Lenore Launer

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Similar decline in mortality rate of older persons with and without type 2 diabetes between 1993 and 2004 the Icelandic population-based Reykjavik and AGES-Reykjavik cohort studies
    Elin Olafsdottir
    Icelandic Heart Association Research Institute, Kopavogur, Iceland
    BMC Public Health 13:36. 2013
  2. pmc Socioeconomic factors from midlife predict mobility limitation and depressed mood three decades later; findings from the AGES-Reykjavik Study
    Danielle A I Groffen
    Department of Social Medicine, CAPHRI School for Public Health and Primary Care, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    BMC Public Health 13:101. 2013
  3. pmc Type 3 finger length pattern is associated with total knee replacements due to osteoarthritis but not with hip replacements or hand osteoarthritis in the elderly: the AGES-Reykjavik study
    Kristin Sigurjonsdottir
    University of Iceland, Reykjavik, Iceland
    BMC Musculoskelet Disord 14:112. 2013
  4. pmc The use of digital photographs for the diagnosis of hand osteoarthritis: the AGES-Reykjavik study
    Helgi Jonsson
    Landspitalinn University Hospital, University of Iceland, IS 108 Fossvogur, Reykjavik, Iceland
    BMC Musculoskelet Disord 13:20. 2012
  5. pmc Lowering midlife levels of systolic blood pressure as a public health strategy to reduce late-life dementia: perspective from the Honolulu Heart Program/Honolulu Asia Aging Study
    Lenore J Launer
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD 20892, USA
    Hypertension 55:1352-9. 2010
  6. ncbi request reprint Epidemiology of white-matter lesions
    Lenore J Launer
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD 20892, USA
    Int Psychogeriatr 15:99-103. 2003
  7. ncbi request reprint Epidemiologic evidence of oxidative stress in the brain
    Lenore J Launer
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    Eur J Epidemiol 19:99-100. 2004
  8. ncbi request reprint Epidemiology of white matter lesions
    Lenore J Launer
    Laboratory of Epidemiology, Demography, Biometry National Institute on Aging, Bethesda, Maryland 20892, USA
    Top Magn Reson Imaging 15:365-7. 2004
  9. ncbi request reprint Prevention of AD: the which, when, and on whom?
    Lenore J Launer
    Laboratory for Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue, Bethesda, MD 20892, USA
    Alzheimer Dis Assoc Disord 20:S75-8. 2006
  10. ncbi request reprint Diabetes and brain aging: epidemiologic evidence
    Lenore J Launer
    Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue, Suite 3C 309, Bethesda, MD 20892, USA
    Curr Diab Rep 5:59-63. 2005

Detail Information

Publications86

  1. pmc Similar decline in mortality rate of older persons with and without type 2 diabetes between 1993 and 2004 the Icelandic population-based Reykjavik and AGES-Reykjavik cohort studies
    Elin Olafsdottir
    Icelandic Heart Association Research Institute, Kopavogur, Iceland
    BMC Public Health 13:36. 2013
    ..The objective of this study was to estimate the secular trend of cardiovascular and all-cause mortality rates in two population-based cohorts of older persons, with and without type 2 diabetes, examined 11 years apart...
  2. pmc Socioeconomic factors from midlife predict mobility limitation and depressed mood three decades later; findings from the AGES-Reykjavik Study
    Danielle A I Groffen
    Department of Social Medicine, CAPHRI School for Public Health and Primary Care, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    BMC Public Health 13:101. 2013
    ..The present study aims to examine the effect of midlife socioeconomic factors on mobility limitation and depressed mood three decades later...
  3. pmc Type 3 finger length pattern is associated with total knee replacements due to osteoarthritis but not with hip replacements or hand osteoarthritis in the elderly: the AGES-Reykjavik study
    Kristin Sigurjonsdottir
    University of Iceland, Reykjavik, Iceland
    BMC Musculoskelet Disord 14:112. 2013
    ..This large cross-sectional study tests the hypothesis that the type 3 pattern is associated with total joint replacements due to osteoarthritis in a large population based study...
  4. pmc The use of digital photographs for the diagnosis of hand osteoarthritis: the AGES-Reykjavik study
    Helgi Jonsson
    Landspitalinn University Hospital, University of Iceland, IS 108 Fossvogur, Reykjavik, Iceland
    BMC Musculoskelet Disord 13:20. 2012
    ....
