Michael S Lauer

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint In search of fewer independent risk factors
    Daniel J Brotman
    Department of General Internal Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Arch Intern Med 165:138-45. 2005
  2. ncbi request reprint A policy for science
    Michael S Lauer
    Office of the Director, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute NIH, Bethesda, MD 20892, USA
    J Am Coll Cardiol 59:2154-6. 2012
  3. doi request reprint Commentary: How the debate about comparative effectiveness research should impact the future of clinical trials
    Michael S Lauer
    Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    Stat Med 31:3051-3. 2012
  4. pmc Advancing cardiovascular research
    Michael S Lauer
    Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, 6701 Rockledge Dr, Rm 8128, Bethesda, MD 20892, USA
    Chest 141:500-5. 2012
  5. ncbi request reprint An externally validated model for predicting long-term survival after exercise treadmill testing in patients with suspected coronary artery disease and a normal electrocardiogram
    Michael S Lauer
    Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Ann Intern Med 147:821-8. 2007
  6. doi request reprint Commentary: Will academia embrace comparative effectiveness research?
    Michael S Lauer
    Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, USA
    Acad Med 86:671-3. 2011
  7. ncbi request reprint Screening for coronary heart disease: has the time for universal imaging arrived?
    Michael S Lauer
    Division of Prevention and Population Science, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cleve Clin J Med 74:645-50, 653-4, 656. 2007
  8. doi request reprint Autonomic function and prognosis
    Michael S Lauer
    Director, Division of Prevention and Population Sciences, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Rockledge Center II, Room 10021, Bethesda, MD 20892, USA
    Cleve Clin J Med 76:S18-22. 2009
  9. ncbi request reprint External prognostic validations and comparisons of age- and gender-adjusted exercise capacity predictions
    Esther S H Kim
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA
    J Am Coll Cardiol 50:1867-75. 2007
  10. ncbi request reprint Heart rate recovery after exercise is a predictor of mortality, independent of the angiographic severity of coronary disease
    Deepak P Vivekananthan
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Am Coll Cardiol 42:831-8. 2003

Detail Information

Publications93

  1. ncbi request reprint In search of fewer independent risk factors
    Daniel J Brotman
    Department of General Internal Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Arch Intern Med 165:138-45. 2005
    ..A glossary and schema are provided to help clinicians and researchers understand and discuss these matters effectively...
  2. ncbi request reprint A policy for science
    Michael S Lauer
    Office of the Director, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute NIH, Bethesda, MD 20892, USA
    J Am Coll Cardiol 59:2154-6. 2012
    ..Such a policy for science could create a culture that incentivizes and invigorates the rapid generation of evidence, ultimately engaging all clinicians, all patients, and indeed all stakeholders into the scientific enterprise...
  3. doi request reprint Commentary: How the debate about comparative effectiveness research should impact the future of clinical trials
    Michael S Lauer
    Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    Stat Med 31:3051-3. 2012
    ..In this commentary, I argue for the ongoing and critical role of randomization in comparative effectiveness, noting the key differences between practical and explanatory trials...
  4. pmc Advancing cardiovascular research
    Michael S Lauer
    Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, 6701 Rockledge Dr, Rm 8128, Bethesda, MD 20892, USA
    Chest 141:500-5. 2012
    ....
  5. ncbi request reprint An externally validated model for predicting long-term survival after exercise treadmill testing in patients with suspected coronary artery disease and a normal electrocardiogram
    Michael S Lauer
    Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Ann Intern Med 147:821-8. 2007
    ..Posttest risk stratification is based on the Duke treadmill score, which includes only functional capacity and measures of ischemia...
  6. doi request reprint Commentary: Will academia embrace comparative effectiveness research?
    Michael S Lauer
    Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, USA
    Acad Med 86:671-3. 2011
    ....
  7. ncbi request reprint Screening for coronary heart disease: has the time for universal imaging arrived?
    Michael S Lauer
    Division of Prevention and Population Science, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cleve Clin J Med 74:645-50, 653-4, 656. 2007
    ..Physicians should follow established guidelines such as those of the third AdultTreatment Panel of the National Cholesterol Education Program...
  8. doi request reprint Autonomic function and prognosis
    Michael S Lauer
    Director, Division of Prevention and Population Sciences, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Rockledge Center II, Room 10021, Bethesda, MD 20892, USA
    Cleve Clin J Med 76:S18-22. 2009
    ..Future research must determine how to exploit the associations between autonomic system dysfunction and poor prognosis to improve patient outcomes...
