Yingying Le

Summary

Affiliation: National Cancer Institute
Country: USA

Publications

  1. ncbi request reprint Chemokines and chemokine receptors: their manifold roles in homeostasis and disease
    Yingying Le
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Cell Mol Immunol 1:95-104. 2004
  2. pmc Signal relay by CC chemokine receptor 2 (CCR2) and formylpeptide receptor 2 (Fpr2) in the recruitment of monocyte-derived dendritic cells in allergic airway inflammation
    Keqiang Chen
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 288:16262-73. 2013
  3. doi request reprint A critical role for the g protein-coupled receptor mFPR2 in airway inflammation and immune responses
    Keqiang Chen
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Maryland, USA
    J Immunol 184:3331-5. 2010
  4. ncbi request reprint Formylpeptide receptor FPR and the rapid growth of malignant human gliomas
    Ye Zhou
    Laboratory of Molecular Immunoregulation, CCR, NCI Frederick, Building 560, Room 31 40, Frederick, MD 21702 1201, USA
    J Natl Cancer Inst 97:823-35. 2005
  5. pmc Formylpeptide receptor-2 contributes to colonic epithelial homeostasis, inflammation, and tumorigenesis
    Keqiang Chen
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA
    J Clin Invest 123:1694-704. 2013
  6. ncbi request reprint Role of formyl peptide receptor-like 1 (FPRL1/FPR2) in mononuclear phagocyte responses in Alzheimer disease
    Pablo Iribarren
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Bldg 560, Frederick, MD 21702, USA
    Immunol Res 31:165-76. 2005
  7. ncbi request reprint Silencing the formylpeptide receptor FPR by short-interfering RNA
    Yingying Le
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Bldg 560, Room 31 40, MD 21702 1201, USA
    Mol Pharmacol 66:1022-8. 2004
  8. ncbi request reprint Bacterial lipopolysaccharide selectively up-regulates the function of the chemotactic peptide receptor formyl peptide receptor 2 in murine microglial cells
    You hong Cui
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, National Cancer Institute, Building 560, Frederick, MD 21702, USA
    J Immunol 168:434-42. 2002
  9. ncbi request reprint Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor
    GuoGuang Ying
    Laboratory of Molecular Immunoregulation and Basic Research Program, SAIC Frederick, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    J Immunol 172:7078-85. 2004
  10. ncbi request reprint TGF-beta1 disrupts endotoxin signaling in microglial cells through Smad3 and MAPK pathways
    Yingying Le
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, and Basic Research Program, Science Applications International Corporation Frederick, National Cancer Institute Frederick, Frederick, MD 21702, USA
    J Immunol 173:962-8. 2004