  5. pmc Lowering midlife levels of systolic blood pressure as a public health strategy to reduce late-life dementia: perspective from the Honolulu Heart Program/Honolulu Asia Aging Study
    Lenore J Launer
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD 20892, USA
    Hypertension 55:1352-9. 2010
    ....
  6. ncbi request reprint Epidemiology of white-matter lesions
    Lenore J Launer
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD 20892, USA
    Int Psychogeriatr 15:99-103. 2003
    ..WML increase in prevalence with age. Several cardiovascular risk factors and cognitive, emotional, and physical function consequences of WML have been identified. These are reviewed briefly in this report...
  7. ncbi request reprint Epidemiologic evidence of oxidative stress in the brain
    Lenore J Launer
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    Eur J Epidemiol 19:99-100. 2004
  8. ncbi request reprint Epidemiology of white matter lesions
    Lenore J Launer
    Laboratory of Epidemiology, Demography, Biometry National Institute on Aging, Bethesda, Maryland 20892, USA
    Top Magn Reson Imaging 15:365-7. 2004
    ..The genetic contributions to white matter lesions are also reviewed...
  9. ncbi request reprint Prevention of AD: the which, when, and on whom?
    Lenore J Launer
    Laboratory for Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue, Bethesda, MD 20892, USA
    Alzheimer Dis Assoc Disord 20:S75-8. 2006
  10. ncbi request reprint Diabetes and brain aging: epidemiologic evidence
    Lenore J Launer
    Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue, Suite 3C 309, Bethesda, MD 20892, USA
    Curr Diab Rep 5:59-63. 2005
    ..Epidemiologic data on diabetes and brain aging are reviewed. A brief overview is also given of the physiologic mechanisms supporting the epidemiologic data...
  11. ncbi request reprint Population-based studies of AD: message and methods: an epidemiologic view
    L J Launer
    Laboratory for Epidemiology, Biometry and Demography, Gateway Building 3C 309, 7201 Wisconsin Avenue, Bethesda, MD 20892, USA
    Stat Med 23:191-7. 2004
    ..To reduce bias from prospective epidemiologic studies, not only are new approaches to definition of disease and exposure needed, but new epidemiologic or statistical methods may be required as well...
  12. pmc AD brain pathology: vascular origins? Results from the HAAS autopsy study
    Lenore J Launer
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, 7201 Wisconsin Ave, 3C 309 Bethesda, MD 20892, USA
    Neurobiol Aging 29:1587-90. 2008
    ..Our study suggests the burden of vascular and AD type lesions are independent of each other, and are consistent with an additive effect of the two types of lesions on cognitive impairment...
  13. ncbi request reprint Next steps in Alzheimer's disease research: interaction between epidemiology and basic science
    Lenore J Launer
    National Institute on Aging, Bethesda, MD 20892, USA
    Curr Alzheimer Res 4:141-3. 2007
    ..This is followed by a discussion of how these findings could inform the design of basic research strategies that may further the translation of bench science to the clinic and public health arena...
  14. pmc Counting dementia: There is no one "best" way
    Lenore J Launer
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    Alzheimers Dement 7:10-4. 2011
    ..The choice of going deep or wide depends on the goal of the ascertainment. These goals are discussed, as well as the emerging issues that may change the way dementia cases are classified...
  15. pmc Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy
    Lenore J Launer
    Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Lancet Neurol 10:969-77. 2011
    ..People with type 2 diabetes are at risk of cognitive impairment and brain atrophy. We aimed to compare the effects on cognitive function and brain volume of intensive versus standard glycaemic control...
  16. ncbi request reprint Nonsteroidal anti-inflammatory drug use and the risk for Alzheimer's disease: dissecting the epidemiological evidence
    Lenore Launer
    Laboratory for Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland 28092, USA
    Drugs 63:731-9. 2003
    ..At present, no recommendations can be made concerning the when, what, who and for how long a person should take an NSAID to reduce his or her risk for AD...
  17. pmc Microinfarcts, brain atrophy, and cognitive function: the Honolulu Asia Aging Study Autopsy Study
    Lenore J Launer
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD 20892, USA
    Ann Neurol 70:774-80. 2011
    ....