  9. ncbi request reprint External prognostic validations and comparisons of age- and gender-adjusted exercise capacity predictions
    Esther S H Kim
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA
    J Am Coll Cardiol 50:1867-75. 2007
    ..The purpose of this study was to externally validate the prognostic value of age- and gender-based nomograms and categorical definitions of impaired exercise capacity (EC)...
  10. ncbi request reprint Heart rate recovery after exercise is a predictor of mortality, independent of the angiographic severity of coronary disease
    Deepak P Vivekananthan
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Am Coll Cardiol 42:831-8. 2003
    ..We sought to determine whether abnormal heart rate recovery predicts mortality independent of the angiographic severity of coronary disease...
  11. ncbi request reprint Prediction of death or myocardial infarction by exercise single photon emission computed tomography perfusion scintigraphy in patients who have had recent coronary artery stenting
    Vivek Rajagopal
    Department of Cardiovascular, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am Heart J 149:534-40. 2005
    ..We sought to determine if exercise nuclear testing provides independent prognostic information in patients after coronary stenting...
  12. pmc Microvolt T-wave alternans, peak oxygen consumption, and outcome in patients with severely impaired left ventricular systolic function
    Eiran Z Gorodeski
    Department of Cardiovascular Medicine of Cleveland Clinic, Cleveland, Ohio 32610, USA
    J Heart Lung Transplant 28:689-96. 2009
    ..Abnormal microvolt T-wave alternans (MTWA) and low peak oxygen consumption (VO2) both predict poor outcome in heart failure. However, their independent predictive properties have not been assessed in large-scale cohorts...
  13. doi request reprint Quantitative electrocardiographic measures and long-term mortality in exercise test patients with clinically normal resting electrocardiograms
    Eiran Z Gorodeski
    Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA
    Am Heart J 158:61-70.e1. 2009
    ..It is unknown if subtle ECG findings in those patients with clinically normal resting ECGs have prognostic significance...
  14. ncbi request reprint Predictors of revascularization method and long-term outcome of percutaneous coronary intervention or repeat coronary bypass surgery in patients with multivessel coronary disease and previous coronary bypass surgery
    Sorin J Brener
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk F 25, Cleveland, OH 44195 USA
    Eur Heart J 27:413-8. 2006
    ..The optimal revascularization strategy in patients with symptomatic multivessel coronary artery disease (CAD) and previous coronary artery bypass grafting (CABG) remains unknown...
  15. ncbi request reprint Importance of treadmill exercise time as an initial prognostic screening tool in patients with systolic left ventricular dysfunction
    Eileen Hsich
    Department of Cardiovascular Medicine, Cleveland Clinic and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Circulation 119:3189-97. 2009
    ..We sought to determine whether treadmill exercise time may be of value as an initial prognostic screening tool in ambulatory patients with impaired systolic function who are referred for cardiopulmonary exercise testing...
  16. pmc Emerging cardiovascular risk factors that account for a significant portion of attributable mortality risk in chronic kidney disease
    Mehdi H Shishehbor
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Cardiol 101:1741-6. 2008
    ..5 micromol/L (the top tertile) were associated with a sevenfold greater mortality risk. In conclusion, homocysteine and fibrinogen levels explain nearly 40% of the attributable mortality risk from CKD...
  17. ncbi request reprint Heart rate recovery and impact of myocardial revascularization on long-term mortality
    Michael S Chen
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Circulation 110:2851-7. 2004
    ..We sought to determine whether HRR can identify patients likely to have improved survival after revascularization...
  18. ncbi request reprint Can we reliably predict long-term mortality after exercise testing? An external validation
    Barbara Hesse
    Department of Cardiology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am Heart J 150:307-14. 2005
    ..The aim of the study was to derive and externally validate a mortality prediction rule for patients undergoing exercise testing...
  19. ncbi request reprint Quantitative measures of electrocardiographic left ventricular mass, conduction, and repolarization, and long-term survival after coronary artery bypass grafting
    Michael S Lauer
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Circulation 116:888-93. 2007
    ..We assessed the prognostic value of preoperative quantitative electrocardiography in patients who underwent isolated coronary artery bypass grafting...
