Ellen Leibenluft

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Irritability in pediatric mania and other childhood psychopathology
    Ellen Leibenluft
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health DHHS, 10 Center Drive, Room 4N 208, MSC 1255, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 1008:201-18. 2003
  2. pmc Pediatric bipolar disorder comes of age
    Ellen Leibenluft
    Section on Bipolar Spectrum Disorders, Emotion and Development Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 65:1122-4. 2008
  3. ncbi Defining clinical phenotypes of juvenile mania
    Ellen Leibenluft
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1255, USA
    Am J Psychiatry 160:430-7. 2003
  4. ncbi Chronic versus episodic irritability in youth: a community-based, longitudinal study of clinical and diagnostic associations
    Ellen Leibenluft
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    J Child Adolesc Psychopharmacol 16:456-66. 2006
  5. ncbi Mothers' neural activation in response to pictures of their children and other children
    Ellen Leibenluft
    Pediatrics and Developmental Neuropsychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Biol Psychiatry 56:225-32. 2004
  6. ncbi Neural circuitry engaged during unsuccessful motor inhibition in pediatric bipolar disorder
    Ellen Leibenluft
    Emotion and Development Branch, Mood and Anxiety Disorders Program, NIMH, NIH, Health and Human Services, Bldg 15k, MSC 2670, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 164:52-60. 2007
  7. pmc Severe mood dysregulation, irritability, and the diagnostic boundaries of bipolar disorder in youths
    Ellen Leibenluft
    Section on Bipolar Spectrum Disorders, Emotion and Development Branch, NIMH, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 168:129-42. 2011
  8. ncbi Pediatric bipolar disorder
    Ellen Leibenluft
    Section on Bipolar Spectrum Disorders, Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda MD, USA
    Annu Rev Clin Psychol 4:163-87. 2008
  9. ncbi Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder
    Erin B McClure
    Emotional Development and Affective Neuroscience Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH DHHS, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:97-106. 2007
  10. ncbi Brain systems underlying response flexibility in healthy and bipolar adolescents: an event-related fMRI study
    Eric E Nelson
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Building 106 C, 5413 W Cedar Lane, Bethesda, MD 20892, USA
    Bipolar Disord 9:810-9. 2007

Collaborators

Detail Information

Publications92

  1. ncbi Irritability in pediatric mania and other childhood psychopathology
    Ellen Leibenluft
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health DHHS, 10 Center Drive, Room 4N 208, MSC 1255, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 1008:201-18. 2003
    ..Examples of such paradigms are described, and the pharmacology of irritability is reviewed briefly...
  2. pmc Pediatric bipolar disorder comes of age
    Ellen Leibenluft
    Section on Bipolar Spectrum Disorders, Emotion and Development Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 65:1122-4. 2008
  3. ncbi Defining clinical phenotypes of juvenile mania
    Ellen Leibenluft
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1255, USA
    Am J Psychiatry 160:430-7. 2003
    ..The authors suggest criteria for a range of narrow to broad phenotypes of bipolar disorder in children, differentiated according to the characteristics of the manic or hypomanic episodes, and present methods for validation of the criteria...
  4. ncbi Chronic versus episodic irritability in youth: a community-based, longitudinal study of clinical and diagnostic associations
    Ellen Leibenluft
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    J Child Adolesc Psychopharmacol 16:456-66. 2006
    ..In psychiatric nosology, a distinction is made between chronic and episodic irritability. This study examines the validity of this distinction...
  5. ncbi Mothers' neural activation in response to pictures of their children and other children
    Ellen Leibenluft
    Pediatrics and Developmental Neuropsychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Biol Psychiatry 56:225-32. 2004
    ..Considerable literature has focused on neural responses evoked by face viewing. We extend that literature and explore the neural correlates of maternal attachment with an fMRI study in which mothers view photographs of their own children...
  6. ncbi Neural circuitry engaged during unsuccessful motor inhibition in pediatric bipolar disorder
    Ellen Leibenluft
    Emotion and Development Branch, Mood and Anxiety Disorders Program, NIMH, NIH, Health and Human Services, Bldg 15k, MSC 2670, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 164:52-60. 2007
    ..They also compared activation in medicated versus unmedicated children with bipolar disorder and in children with bipolar disorder and attention deficit hyperactivity disorder (ADHD) versus those with bipolar disorder without ADHD...
  7. pmc Severe mood dysregulation, irritability, and the diagnostic boundaries of bipolar disorder in youths
    Ellen Leibenluft
    Section on Bipolar Spectrum Disorders, Emotion and Development Branch, NIMH, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 168:129-42. 2011
    ..No specific treatment for severe mood dysregulation currently exists, but verification of its identity as a syndrome distinct from bipolar disorder by further research should include treatment trials...