  18. ncbi request reprint Demonstrating the case that AD is a vascular disease: epidemiologic evidence
    Lenore J Launer
    Intramural Research Program, Laboratory of Epidemiology, Demography and Biometry, Neuroepidemiology Section, National Institute on Aging, 7201 Wisconsin Avenue, Gateway Building, Suite 3C 309, Bethesda, MD 20892 9205, USA
    Ageing Res Rev 1:61-77. 2002
    ..This article reviews the epidemiologic evidence supporting an association between AD and two major vascular risk factors-blood pressure and diabetes. Both methodologic and biologic explanations for these associations are discussed...
  19. ncbi request reprint Regional variability in the prevalence of cerebral white matter lesions: an MRI study in 9 European countries (CASCADE)
    L J Launer
    Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, Bethesda, MD 20892, USA
    Neuroepidemiology 26:23-9. 2006
    ..As a means of hypothesis generation and for health planning, further research on the geographic distribution of WML may lead to the identification of new risk factors for these lesions...
  20. ncbi request reprint The epidemiologic study of dementia: a life-long quest?
    L J Launer
    Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neurobiol Aging 26:335-40. 2005
    ..To better understand which risk factors lead to disease initiation, progression and prognosis, a life course approach to the epidemiologic study of dementia is needed...
  21. doi request reprint Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon4: the Cardiovascular Health Study Cognition Study
    Fumiko Irie
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Ave, Bethesda, MD, USA
    Arch Neurol 65:89-93. 2008
    ..Diabetes and the apolipoprotein E epsilon4 allele (APOE epsilon4) increase the risk for Alzheimer disease (AD). We hypothesize that APOE epsilon4 may modify the risk for AD in individuals with diabetes...
  22. ncbi request reprint Midlife pulse pressure and incidence of dementia: the Honolulu-Asia Aging Study
    Michael H Freitag
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    Stroke 37:33-7. 2006
    ..This study explores whether this association is attributable to the pulsatile, ie, pulse pressure (PP), or the nonpulsatile component of blood pressure (BP)...
  23. ncbi request reprint Midlife dietary intake of antioxidants and risk of late-life incident dementia: the Honolulu-Asia Aging Study
    Danielle Laurin
    Neuroepidemiology Section, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Epidemiol 159:959-67. 2004
    ..This analysis suggests that midlife dietary intake of antioxidants does not modify the risk of late-life dementia or its most prevalent subtypes...
  24. pmc Coronary artery calcium, brain function and structure: the AGES-Reykjavik Study
    Jean Sébastien Vidal
    National Institutes of Health, NIA LEDB, 7201 Wisconsin Ave, Gateway Building, Suite 3C309, Bethesda, MD 20892 9205, USA
    Stroke 41:891-7. 2010
    ..Several cardiovascular risk factors are associated with cognitive disorders in older persons. Little is known about the association of the burden of coronary atherosclerosis with brain structure and function...
  25. ncbi request reprint [Trends in body weight and diabetes in forty years in Iceland]
    Bolli Thorsson
    Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, MD, USA
    Laeknabladid 95:259-66. 2009
    ..Obesity and diabetes are increasing problems worldwide. Therefore, new data on these issues are of importance. Here, we publish data on body mass index (BMI) and prevalence of diabetes of type 2 in Iceland...
  26. pmc Microvascular lesions in the brain and retina: The age, gene/environment susceptibility-Reykjavik study
    Chengxuan Qiu
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue, Bethesda, MD 20892, USA
    Ann Neurol 65:569-76. 2009
    ..To investigate whether the severity and location of cerebral white matter hyperintensities (WMHs) and brain infarcts are correlated with the signs of retinal microvascular abnormalities in the elderly...
  27. ncbi request reprint Insulin-degrading enzyme haplotypes affect insulin levels but not dementia risk
    Lauren Marlowe
    Laboratorie of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, MD 20892, USA
    Neurodegener Dis 3:320-6. 2006
    ..Insulin-degrading enzyme (IDE) polymorphism is hypothesized to regulate insulin levels as well as processes involved in neuronal compromise found in dementia...
  28. pmc Coronary artery calcium and physical performance as determinants of mortality in older age: the AGES-Reykjavik Study
    Mikaela B von Bonsdorff
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, MD, USA Gerontology Research Center and Department of Health Sciences, University of Jyvaskyla, Finland Electronic address
    Int J Cardiol 168:2094-9. 2013
    ..We investigated the association between the extent of CAC and physical performance among older individuals and explored these individual and combined effects on cardiovascular disease (CVD) mortality and non-CVD mortality...