  20. ncbi request reprint In unstable angina or non-ST-segment acute coronary syndrome, should patients with multivessel coronary artery disease undergo multivessel or culprit-only stenting?
    Mehdi H Shishehbor
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA
    J Am Coll Cardiol 49:849-54. 2007
    ....
  21. ncbi request reprint Value of exercise capacity and heart rate recovery in older people
    Barbara Messinger-Rapport
    Section of Geriatric Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Am Geriatr Soc 51:63-8. 2003
    ..To evaluate the prognostic value in older adults of two predictors of mortality: impaired functional capacity and an attenuated heart rate recovery...
  22. ncbi request reprint Severe frequent ventricular ectopy after exercise as a predictor of death in patients with heart failure
    James O O'Neill
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Ohio 44195, USA
    J Am Coll Cardiol 44:820-6. 2004
    ..The study was done to determine the prognostic importance of frequent ventricular ectopy in recovery after exercise among patients with systolic heart failure (HF)...
  23. ncbi request reprint Heart rate response during dipyridamole stress as a predictor of mortality in patients with normal myocardial perfusion and normal electrocardiograms
    Rohit Bhatheja
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Cardiol 95:1159-64. 2005
    ..Thus, among patients who have normal myocardial perfusion and normal electrocardiograms, a blunted heart rate response to vasodilator stress is predictive of a marked increase in risk of death...
  24. doi request reprint Impact of blood transfusion on short- and long-term mortality in patients with ST-segment elevation myocardial infarction
    Mehdi H Shishehbor
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    JACC Cardiovasc Interv 2:46-53. 2009
    ..We sought to examine the short- and long-term outcomes of blood transfusion in patients presenting with ST-segment elevation myocardial infarction (STEMI)...
  25. ncbi request reprint Association of socioeconomic status with functional capacity, heart rate recovery, and all-cause mortality
    Mehdi H Shishehbor
    Department of Cardiovascular Medicine, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    JAMA 295:784-92. 2006
    ..Lower socioeconomic status (SES) confers heightened cardiovascular risk and mortality, although the mediating pathways are unclear...
  26. ncbi request reprint Global risk scores and exercise testing for predicting all-cause mortality in a preventive medicine program
    Mehmet K Aktas
    Department of Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    JAMA 292:1462-8. 2004
    ..The usefulness of exercise stress test results and global cardiovascular risk systems for predicting all-cause mortality in asymptomatic individuals seen in clinical settings is unclear...
  27. pmc Use of hundreds of electrocardiographic biomarkers for prediction of mortality in postmenopausal women: the Women's Health Initiative
    Eiran Z Gorodeski
    Heart and Vascular Institute, Cleveland, OH, USA
    Circ Cardiovasc Qual Outcomes 4:521-32. 2011
    ..Quantitative ECG biomarkers have prognostic importance and may be markers of subclinical disease in apparently healthy postmenopausal women...
  28. ncbi request reprint Long-term prognostic value of peak oxygen consumption in women versus men with heart failure and severely impaired left ventricular systolic function
    Eileen Hsich
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Cardiol 100:291-5. 2007
    ..In conclusion, in this large cohort, peak VO(2) predicted survival in women and men whether or not coronary artery disease was present, but an interaction was noted between coronary artery, gender, and survival...
  29. ncbi request reprint Peak oxygen consumption as a predictor of death in patients with heart failure receiving beta-blockers
    James O O'Neill
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 111:2313-8. 2005
    ..Beta-blockers reduce mortality in patients with heart failure, without influencing peak VO2, raising the possibility that peak VO2 is no longer suitable as an indicator of prognosis in these patients...
  30. ncbi request reprint Chronotropic incompetence as a predictor of death among patients with normal electrograms taking beta blockers (metoprolol or atenolol)
    Mohammed N Khan
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Cardiol 96:1328-33. 2005
    ..In conclusion, in patients taking beta blockers, chronotropic incompetence is independently predictive of death...
  31. ncbi request reprint Prognostic importance of presenting symptoms in patients undergoing exercise testing for evaluation of known or suspected coronary disease
    R Christopher Jones
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Ohio 44195, USA
    Am J Med 117:380-9. 2004
    ..We sought to determine the independent prognostic value of chest symptoms...