  8. ncbi Pediatric bipolar disorder
    Ellen Leibenluft
    Section on Bipolar Spectrum Disorders, Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda MD, USA
    Annu Rev Clin Psychol 4:163-87. 2008
    ..Throughout the review, we pay particular attention to youths with severe chronic irritability, hyperarousal, and hyperreactivity, who reflect the population in whom the diagnosis of BD is most debated...
  9. ncbi Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder
    Erin B McClure
    Emotional Development and Affective Neuroscience Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH DHHS, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:97-106. 2007
    ..However, in pediatric anxiety, no research has examined attention modulation of neural response to threat cues...
  10. ncbi Brain systems underlying response flexibility in healthy and bipolar adolescents: an event-related fMRI study
    Eric E Nelson
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Building 106 C, 5413 W Cedar Lane, Bethesda, MD 20892, USA
    Bipolar Disord 9:810-9. 2007
    ..The present study was undertaken to determine if neuronal responses differed between BD and control subjects on a simple motor response flexibility task...
  11. pmc Processing of differentially valued rewards and punishments in youths with bipolar disorder or severe mood dysregulation
    Geoff Rau
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1289, USA
    J Child Adolesc Psychopharmacol 18:185-96. 2008
    ..Therefore, we hypothesized that SMD, but not BD, youths would be impaired on a decision-making task that has identified reward- and punishment-processing deficits in individuals with psychopathy...
  12. ncbi Deficits in social cognition and response flexibility in pediatric bipolar disorder
    Erin B McClure
    Mood and Anxiety Disorders Program, NIMH, 15K North Dr, Room 102, MSC 2670, Bethesda, MD 20892, USA
    Am J Psychiatry 162:1644-51. 2005
    ..The purpose of this study was to test the hypothesis that youths with bipolar disorder would perform more poorly than matched healthy comparison subjects on measures of social cognition, motor inhibition, and response flexibility...
  13. pmc Neural activation during encoding of emotional faces in pediatric bipolar disorder
    Daniel P Dickstein
    Division of Intramural Research Program, National Institute of Mental Health, Pediatrics and Developmental Neuropsychiatry Branch, Bethesda, MD 20892 2670, USA
    Bipolar Disord 9:679-92. 2007
    ..To begin to address these limitations, the current study tests the hypothesis that pediatric BD (PBD) subjects exhibit altered neural activation during encoding of emotional faces compared to typically developing controls...
  14. ncbi Different psychophysiological and behavioral responses elicited by frustration in pediatric bipolar disorder and severe mood dysregulation
    Brendan A Rich
    Pediatrics and Developmental Neuropsychiatry Branch, Section on Development and Affective Neuroscience, NIMH Mood and Anxiety Program, Bethesda, MD 20892, USA
    Am J Psychiatry 164:309-17. 2007
    ..e., a history of at least one manic or hypomanic episode with euphoric mood) as well as those with no diagnosis (i.e., healthy comparison children)...
  15. pmc Amygdala activation during emotion processing of neutral faces in children with severe mood dysregulation versus ADHD or bipolar disorder
    Melissa A Brotman
    Emotion and Development Branch, Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Psychiatry 167:61-9. 2010
    ..The authors compared amygdala response during emotional and nonemotional ratings of neutral faces in youths with these disorders as well as a group of healthy comparison youths...
  16. doi Reduced amygdala response to fearful expressions in children and adolescents with callous-unemotional traits and disruptive behavior disorders
    Abigail A Marsh
    Mood and Anxiety Program, NIMH, 15K North Dr, MSC 2670, Bethesda, MD 20892, USA
    Am J Psychiatry 165:712-20. 2008
    ..Moreover, despite high comorbidity of callous-unemotional traits and attention deficit hyperactivity disorder (ADHD), no research has attempted to distinguish neural correlates of pediatric callous-unemotional traits and ADHD...
  17. ncbi Increased amygdala activity during successful memory encoding in adolescent major depressive disorder: An FMRI study
    Roxann Roberson-Nay
    Section on Development and Affective Neuroscience, National Institute of Mental Health Intramural Research Program, Bethesda, Maryland, USA
    Biol Psychiatry 60:966-73. 2006
    ..This study tests the hypothesis that adolescent MDD is associated with abnormal amygdala activity during evocative-face viewing...
