Kyoung Mu Lee

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Polymorphisms in immunoregulatory genes, smoky coal exposure and lung cancer risk in Xuan Wei, China
    Kyoung Mu Lee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
    Carcinogenesis 28:1437-41. 2007
  2. pmc Nitric oxide synthase gene polymorphisms and prostate cancer risk
    Kyoung Mu Lee
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Carcinogenesis 30:621-5. 2009
  3. ncbi request reprint One-carbon metabolism gene polymorphisms and risk of non-Hodgkin lymphoma in Australia
    Kyoung Mu Lee
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd EPS 8118, Bethesda, MD 20892 7240, USA
    Hum Genet 122:525-33. 2007
  4. pmc Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut
    Kyoung Mu Lee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Am J Hematol 85:560-3. 2010
  5. doi request reprint Occupational trichloroethylene exposure and risk of lymphatic and haematopoietic cancers: a meta-analysis
    Sara Karami
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20852, USA
    Occup Environ Med 70:591-9. 2013
  6. pmc Variation in lung cancer risk by smoky coal subtype in Xuanwei, China
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Int J Cancer 123:2164-9. 2008
  7. ncbi request reprint Genetic polymorphisms of NOS3 are associated with the risk of invasive breast cancer with lymph node involvement
    Kyoung Mu Lee
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Breast Cancer Res Treat 106:433-8. 2007
  8. pmc Genetic variation in cell cycle and apoptosis related genes and multiple myeloma risk
    H Dean Hosgood
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, United States
    Leuk Res 33:1609-14. 2009
  9. doi request reprint Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia
    H Dean Hosgood
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 8118, MCS 7240, Bethesda, MD 20892 7240, USA
    Hum Genet 131:1197-203. 2012
  10. pmc Polymorphisms in genes involved in innate immunity and susceptibility to benzene-induced hematotoxicity
    Min Shen
    Division of Cancer Epidemiology and Genetics NCI, NIH, DHHS, Bethesda MD 20892, U S A
    Exp Mol Med 43:374-8. 2011

Detail Information

Publications32

  1. ncbi request reprint Polymorphisms in immunoregulatory genes, smoky coal exposure and lung cancer risk in Xuan Wei, China
    Kyoung Mu Lee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
    Carcinogenesis 28:1437-41. 2007
    ..11, 95% CI = 0.03-0.44; P(interaction) = 0.03). In conclusion, genetic variation in immunoregulatory genes may play an important role in the development of lung cancer in this population...
  2. pmc Nitric oxide synthase gene polymorphisms and prostate cancer risk
    Kyoung Mu Lee
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Carcinogenesis 30:621-5. 2009
    ..61, 1.18-2.19; P(interaction) = 0.01). Our results suggest that NOS gene polymorphisms are genetic susceptibility factors for aggressive prostate cancer...
  3. ncbi request reprint One-carbon metabolism gene polymorphisms and risk of non-Hodgkin lymphoma in Australia
    Kyoung Mu Lee
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd EPS 8118, Bethesda, MD 20892 7240, USA
    Hum Genet 122:525-33. 2007
    ..01). In conclusion, the results of this study suggest that genetic polymorphisms of one-carbon metabolism genes such as MTHFR and TYMS may influence susceptibility to NHL...
  4. pmc Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut
    Kyoung Mu Lee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Am J Hematol 85:560-3. 2010
    ..Additional studies are needed to replicate these findings and, more generally, to explore the manner in which genes and receptors may influence the pathogenesis of this poorly understood malignancy...
  5. doi request reprint Occupational trichloroethylene exposure and risk of lymphatic and haematopoietic cancers: a meta-analysis
    Sara Karami
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20852, USA
    Occup Environ Med 70:591-9. 2013
    ..Our updated meta-analysis of NHL, which incorporates new analytical results from three cohort and four case-control studies, supports an association between occupational TCE exposure and NHL. ..