  32. ncbi request reprint Propensity analysis of long-term survival after surgical or percutaneous revascularization in patients with multivessel coronary artery disease and high-risk features
    Sorin J Brener
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Ave, Desk F 25, Cleveland, Ohio 44195, USA
    Circulation 109:2290-5. 2004
    ....
  33. pmc Identifying important risk factors for survival in patient with systolic heart failure using random survival forests
    Eileen Hsich
    Heart and Vascular Institute, Department of Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Circ Cardiovasc Qual Outcomes 4:39-45. 2011
    ..RSF are a potentially powerful extensions of classification and regression trees, with lower variance and bias...
  34. ncbi request reprint Exercise-induced QT/R-R-interval hysteresis as a predictor of myocardial ischemia
    Michael S Lauer
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, OH 44195, USA
    J Electrocardiol 39:315-23. 2006
    ..We sought to assess the association between QT/RR hysteresis and imaging evidence of myocardial ischemia...
  35. ncbi request reprint Is systolic blood pressure recovery after exercise a predictor of mortality?
    Keith Ellis
    Department of Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am Heart J 147:287-92. 2004
    ..An attenuated systolic blood pressure recovery after exercise has been associated with the severity of atherosclerotic heart disease...
  36. doi request reprint Survival rates of children with acute lymphoblastic leukemia presenting to a pediatric rheumatologist in the United States
    Philip J Hashkes
    Section of Pediatric Rheumatology, Cleveland Clinic, Cleveland, OH, USA
    J Pediatr Hematol Oncol 33:424-8. 2011
    ..We examined the survival and causes of death of these patients presenting to a pediatric rheumatologist and compared the rates with that reported in the hematology-oncology literature...
  37. ncbi request reprint Frequent ventricular ectopy after exercise as a predictor of death
    Joseph P Frolkis
    Department of General Internal Medicine, Cleveland Clinic Foundation, Cleveland 44195, USA
    N Engl J Med 348:781-90. 2003
    ..We hypothesized that ventricular ectopy after exercise (i.e., during the recovery phase) would predict an increased risk of death better than ventricular ectopy during exercise...
  38. ncbi request reprint Myocardial viability testing and the effect of early intervention in patients with advanced left ventricular systolic dysfunction
    Khaldoun G Tarakji
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Circulation 113:230-7. 2006
    ..We performed a propensity analysis to determine whether there might be a survival advantage from revascularization...
  39. ncbi request reprint Impact of mitral valve annuloplasty combined with revascularization in patients with functional ischemic mitral regurgitation
    Tomislav Mihaljevic
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 49:2191-201. 2007
    ..The aim of this work was to determine whether mitral valve (MV) annuloplasty benefits patients with moderate/severe (3+/4+) functional ischemic mitral regurgitation (MR) who undergo coronary artery bypass grafting (CABG)...
  40. ncbi request reprint Impact of donor spontaneous intracranial hemorrhage on outcome after heart transplantation
    Mohamad H Yamani
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Cleveland, OH, USA
    Am J Transplant 4:257-61. 2004
    ..9%, p=0.0012). There was a trend towards an increased rate of allograft vasculopathy in the ICB group (competing risks adjusted hazard ratio 1.39, 95% CI 0.90-2.13, p = 0.14)...
  41. pmc Quantitative electrocardiography for predicting postoperative atrial fibrillation after cardiac surgery
    Florian Rader
    Heart and Vascular Center, Case Western Reserve University, MetroHealth Campus, Cleveland, OH 44118, USA
    J Electrocardiol 44:761-7. 2011
    ..Atrial fibrillation (AF) after cardiac surgery is a common marker of poor outcomes. Quantitative electrocardiographic (ECG) measurements may be valuable predictors of postoperative AF...
  42. ncbi request reprint Association of an abnormal exercise heart rate recovery with pulmonary function abnormalities
    Niranjan Seshadri
    Department of Cardiology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Chest 125:1286-91. 2004
    ..Heart rate recovery (HRR) after exercise correlates with decreased vagal tone and mortality. Patients with COPD may have altered autonomic tone. We sought to determine the association of HRR with spirometry measures of pulmonary function...
  43. ncbi request reprint Association of atheroma as assessed by intraoperative transoesophageal echocardiography with long-term mortality in patients undergoing cardiac surgery
    Senthil K Thambidorai
    Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Avenue Desk F15, Cleveland, OH 44195, USA
    Eur Heart J 28:1454-61. 2007
    ..To determine whether the presence and severity of aortic atheroma predict long-term all-cause mortality among patients undergoing cardiac surgery...