  18. pmc Amygdala and ventrolateral prefrontal cortex function during anticipated peer evaluation in pediatric social anxiety
    Amanda E Guyer
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, 15K North Dr, Room 208, Bethesda, MD 20892 2670, USA
    Arch Gen Psychiatry 65:1303-12. 2008
    ..Such fear-circuitry dysfunction may also manifest when anticipated social evaluation leads socially anxious adolescents to misperceive peers as threatening...
  19. pmc A developmental examination of amygdala response to facial expressions
    Amanda E Guyer
    National Institutes of Health NIH, Bethesda, MD 20892 2670, USA
    J Cogn Neurosci 20:1565-82. 2008
    ....
  20. pmc Normative data on development of neural and behavioral mechanisms underlying attention orienting toward social-emotional stimuli: an exploratory study
    Kara M Lindstrom
    Mood and Anxiety Program, National Institutes of Mental Health, National Institute of Health, Bethesda, MD 20892 2670, USA
    Brain Res 1292:61-70. 2009
    ..Implications for future work on developmental changes in attention-emotion processing are discussed...
  21. doi Facial emotion labeling deficits in children and adolescents at risk for bipolar disorder
    Melissa A Brotman
    Mood and Anxiety Disorders Program, NIMH, NIH, Bethesda, MD 20892, USA
    Am J Psychiatry 165:385-9. 2008
    ....
  22. pmc Abnormal fusiform activation during emotional-face encoding assessed with functional magnetic resonance imaging
    Nancy E Adleman
    Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Psychiatry Res 212:161-3. 2013
    ..Fusiform activation abnormalities in BD were correlated with mania severity and may therefore represent a trait and state BD biomarker...
  23. pmc Attention bias of anxious youth during extended exposure of emotional face pairs: an eye-tracking study
    Tomer Shechner
    Section on Developmental Affective Neuroscience, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Depress Anxiety 30:14-21. 2013
    ..Using eye-tracking methodology, the current study measured attention biases in anxious and nonanxious youth, using unrestricted free viewing of angry, happy, and neutral faces...
  24. pmc A developmental study of the neural circuitry mediating motor inhibition in bipolar disorder
    Judah D Weathers
    Section on Bipolar Spectrum Disorders, Emotion and Development Branch, NIMH, Bethesda, MD, USA
    Am J Psychiatry 169:633-41. 2012
    ..The authors compared the neural circuitry mediating this process in bipolar youths relative to bipolar adults and in healthy volunteers...
  25. doi Affective prosody labeling in youths with bipolar disorder or severe mood dysregulation
    Christen M Deveney
    Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA
    J Child Psychol Psychiatry 53:262-70. 2012
    ..Little research focuses on the processing of emotional prosody, or tone of verbal speech, in clinical populations...
  26. pmc Neural recruitment during failed motor inhibition differentiates youths with bipolar disorder and severe mood dysregulation
    Christen M Deveney
    Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, 15K North Drive, MSC 2670, Bethesda, MD 20892 2670, USA
    Biol Psychol 89:148-55. 2012
    ..Exploratory analyses indicate that, in BD youths, reduced activation in the right ACC may be independent of comorbid ADHD. These findings highlight neural distinctions between the phenotypically related BD and SMD populations...
  27. pmc Neural connectivity in children with bipolar disorder: impairment in the face emotion processing circuit
    Brendan A Rich
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda 20892 2670, MD, USA
    J Child Psychol Psychiatry 49:88-96. 2008
    ....
  28. ncbi Experience-dependent plasticity for attention to threat: Behavioral and neurophysiological evidence in humans
    Christopher S Monk
    National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 56:607-10. 2004
    ..Examination of plasticity of attention bias with individuals at risk for anxiety disorders may reveal how threatening stimuli come to be categorized differently in this population over time...
  29. doi Proton magnetic resonance spectroscopy in youth with severe mood dysregulation
    Daniel P Dickstein
    Unit on Bipolar Spectrum Disorders, Division of Intramural Research Programs, National Institute of Mental Health, Bethesda, MD, USA
    Psychiatry Res 163:30-9. 2008
    ....
  30. pmc Striatal dysfunction during failed motor inhibition in children at risk for bipolar disorder
    Christen M Deveney
    Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD 20892 2670, USA
    Prog Neuropsychopharmacol Biol Psychiatry 38:127-33. 2012
    ..This study examined the neural correlates of motor inhibition in a sample of symptom-free youths at familial risk for BD...
  31. pmc Neural correlates of cognitive flexibility in children at risk for bipolar disorder
    Pilyoung Kim
    Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD 20892 2670, USA
    J Psychiatr Res 46:22-30. 2012
    ..Youth with bipolar disorder (BD) show behavioral and neural deficits in cognitive flexibility; however, whether such deficits exist among youths at risk for BD has not been explored...
