Research Topics
Genomes and Genes
| Kyoung Mu LeeSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Polymorphisms in immunoregulatory genes, smoky coal exposure and lung cancer risk in Xuan Wei, ChinaKyoung Mu Lee
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
Carcinogenesis 28:1437-41. 2007..11, 95% CI = 0.03-0.44; P(interaction) = 0.03). In conclusion, genetic variation in immunoregulatory genes may play an important role in the development of lung cancer in this population...- One-carbon metabolism gene polymorphisms and risk of non-Hodgkin lymphoma in AustraliaKyoung Mu Lee
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd EPS 8118, Bethesda, MD 20892 7240, USA
Hum Genet 122:525-33. 2007..01). In conclusion, the results of this study suggest that genetic polymorphisms of one-carbon metabolism genes such as MTHFR and TYMS may influence susceptibility to NHL... 
Nitric oxide synthase gene polymorphisms and prostate cancer riskKyoung Mu Lee
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Carcinogenesis 30:621-5. 2009..61, 1.18-2.19; P(interaction) = 0.01). Our results suggest that NOS gene polymorphisms are genetic susceptibility factors for aggressive prostate cancer...- Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in ConnecticutKyoung Mu Lee
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Am J Hematol 85:560-3. 2010..Additional studies are needed to replicate these findings and, more generally, to explore the manner in which genes and receptors may influence the pathogenesis of this poorly understood malignancy... - Variation in lung cancer risk by smoky coal subtype in Xuanwei, ChinaQing Lan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
Int J Cancer 123:2164-9. 2008..2) coal types and lower for coal from other subtypes. These findings strongly suggest that in Xuanwei and elsewhere, the carcinogenic potential of coal combustion products can exhibit substantial local variation by specific coal source... - Genetic polymorphisms of NOS3 are associated with the risk of invasive breast cancer with lymph node involvementKyoung Mu Lee
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Breast Cancer Res Treat 106:433-8. 2007..77, 95% CI = 0.59-0.99). Our results suggest that genetic polymorphisms in NOS3 modify individual susceptibility to invasive breast cancer with lymph node involvement in Korean women... - Genetic variation in cell cycle and apoptosis related genes and multiple myeloma riskH Dean Hosgood
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, United States
Leuk Res 33:1609-14. 2009..005). Haplotype analyses supported the SNP findings. These findings suggest that genetic variation in cell cycle and apoptosis genes may play a key role in multiple myeloma and warrant further investigation through replication studies... 
Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in AsiaH Dean Hosgood
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 8118, MCS 7240, Bethesda, MD 20892 7240, USA
Hum Genet 131:1197-203. 2012..037; allelic risk = 0.82, 95% CI = 0.67-0.99). Our findings provide strong evidence that genetic variation in TP63 is associated with the risk of lung adenocarcinoma among Asian females in the absence of tobacco smoking...- Polymorphisms in genes involved in innate immunity and susceptibility to benzene-induced hematotoxicityMin Shen
Division of Cancer Epidemiology and Genetics NCI, NIH, DHHS, Bethesda MD 20892, U S A
Exp Mol Med 43:374-8. 2011..0008) with WBCs even though the three SNPs were not significant individually. Our study suggests that polymorphisms in innate immunity genes may play a role in benzene-induced hematotoxicity; however, independent replication is necessary... - Occupational trichloroethylene exposure and kidney cancer risk: a meta-analysisSara Karami
National Cancer Institute, Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, 6120 Executive Blvd, EPS 8102, Rockville, MD 20852, USA
Occup Environ Med 69:858-67. 2012..We updated meta-analyses of published case-control and cohort studies exploring occupational TCE exposure and kidney cancer risk, incorporating new analytical results from three recently published cohort studies and a case-control study... - Personal use of hair dye and cancer risk in a prospective cohort of Chinese womenJulie Bloch Mendelsohn
Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health, Bethesda, MD, USA
Cancer Sci 100:1088-91. 2009..We generally found no evidence of an association between personal use of hair dye and cancer risk, although our study is limited by small numbers for certain cancer types... - CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populationsKyoung Mu Lee
Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
Cancer Epidemiol Biomarkers Prev 17:1120-6. 2008..However, further investigation is warranted considering the relatively small sample size when subgroup analyses were done and the lack of environmental exposure data other than smoking... - Functional variant of manganese superoxide dismutase (SOD2 V16A) polymorphism is associated with prostate cancer risk in the prostate, lung, colorectal, and ovarian cancer studyDaehee Kang
Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
Cancer Epidemiol Biomarkers Prev 16:1581-6. 2007..These results suggest that the Ala variant of SOD2 is associated with moderately increased risk of prostate cancer, particularly among men with lower intakes of dietary and supplemental vitamin E... - Gene-environment interactions between the smoking habit and polymorphisms in the DNA repair genes, APE1 Asp148Glu and XRCC1 Arg399Gln, in Japanese lung cancer riskHidemi Ito
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya Aichi, Japan
Carcinogenesis 25:1395-401. 2004..936) and that with light smoking was 2.67 (95% CI 1.00-7.68, P = 0.049). These results suggest that APE1 Asp148Glu and XRCC1 Arg399Gln polymorphisms might modify the risk of lung cancer attributable to cigarette smoking exposure... - Genetic polymorphisms of SULT1A1 and SULT1E1 and the risk and survival of breast cancerJi Yeob Choi
Department of Preventive Medicine, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon dong Chongno gu, Seoul 110 799, Korea
Cancer Epidemiol Biomarkers Prev 14:1090-5. 2005..2; 95% CI, 1.15-15.15). These findings suggest that genetic polymorphisms of SULT1E1 are associated with increased risk and a disease free survival of breast cancer in Korean women... - Rare variant of hypoxia-inducible factor-1alpha (HIF-1A) and breast cancer risk in Korean womenJi Young Lee
Department of Preventive Medicine, Seoul National University College of Medicine, Jongnoo Gu, Seoul, South Korea
Clin Chim Acta 389:167-70. 2008..Tumors exhibiting extensive hypoxia are more aggressive than tumors oxygenized better... - Cytochrome P450 1A1 (CYP1A1) polymorphisms and breast cancer risk in Korean womenAesun Shin
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 110 799, Korea
Exp Mol Med 39:361-6. 2007..18 (0.06-0.58)] or with a shorter lifetime exposure to estrogen [OR=0.23 (0.07-0.81)]. The results obtained suggest that the CYP1A1 MspI polymorphisms could affect susceptibility to breast cancer... - Lack of association of transforming growth factor-beta1 polymorphisms and haplotypes with prostate cancer risk in the prostate, lung, colorectal, and ovarian trialDaehee Kang
Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-799, Korea
Cancer Epidemiol Biomarkers Prev 16:1303-5. 2007 - Dose-dependent protective effect of breast-feeding against breast cancer among ever-lactated women in KoreaYeonju Kim
Departments of Preventive Medicine, Seoul National University College of Medicine, Yongon dong Chongno gu, Seoul, Republic of Korea
Eur J Cancer Prev 16:124-9. 2007..006). This study confirms that lactation has an apparent dose-dependent protective effect against breast cancer in Korean women... - CYP2E1 and NQO1 genotypes, smoking and bladder cancerJi Yeob Choi
Department of Preventive Medicine, Seoul National University College of Medicine, Korea
Pharmacogenetics 13:349-55. 2003..We conducted a hospital based case-control study to evaluate the potential association between genetic polymorphisms of CYP2E1 (C1019T in the 5' flanking region) and NQO1 (C609T in exon 6) and bladder cancer risk in Asian population... - N-acetyltransferase (NAT1, NAT2) and glutathione S-transferase (GSTM1, GSTT1) polymorphisms in breast cancerKyoung Mu Lee
Department of Preventive Medicine, Seoul National University College of Medicine, Cancer Research Institute, 28 Yongon Dong, Chongno Gu, Seoul 110 799, South Korea