  44. ncbi request reprint Association of educational status with heart rate recovery: a population-based propensity analysis
    Mehdi H Shishehbor
    Department of Internal Medicine MHS, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Med 113:643-9. 2002
    ..Lower educational level may be associated with automatic imbalance. We sought to assess the association of educational level with heart rate recovery...
  45. ncbi request reprint Use of the logical analysis of data method for assessing long-term mortality risk after exercise electrocardiography
    Michael S Lauer
    Department of Cardiology of the Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 106:685-90. 2002
    ..In this study, we used Logical Analysis of Data for risk stratification and compared it to regression techniques...
  46. ncbi request reprint Association of diabetes mellitus with abnormal heart rate recovery in patients without known coronary artery disease
    Niranjan Seshadri
    Department of Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Cardiol 91:108-11. 2003
  47. ncbi request reprint Constrictive pericarditis: etiology and cause-specific survival after pericardiectomy
    Stefan C Bertog
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 43:1445-52. 2004
    ..We sought to determine the association of etiology of constrictive pericarditis (CP), pericardial calcification (CA), and other clinical variables with long-term survival after pericardiectomy...
  48. ncbi request reprint Association of triglyceride-to-HDL cholesterol ratio with heart rate recovery
    Mehdi H Shishehbor
    Department of Internal Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Diabetes Care 27:936-41. 2004
    ..Utilizing triglyceride/HDL cholesterol concentration as a marker of insulin resistance, we sought to assess the association between insulin resistance and HRR...
  49. doi request reprint Mortality outcomes in pediatric rheumatology in the US
    Philip J Hashkes
    Cleveland Clinic, Cleveland, Ohio, USA
    Arthritis Rheum 62:599-608. 2010
    ..To describe mortality rates, causes of death, and potential mortality risk factors in pediatric rheumatic diseases in the US...
  50. doi request reprint The role of comparative effectiveness research in transfusion medicine clinical trials: proceedings of a National Heart, Lung, and Blood Institute workshop
    Morris A Blajchman
    McMaster University, Hamilton, Ontario, Canada
    Transfusion 52:1363-78. 2012
    ....
  51. ncbi request reprint Troponin T levels in patients with acute coronary syndromes, with or without renal dysfunction
    Ronnier J Aviles
    Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, OH 44951, USA
    N Engl J Med 346:2047-52. 2002
    ..However, there is concern that renal dysfunction may impair the prognostic value, because cardiac troponin T may be cleared by the kidney...
  52. ncbi request reprint Predictors of mortality in patients with heart failure and preserved systolic function in the Digitalis Investigation Group trial
    R Christopher Jones
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 44:1025-9. 2004
    ..We identified predictors of mortality in patients with preserved ejection fraction (EF) and clinical heart failure (HF)...
  53. ncbi request reprint Cardiovascular medicine update 2007: perioperative risk, carotid angioplasty, drug-eluting stents, stronger statins
    Michael S Lauer
    Departments of Cardiovascular Medicine and Quantitative Health Sciences, Cleveland Clinic, Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 74:505-11. 2007
    ..Patients with known coronary heart disease have better outcomes if they receive aggressive statin therapy (eg, atorvastatin [Lipitor] 80 mg/day) to lower their serum levels of low-density lipoprotein cholesterol to less than 70 mg/dL...
  54. ncbi request reprint The prognostic value of estimated creatinine clearance alongside functional capacity in ambulatory patients with chronic congestive heart failure
    Niall G Mahon
    Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 40:1106-13. 2002
    ..The goal of this study was to determine the prognostic significance of estimated creatinine clearance (CrCl) in relation to 6-min walk distance in ambulatory patients with congestive heart failure (HF)...
  55. ncbi request reprint Aortic valve replacement in patients with mild or moderate aortic stenosis and coronary bypass surgery
    Jeremy J Pereira
    Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Med 118:735-42. 2005
    ..To assess whether there is survival benefit for patients with mild or moderate aortic stenosis if they undergo aortic valve replacement at the time of coronary artery bypass surgery...