  32. ncbi Using affect-modulated startle to study phenotypes of pediatric bipolar disorder
    Brendan A Rich
    Pediatrics and Developmental Neuropsychiatry Branch, Department of Health and Human Services, National Institutes of Health, Bethesda, MD 20892, USA
    Bipolar Disord 7:536-45. 2005
    ..The current study used affect-modulated startle to examine potential differences in reactivity to emotional stimuli (reward and punishment) in narrow and broad phenotype PBD and controls...
  33. ncbi Parental diagnoses in youth with narrow phenotype bipolar disorder or severe mood dysregulation
    Melissa A Brotman
    Emotion and Development Branch and the Genetic Basis of Mood and Anxiety Disorders Unit, Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Psychiatry 164:1238-41. 2007
    ..The authors compared axis I diagnoses in parents of children with narrow phenotype bipolar disorder and parents of youth with severe mood dysregulation...
  34. ncbi Comorbid anxiety in phenotypes of pediatric bipolar disorder
    Daniel P Dickstein
    Mood and Anxiety Disorders Program, Pediatrics and Developmental Neuropsychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892 1255, USA
    J Child Adolesc Psychopharmacol 15:534-48. 2005
    ..Adult BPD studies suggest comorbid anxiety disorders are common and impact treatment outcome. We explored the association of comorbid anxiety with two phenotypes of pediatric BPD...
  35. ncbi Attention bias to threat faces in children with bipolar disorder and comorbid lifetime anxiety disorders
    Melissa A Brotman
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Biol Psychiatry 61:819-21. 2007
    ..Although comorbid anxiety disorders are common in children with bipolar disorder (BD), it is unclear how this comorbidity impacts the pathophysiology of the illness...
  36. ncbi A developmental examination of gender differences in brain engagement during evaluation of threat
    Erin B McClure
    Section on Development and Affective Neuroscience, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 55:1047-55. 2004
    ..Recent theoretical models suggest that developmental changes in brain functioning play important roles in the emergence of such gender differences...
  37. ncbi Cognitive flexibility in phenotypes of pediatric bipolar disorder
    Daniel P Dickstein
    National Institute of Mental Health, Pediatrics and Developmental Neuropsychiatry Branch, 9000 Rockville Pike, MSC 2670 Building 15K Room 204, Bethesda MD 20892 2670, USA
    J Am Acad Child Adolesc Psychiatry 46:341-55. 2007
    ..6 +/- 2.4 years). Cognitive flexibility is relevant to symptoms of BD involving dysfunctional reward systems (e.g., excessive goal-directed activity and pleasure-seeking in mania; anhedonia in depression)...
  38. pmc Amygdala hyperactivation during face emotion processing in unaffected youth at risk for bipolar disorder
    Aviva K Olsavsky
    Section on Bipolar Spectrum Disorders, Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health NIH, US Department of Health and Human Services, Bethesda, Maryland, USA
    J Am Acad Child Adolesc Psychiatry 51:294-303. 2012
    ..e., those with a first-degree BD relative) will demonstrate amygdala hyperactivation when viewing fearful and happy faces. The at-risk youth were unaffected, in that they had no history of mood disorder...
  39. pmc Neural correlates of reversal learning in severe mood dysregulation and pediatric bipolar disorder
    Nancy E Adleman
    National Institute of Mental Health NIMH, National Institutes of Health NIH, Department of Health and Human Services, USA
    J Am Acad Child Adolesc Psychiatry 50:1173-1185.e2. 2011
    ..Functional magnetic resonance imaging was used to examine neural correlates of cognitive flexibility deficits in patients with SMD and BD versus healthy volunteers (HV)...
  40. pmc Risk for bipolar disorder is associated with face-processing deficits across emotions
    Melissa A Brotman
    National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    J Am Acad Child Adolesc Psychiatry 47:1455-61. 2008
    ..It is unclear whether this deficit in at-risk youths is present across all emotions or if the impairment presents initially as an emotion-specific dysfunction that then generalizes to other emotions as the symptoms of BD become manifest...
  41. pmc Face emotion labeling deficits in children with bipolar disorder and severe mood dysregulation
    Brendan A Rich
    National Institute of Mental Health, National Institutes of Health, Building 15K, Room 204, MSC2670, Bethesda, MD 20892 2670, USA
    Dev Psychopathol 20:529-46. 2008
    ..These deficits are associated with psychosocial impairments. Understanding the neural circuitry associated with face-labeling deficits has the potential to clarify the pathophysiology of these disorders...