  29. pmc Multiple imputation for estimating the risk of developing dementia and its impact on survival
    Binbing Yu
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, MD 20892, USA
    Biom J 52:616-27. 2010
    ..Data from the Honolulu Asia Aging Study are analyzed to estimate the age-specific and cumulative risks of dementia and to examine the effect of major risk factors on dementia onset and death...
  30. ncbi request reprint Migraine and MTHFR C677T genotype in a population-based sample
    Ann I Scher
    Department of Preventive Medicine and Biometrics, Uniformed Services University, Bethesda, MD 20814 4799, USA
    Ann Neurol 59:372-5. 2006
    ..We assessed the association of the MTHFR C677T variant with migraine and the mediating effect of cardiovascular risk factors and metabolic markers of genotype status...
  31. ncbi request reprint Neurological examination findings to predict limitations in mobility and falls in older persons without a history of neurological disease
    Luigi Ferrucci
    Longitudinal Studies Section, Clinical Research Branch, National Instituts on Aging, National Institute of Health, Baltimore, Maryland 21225, USA
    Am J Med 116:807-15. 2004
    ..To estimate the prevalence of neurological signs and their association with limitations in mobility and falls in a sample of older persons without known neurological disease...
  32. ncbi request reprint The relation between apolipoprotein A-I and dementia: the Honolulu-Asia aging study
    Jane S Saczynski
    Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, MD 20892, USA
    Am J Epidemiol 165:985-92. 2007
    ..These results raise the possibility that different lipoprotein components of cholesterol may be differentially associated with dementia...
  33. pmc Correlation of echocardiographic findings with cerebral infarction in elderly adults: the AGES-Reykjavik study
    Dorothea McAreavey
    NIH Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Stroke 41:2223-8. 2010
    ..In this cross-sectional analysis of elderly subjects, we investigated the relationship of a comprehensive set of echocardiographic measures with cerebral infarction detected by MRI...
  34. pmc Genome-wide association study of blood pressure and hypertension
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 41:677-87. 2009
    ..Identifying genes associated with blood pressure advances our understanding of blood pressure regulation and highlights potential drug targets for the prevention or treatment of hypertension...
  35. pmc Age, Gene/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics
    Tamara B Harris
    Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, MD 20892 9205, USA
    Am J Epidemiol 165:1076-87. 2007
    ..This approach should facilitate identification of genetic factors that contribute to healthy aging as well as the chronic conditions common in old age...
  36. pmc Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium
    Santhi K Ganesh
    National Human Genome Research Institute, Division of Intramural Research, Bethesda, MD, USA
    Nat Genet 41:1191-8. 2009
    ..This study has identified new determinants of erythrocyte traits, offering insight into common variants underlying variation in erythrocyte measures...
  37. pmc Red cell distribution width and mortality in older adults: a meta-analysis
    Kushang V Patel
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland 20892 9205, USA
    J Gerontol A Biol Sci Med Sci 65:258-65. 2010
    ..Whether RDW is prognostic in more representative community-based populations is unclear...
  38. pmc Alterations in the red blood cell membrane proteome in alzheimer's subjects reflect disease-related changes and provide insight into altered cell morphology
    Joy G Mohanty
    National Institute on Aging, Baltimore, MD, USA
    Proteome Sci 8:11. 2010
    ....
  39. ncbi request reprint A TGF-beta1 polymorphism association with dementia and neuropathologies: the HAAS
    Rita Peila
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue, Suite 3C 309, Bethesda, MD 20892 9205, USA
    Neurobiol Aging 28:1367-73. 2007
    ..2-0.9). The CC genotype was associated with an increase risk of neocortical plaques (OR(CC)=4.34, CI: 1.6-11.8). These preliminary data suggest that the TGF genetic variability may be important in the risk of vascular related dementia...
  40. ncbi request reprint The effect of social engagement on incident dementia: the Honolulu-Asia Aging Study
    Jane S Saczynski
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, MD 20892 9205, USA
    Am J Epidemiol 163:433-40. 2006
    ..12, 3.13). Although low social engagement in late life is associated with risk of dementia, levels of late-life social engagement may already have been modified by the dementing process and may be associated with prodromal dementia...