  56. ncbi request reprint The rudimentary phase of personalised medicine: coronary risk scores
    Eric J Topol
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Lancet 362:1776-7. 2003
  57. ncbi request reprint Preprocedural white blood cell count and death after percutaneous coronary intervention
    Hitinder S Gurm
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am Heart J 146:692-8. 2003
    ..An elevation in the white blood cell (WBC) count is a nonspecific response to inflammation. We hypothesized that an elevated WBC count would be a predictor of death in patients undergoing PCI...
  58. ncbi request reprint Cardiologist on trial: reflections on credible evidence
    Michael S Lauer
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44905, USA
    J Am Coll Cardiol 40:563-4. 2002
    ..Those experts who are able to have their reports pass peer review would be presented to the jury as having a greater level of credibility...
  59. ncbi request reprint Clinical practice. Aspirin for primary prevention of coronary events
    Michael S Lauer
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    N Engl J Med 346:1468-74. 2002
  60. pmc Publication of trials funded by the National Heart, Lung, and Blood Institute
    David Gordon
    From the Office of Special Projects of the Division of Cardiovascular Sciences D G, W T P, A M, Office of Science and Technology M A, the Clinical Applications and Prevention Branch of the Division of Cardiovascular Sciences P G K, and Office of the Director of the Division of Cardiovascular Sciences M S L all at the National Heart, Lung, and Blood Institute, Bethesda, MD
    N Engl J Med 369:1926-34. 2013
    ..Factors affecting the speed of publication of the main results of government-funded trials have not been well characterized...
  61. pmc Cardiovascular epidemiology in a changing world--challenges to investigators and the National Heart, Lung, and Blood Institute
    Paul D Sorlie
    Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Bethesda, MD 20892
    Am J Epidemiol 175:597-601. 2012
    ....
  62. ncbi request reprint Inflammation as a risk factor for atrial fibrillation
    Ronnier J Aviles
    Department of Cardiovascular Medicine, Desk F15, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, Ohio 44951, USA
    Circulation 108:3006-10. 2003
    ..The relationship between CRP and prediction of AF has not been studied in a large population-based cohort...
  63. ncbi request reprint Association of fasting plasma glucose with heart rate recovery in healthy adults: a population-based study
    Claudia Panzer
    Department of Internal Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Diabetes 51:803-7. 2002
    ..0003). An abnormal heart rate recovery added to impaired fasting plasma glucose for the prediction of death. Fasting plasma glucose is strongly and independently associated with abnormal heart rate recovery, even at nondiabetic levels...
  64. ncbi request reprint Is routine functional testing after coronary bypass surgery worthwhile?
    Michael S Lauer
    Department of Cardiovascular Medicine of the Cleveland Clinic Lerner College of Medicine of CWRU, Cleveland, Ohio, USA
    J Invasive Cardiol 18:153-4. 2006
  65. ncbi request reprint Survival after aortic valve replacement for severe aortic stenosis with low transvalvular gradients and severe left ventricular dysfunction
    Jeremy J Pereira
    Department of Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 39:1356-63. 2002
    ..We sought to assess whether aortic valve replacement (AVR) among patients with severe aortic stenosis (AS), severe left ventricular (LV) dysfunction and a low transvalvular gradient (TVG) is associated with improved survival...
  66. ncbi request reprint Heart rate recovery following maximal exercise testing as a predictor of cardiovascular disease and all-cause mortality in men with diabetes
    Yiling J Cheng
    Cooper Institute, Center for Epidemiological Research, Dallas, Texas 75230, USA
    Diabetes Care 26:2052-7. 2003
    ..Heart rate recovery (HRR) is an independent prognostic indicator for cardiovascular disease (CVD) and all-cause mortality in healthy men. We examined the association of HRR to CVD-related and all-cause mortality in men with diabetes...
  67. ncbi request reprint Prognostic value of normal exercise and adenosine (99m)Tc-tetrofosmin SPECT imaging: results from the multicenter registry of 4,728 patients
    Leslee J Shaw
    Atlanta Cardiovascular Research Institute, Atlanta, Georgia 30342, USA
    J Nucl Med 44:134-9. 2003
    ..A total of 4,728 consecutively tested patients who underwent stress (99m)Tc-tetrofosmin SPECT at 5 U.S. hospitals were included in this series...