  42. ncbi Specificity of facial expression labeling deficits in childhood psychopathology
    Amanda E Guyer
    Mood and Anxiety Program MAP, National Institute of Mental Health NIMH, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD, USA
    J Child Psychol Psychiatry 48:863-71. 2007
    ..We examined whether face-emotion labeling deficits are illness-specific or an epiphenomenon of generalized impairment in pediatric psychiatric disorders involving mood and behavioral dysregulation...
  43. pmc Abnormal ventromedial prefrontal cortex function in children with psychopathic traits during reversal learning
    Elizabeth C Finger
    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Arch Gen Psychiatry 65:586-94. 2008
    ....
  44. ncbi Autism spectrum traits in children with mood and anxiety disorders
    Kenneth E Towbin
    Mood and Anxiety Program, National Institute of Mental Health, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Child Adolesc Psychopharmacol 15:452-64. 2005
    ..These results demonstrate a need to develop valid and reliable instruments to screen for ASDs in children presenting outside of ASD clinics...
  45. ncbi Emotion recognition deficits in pediatric anxiety disorders: implications for amygdala research
    Josh Easter
    Section on Development and Affective Neuroscience, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland 20892 2670, USA
    J Child Adolesc Psychopharmacol 15:563-70. 2005
    ..This study examines the relationship between face-emotion recognition and anxiety in a sample of children and adolescents participating in a brain-imaging study of amygdala structure and function...
  46. pmc A developmental study on the neural circuitry mediating response flexibility in bipolar disorder
    Judah Weathers
    Section on Bipolar Spectrum Disorders, Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD, USA
    Psychiatry Res 214:56-65. 2013
    ..Future studies should use longitudinal fMRI to examine the developmental trajectory of the neural circuitry mediating response flexibility in BD...
  47. pmc Cross-sectional and longitudinal abnormalities in brain structure in children with severe mood dysregulation or bipolar disorder
    Nancy E Adleman
    National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Child Psychol Psychiatry 53:1149-56. 2012
    ..Furthermore, the developmental trajectories of structural abnormalities in BD or SMD are unknown. This study provides such data in BD, SMD, and HV...
  48. pmc Adult outcomes of youth irritability: a 20-year prospective community-based study
    Argyris Stringaris
    Section on Bipolar Spectrum Disorders, Emotion and Development Branch, Mood and Anxiety Program, NIMH Bldg 15K, MSC 2670, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 166:1048-54. 2009
    ..This study examines the extent to which youth irritability is related to adult psychiatric outcomes by testing the hypothesis that it predicts depressive and generalized anxiety disorders...
  49. pmc Altered neural function in pediatric bipolar disorder during reversal learning
    Daniel P Dickstein
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892, USA
    Bipolar Disord 12:707-19. 2010
    ..Here, we use event-related functional magnetic resonance imaging (fMRI) to elucidate neural correlates of reversal learning deficits in euthymic BD youth compared to typically developing controls...
  50. ncbi The impact of reward, punishment, and frustration on attention in pediatric bipolar disorder
    Brendan A Rich
    Pediatrics and Developmental Neuropsychiatry Branch, Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1255, USA
    Biol Psychiatry 58:532-9. 2005
    ..We tested the hypothesis that frustration adversely impacts attention and behavior in children with bipolar disorder (BPD)...
  51. pmc The neural correlates of emotion-based cognitive control in adults with early childhood behavioral inhibition
    Johanna M Jarcho
    Section on Developmental and Affective Neuroscience, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, United States
    Biol Psychol 92:306-14. 2013
    ..These data suggest that the brain regions underlying cognitive control processes are differentially influenced by childhood behavioral inhibition, and may be differently related to psychopathology...
  52. pmc The pathology of social phobia is independent of developmental changes in face processing
    Karina S Blair
    Mood and Anxiety Program, National Institute of Mental Health, USA
    Am J Psychiatry 168:1202-9. 2011
    ..The authors examined neural responses to facial expressions in adults and adolescents with social phobia to determine whether the neural correlates of adult social phobia during face processing also manifest in adolescent social phobia...
  53. pmc Practitioner review: the assessment of bipolar disorder in children and adolescents
    Argelinda Baroni
    Section on Bipolar Spectrum Disorders, Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    J Child Psychol Psychiatry 50:203-15. 2009
    ..Controversy exists about whether youth with non-episodic irritability and symptoms of attention deficit hyperactivity disorder (ADHD) should be considered to have a developmental presentation of mania...
