Michael J Lenardo
Affiliation: National Institutes of Health
Lenardo M, Lo B, Lucas C. Genomics of Immune Diseases and New Therapies. Annu Rev Immunol. 2016;34:121-49 pubmed publisher
Comrie W, Faruqi A, Price S, Zhang Y, Rao V, Su H, et al
. RELA haploinsufficiency in CD4 lymphoproliferative disease with autoimmune cytopenias. J Allergy Clin Immunol. 2018;141:1507-1510.e8 pubmed publisher
Chaigne Delalande B, Lenardo M. Divalent cation signaling in immune cells. Trends Immunol. 2014;35:332-44 pubmed publisher
..Developing a better understanding of these signaling cations may lead to new therapeutic strategies for immune disorders. ..
Lucas C, Zhang Y, Venida A, Wang Y, Hughes J, McElwee J, et al
. Heterozygous splice mutation in PIK3R1 causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3K. J Exp Med. 2014;211:2537-47 pubmed publisher
Lucas C, Lenardo M. Identifying genetic determinants of autoimmunity and immune dysregulation. Curr Opin Immunol. 2015;37:28-33 pubmed publisher
..Mendelian disease mutations, as experiments of nature, reveal human loci that are indispensable for immune regulation and, therefore, most promising as therapeutic targets. ..
GrÃ¶nholm J, Lenardo M. Novel diagnostic and therapeutic approaches for autoimmune diabetes--a prime time to treat insulitis as a disease. Clin Immunol. 2015;156:109-18 pubmed publisher
..Here, we outline diagnostic and therapeutic strategies to overcome pancreatic Î²-cell destroying insulitis. ..
Zhang Q, Lenardo M, Baltimore D. 30 Years of NF-ÎºB: A Blossoming of Relevance to Human Pathobiology. Cell. 2017;168:37-57 pubmed publisher
..Here, we summarize elaborate regulatory pathways involving this transcription factor and use recent discoveries in human genetic diseases to place specific proteins within their relevant medical and biological contexts. ..
Majri S, Fritz J, Villarino A, Zheng L, Kanellopoulou C, Chaigne Delalande B, et al
. STAT5B: A Differential Regulator of the Life and Death of CD4+ Effector Memory T Cells. J Immunol. 2018;200:110-118 pubmed publisher
..Hence, STAT5B is a crucial regulator of RICD in memory T cells in mice and humans. ..
Wang J, Lenardo M. Roles of caspases in apoptosis, development, and cytokine maturation revealed by homozygous gene deficiencies. J Cell Sci. 2000;113 ( Pt 5):753-7 pubmed
..These studies suggest that caspases function in cell signaling events including apoptosis, cell growth and differentiation. ..