L J Launer

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Is there epidemiologic evidence that anti-oxidants protect against disorders in cognitive function?
    L J Launer
    Epidemiology, Demography, Biometry Program, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Ave, 3C 309, Bethesda, MD 20892 USA
    J Nutr Health Aging 4:197-201. 2000
  2. ncbi request reprint CASCADE: a European collaborative study on vascular determinants of brain lesions. Study design and objectives
    L J Launer
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Neuroepidemiology 19:113-20. 2000
  3. ncbi request reprint Midlife blood pressure and dementia: the Honolulu-Asia aging study
    L J Launer
    Epidemiology, Demography and Biometry Program, National Institute on Aging, National Institutes of Health, Gateway Building 3C 309, 7201 Wisconsin Avenue, Bethesda, MD 20892, USA
    Neurobiol Aging 21:49-55. 2000
  4. ncbi request reprint Cholesterol and neuropathologic markers of AD: a population-based autopsy study
    L J Launer
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neurology 57:1447-52. 2001
  5. ncbi request reprint APOE-epsilon4 predicts incident AD in Japanese-American men: the honolulu-asia aging study
    R J Havlik
    Epidemiology, Demography and Biometry Program, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neurology 54:1526-9. 2000
  6. ncbi request reprint Association between blood pressure, white matter lesions, and atrophy of the medial temporal lobe
    T den Heijer
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurology 64:263-7. 2005
  7. ncbi request reprint Analysis and validation of automated skull stripping tools: a validation study based on 296 MR images from the Honolulu Asia aging study
    S W Hartley
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neuroimage 30:1179-86. 2006
  8. ncbi request reprint Serum carotenoids and cerebral white matter lesions: the Rotterdam scan study
    T den Heijer
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    J Am Geriatr Soc 49:642-6. 2001
  9. ncbi request reprint Regional variability in the prevalence of cerebral white matter lesions: an MRI study in 9 European countries (CASCADE)
    L J Launer
    Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, Bethesda, MD 20892, USA
    Neuroepidemiology 26:23-9. 2006
  10. ncbi request reprint CSF Abeta 42 levels correlate with amyloid-neuropathology in a population-based autopsy study
    D Strozyk
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, NIH, Bethesda, MD 20892, USA
    Neurology 60:652-6. 2003

Detail Information

Publications39

  1. ncbi request reprint Is there epidemiologic evidence that anti-oxidants protect against disorders in cognitive function?
    L J Launer
    Epidemiology, Demography, Biometry Program, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Ave, 3C 309, Bethesda, MD 20892 USA
    J Nutr Health Aging 4:197-201. 2000
    ..A discussion is provided of methodologic limitations of existing studies and possible directions for future investigations...
  2. ncbi request reprint CASCADE: a European collaborative study on vascular determinants of brain lesions. Study design and objectives
    L J Launer
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Neuroepidemiology 19:113-20. 2000
    ..The objectives and design of the CASCADE project are described...
  3. ncbi request reprint Midlife blood pressure and dementia: the Honolulu-Asia aging study
    L J Launer
    Epidemiology, Demography and Biometry Program, National Institute on Aging, National Institutes of Health, Gateway Building 3C 309, 7201 Wisconsin Avenue, Bethesda, MD 20892, USA
    Neurobiol Aging 21:49-55. 2000
    ..This study suggests elevated levels of blood pressure in middle age can increase the risk for late age dementia in men never treated with anti-hypertensive medication...
  4. ncbi request reprint Cholesterol and neuropathologic markers of AD: a population-based autopsy study
    L J Launer
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neurology 57:1447-52. 2001
    ....
  5. ncbi request reprint APOE-epsilon4 predicts incident AD in Japanese-American men: the honolulu-asia aging study
    R J Havlik
    Epidemiology, Demography and Biometry Program, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neurology 54:1526-9. 2000
    ..Men with an APOE4 allele had a significantly increased risk of AD of 2.39 (95% CI, 1.07, 5.31), after adjusting for age and education. There was no significant relationship of APOE4 with other subtypes of dementia...