  6. pmc Variation in lung cancer risk by smoky coal subtype in Xuanwei, China
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Int J Cancer 123:2164-9. 2008
    ..2) coal types and lower for coal from other subtypes. These findings strongly suggest that in Xuanwei and elsewhere, the carcinogenic potential of coal combustion products can exhibit substantial local variation by specific coal source...
  7. ncbi request reprint Genetic polymorphisms of NOS3 are associated with the risk of invasive breast cancer with lymph node involvement
    Kyoung Mu Lee
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Breast Cancer Res Treat 106:433-8. 2007
    ..77, 95% CI = 0.59-0.99). Our results suggest that genetic polymorphisms in NOS3 modify individual susceptibility to invasive breast cancer with lymph node involvement in Korean women...
  8. pmc Genetic variation in cell cycle and apoptosis related genes and multiple myeloma risk
    H Dean Hosgood
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, United States
    Leuk Res 33:1609-14. 2009
    ..005). Haplotype analyses supported the SNP findings. These findings suggest that genetic variation in cell cycle and apoptosis genes may play a key role in multiple myeloma and warrant further investigation through replication studies...
  9. doi request reprint Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia
    H Dean Hosgood
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 8118, MCS 7240, Bethesda, MD 20892 7240, USA
    Hum Genet 131:1197-203. 2012
    ..037; allelic risk = 0.82, 95% CI = 0.67-0.99). Our findings provide strong evidence that genetic variation in TP63 is associated with the risk of lung adenocarcinoma among Asian females in the absence of tobacco smoking...
  10. pmc Polymorphisms in genes involved in innate immunity and susceptibility to benzene-induced hematotoxicity
    Min Shen
    Division of Cancer Epidemiology and Genetics NCI, NIH, DHHS, Bethesda MD 20892, U S A
    Exp Mol Med 43:374-8. 2011
    ..0008) with WBCs even though the three SNPs were not significant individually. Our study suggests that polymorphisms in innate immunity genes may play a role in benzene-induced hematotoxicity; however, independent replication is necessary...
  11. doi request reprint Occupational trichloroethylene exposure and kidney cancer risk: a meta-analysis
    Sara Karami
    National Cancer Institute, Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, 6120 Executive Blvd, EPS 8102, Rockville, MD 20852, USA
    Occup Environ Med 69:858-67. 2012
    ..We updated meta-analyses of published case-control and cohort studies exploring occupational TCE exposure and kidney cancer risk, incorporating new analytical results from three recently published cohort studies and a case-control study...
  12. pmc Personal use of hair dye and cancer risk in a prospective cohort of Chinese women
    Julie Bloch Mendelsohn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health, Bethesda, MD, USA
    Cancer Sci 100:1088-91. 2009
    ..We generally found no evidence of an association between personal use of hair dye and cancer risk, although our study is limited by small numbers for certain cancer types...
  13. ncbi request reprint Gene-environment interactions between the smoking habit and polymorphisms in the DNA repair genes, APE1 Asp148Glu and XRCC1 Arg399Gln, in Japanese lung cancer risk
    Hidemi Ito
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya Aichi, Japan
    Carcinogenesis 25:1395-401. 2004
    ..936) and that with light smoking was 2.67 (95% CI 1.00-7.68, P = 0.049). These results suggest that APE1 Asp148Glu and XRCC1 Arg399Gln polymorphisms might modify the risk of lung cancer attributable to cigarette smoking exposure...
  14. doi request reprint CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations
    Kyoung Mu Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
    Cancer Epidemiol Biomarkers Prev 17:1120-6. 2008
    ..However, further investigation is warranted considering the relatively small sample size when subgroup analyses were done and the lack of environmental exposure data other than smoking...