  41. ncbi request reprint Reducing the risk of dementia: efficacy of long-term treatment of hypertension
    Rita Peila
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Stroke 37:1165-70. 2006
    ..We evaluated the risk of dementia and cognitive decline associated with duration of antihypertensive treatment...
  42. ncbi request reprint Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study
    Rita Peila
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    Diabetes 51:1256-62. 2002
    ..6, 1.5-29.6). Type 2 diabetes is a risk factor for AD and VsD. The association between diabetes and AD is particularly strong among carriers of the APOE epsilon4 allele. The neuropathological data are consistent with the clinical results...
  43. ncbi request reprint Fasting insulin and incident dementia in an elderly population of Japanese-American men
    Rita Peila
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Room 3C 309 Gateway Building, 7201 Wisconsin Avenue, Bethesda, MD 20892, USA
    Neurology 63:228-33. 2004
    ..To evaluate the association of fasting insulin level to incident dementia in a cohort of elderly men...
  44. ncbi request reprint Variability in midlife systolic blood pressure is related to late-life brain white matter lesions: the Honolulu-Asia Aging study
    Richard J Havlik
    Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Stroke 33:26-30. 2002
    ..Besides the associations with advanced age and high blood pressure (BP), variability in systolic BP (SBP) and the resulting changes in blood flow to the deep arteries of the brain may be contributing factors...
  45. pmc Persistence of the effect of birth size on dysglycaemia and type 2 diabetes in old age: AGES-Reykjavik Study
    Mikaela B von Bonsdorff
    Laboratory of Epidemiology, Demography and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, MD, USA
    Age (Dordr) 35:1401-9. 2013
    ..93; 95 % CI, 2.14-11.37). Excessive weight gain in adulthood might be particularly detrimental to the health of old individuals with low birth weight...
  46. pmc Multiple loci associated with indices of renal function and chronic kidney disease
    Anna Kottgen
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
    Nat Genet 41:712-7. 2009
    ..Our findings provide new insights into CKD pathogenesis and underscore the importance of common genetic variants influencing renal function and disease...
  47. doi request reprint Retinal and cerebral microvascular signs and diabetes: the age, gene/environment susceptibility-Reykjavik study
    Chengxuan Qiu
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health NIH, Bethesda, Maryland 20892, USA
    Diabetes 57:1645-50. 2008
    ..We sought to examine whether microvascular lesions in the retina and in the brain are associated and whether this association differs among people with and without diabetes...
  48. ncbi request reprint Abnormal T-wave axis is associated with coronary artery calcification in older adults
    Matthew L Scherer
    National Institute on Aging, Laboratory of Epidemiology, Demography, and Biometry, NIH, Bethesda, MD, USA
    Scand Cardiovasc J 43:240-8. 2009
    ..To determine whether T-wave axis on the resting electrocardiogram (ECG) is associated with coronary artery calcification (CAC) score, a measurement of coronary atherosclerosis, in older adults...
  49. pmc Intra-individual change over time in DNA methylation with familial clustering
    Hans T Bjornsson
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    JAMA 299:2877-83. 2008
    ..However, changes in methylation or other epigenetic marks over time in a given individual have not yet been investigated...
  50. pmc Migraine headache in middle age and late-life brain infarcts
    Ann I Scher
    Uniformed Services University, Bethesda, Maryland, USA
    JAMA 301:2563-70. 2009
    ..Migraine is considered to be an episodic condition with no long-term consequences. However, recent studies suggest that migraine attacks may be associated with pathologic changes in the brain, particularly in the cerebellum...
  51. ncbi request reprint Sex hormones and neuropathology in elderly men: the HAAS
    Dorothea Strozyk
    Laboratory of Epidemiology, Demography and Biometry, National Institutes on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neurobiol Aging 28:62-8. 2007
    ..This community-based autopsy study suggests that peripheral levels of sex hormones are associated with neurofibrillary tangles and micro-infarcts, but not with other neuropathologic markers of brain disease in elderly men...
  52. pmc New loci associated with kidney function and chronic kidney disease
    Anna Kottgen
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
    Nat Genet 42:376-84. 2010
    ..These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney...