  54. ncbi Amygdala and nucleus accumbens in responses to receipt and omission of gains in adults and adolescents
    Monique Ernst
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 15K North Drive, Bethesda, MD 20892 2670, USA
    Neuroimage 25:1279-91. 2005
    ..These developmental differences, if replicated, may have important implications for the development of early-onset disorders of emotion and motivation...
  55. pmc A genome-wide association study of amygdala activation in youths with and without bipolar disorder
    Xinmin Liu
    National Institute of Mental Health, Bethesda, MD 20892, USA
    J Am Acad Child Adolesc Psychiatry 49:33-41. 2010
    ..We undertook a genome-wide association study to explore the genetic architecture of this neuroimaging phenotype...
  56. ncbi Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in children
    Melissa A Brotman
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 60:991-7. 2006
    ..This syndrome has been called the "broad BD phenotype" or severe mood dysregulation (SMD). This study examines prevalence, concurrent Axis I diagnoses, and longitudinal outcome of SMD in an epidemiologic sample...
  57. ncbi Adolescent immaturity in attention-related brain engagement to emotional facial expressions
    Christopher S Monk
    Section on Development and Affective Neuroscience and Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Neuroimage 20:420-8. 2003
    ..These findings suggest that adults show greater modulation of activity in relevant brain structures based on attentional demands, whereas adolescents exhibit greater modulation based on emotional content...
  58. pmc Developmental effects of decision-making on sensitivity to reward: an fMRI study
    Johanna M Jarcho
    Section of Developmental and Affective Neuroscience, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Building 15 K, Bethesda, MD 20892, United States
    Dev Cogn Neurosci 2:437-47. 2012
    ..Instead, neural responding in striatum, prefrontal cortex and precuneus is influenced by both situational demands and developmental factors. This suggests nuanced maturational effects in adolescent reward sensitivity...
  59. pmc Differing amygdala responses to facial expressions in children and adults with bipolar disorder
    Pilyoung Kim
    NIMH, Bethesda, MD, USA
    Am J Psychiatry 169:642-9. 2012
    ..The authors used functional MRI to compare amygdala activity during a face processing task in children and adults with bipolar disorder and in healthy comparison subjects...
  60. ncbi Deficits on a probabilistic response-reversal task in patients with pediatric bipolar disorder
    Tristan Gorrindo
    Mood and Anxiety Program, National Institute of Mental Health, Bldg 10, Rm 4N 208, 10 Center Dr MSC 1255, Bethesda, MD 20892 1255, USA
    Am J Psychiatry 162:1975-7. 2005
    ....
  61. pmc Early-life stress is associated with impairment in cognitive control in adolescence: an fMRI study
    Sven C Mueller
    Section of Developmental and Affective Neuroscience, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, 15K North Drive, Bethesda, MD 20892, USA
    Neuropsychologia 48:3037-44. 2010
    ..incorrect "change" responses recruited the inferior prefrontal cortex (BA 44/46) more strongly in ES subjects than controls. These data suggest impaired cognitive control in youth who experienced ES...
  62. ncbi Social and emotional attachment in the neural representation of faces
    M Ida Gobbini
    Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20982, USA
    Neuroimage 22:1628-35. 2004
    ..These results suggest that familiarity causes changes in neural response that extend beyond a visual memory for a face...
  63. ncbi Memory and learning in pediatric bipolar disorder
    Erin B McClure
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
    J Am Acad Child Adolesc Psychiatry 44:461-9. 2005
    ..To test the hypothesis that patients with pediatric bipolar disorder (PBPD) would demonstrate impairment relative to diagnosis-free controls of comparable age, gender, and IQ on measures of memory functioning...
  64. ncbi Developmental differences in neuronal engagement during implicit encoding of emotional faces: an event-related fMRI study
    Eric E Nelson
    Section on Development and Affective Neuroscience, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 1381, USA
    J Child Psychol Psychiatry 44:1015-24. 2003
    ..Prior studies document strong interactions between emotional and mnemonic processes. These interactions have been shown to vary across development and psychopathology, particularly mood and anxiety disorders...
  65. pmc Autism spectrum disorder scale scores in pediatric mood and anxiety disorders
    Daniel S Pine
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 15K North Drive, Bethesda, MD 20892 2670, USA
    J Am Acad Child Adolesc Psychiatry 47:652-61. 2008
    ..To compare scores on autism spectrum disorder (ASD) symptom scales in healthy youths and youths with mood or anxiety disorders...
  66. ncbi Clinical correlates of episodicity in juvenile mania
    Robinder K Bhangoo
    The Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    J Child Adolesc Psychopharmacol 13:507-14. 2003
    ..We hypothesized that the episodic group would be more likely to have a history of psychosis and a parental history of BPD, whereas the chronic group would be more likely to have conduct disorder...
