Research Topics
| Yingying LeSummaryAffiliation: National Cancer Institute Country: USA Publications
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Detail Information
Publications
Chemokines and chemokine receptors: their manifold roles in homeostasis and diseaseYingying Le
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
Cell Mol Immunol 1:95-104. 2004..Therefore, chemokines and their receptors are important targets for modulation of host responses in pathophysiological conditions and for therapeutic intervention of human diseases...
A critical role for the g protein-coupled receptor mFPR2 in airway inflammation and immune responsesKeqiang Chen
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Maryland, USA
J Immunol 184:3331-5. 2010..This study reveals a critical role for mFPR2 in the progression of allergic airway inflammation and immune responses...- Formylpeptide receptor FPR and the rapid growth of malignant human gliomasYe Zhou
Laboratory of Molecular Immunoregulation, CCR, NCI Frederick, Building 560, Room 31 40, Frederick, MD 21702 1201, USA
J Natl Cancer Inst 97:823-35. 2005..We previously showed that selected human glioma cell lines also express functional FPR. We therefore investigated the relationship between FPR expression and the biologic behavior of glioma cells... - Role of formyl peptide receptor-like 1 (FPRL1/FPR2) in mononuclear phagocyte responses in Alzheimer diseasePablo Iribarren
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Bldg. 560, Frederick, MD 21702, USA
Immunol Res 31:165-76. 2005..This review discusses recent findings relevant to the function and regulation of FPRL1/FPR2 in mononuclear phagocytes by pro- and antiinflammatory signals and its potential as a therapeutic target in AD... - Silencing the formylpeptide receptor FPR by short-interfering RNAYingying Le
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Bldg 560, Room 31 40, MD 21702 1201, USA
Mol Pharmacol 66:1022-8. 2004.... - Bacterial lipopolysaccharide selectively up-regulates the function of the chemotactic peptide receptor formyl peptide receptor 2 in murine microglial cellsYou-Hong Cui
Laboratory of Molecular Immunoregulation, Division of Basic Sciences, National Cancer Institute, Building 560, Frederick, MD 21702, USA
J Immunol 168:434-42. 2002..Thus, LPS selectively modulates the function of chemoattractant receptors in microglia and may promote host response in inflammatory diseases in the CNS... - Receptor "hijacking" by malignant glioma cells: a tactic for tumor progressionJian Huang
Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Building 560, Room 31 76, Frederick, MD 21702 1201, USA
Cancer Lett 267:254-61. 2008..Thus, FPR hijacked by human glioblastoma cells exploits the function of EGFR to promote rapid tumor progression... - Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptorGuoGuang Ying
Laboratory of Molecular Immunoregulation and. Basic Research Program, SAIC-Frederick, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
J Immunol 172:7078-85. 2004..We conclude that Humanin shares human FPRL1 and mouse FPR2 with Abeta(42) and suggest that Humanin may exert its neuroprotective effects by competitively inhibiting the access of FPRL1 to Abeta(42)... - TGF-beta1 disrupts endotoxin signaling in microglial cells through Smad3 and MAPK pathwaysYingying Le
Laboratory of Molecular Immunoregulation, Center for Cancer Research, and Basic Research Program, Science Applications International Corporation-Frederick, National Cancer Institute-Frederick, Frederick, MD 21702, USA
J Immunol 173:962-8. 2004..Thus, TGF-beta1 may exert a protective role in CNS diseases characterized by microglial cell activation by proinflammatory stimulants... 
Formylpeptide receptor-2 contributes to colonic epithelial homeostasis, inflammation, and tumorigenesisKeqiang Chen
Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA
J Clin Invest 123:1694-704. 2013..These results indicate that FPR2 is critical in mediating homeostasis, inflammation, and epithelial repair processes in the colon...- Identification of functional domains in the formyl peptide receptor-like 1 for agonist-induced cell chemotaxisYingying Le
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, MD, USA
FEBS J 272:769-78. 2005..Considering the potential importance of FPRL1 in inflammation and neurodegenerative diseases, the identification of functional domains in this receptor will provide valuable information for the design of specific receptor antagonists... - Receptors for chemotactic formyl peptides as pharmacological targetsYingying Le
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, MD 21702, USA
Int Immunopharmacol 2:1-13. 2002..Thus, by interacting with a variety of exogenous and host-derived agonists, formyl peptide receptors may play important roles in proinflammatory and immunological diseases and constitute a novel group of pharmacological targets... - The role of dendritic cells in neurodegenerative diseasesPablo Iribarren
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Building 560, Room 31 40, Frederick, MD 21702, USA
Arch Immunol Ther Exp (Warsz) 50:187-96. 2002..This review will discuss recent findings pertinent to DCs and other antigen-presenting cells in the CNS in health and disease states... - Formyl-peptide receptors revisitedYingying Le
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, MD 21702, USA
Trends Immunol 23:541-8. 2002.... - Manipulating chemoattractant and receptor genesYingying Le
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
In Vivo 16:1-23. 2002.... - The role of chemokine receptors in the promotion of viral infectionsYingying Le
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, MD, USA
Contrib Microbiol 10:210-31. 2003 - Potential role of the formyl peptide receptor-like 1 (FPRL1) in inflammatory aspects of Alzheimer's diseaseYouhong Cui
Biochemistry Section, Lanzhou Military Medical University, Lanzhou, People's Republic of China
J Leukoc Biol 72:628-35. 2002..Therefore, FPRL1 may constitute an additional molecular target for the development of therapeutic agents for AD... - Biologically active peptides interacting with the G protein-coupled formylpeptide receptorYingying Le
Laboratory of Immunologic and Inflammatory Diseases, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences Graduate School of the Chinese Academy of Sciences, Shanghai, PR China
Protein Pept Lett 14:846-53. 2007..Therefore, formylpeptide receptor ligands, by interacting with FPRs, play important roles in host defense and in the rapid progression of human glioblastoma... - The immunopharmacological properties of transforming growth factor betaYingying Le
Laboratory of Immunologic and Inflammatory Diseases, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, P R China
Int Immunopharmacol 5:1771-82. 2005.... - F2L, a peptide derived from heme-binding protein, chemoattracts mouse neutrophils by specifically activating Fpr2, the low-affinity N-formylpeptide receptorJi Liang Gao
Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 178:1450-6. 2007..Moreover, neutrophils from mice genetically deficient in Fpr2 failed to respond to F2L. Thus, Fpr2 is a mouse receptor for F2L, and can be targeted for the study of F2L action in mouse models... - IL-4 down-regulates lipopolysaccharide-induced formyl peptide receptor 2 in murine microglial cells by inhibiting the activation of mitogen-activated protein kinasesPablo Iribarren
Laboratory of Molecular Immunoregulation, Lanzhou Military Medical University, Lanzhou, People s Republic of China
J Immunol 171:5482-8. 2003..These results suggest that IL-4 may play an important role in the maintenance of homeostasis of CNS and in the regulation of the disease process characterized by microglial activation in response to proinflammatory stimulants... - Cutting edge: vasoactive intestinal peptide acts as a potent suppressor of inflammation in vivo by trans-deactivating chemokine receptorsMichael C Grimm
Department of Medicine, St George Clinical School and Inflammation Research Unit, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia
J Immunol 171:4990-4. 2003..Circulating mononuclear cells from VIP-infused mice were unable to respond to chemokines. VIP may provide a novel approach to treatment of inflammatory diseases through inhibition of chemokine-dependent leukocyte recruitment...