  53. ncbi request reprint Vitamin E and C supplements and risk of dementia
    Danielle Laurin
    JAMA 288:2266-8. 2002
  54. ncbi request reprint Atorvastatin for the treatment of mild to moderate Alzheimer disease: preliminary results
    D Larry Sparks
    Author Affiliations Sun Health Research Institute, Sun City, AZ 85351, USA
    Arch Neurol 62:753-7. 2005
    ....
  55. ncbi request reprint The association between blood pressure, hypertension, and cerebral white matter lesions: cardiovascular determinants of dementia study
    Ewoud J van Dijk
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Hypertension 44:625-30. 2004
    ..Successful treatment of hypertension may reduce this risk; however, a potential negative effect of decreasing diastolic blood pressure level on the occurrence of severe periventricular white matter lesions should be taken into account...
  56. ncbi request reprint A 32-year prospective study of change in body weight and incident dementia: the Honolulu-Asia Aging Study
    Robert Stewart
    Institute of Psychiatry, London, United Kingdom
    Arch Neurol 62:55-60. 2005
    ..The course of weight loss associated with dementia is unclear, particularly prior to and around the onset of the clinical syndrome...
  57. ncbi request reprint Inverse association of tea and flavonoid intakes with incident myocardial infarction: the Rotterdam Study
    Johanna M Geleijnse
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, Netherlands
    Am J Clin Nutr 75:880-6. 2002
    ..Dietary flavonoids may protect against cardiovascular disease, but evidence is still conflicting. Tea is the major source of flavonoids in Western populations...
  58. ncbi request reprint Midlife blood pressure and the risk of hippocampal atrophy: the Honolulu Asia Aging Study
    Esther S C Korf
    Department of Neurology and Alzheimer Center, Universiteit Medical Center, Amsterdam, The Netherlands
    Hypertension 44:29-34. 2004
    ..51; CI=1.26; 9.74). In conclusion, treatment with antihypertensive treatment modifies the association of BP and HA, such that high levels of BP adversely affect the hippocampus in persons never treated with antihypertensives...
  59. ncbi request reprint Magnetic resonance imaging of the brain in diabetes: the Cardiovascular Determinants of Dementia (CASCADE) Study
    Reinhold Schmidt
    Department of Neurology, Medical University Graz, Graz, Austria
    Diabetes 53:687-92. 2004
    ..Cognitive and pathological data are needed to determine the clinical significance of these findings as well as to understand the mechanisms underlying these associations...
  60. ncbi request reprint Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia Aging Study
    Reinhold Schmidt
    Department of Neurology, Karl Franzens University, Graz, Austria
    Ann Neurol 52:168-74. 2002
    ..These data support the view that inflammatory markers may reflect not only peripheral disease, but also cerebral disease mechanisms related to dementia, and that these processes are measurable long before clinical symptoms appear...
  61. ncbi request reprint Cigarette smoking and alcohol consumption in relation to cognitive performance in middle age
    Sandra Kalmijn
    Julius Centre for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Epidemiol 156:936-44. 2002
    ..This finding suggests that actions to prevent cognitive decline can be taken in middle age...
  62. ncbi request reprint Endogenous estradiol and risk of dementia in women and men: the Rotterdam Study
    Mirjam I Geerlings
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Ann Neurol 53:607-15. 2003
    ..The findings do not support the hypothesis that higher levels of endogenous estradiol reduce risk of dementia, neither in women nor in men...
  63. ncbi request reprint Mid-life smoking and late-life dementia: the Honolulu-Asia Aging Study
    Suzanne L Tyas
    Sanders Brown Center on Aging, Kentucky School of Public Health, University of Kentucky, 203B Sanders Brown Building, Lexington, KY, USA
    Neurobiol Aging 24:589-96. 2003
    ..This study suggests that amount smoked is associated with an increasing risk of AD and Alzheimer-type neuropathology up to heavy smoking levels. The lack of association in very heavy smokers may be due to a hardy survivor effect...
  64. ncbi request reprint High prevalence of white matter hyperintensities in normal aging: relation to blood pressure and cognition
    Hedvig Söderlund
    Department of Psychology, Stockholm University, Stockholm, Sweden
    Cortex 39:1093-105. 2003
    ..Periventricular WMHs had a negative effect on episodic memory, although the relation was not linear. Collectively, the notion that white matter hyperintensities impair cognitive function got weak support in this Swedish sample...