  67. ncbi Frontotemporal alterations in pediatric bipolar disorder: results of a voxel-based morphometry study
    Daniel P Dickstein
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 62:734-41. 2005
    ..While numerous magnetic resonance imaging (MRI) studies have evaluated adults with bipolar disorder (BPD), few have examined MRI changes in children with BPD...
  68. pmc A developmental neuroimaging investigation of the change paradigm
    LAURA A THOMAS
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health DHHS, 15K North Drive, Bethesda, MD 20892, USA
    Dev Sci 14:148-61. 2011
    ..These results are consistent with data from previous task-switching experiments and inform developmental understandings of cognitive flexibility...
  69. pmc Increased intrasubject variability in response time in youths with bipolar disorder and at-risk family members
    Melissa A Brotman
    National Institute of Mental Health, Mood and Anxiety Program, 15K North Drive, Room 208, Bethesda, MD 20892, USA
    J Am Acad Child Adolesc Psychiatry 48:628-35. 2009
    ..We tested the hypothesis that, compared with controls, both youths with BD and those at familial risk for the disorder would have increased ISV-RT...
  70. pmc Attention orientation in parents exposed to the 9/11 terrorist attacks and their children
    Kara M Lindstrom
    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Psychiatry Res 187:261-6. 2011
    ..Larger, prospective studies might examine relationships within families among traumatic exposures, psychopathology, and information-processing functions...
  71. ncbi Choice selection and reward anticipation: an fMRI study
    Monique Ernst
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 15K North Drive, Bethesda, MD 20892 2670, USA
    Neuropsychologia 42:1585-97. 2004
    ....
  72. ncbi Neuropsychological performance in pediatric bipolar disorder
    Daniel P Dickstein
    National Institute of Mental Health Mood and Anxiety Disorders Program, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1255, USA
    Biol Psychiatry 55:32-9. 2004
    ..We sought to examine whether neuropsychological function in children with bipolar disorder resembles that in adults with the illness and to extend our knowledge about cognitive function in pediatric bipolar disorder...
  73. pmc Limbic hyperactivation during processing of neutral facial expressions in children with bipolar disorder
    Brendan A Rich
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 2670, USA
    Proc Natl Acad Sci U S A 103:8900-5. 2006
    ..Results implicate deficient emotion-attention interactions in the pathophysiology of BD in youth and suggest that developmental psychobiology approaches to chronic mental illness have broad applicability...
  74. ncbi Neurologic examination abnormalities in children with bipolar disorder or attention-deficit/hyperactivity disorder
    Daniel P Dickstein
    National Institute of Mental Health, Pediatrics and Developmental Neuropsychiatry Branch, 10 Center Drive MSC 1255, Building 10 Room 4N208, Bethesda MD 20892 1255, USA
    Biol Psychiatry 58:517-24. 2005
    ..To move beyond diagnosis toward unique pathophysiology, we evaluated both ADHD and BPD children for neurologic examination abnormalities (NEAs) in comparison with normal control (NC) children...
  75. pmc What does distractibility in ADHD reveal about mechanisms for top-down attentional control?
    Stacia R Friedman-Hill
    Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Cognition 115:93-103. 2010
    ....
  76. ncbi The social re-orientation of adolescence: a neuroscience perspective on the process and its relation to psychopathology
    Eric E Nelson
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892, USA
    Psychol Med 35:163-74. 2005
    ..While such changes in social behavior have been well documented in the literature, relatively few neurophysiological explanations for these behavioral changes have been presented...
  77. ncbi Reward-related processes in pediatric bipolar disorder: a pilot study
    Monique Ernst
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 15K North Drive, Room 118, Bethesda, MD 20892 2670, USA
    J Affect Disord 82:S89-S101. 2004
    ..We hypothesized that relative to healthy children, children with BPD would select risky options more frequently, be less confident in a favorable outcome, and report stronger emotional responses to outcomes...
  78. ncbi Affective neuroscience and the study of normal and abnormal emotion regulation
    Robinder K Bhangoo
    Pediatrics and Developmental Neuropsychiatry Branch, National Institute of Mental Health, Room 4N 208, NIMH Building 10, 10 Center Drive, MCS 1255, Bethesda, MD 20892, USA
    Child Adolesc Psychiatr Clin N Am 11:519-32. 2002
    ..Understanding the normal development of emotions and regulation of emotion will provide new avenues of research into the complex problem of severe mood disorders...
