ROLE OF BACTERIAL TOXINS IN HUMAN SKIN DISEASE
    Donald Leung; Fiscal Year: 2009
    ..aureus amplifies AD skin inflammation. These studies are likely to identify novel therapeutic approaches in the control of S. aureus infection and modulation of T regulatory cell activity. ..
  2. MECHANISMS OF STEROID RESISTANT ASTHMA
    Donald Leung; Fiscal Year: 2007
    ....
  3. THE ROLE OF BACTERIAL TOXINS IN HUMAN SKIN DISEASE
    Donald Leung; Fiscal Year: 2007
    ..aureus amplifies AD skin inflammation. These studies are likely to identify novel therapeutic approaches in the control of S. aureus infection and modulation of T regulatory cell activity. ..
  4. MECHANISMS OF STEROID RESISTANT ASTHMA
    Donald Leung; Fiscal Year: 2009
    ....
  5. THE ROLE OF BACTERIAL TOXINS IN HUMAN SKIN DISEASE
    Donald Leung; Fiscal Year: 2004
    ..With the increased prevalence of antibiotic resistant S. aureus and drug allergy, it is essential to develop new non-antibiotic strategies in combating bacterial toxin-mediated skin diseases. ..
  6. The Role of bacterial toxins in human skin disease.
    DONALD YM contact LEUNG; Fiscal Year: 2010
    ..Data from this grant may lead to more effective treatment strategies for this serious public health issue. ..
  7. ROLE OF BACTERIAL TOXINS IN HUMAN SKIN DISEASES
    Donald Leung; Fiscal Year: 1993
    ..In particular, identification of the T cells that react to S. aureus infection in AD or psoriasis, may allow us to more readily diagnose and treat those patients whose skin disease are flared by bacterial infection...
  8. ROLE OF BACTERIAL TOXINS IN HUMAN SKIN DISEASE
    Donald Leung; Fiscal Year: 1999
    ..In particular, identification of the T cells that react to S. aureus infection in AD or psoriasis, may allow us to more readily diagnose and treat those patients whose skin disease are flared by bacterial infection. ..
  9. IMMUNOMODULATION OF VACCINIA-INDUCED ANTIMICROBIAL PEPT*
    Donald Leung; Fiscal Year: 2005
    ..abstract_text> ..
  10. MECHANISMS OF STEROID RESISTANT ASTHMA
    DONALD YM LEUNG; Fiscal Year: 2010
    ....