Cancer Lett 196:179-86. 2003..1, 95% CI=1.0-9.1). These results suggest that genetic polymorphisms of NAT1 and NAT2 have no independent effect on breast cancer risk, but they modulate breast cancer risk in the presence of GSTM1 and GSTT1 null genotypes... - Genetic polymorphisms of GSTM1, p21, p53 and HPV infection with cervical cancer in Korean womenSang Ah Lee
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea
Gynecol Oncol 93:14-8. 2004..The multiplicative interaction of GSTM1 and GSTT1 genotype with p21, p53 polymorphism, and HPV genotype was also investigated... - Genetic polymorphism of CYP17 and breast cancer risk in Korean womenMyung Hee Shin
Department of Social and Preventive Medicine, Sungkyunkwan University School of Medicine, 300 Chunchun dong, Jangan gu, Suwon, Gyeongi do 440 746, Korea
Exp Mol Med 37:11-7. 2005.... - Genetic polymorphisms of TGF-beta1 & TNF-beta and breast cancer riskKyoung Mu Lee
Department of Preventive Medicine, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 799, Korea
Breast Cancer Res Treat 90:149-55. 2005..To evaluate the potential influences of TGF-beta1 T29C and TNF-beta A252G gene polymorphisms on breast cancer risk, a case-control study was conducted in Korea... - Genetic polymorphisms of ataxia telangiectasia mutated and breast cancer riskKyoung Mu Lee
Department of Preventive Medicine, Cancer Research Institute, Seoul National University, College of Medicine, 28 Yongon dong Chongno gu, Seoul 110 799, Korea
Cancer Epidemiol Biomarkers Prev 14:821-5. 2005..01). Our results thus suggest that genetic polymorphisms of ATM play an important role in the development of breast cancer in Korean women... - Genetic polymorphisms of selected DNA repair genes, estrogen and progesterone receptor status, and breast cancer riskKyoung Mu Lee
Department of Preventive Medicine, Seoul National University College of Medicine, Chongno Gu, Seoul, Korea
Clin Cancer Res 11:4620-6. 2005..To evaluate the role of genetic polymorphisms of DNA repair genes in breast cancer, we conducted a hospital-based case-control study of Korean women... - Association of paternal age at birth and the risk of breast cancer in offspring: a case control studyJi Yeob Choi
Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon dong Chongno gu, Seoul 110 799 Korea
BMC Cancer 5:143. 2005..To evaluate the association between paternal and maternal age at birth with the risk of breast cancer in female offspring, a case-control study was conducted in Korea... - Genetic polymorphisms of interleukin-1 beta (IL-1B) and IL-1 receptor antagonist (IL-1RN) and breast cancer risk in Korean womenKyoung Mu Lee
Cancer Research Institute, Institute of Environmental Medicine, SNUMRC, and Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, Korea
Breast Cancer Res Treat 96:197-202. 2006..To evaluate the potential role of genetic polymorphisms of interleukin-1 beta (IL-1B) and IL-1 receptor antagonist (IL-1RN) on breast cancer development, a hospital-based case-control study was conducted in Korea... - Interactive effect of genetic polymorphism of glutathione S-transferase M1 and smoking on squamous cell lung cancer risk in KoreaKyoung Mu Lee
Department of Preventive Medicine and Institute of Environmental Medicine, Seoul National University College of Medicine, Cancer Research Institute, Seoul 110 799, Korea
Oncol Rep 16:1035-9. 2006..04). These results suggest that the GSTM1 null genotype is associated with squamous cell lung cancer and modifies the effect of smoking on squamous cell lung cancer development in Korean males... - Genetic polymorphism of XRCC3 Thr241Met and breast cancer risk: case-control study in Korean women and meta-analysis of 12 studiesSang Ah Lee
Department of Preventive Medicine, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon dong Chongno gu, Seoul 110 799, South Korea
Breast Cancer Res Treat 103:71-6. 2007.... - Reproductive factors, glutathione S-transferase M1 and T1 genetic polymorphism and breast cancer riskSue Kyung Park
Department of Preventive Medicine, Konkuk University College of Medicine, Chungju, Korea
Breast Cancer Res Treat 78:89-96. 2003..01). Our findings suggest that genetic polymorphisms GSTM1/T1 could modify estrogen-related breast cancer risk...