  6. ncbi request reprint Association between blood pressure, white matter lesions, and atrophy of the medial temporal lobe
    T den Heijer
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurology 64:263-7. 2005
    ..Alternatively, in persons with high blood pressure, increased numbers of neurofibrillary tangles and amyloid plaques at autopsy have also been observed, suggesting direct links between blood pressure and AD...
  7. ncbi request reprint Analysis and validation of automated skull stripping tools: a validation study based on 296 MR images from the Honolulu Asia aging study
    S W Hartley
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neuroimage 30:1179-86. 2006
    ..Although method accuracy was statistically associated with some subject characteristics, the extent of the misclassification (in terms of percent of brain volume) was small...
  8. ncbi request reprint Serum carotenoids and cerebral white matter lesions: the Rotterdam scan study
    T den Heijer
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    J Am Geriatr Soc 49:642-6. 2001
    ..Longitudinal studies with repeated measurements of both carotenoids and WMLs are necessary to explore this hypothesis further...
  9. ncbi request reprint Regional variability in the prevalence of cerebral white matter lesions: an MRI study in 9 European countries (CASCADE)
    L J Launer
    Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, Bethesda, MD 20892, USA
    Neuroepidemiology 26:23-9. 2006
    ..As a means of hypothesis generation and for health planning, further research on the geographic distribution of WML may lead to the identification of new risk factors for these lesions...
  10. ncbi request reprint CSF Abeta 42 levels correlate with amyloid-neuropathology in a population-based autopsy study
    D Strozyk
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, NIH, Bethesda, MD 20892, USA
    Neurology 60:652-6. 2003
    ..To investigate the relationship of amyloid neuropathology to postmortem CSF Abeta 42 levels in an autopsy sample of Japanese American men from the population-based Honolulu-Asia Aging Study...
  11. ncbi request reprint Joint effect of the APOE gene and midlife systolic blood pressure on late-life cognitive impairment: the Honolulu-Asia aging study
    R Peila
    Epidemiology, Demography and Biometry Program, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    Stroke 32:2882-9. 2001
    ..The aim of this study was to explore the joint effect of the APOE epsilon4 allele and midlife systolic blood pressure (SBP) on the risk for poor cognitive function in late life...
  12. ncbi request reprint Hippocampal shape analysis in Alzheimer's disease: a population-based study
    A I Scher
    Department of Preventive Medicine and Biometrics, Uniformed Services University, Bethesda, MD 20814, USA
    Neuroimage 36:8-18. 2007
    ..In this study, we use structural imaging techniques to model hippocampal size and regional shape differences between elderly men with incident AD and a non-demented comparison group of elderly men...
  13. pmc Ventral striatal volume is associated with cognitive decline in older people: a population based MR-study
    L W de Jong
    Laboratory of Epidemiology, Demography and Biometry, of the National Institutes on Aging NIH, Bethesda, MD, USA
    Neurobiol Aging 33:424.e1-10. 2012
    ..e. cerebro-vascular damage and hippocampal volume. The present study suggests a role for the ventral striatum in the development of clinical dementia...
  14. ncbi request reprint Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease
    A Ruitenberg
    Department of Epidemiology and Biostatistics, Eramus Medical Center, Rotterdam, The Netherlands
    N Engl J Med 345:1515-21. 2001
    ..The use of NSAIDs was not associated with a reduction in the risk of vascular dementia. CONCLUSIONS: The long-term use of NSAIDs may protect against Alzheimer's disease but not against vascular dementia...
  15. ncbi request reprint Reproductive period and risk of dementia in postmenopausal women
    M I Geerlings
    Department of Epidemiology and Biostatistics, Erasmus University Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    JAMA 285:1475-81. 2001
    ..Exogenous estrogen use may lower risk of dementia in postmenopausal women. A relationship between long-term exposure to endogenous estrogens and incident dementia has been hypothesized but not studied...
  16. ncbi request reprint Prognosis of Alzheimer's disease: the Rotterdam Study
    A Ruitenberg
    Department of Epidemiology and Biostatistics, Erasmus University, Rotterdam, The Netherlands
    Neuroepidemiology 20:188-95. 2001
    ..These prognostic risk functions can provide information on the decline of Alzheimer patients and might be used to better evaluate the effect of treatments for AD...
