Fabian Leinisch

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Investigation of spin-trapping artifacts formed by the Forrester-Hepburn mechanism
    Fabian Leinisch
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA Electronic address
    Free Radic Biol Med 65:1497-505. 2013
  2. pmc Simplified synthesis of isotopically labeled 5,5-dimethyl-pyrroline N-oxide
    Fabian Leinisch
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Molecules 16:8428-36. 2011
  3. pmc Evaluation of the Forrester-Hepburn mechanism as an artifact source in ESR spin-trapping
    Fabian Leinisch
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, North Carolina 27709, USA
    Chem Res Toxicol 24:2217-26. 2011
  4. ncbi request reprint DNA cleavage and detection of DNA radicals formed from hydralazine and copper (II) by ESR and immuno-spin trapping
    Birandra K Sinha
    Laboratory of Toxicology and Pharmacology, National Institutes of Environmental Health Sciences, Research Triangle Park, North Carolina, United States
    Chem Res Toxicol 27:674-82. 2014
  5. doi request reprint Catalase has a key role in protecting cells from the genotoxic effects of monomethylarsonous acid: a highly active metabolite of arsenic
    Jorge G Muñiz Ortiz
    Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Mol Mutagen 54:317-26. 2013

Collaborators

Detail Information

Publications5

  1. pmc Investigation of spin-trapping artifacts formed by the Forrester-Hepburn mechanism
    Fabian Leinisch
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA Electronic address
    Free Radic Biol Med 65:1497-505. 2013
    ..We investigated the known ene reaction of DBNBS and tryptophan in more detail. We found that a strong artifact signal is induced by light; however, with atypically long incubations, we found that the artifact is also formed thermally. ..
  2. pmc Simplified synthesis of isotopically labeled 5,5-dimethyl-pyrroline N-oxide
    Fabian Leinisch
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Molecules 16:8428-36. 2011
    ..This facile, straightforward process allows synthesizing isotopically labeled DMPO analogs in a 4-step reaction without special equipment...
  3. pmc Evaluation of the Forrester-Hepburn mechanism as an artifact source in ESR spin-trapping
    Fabian Leinisch
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, North Carolina 27709, USA
    Chem Res Toxicol 24:2217-26. 2011
    ....
  4. ncbi request reprint DNA cleavage and detection of DNA radicals formed from hydralazine and copper (II) by ESR and immuno-spin trapping
    Birandra K Sinha
    Laboratory of Toxicology and Pharmacology, National Institutes of Environmental Health Sciences, Research Triangle Park, North Carolina, United States
    Chem Res Toxicol 27:674-82. 2014
    ..Our results suggest that free hydroxyl radicals may not be the main damaging species causing DNA cleavage and that possibly Cu-peroxide complexes, formed from Cu(+)-H2O2, are responsible for this hydralazine-Cu(2+)-induced DNA cleavage...
  5. doi request reprint Catalase has a key role in protecting cells from the genotoxic effects of monomethylarsonous acid: a highly active metabolite of arsenic
    Jorge G Muñiz Ortiz
    Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Mol Mutagen 54:317-26. 2013
    ..These experiments suggest that CAT is involved in protecting cells against the genotoxic effects of the ·OH generated by MMA(III) ...