Stuart Fj Le Grice

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Revisiting plus-strand DNA synthesis in retroviruses and long terminal repeat retrotransposons: dynamics of enzyme: substrate interactions
    Daniele Fabris
    Department of Chemistry and Biochemistry, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21228, USA
    Viruses 1:657-77. 2009
  2. pmc Probing Retroviral and Retrotransposon Genome Structures: The "SHAPE" of Things to Come
    Joanna Sztuba-Solinska
    RT Biochemistry Section, HIV Drug Resistance Program, National Cancer Institute, Fredrick, MD 21702 1201, USA
    Mol Biol Int 2012:530754. 2012
  3. pmc Exploring Ty1 retrotransposon RNA structure within virus-like particles
    Katarzyna J Purzycka
    RT Biochemistry Section, HIV Drug Resistance Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA
    Nucleic Acids Res 41:463-73. 2013
  4. pmc Structural complexity of Dengue virus untranslated regions: cis-acting RNA motifs and pseudoknot interactions modulating functionality of the viral genome
    Joanna Sztuba-Solinska
    RT Biochemistry Section, HIV Drug Resistance Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA
    Nucleic Acids Res 41:5075-89. 2013
  5. pmc The HIV-2 Rev-response element: determining secondary structure and defining folding intermediates
    Sabrina Lusvarghi
    HIV Drug Resistance Program, Reverse Transcriptase Biochemistry Section, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA
    Nucleic Acids Res 41:6637-49. 2013
  6. pmc Human immunodeficiency virus reverse transcriptase: 25 years of research, drug discovery, and promise
    Stuart F J Le Grice
    RT Biochemistry Section, HIV Drug Resistance Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA
    J Biol Chem 287:40850-7. 2012
  7. pmc The xenotropic murine leukemia virus-related retrovirus debate continues at first international workshop
    Jonathan P Stoye
    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
    Retrovirology 7:113. 2010

Collaborators

  • David J Garfinkel
  • Daniele Fabris
  • Joanna Sztuba-Solinska
  • Katarzyna J Purzycka
  • Sabrina Lusvarghi
  • Jason W Rausch
  • Jonathan P Stoye
  • Radhakrishnan Padmanabhan
  • Emiko Matsuda
  • Michal Legiewicz
  • Agniva Saha
  • Tadahisa Teramoto
  • Stuart F J Le Grice
  • Bruce A Shapiro
  • Linda D Eizentstat
  • Gary T Pauly
  • Robert H Silverman
  • Charles A Boucher

Detail Information

Publications8

  1. pmc Revisiting plus-strand DNA synthesis in retroviruses and long terminal repeat retrotransposons: dynamics of enzyme: substrate interactions
    Daniele Fabris
    Department of Chemistry and Biochemistry, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21228, USA
    Viruses 1:657-77. 2009
    ..Our studies also indicate that nonnucleoside RT inhibitors affect enzyme orientation, suggesting initiation of plus-strand DNA synthesis as a potential therapeutic target...
  2. pmc Probing Retroviral and Retrotransposon Genome Structures: The "SHAPE" of Things to Come
    Joanna Sztuba-Solinska
    RT Biochemistry Section, HIV Drug Resistance Program, National Cancer Institute, Fredrick, MD 21702 1201, USA
    Mol Biol Int 2012:530754. 2012
    ..This paper summarizes contributions from SHAPE towards our understanding of the structure of retroviral genomes, modifications to which technology that have been developed to address some of its limitations, and future challenges...
  3. pmc Exploring Ty1 retrotransposon RNA structure within virus-like particles
    Katarzyna J Purzycka
    RT Biochemistry Section, HIV Drug Resistance Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA
    Nucleic Acids Res 41:463-73. 2013
    ..Our results support the idea that antisense RNAs inhibit retrotransposition by targeting Ty1 protein function rather than annealing with the RNA genome...
  4. pmc Structural complexity of Dengue virus untranslated regions: cis-acting RNA motifs and pseudoknot interactions modulating functionality of the viral genome
    Joanna Sztuba-Solinska
    RT Biochemistry Section, HIV Drug Resistance Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA
    Nucleic Acids Res 41:5075-89. 2013
    ..In addition, our studies targeting elements of the 3' DB and its complementary region PK1 indicated that communication between 5'-3' terminal regions strongly depends on structure and sequence composition of the 5' cyclization region...
  5. pmc The HIV-2 Rev-response element: determining secondary structure and defining folding intermediates
    Sabrina Lusvarghi
    HIV Drug Resistance Program, Reverse Transcriptase Biochemistry Section, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA
    Nucleic Acids Res 41:6637-49. 2013
    ..The 3D models for the HIV-2 RRE and folding intermediates are also presented, wherein the Rev-binding stem-loops (IIB and I) are located coaxially in the former, which is in agreement with previous models for HIV-1 Rev-RRE binding. ..
  6. pmc Human immunodeficiency virus reverse transcriptase: 25 years of research, drug discovery, and promise
    Stuart F J Le Grice
    RT Biochemistry Section, HIV Drug Resistance Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA
    J Biol Chem 287:40850-7. 2012
    ..Salient features of HIV-1 RT and extension of these findings into programs of drug discovery are reviewed here...
  7. pmc The xenotropic murine leukemia virus-related retrovirus debate continues at first international workshop
    Jonathan P Stoye
    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
    Retrovirology 7:113. 2010
    ..The current status of XMRV research, concerns among the scientific community and suggestions for future actions are summarized in this meeting report...