  17. ncbi request reprint Brain lesions on MRI and endogenous sex hormones in elderly men
    Fumiko Irie
    National Institute on Aging, Laboratory of Epidemiology, Demography, and Biometry, Gateway Building, Room 3C 309, 7201 Wisconsin Avenue, Bethesda, MD 20892, USA
    Neurobiol Aging 27:1137-44. 2006
    ..Because the levels of hormone were measured close in time to the acquisition of the MRI, these associations may reflect neurodegeneration in brain regions regulating hormone levels...
  18. ncbi request reprint Pharmacologic agents associated with a preventive effect on Alzheimer's disease: a review of the epidemiologic evidence
    B A in 't Veld
    Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Epidemiol Rev 24:248-68. 2002
  19. ncbi request reprint Cerebral amyloid angiopathy and cognitive function: the HAAS autopsy study
    L A Pfeifer
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging NIH, 7201 Wisconsin Avenue, Bethesda, MD 20892, USA
    Neurology 58:1629-34. 2002
    ..To investigate the relationship between cerebral amyloid angiopathy (CAA), dementia, and cognitive function in an autopsy sample of 211 Japanese-American men from the population-based Honolulu-Asia Aging Study...
  20. ncbi request reprint The epidemiologic study of dementia: a life-long quest?
    L J Launer
    Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neurobiol Aging 26:335-40. 2005
    ..To better understand which risk factors lead to disease initiation, progression and prognosis, a life course approach to the epidemiologic study of dementia is needed...
  21. ncbi request reprint Hippocampal, amygdalar, and global brain atrophy in different apolipoprotein E genotypes
    T den Heijer
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurology 59:746-8. 2002
    ..Carriers of epsilon4 had significantly more hippocampal and amygdalar atrophy than epsilon3epsilon3 subjects, but not more global brain atrophy. Carriers of epsilon2 did not have less brain atrophy than epsilon3epsilon3 subjects...
  22. ncbi request reprint Inflammation and dementia: epidemiologic evidence
    R Peila
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Acta Neurol Scand Suppl 185:102-6. 2006
    ..There are many outstanding questions about the role of inflammation in CD and how best to measure it in the context of population-based studies...
  23. ncbi request reprint Rates and risk factors for dementia and Alzheimer's disease: results from EURODEM pooled analyses. EURODEM Incidence Research Group and Work Groups. European Studies of Dementia
    L J Launer
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Neurology 52:78-84. 1999
    ..To investigate the risk of AD associated with a family history of dementia, female gender, low levels of education, smoking, and head trauma...
  24. pmc Cerebral microbleeds, retinopathy, and dementia: the AGES-Reykjavik Study
    C Qiu
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, MD, USA
    Neurology 75:2221-8. 2010
    ..To determine whether microvascular damage, indicated by cerebral microbleeds (CMBs) and retinal microvascular signs, is associated with cognitive function and dementia in older persons...
  25. ncbi request reprint Birth weight, growth, and blood pressure: an annual follow-up study of children aged 5 through 21 years
    C S Uiterwaal
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Hypertension 30:267-71. 1997
    ..Birth weight is not related to change of blood pressure with increasing age. Low birth weight in combination with high current body mass index seems to be of particular importance in the development of high blood pressure...
  26. ncbi request reprint Cardiovascular risk factors and migraine: the GEM population-based study
    A I Scher
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    Neurology 64:614-20. 2005
    ..In this study, the authors compare the cardiovascular risk profile of adult migraineurs to that of nonmigraineurs...
  27. ncbi request reprint Population-based studies of AD: message and methods: an epidemiologic view
    L J Launer
    Laboratory for Epidemiology, Biometry and Demography, Gateway Building 3C 309, 7201 Wisconsin Avenue, Bethesda, MD 20892, USA
    Stat Med 23:191-7. 2004
    ..To reduce bias from prospective epidemiologic studies, not only are new approaches to definition of disease and exposure needed, but new epidemiologic or statistical methods may be required as well...
  28. doi request reprint Do red blood cell-beta-amyloid interactions alter oxygen delivery in Alzheimer's disease?