  65. ncbi request reprint Atorvastatin therapy lowers circulating cholesterol but not free radical activity in advance of identifiable clinical benefit in the treatment of mild-to-moderate AD
    D Larry Sparks
    SunHealth Research Institute, USA
    Curr Alzheimer Res 2:343-53. 2005
    ..Accordingly, atorvastatin therapy may be an effective treatment and may slow the progression of AD among mild-to-moderately affected patients...
  66. pmc Cognitive impairment: an increasingly important complication of type 2 diabetes: the age, gene/environment susceptibility--Reykjavik study
    Jane S Saczynski
    Division of Geriatric Medicine, University of Massachusetts Medical School, Biotech Four, Suite 315, 377 Plantation Street, Worcester, MA 01605, USA
    Am J Epidemiol 168:1132-9. 2008
    ..01) and poorer memory performance (beta = -0.22; P < 0.05). Persons with type 2 diabetes have poorer cognitive performance than normoglycemics, particularly in PS. Those with undiagnosed diabetes have the lowest cognitive performance...
  67. ncbi request reprint Apolipoprotein E genotype and statins affect CRP levels through independent and different mechanisms: AGES-Reykjavik Study
    Gudny Eiriksdottir
    Atherosclerosis 186:222-4. 2006
    ....
  68. ncbi request reprint Endogenous sex hormones, cognitive decline, and future dementia in old men
    Mirjam I Geerlings
    University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands
    Ann Neurol 60:346-55. 2006
    ..To estimate the association of endogenous levels of bioavailable testosterone and estradiol with risk for cognitive decline and dementia in old men...
  69. ncbi request reprint Cerebral changes on MRI and cognitive function: the CASCADE study
    Hedvig Söderlund
    The Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Canada, and Department of Psychology, Stockholm University, Stockholm, Sweden
    Neurobiol Aging 27:16-23. 2006
    ..The findings are consistent with findings from lesion and functional neuroimaging studies...
  70. ncbi request reprint Association of interleukin-1 gene polymorphisms with dementia in a community-based sample: the Honolulu-Asia Aging Study
    Berran Yucesoy
    Toxicology and Molecular Biology Branch, Biostatistics Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Neurobiol Aging 27:211-7. 2006
    ..There was no difference in the IL-1beta (+3953) frequency among the groups. Our results support the hypothesis that certain genetic variations contained within the IL-1 gene family contribute to the pathogenesis of dementia...
  71. ncbi request reprint Bowel movement frequency in late-life and incidental Lewy bodies
    Robert D Abbott
    Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville, Virginia 22908 0717, and Veterans Affairs Pacific Islands Health Care System, Honolulu, HI, USA
    Mov Disord 22:1581-6. 2007
    ..Infrequent bowel movements are associated with ILB. Findings provide evidence that constipation can predate the extrapyramidal signs of PD. Constipation could be one of the earliest markers of the beginning of PD processes...
  72. ncbi request reprint The Action to Control Cardiovascular Risk in Diabetes Memory in Diabetes Study (ACCORD-MIND): rationale, design, and methods
    Jeff D Williamson
    Roena B Kulynych Center for Memory, Cognition Research, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Cardiol 99:112i-122i. 2007
    ..This report presents the design, rationale, and methods of the ACCORD-MIND substudy...
  73. pmc White matter lesions and the risk of incident hip fracture in older persons: results from the progetto veneto anziani study
    Maria Chiara Corti
    Azienda Unità Locale Socio Sanitaria 16, Via Scrovegni 14, 35131 Padova, Italy
    Arch Intern Med 167:1745-51. 2007
    ..White matter lesions (WMLs) are associated with hypertension, an increased risk of falling, and impaired physical and cognitive performance that may affect the mechanical effect of falls...
  74. ncbi request reprint Ankle-to-brachial index and dementia: the Honolulu-Asia Aging Study
    Danielle Laurin
    Laval University Geriatrics Research Unit, Centre de recherche du CHA, and Faculty of Pharmacy, Laval University, Quebec City, Quebec, Canada
    Circulation 116:2269-74. 2007
    ..Evidence indicates the existence of vascular components in the pathogenesis of dementia. Here, we examine the association of ABI with dementia and subtypes...