  15. ncbi request reprint Functional variant of manganese superoxide dismutase (SOD2 V16A) polymorphism is associated with prostate cancer risk in the prostate, lung, colorectal, and ovarian cancer study
    Daehee Kang
    Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
    Cancer Epidemiol Biomarkers Prev 16:1581-6. 2007
    ..These results suggest that the Ala variant of SOD2 is associated with moderately increased risk of prostate cancer, particularly among men with lower intakes of dietary and supplemental vitamin E...
  16. ncbi request reprint Genetic polymorphisms of SULT1A1 and SULT1E1 and the risk and survival of breast cancer
    Ji Yeob Choi
    Department of Preventive Medicine, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon dong Chongno gu, Seoul 110 799, Korea
    Cancer Epidemiol Biomarkers Prev 14:1090-5. 2005
    ..2; 95% CI, 1.15-15.15). These findings suggest that genetic polymorphisms of SULT1E1 are associated with increased risk and a disease free survival of breast cancer in Korean women...
  17. ncbi request reprint N-acetyltransferase (NAT1, NAT2) and glutathione S-transferase (GSTM1, GSTT1) polymorphisms in breast cancer
    Kyoung Mu Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, Cancer Research Institute, 28 Yongon Dong, Chongno Gu, Seoul 110 799, South Korea
    Cancer Lett 196:179-86. 2003
    ..1, 95% CI=1.0-9.1). These results suggest that genetic polymorphisms of NAT1 and NAT2 have no independent effect on breast cancer risk, but they modulate breast cancer risk in the presence of GSTM1 and GSTT1 null genotypes...
  18. ncbi request reprint CYP2E1 and NQO1 genotypes, smoking and bladder cancer
    Ji Yeob Choi
    Department of Preventive Medicine, Seoul National University College of Medicine, Korea
    Pharmacogenetics 13:349-55. 2003
    ..We conducted a hospital based case-control study to evaluate the potential association between genetic polymorphisms of CYP2E1 (C1019T in the 5' flanking region) and NQO1 (C609T in exon 6) and bladder cancer risk in Asian population...
  19. ncbi request reprint Rare variant of hypoxia-inducible factor-1alpha (HIF-1A) and breast cancer risk in Korean women
    Ji Young Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, Jongnoo Gu, Seoul, South Korea
    Clin Chim Acta 389:167-70. 2008
    ..Tumors exhibiting extensive hypoxia are more aggressive than tumors oxygenized better...
  20. ncbi request reprint Genetic polymorphism of CYP17 and breast cancer risk in Korean women
    Myung Hee Shin
    Department of Social and Preventive Medicine, Sungkyunkwan University School of Medicine, 300 Chunchun dong, Jangan gu, Suwon, Gyeongi do 440 746, Korea
    Exp Mol Med 37:11-7. 2005
    ....
  21. ncbi request reprint Cytochrome P450 1A1 (CYP1A1) polymorphisms and breast cancer risk in Korean women
    Aesun Shin
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 110 799, Korea
    Exp Mol Med 39:361-6. 2007
    ..18 (0.06-0.58)] or with a shorter lifetime exposure to estrogen [OR=0.23 (0.07-0.81)]. The results obtained suggest that the CYP1A1 MspI polymorphisms could affect susceptibility to breast cancer...
  22. ncbi request reprint Genetic polymorphisms of TGF-beta1 & TNF-beta and breast cancer risk
    Kyoung Mu Lee
    Department of Preventive Medicine, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 799, Korea
    Breast Cancer Res Treat 90:149-55. 2005
    ..To evaluate the potential influences of TGF-beta1 T29C and TNF-beta A252G gene polymorphisms on breast cancer risk, a case-control study was conducted in Korea...
  23. ncbi request reprint Genetic polymorphisms of ataxia telangiectasia mutated and breast cancer risk
    Kyoung Mu Lee
    Department of Preventive Medicine, Cancer Research Institute, Seoul National University, College of Medicine, 28 Yongon dong Chongno gu, Seoul 110 799, Korea
    Cancer Epidemiol Biomarkers Prev 14:821-5. 2005
    ..01). Our results thus suggest that genetic polymorphisms of ATM play an important role in the development of breast cancer in Korean women...