    Joy G Mohanty
    Molecular Dynamics Section, National Institute on Aging, Baltimore, MD, USA
    Adv Exp Med Biol 614:29-35. 2008
    ..These results suggest that Abeta interactions with RBCs in AD subjects can result in impaired oxygen transport and delivery, which will have important implications for AD...
  29. pmc Cohort study of effect of being overweight and change in weight on risk of coronary heart disease in old age
    T B Harris
    Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, MD, USA
    BMJ 314:1791-4. 1997
    ..To evaluate risk of late life coronary heart disease associated with being overweight in late middle or old age and to assess whether weight change modifies this risk...
  30. ncbi request reprint Serum thyroxine level and cognitive decline in euthyroid older women
    S Volpato
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neurology 58:1055-61. 2002
    ..Clinical and subclinical hypothyroidism is associated with cognitive impairment...
  31. pmc Association of heat shock proteins with all-cause mortality
    L Broer
    Department of Epidemiology, Erasmus Medical Center, Dr Molewaterplein 50, PO Box 2040, 3000, CA, Rotterdam, The Netherlands
    Age (Dordr) 35:1367-76. 2013
    ..In the replication phase, only HSF2 (rs1416733) remained significantly associated with all-cause mortality. Rs1416733 is a known cis-eQTL for HSF2. Our findings suggest a role of HSF2 in all-cause mortality...
  32. pmc Low blood pressure and antihypertensive treatment are independently associated with physical and mental health status in patients with arterial disease: the SMART study
    M Muller
    Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    J Intern Med 274:241-51. 2013
    ..To investigate the independent effects of antihypertensive treatment and blood pressure (BP) levels on physical and mental health status in patients with arterial disease...
  33. ncbi request reprint Serum estradiol and risk of stroke in elderly men
    R D Abbott
    Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville, VA 22908 0717, USA
    Neurology 68:563-8. 2007
    ..To determine if levels of serum estradiol and testosterone can predict stroke in a population-based sample of elderly men...
  34. ncbi request reprint Dietary intake of fatty acids and fish in relation to cognitive performance at middle age
    S Kalmijn
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    Neurology 62:275-80. 2004
    ..To examine the associations of fatty acid and fish intake with cognitive function...
  35. ncbi request reprint Effect of smoking on global cognitive function in nondemented elderly
    A Ott
    Department of Epidemiology and Biostatistics Drs Hofman, Launer, Ott, and Stijnen, Erasmus University Medical Centre, The Netherlands
    Neurology 62:920-4. 2004
    ..Contrary to early case-control studies that suggested smoking protects against Alzheimer disease (AD), recent prospective studies have shown that elderly who smoke may be at increased risk for dementia...
  36. ncbi request reprint Quantification of regional glial fibrillary acidic protein levels in Alzheimer's disease
    G W Ross
    Department of Veterans Affairs, Honolulu, HI, USA
    Acta Neurol Scand 107:318-23. 2003
    ..Our objectives were to quantify glial fibrillary acidic protein (GFAP) in brains of Alzheimer's disease (AD) cases, and non-AD controls to determine the regions with the most severe gliosis in AD...
  37. ncbi request reprint Syncope in migraine: the population-based CAMERA study
    R D Thijs
    Department of Neurology and Clinical Neurophysiology, Leiden University Medical Center, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Neurology 66:1034-7. 2006
    ..To examine the association between migraine and syncope-related autonomic nervous system (ANS) symptoms...
  38. ncbi request reprint The relationship of APOE genotype to cognitive functioning in older African-American and Caucasian community residents
    G G Fillenbaum
    Center for the Study of Aging and Human Development, Department of Psychiatry, and Division of Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Geriatr Soc 49:1148-55. 2001
    ..To determine whether cognitive decline associated with the apolipoprotein E (APOE) epsilon4 allele is different in older African Americans than it is in Caucasians...
  39. ncbi request reprint Intracranial compartment volumes in normal pressure hydrocephalus: volumetric assessment versus outcome
    W M Palm
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    AJNR Am J Neuroradiol 27:76-9. 2006
    ..The purpose of this study is to explore the association between preoperative intracranial compartment volumes and postoperative improvement...