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Chemokines and chemokine receptors: their manifold roles in homeostasis and disease
    Yingying Le
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Cell Mol Immunol 1:95-104. 2004
    ..Therefore, chemokines and their receptors are important targets for modulation of host responses in pathophysiological conditions and for therapeutic intervention of human diseases...
  2. pmc Signal relay by CC chemokine receptor 2 (CCR2) and formylpeptide receptor 2 (Fpr2) in the recruitment of monocyte-derived dendritic cells in allergic airway inflammation
    Keqiang Chen
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 288:16262-73. 2013
    ..Our study demonstrates that the interaction of CCR2 and Fpr2 with their endogenous ligands sequentially mediates the trafficking of DCs within the inflamed lung...
  3. doi request reprint A critical role for the g protein-coupled receptor mFPR2 in airway inflammation and immune responses
    Keqiang Chen
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Maryland, USA
    J Immunol 184:3331-5. 2010
    ..This study reveals a critical role for mFPR2 in the progression of allergic airway inflammation and immune responses...
  4. ncbi request reprint Formylpeptide receptor FPR and the rapid growth of malignant human gliomas
    Ye Zhou
    Laboratory of Molecular Immunoregulation, CCR, NCI Frederick, Building 560, Room 31 40, Frederick, MD 21702 1201, USA
    J Natl Cancer Inst 97:823-35. 2005
    ..We previously showed that selected human glioma cell lines also express functional FPR. We therefore investigated the relationship between FPR expression and the biologic behavior of glioma cells...
  5. pmc Formylpeptide receptor-2 contributes to colonic epithelial homeostasis, inflammation, and tumorigenesis
    Keqiang Chen
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA
    J Clin Invest 123:1694-704. 2013
    ..These results indicate that FPR2 is critical in mediating homeostasis, inflammation, and epithelial repair processes in the colon...
  6. ncbi request reprint Role of formyl peptide receptor-like 1 (FPRL1/FPR2) in mononuclear phagocyte responses in Alzheimer disease
    Pablo Iribarren
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Bldg 560, Frederick, MD 21702, USA
    Immunol Res 31:165-76. 2005
    ..This review discusses recent findings relevant to the function and regulation of FPRL1/FPR2 in mononuclear phagocytes by pro- and antiinflammatory signals and its potential as a therapeutic target in AD...
  7. ncbi request reprint Silencing the formylpeptide receptor FPR by short-interfering RNA
    Yingying Le
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Bldg 560, Room 31 40, MD 21702 1201, USA
    Mol Pharmacol 66:1022-8. 2004
    ....
  8. ncbi request reprint Bacterial lipopolysaccharide selectively up-regulates the function of the chemotactic peptide receptor formyl peptide receptor 2 in murine microglial cells
    You hong Cui
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, National Cancer Institute, Building 560, Frederick, MD 21702, USA
    J Immunol 168:434-42. 2002
    ..Thus, LPS selectively modulates the function of chemoattractant receptors in microglia and may promote host response in inflammatory diseases in the CNS...
  9. ncbi request reprint Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor
    GuoGuang Ying
    Laboratory of Molecular Immunoregulation and Basic Research Program, SAIC Frederick, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    J Immunol 172:7078-85. 2004
    ..We conclude that Humanin shares human FPRL1 and mouse FPR2 with Abeta(42) and suggest that Humanin may exert its neuroprotective effects by competitively inhibiting the access of FPRL1 to Abeta(42)...
  10. ncbi request reprint TGF-beta1 disrupts endotoxin signaling in microglial cells through Smad3 and MAPK pathways
    Yingying Le
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, and Basic Research Program, Science Applications International Corporation Frederick, National Cancer Institute Frederick, Frederick, MD 21702, USA
    J Immunol 173:962-8. 2004
    ..Thus, TGF-beta1 may exert a protective role in CNS diseases characterized by microglial cell activation by proinflammatory stimulants...
  11. doi request reprint Receptor "hijacking" by malignant glioma cells: a tactic for tumor progression
    Jian Huang
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Building 560, Room 31 76, Frederick, MD 21702 1201, USA
    Cancer Lett 267:254-61. 2008
    ..Thus, FPR hijacked by human glioblastoma cells exploits the function of EGFR to promote rapid tumor progression...
  12. ncbi request reprint Identification of functional domains in the formyl peptide receptor-like 1 for agonist-induced cell chemotaxis
    Yingying Le
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, MD, USA
    FEBS J 272:769-78. 2005
    ..Considering the potential importance of FPRL1 in inflammation and neurodegenerative diseases, the identification of functional domains in this receptor will provide valuable information for the design of specific receptor antagonists...
  13. ncbi request reprint Receptors for chemotactic formyl peptides as pharmacological targets
    Yingying Le
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, MD 21702, USA
    Int Immunopharmacol 2:1-13. 2002
    ..Thus, by interacting with a variety of exogenous and host-derived agonists, formyl peptide receptors may play important roles in proinflammatory and immunological diseases and constitute a novel group of pharmacological targets...
  14. ncbi request reprint The role of dendritic cells in neurodegenerative diseases
    Pablo Iribarren
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Building 560, Room 31 40, Frederick, MD 21702, USA
    Arch Immunol Ther Exp (Warsz) 50:187-96. 2002
    ..This review will discuss recent findings pertinent to DCs and other antigen-presenting cells in the CNS in health and disease states...
  15. ncbi request reprint Formyl-peptide receptors revisited
    Yingying Le
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, MD 21702, USA
    Trends Immunol 23:541-8. 2002
    ....
  16. ncbi request reprint Manipulating chemoattractant and receptor genes
    Yingying Le
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    In Vivo 16:1-23. 2002
    ....
  17. ncbi request reprint The role of chemokine receptors in the promotion of viral infections
    Yingying Le
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, MD, USA
    Contrib Microbiol 10:210-31. 2003
  18. ncbi request reprint Potential role of the formyl peptide receptor-like 1 (FPRL1) in inflammatory aspects of Alzheimer's disease
    Youhong Cui
    Biochemistry Section, Lanzhou Military Medical University, Lanzhou, People s Republic of China
    J Leukoc Biol 72:628-35. 2002
    ..Therefore, FPRL1 may constitute an additional molecular target for the development of therapeutic agents for AD...
  19. ncbi request reprint Biologically active peptides interacting with the G protein-coupled formylpeptide receptor
    Yingying Le
    Laboratory of Immunologic and Inflammatory Diseases, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences Graduate School of the Chinese Academy of Sciences, Shanghai, PR China
    Protein Pept Lett 14:846-53. 2007
    ..Therefore, formylpeptide receptor ligands, by interacting with FPRs, play important roles in host defense and in the rapid progression of human glioblastoma...
  20. ncbi request reprint The immunopharmacological properties of transforming growth factor beta
    Yingying Le
    Laboratory of Immunologic and Inflammatory Diseases, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, P R China
    Int Immunopharmacol 5:1771-82. 2005
    ....
  21. ncbi request reprint F2L, a peptide derived from heme-binding protein, chemoattracts mouse neutrophils by specifically activating Fpr2, the low-affinity N-formylpeptide receptor
    Ji Liang Gao
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 178:1450-6. 2007
    ..Moreover, neutrophils from mice genetically deficient in Fpr2 failed to respond to F2L. Thus, Fpr2 is a mouse receptor for F2L, and can be targeted for the study of F2L action in mouse models...
  22. ncbi request reprint IL-4 down-regulates lipopolysaccharide-induced formyl peptide receptor 2 in murine microglial cells by inhibiting the activation of mitogen-activated protein kinases
    Pablo Iribarren
    Laboratory of Molecular Immunoregulation, Lanzhou Military Medical University, Lanzhou, People s Republic of China
    J Immunol 171:5482-8. 2003
    ..These results suggest that IL-4 may play an important role in the maintenance of homeostasis of CNS and in the regulation of the disease process characterized by microglial activation in response to proinflammatory stimulants...
  23. ncbi request reprint Cutting edge: vasoactive intestinal peptide acts as a potent suppressor of inflammation in vivo by trans-deactivating chemokine receptors
    Michael C Grimm
    Department of Medicine, St George Clinical School and Inflammation Research Unit, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia
    J Immunol 171:4990-4. 2003
    ..Circulating mononuclear cells from VIP-infused mice were unable to respond to chemokines. VIP may provide a novel approach to treatment of inflammatory diseases through inhibition of chemokine-dependent leukocyte recruitment...