  24. ncbi request reprint Genetic polymorphisms of selected DNA repair genes, estrogen and progesterone receptor status, and breast cancer risk
    Kyoung Mu Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, Chongno Gu, Seoul, Korea
    Clin Cancer Res 11:4620-6. 2005
    ..To evaluate the role of genetic polymorphisms of DNA repair genes in breast cancer, we conducted a hospital-based case-control study of Korean women...
  25. pmc Association of paternal age at birth and the risk of breast cancer in offspring: a case control study
    Ji Yeob Choi
    Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon dong Chongno gu, Seoul 110 799 Korea
    BMC Cancer 5:143. 2005
    ..To evaluate the association between paternal and maternal age at birth with the risk of breast cancer in female offspring, a case-control study was conducted in Korea...
  26. ncbi request reprint Genetic polymorphisms of interleukin-1 beta (IL-1B) and IL-1 receptor antagonist (IL-1RN) and breast cancer risk in Korean women
    Kyoung Mu Lee
    Cancer Research Institute, Institute of Environmental Medicine, SNUMRC, and Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, Korea
    Breast Cancer Res Treat 96:197-202. 2006
    ..To evaluate the potential role of genetic polymorphisms of interleukin-1 beta (IL-1B) and IL-1 receptor antagonist (IL-1RN) on breast cancer development, a hospital-based case-control study was conducted in Korea...
  27. ncbi request reprint Interactive effect of genetic polymorphism of glutathione S-transferase M1 and smoking on squamous cell lung cancer risk in Korea
    Kyoung Mu Lee
    Department of Preventive Medicine and Institute of Environmental Medicine, Seoul National University College of Medicine, Cancer Research Institute, Seoul 110 799, Korea
    Oncol Rep 16:1035-9. 2006
    ..04). These results suggest that the GSTM1 null genotype is associated with squamous cell lung cancer and modifies the effect of smoking on squamous cell lung cancer development in Korean males...
  28. ncbi request reprint Genetic polymorphism of XRCC3 Thr241Met and breast cancer risk: case-control study in Korean women and meta-analysis of 12 studies
    Sang Ah Lee
    Department of Preventive Medicine, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon dong Chongno gu, Seoul 110 799, South Korea
    Breast Cancer Res Treat 103:71-6. 2007
    ....
  29. ncbi request reprint Dose-dependent protective effect of breast-feeding against breast cancer among ever-lactated women in Korea
    Yeonju Kim
    Departments of Preventive Medicine, Seoul National University College of Medicine, Yongon dong Chongno gu, Seoul, Republic of Korea
    Eur J Cancer Prev 16:124-9. 2007
    ..006). This study confirms that lactation has an apparent dose-dependent protective effect against breast cancer in Korean women...
  30. ncbi request reprint Genetic polymorphisms of GSTM1, p21, p53 and HPV infection with cervical cancer in Korean women
    Sang Ah Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea
    Gynecol Oncol 93:14-8. 2004
    ..The multiplicative interaction of GSTM1 and GSTT1 genotype with p21, p53 polymorphism, and HPV genotype was also investigated...
  31. ncbi request reprint Lack of association of transforming growth factor-beta1 polymorphisms and haplotypes with prostate cancer risk in the prostate, lung, colorectal, and ovarian trial
    Daehee Kang
    Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
    Cancer Epidemiol Biomarkers Prev 16:1303-5. 2007
  32. ncbi request reprint Reproductive factors, glutathione S-transferase M1 and T1 genetic polymorphism and breast cancer risk
    Sue Kyung Park
    Department of Preventive Medicine, Konkuk University College of Medicine, Chungju, Korea
    Breast Cancer Res Treat 78:89-96. 2003
    ..01). Our findings suggest that genetic polymorphisms GSTM1/T1 could modify estrogen-related breast cancer risk...