Olivier Lespinet

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Characterisation of two snail genes in the gastropod mollusc Patella vulgata. Implications for understanding the ancestral function of the snail-related genes in Bilateria
    Olivier Lespinet
    Centre de Genetique Moleculaire, CNRS UPR 2167, 91198 Gif sur Yvette, France
    Dev Genes Evol 212:186-95. 2002
  2. ncbi request reprint Expression pattern of Brachyury in the mollusc Patella vulgata suggests a conserved role in the establishment of the AP axis in Bilateria
    Nicolas Lartillot
    Centre de Genetique Moleculaire, CNRS batiment 26, 1 Avenue de la Terrasse, F 91198 Gif sur Yvette, France
    Development 129:1411-21. 2002
  3. pmc The role of lineage-specific gene family expansion in the evolution of eukaryotes
    Olivier Lespinet
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
    Genome Res 12:1048-59. 2002
  4. ncbi request reprint A lophotrochozoan twist gene is expressed in the ectomesoderm of the gastropod mollusk Patella vulgata
    Alexander J Nederbragt
    Department of Developmental Biology, Utrecht University, The Netherlands
    Evol Dev 4:334-43. 2002
  5. ncbi request reprint Orphan enzymes could be an unexplored reservoir of new drug targets
    Olivier Lespinet
    Institut de Genetique et Microbiologie, CNRS UMR 8621, Universite Paris Sud, Batiment 400, 91405 Orsay Cedex, France
    Drug Discov Today 11:300-5. 2006
  6. ncbi request reprint Interspecies and intraspecies comparison of microbial proteins: learning about gene ancestry, protein function, and species life style
    Bernard Labedan
    Evolution Moléculaire et Bioinformatique des Génomes, Institut de Genetique et Microbiologie, Universite Paris Sud, Orsay, France
    Methods Biochem Anal 49:415-36. 2006
  7. pmc ORENZA: a web resource for studying ORphan ENZyme activities
    Olivier Lespinet
    Institut de Genetique et Microbiologie, CNRS UMR 8621, Universite Paris Sud, Batiment 400, 91405 Orsay Cedex, France
    BMC Bioinformatics 7:436. 2006
  8. ncbi request reprint The multiple facets of homology and their use in comparative genomics to study the evolution of genes, genomes, and species
    Stéphane Descorps-Declère
    Institut de Genetique et Microbiologie, Batiment 400, Universite Paris Sud XI, 91405 Orsay Cedex, France
    Biochimie 90:595-608. 2008
  9. pmc Assessing the evolutionary rate of positional orthologous genes in prokaryotes using synteny data
    Frédéric Lemoine
    Institut de Genetique et Microbiologie, CNRS UMR 8621, Batiment 400, Universite Paris Sud XI, 91405 Orsay Cedex, France
    BMC Evol Biol 7:237. 2007

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Characterisation of two snail genes in the gastropod mollusc Patella vulgata. Implications for understanding the ancestral function of the snail-related genes in Bilateria
    Olivier Lespinet
    Centre de Genetique Moleculaire, CNRS UPR 2167, 91198 Gif sur Yvette, France
    Dev Genes Evol 212:186-95. 2002
    ..The results are discussed in the light of the evolutionary origin of the mesoderm. Electronic supplementary material to this paper can be obtained by using the Springer LINK server located at http://dx.doi.org/10.1007/s00427-002-0228-1...
  2. ncbi request reprint Expression pattern of Brachyury in the mollusc Patella vulgata suggests a conserved role in the establishment of the AP axis in Bilateria
    Nicolas Lartillot
    Centre de Genetique Moleculaire, CNRS batiment 26, 1 Avenue de la Terrasse, F 91198 Gif sur Yvette, France
    Development 129:1411-21. 2002
    ....
  3. pmc The role of lineage-specific gene family expansion in the evolution of eukaryotes
    Olivier Lespinet
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
    Genome Res 12:1048-59. 2002
    ..LSEs seem to be one of the principal means of adaptation and one of the most important sources of organizational and regulatory diversity in crown-group eukaryotes...
  4. ncbi request reprint A lophotrochozoan twist gene is expressed in the ectomesoderm of the gastropod mollusk Patella vulgata
    Alexander J Nederbragt
    Department of Developmental Biology, Utrecht University, The Netherlands
    Evol Dev 4:334-43. 2002
    ..It therefore remains a question if the mesoderm of all bilaterians is homologous...
  5. ncbi request reprint Orphan enzymes could be an unexplored reservoir of new drug targets
    Olivier Lespinet
    Institut de Genetique et Microbiologie, CNRS UMR 8621, Universite Paris Sud, Batiment 400, 91405 Orsay Cedex, France
    Drug Discov Today 11:300-5. 2006
    ..Strikingly, orphan enzymes can even be found among enzymatic activities successfully used as drug targets. Here, knowledge of sequence would help to develop molecular-targeted therapies, suppressing many drug-related side-effects...
  6. ncbi request reprint Interspecies and intraspecies comparison of microbial proteins: learning about gene ancestry, protein function, and species life style
    Bernard Labedan
    Evolution Moléculaire et Bioinformatique des Génomes, Institut de Genetique et Microbiologie, Universite Paris Sud, Orsay, France
    Methods Biochem Anal 49:415-36. 2006
  7. pmc ORENZA: a web resource for studying ORphan ENZyme activities
    Olivier Lespinet
    Institut de Genetique et Microbiologie, CNRS UMR 8621, Universite Paris Sud, Batiment 400, 91405 Orsay Cedex, France
    BMC Bioinformatics 7:436. 2006
    ..Thus, there is an urgent need to explore these sequence-less EC numbers, in order to progressively close this gap...
  8. ncbi request reprint The multiple facets of homology and their use in comparative genomics to study the evolution of genes, genomes, and species
    Stéphane Descorps-Declère
    Institut de Genetique et Microbiologie, Batiment 400, Universite Paris Sud XI, 91405 Orsay Cedex, France
    Biochimie 90:595-608. 2008
    ..Finally, we show how these homology studies are helpful to annotate genes and genomes and to study the complexity of the relationships between sequence and function of a gene...
  9. pmc Assessing the evolutionary rate of positional orthologous genes in prokaryotes using synteny data
    Frédéric Lemoine
    Institut de Genetique et Microbiologie, CNRS UMR 8621, Batiment 400, Universite Paris Sud XI, 91405 Orsay Cedex, France
    BMC Evol Biol 7:237. 2007
    ..This is a complex and difficult problem in the field of comparative genomics but will help to better understand the way prokaryotic genomes are evolving...