  79. ncbi Emotion regulation in children and adolescents: boundaries between normalcy and bipolar disorder
    Daniel P Dickstein
    Mood and Anxiety Disorder Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
    Dev Psychopathol 18:1105-31. 2006
    ..Taken as a whole, this work implicates a neural circuit encompassing the prefrontal cortex, amygdala, and striatum in the pathophysiology of pediatric BD...
  80. ncbi Facial expression recognition in adolescents with mood and anxiety disorders
    Erin B McClure
    National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 160:1172-4. 2003
    ..The authors examined facial expression recognition in adolescents with mood and anxiety disorders...
  81. ncbi An investigation of prepulse inhibition in pediatric bipolar disorder
    Brendan A Rich
    Pediatrics and Developmental Neuropsychiatry Branch, Unit on Affective Psychophysiology, Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1255, USA
    Bipolar Disord 7:198-203. 2005
    ..Sensorimotor gating deficits may contribute to the emotional and behavioral dysregulation characteristic of pediatric BPD. The current study investigated possible PPI deficits in children with BPD...
  82. pmc Imaging-genetics applications in child psychiatry
    Daniel S Pine
    National Institute of Mental Health Intramural Research Program, Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
    J Am Acad Child Adolesc Psychiatry 49:772-82. 2010
    ..To place imaging-genetics research in the context of child psychiatry...
  83. pmc Perturbed reward processing in pediatric bipolar disorder: an antisaccade study
    Sven C Mueller
    Section of Developmental and Affective Neuroscience National Institute of Mental Health, National Institute of Health, 15K North Drive, Bethesda, MD 20814, USA
    J Psychopharmacol 24:1779-84. 2010
    ..By comparison, no group differences were found on prosaccade trials. The results provide further evidence for deficits in cognitive and reward processing in bipolar disorder...
  84. ncbi fMRI predictors of treatment outcome in pediatric anxiety disorders
    Erin B McClure
    Department of Psychology, Georgia State University, P O Box 5010, Atlanta, GA 30302 5010, USA
    Psychopharmacology (Berl) 191:97-105. 2007
    ..Interest has emerged in this phenomenon as a possible biological marker for individuals who are likely to benefit from tailored treatment approaches...
  85. ncbi Selective reduction in amygdala volume in pediatric anxiety disorders: a voxel-based morphometry investigation
    Michael P Milham
    Beckman Institute, University of Illinois, Urbana, Illinois, USA
    Biol Psychiatry 57:961-6. 2005
    ..We examine the neural correlates of pediatric anxiety disorders, to consider the validity of the categorization scheme used in recent treatment studies...
  86. ncbi Ventrolateral prefrontal cortex activation and attentional bias in response to angry faces in adolescents with generalized anxiety disorder
    Christopher S Monk
    Department of Psychology, University of Michigan, 2000 East Hall, 530 Church St, Ann Arbor, MI 48109, USA
    Am J Psychiatry 163:1091-7. 2006
    ....
  87. ncbi Researching the pathophysiology of pediatric bipolar disorder
    Ellen Leibenluft
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 53:1009-20. 2003
    ..Potential foci for research on the pathophysiology of pediatric BPD include reactivity to standardized positive and negative emotional stimuli, and the interaction between emotion regulation and attentional processes...
  88. ncbi Flying almost blind
    Ellen Leibenluft
    Am J Psychiatry 163:1129-31. 2006
  89. ncbi Dynamic mapping of cortical development before and after the onset of pediatric bipolar illness
    Nitin Gogtay
    Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
    J Child Psychol Psychiatry 48:852-62. 2007
    ..We report the first prospective study of cortical brain development in pediatric bipolar illness for 9 male children, visualized before and after illness onset...
  90. ncbi Toward optimal health: the experts discuss depression. Interview by Jodi Godfrey Meisler
    Leah J Dickstein
    J Womens Health Gend Based Med 11:205-10. 2002
  91. doi Frontiers between attention deficit hyperactivity disorder and bipolar disorder
    Cathryn A Galanter
    Division of Child and Adolescent Psychiatry, Columbia University New York State Psychiatric Institute, 1051 Riverside Drive, 78, New York, NY 10032, USA
    Child Adolesc Psychiatr Clin N Am 17:325-46, viii-ix. 2008
    ..We draw on the research to make clinical recommendations and highlight important directions for future research...
  92. ncbi Management of bipolar disorder during pregnancy and the postpartum period
    Kimberly A Yonkers
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Am J Psychiatry 161:608-20. 2004
    ..The authors summarize knowledge regarding the management of bipolar disorder during pregnancy and the postpartum period, with a focus on managing mania, hypomania, and the psychotic components of the illness...