  75. ncbi request reprint Brain aging in very old men with type 2 diabetes: the Honolulu-Asia Aging Study
    Esther S C Korf
    Neurology and Alzheimer Center, Vrije Universiteit Medical Center, De Boelelaan, Amsterdam, The Netherlands
    Diabetes Care 29:2268-74. 2006
    ....
  76. ncbi request reprint Twenty-six-year change in total cholesterol levels and incident dementia: the Honolulu-Asia Aging Study
    Robert Stewart
    King s College London Institute of Psychiatry, Section of Epidemiology, England
    Arch Neurol 64:103-7. 2007
    ..The relationship between total cholesterol levels and dementia is unclear...
  77. ncbi request reprint White matter lesions and cognitive performance: the role of cognitively complex leisure activity
    Jane S Saczynski
    Division of Geriatric Medicine, University of Massachusetts Medical School, Biotech Four, 377 Plantation Street, Worcester, MA 01605, USA
    J Gerontol A Biol Sci Med Sci 63:848-54. 2008
    ..Among persons with white matter lesions (WMLs), there is a range of cognitive function. We examine whether participation in leisure activities modifies the effect of WML load on cognitive function...
  78. doi request reprint Hemodynamics of increased pulse pressure in older women in the community-based Age, Gene/Environment Susceptibility-Reykjavik Study
    Gary F Mitchell
    Cardiovascular Engineering Inc, 51 Sawyer Road, Suite 100, Waltham, MA 02453, USA
    Hypertension 51:1123-8. 2008
    ..4+/-1.4 mm Hg, P=0.75). Thus, reduced aortic diameter and impaired matching between diameter and flow accounts for the sex difference in pulse pressure in an unselected community-based cohort of older people...
  79. pmc Age effects on hippocampal structural changes in old men: the HAAS
    Yuan Xu
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 1721, USA
    Neuroimage 40:1003-15. 2008
    ..However, the sample sizes of disease groups are relatively low; further studies with more AD/VaD data are needed...
  80. doi request reprint Apolipoprotein E epsilon4 allele genotype and the effect of depressive symptoms on the risk of dementia in men: the Honolulu-Asia Aging Study
    Fumiko Irie
    Pacific Health Research Institute, Honolulu, Hawaii, USA
    Arch Gen Psychiatry 65:906-12. 2008
    ..Recently, depression has also become recognized as a risk factor for dementia. However, the possible effect of the APOE genotype on the association between depression and dementia is unexamined...
  81. pmc Evaluating the quality of longitudinal statistical applications in original publications on Alzheimer's disease
    Chengjie Xiong
    Division of Biostatistics, Washington University, St Louis, MO 63110, USA
    Neuroepidemiology 30:112-9. 2008
    ..To evaluate the quality of longitudinal statistical applications in published studies on Alzheimer's disease (AD)...
  82. ncbi request reprint Regional differences in rates of dementia: MRC-CFAS
    Lenore J Launer
    Lancet Neurol 4:694-5. 2005
  83. ncbi request reprint Nonsteroidal anti-inflammatory drugs and Alzheimer disease: what's next?
    Lenore J Launer
    JAMA 289:2865-7. 2003
  84. pmc Computer-assisted segmentation of white matter lesions in 3D MR images using support vector machine
    Zhiqiang Lao
    Department of Radiology, 3600 Market Street, Suite 380, University of Pennsylvania, Philadelphia, PA 19104, USA
    Acad Radiol 15:300-13. 2008
    ..Brain lesions, especially white matter lesions (WMLs), are associated with cardiac and vascular disease, but also with normal aging. Quantitative analysis of WML in large clinical trials is becoming more and more important...
  85. ncbi request reprint Assessing statistical applications in publications on Alzheimer's disease
    Chengjie Xiong
    Division of Biostatistics, Washington University, St Louis, MO 63110, USA
    Neuroepidemiology 28:235-45. 2007
    ..To evaluate statistical applications in publications on Alzheimer's disease (AD)...
  86. ncbi request reprint Migraine as a risk factor for subclinical brain lesions
    Mark C Kruit
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    JAMA 291:427-34. 2004
    ..Clinical series have suggested an increased prevalence of cerebral infarction and white matter lesions (WMLs) in migraine patients. It is not known whether these lesions are prevalent in the general migraine population...