  68. ncbi request reprint Usefulness of tissue doppler and color M-mode indexes of left ventricular diastolic function in predicting outcomes in systolic left ventricular heart failure (from the ADEPT study)
    Richard W Troughton
    Christchurch School of Medicine, Christchurch, New Zealand
    Am J Cardiol 96:257-62. 2005
    ..For the ratio of early transmitral velocity to early annular velocity, this prediction was additive to deceleration time. Newer diastolic indexes provide an independent prediction of clinical outcomes...
  69. doi request reprint American Heart Association/American College of Cardiology Foundation/Heart Rhythm Society Scientific Statement on Noninvasive Risk Stratification Techniques for Identifying Patients at Risk for Sudden Cardiac Death. A scientific statement from the America
    Jeffrey J Goldberger
    J Am Coll Cardiol 52:1179-99. 2008
  70. ncbi request reprint Abnormal heart-rate recovery after exercise
    Michael S Lauer
    Lancet 360:1176-7. 2002
  71. doi request reprint Effect of exercise training in supervised cardiac rehabilitation programs on prognostic variables from the exercise tolerance test
    Brian J Adams
    Department of Medicine, Section of Cardiology, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 101:1403-7. 2008
    ..These differences translate into a decrease in predicted mortality...
  72. ncbi request reprint What is the best test for a patient with classic angina?
    Michael S Lauer
    Department of Cardiovascular Medicine, Cleveland Clinic, OH 44195, USA
    Cleve Clin J Med 74:123-6. 2007
    ..However, no randomized trials have been done to determine if this strategy leads to better outcomes than with empiric therapy...
  73. ncbi request reprint Chronotropic incompetence: ready for prime time
    Michael S Lauer
    J Am Coll Cardiol 44:431-2. 2004
  74. ncbi request reprint Exercise electrocardiogram testing: beyond the ST segment
    Paul Kligfield
    Division of Cardiology, Weill Medical College of Cornell University and the Cornell Center of The New York Presbyterian Hospital, New York, NY, USA
    Circulation 114:2070-82. 2006
  75. ncbi request reprint Short- and long-term risk stratification in acute coronary syndromes: the added value of quantitative ST-segment depression and multiple biomarkers
    Cynthia M Westerhout
    University of Alberta, Edmonton, Canada
    J Am Coll Cardiol 48:939-47. 2006
    ..The purpose of this study was to develop 30-day and 1-year risk stratification models for non-ST-segment elevation acute coronary syndrome (NSTE-ACS) patients that incorporate quantitative ST-segment depression and novel biomarkers...
  76. ncbi request reprint Development and validation of a simple exercise test score for use in women with symptoms of suspected coronary artery disease
    Anthony P Morise
    Section of Cardiology, Department of Medicine, West Virginia University School of Medicine, Morgantown, WVa 26506, USA
    Am Heart J 144:818-25. 2002
    ....
  77. ncbi request reprint Is heart rate recovery a modifiable risk factor?
    Michael S Lauer
    J Cardiopulm Rehabil 23:88-9. 2003
  78. ncbi request reprint Exercise testing for assessment of autonomic function
    Michael S Lauer
    Am Heart J 144:580-2. 2002
  79. ncbi request reprint Screening for left ventricular systolic dysfunction among patients with risk factors for heart failure
    David W Baker
    Department of Medicine and the Division of General Internal Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Ill 60611, USA
    Am Heart J 146:736-40. 2003
    ..This study determined the prevalence of LVSD with the use of a limited screening echocardiogram among patients with risk factors for HF but no prior HF...
  80. ncbi request reprint The "exercise" part of exercise echocardiography
    Michael S Lauer
    J Am Coll Cardiol 39:1353-5. 2002
  81. ncbi request reprint Comparison of results of carotid stenting followed by open heart surgery versus combined carotid endarterectomy and open heart surgery (coronary bypass with or without another procedure)
    Khaled M Ziada
    Gill Heart Institute, University of Kentucky, Lexington, Kentucky, USA
    Am J Cardiol 96:519-23. 2005
    ..CS may be a safer carotid revascularization option for this challenging patient population...
  82. ncbi request reprint Choosing the right coronary test
    Michael S Lauer
    Department of Cardiovascular Medicine, Cleveland Clinic, OH 44195, USA
    Cleve Clin J Med 74:122. 2007
  83. ncbi request reprint Chest pain on exercise treadmill test predicts future cardiac hospitalizations
    P Michael Ho
    Denver VA Medical Center, USA
    Clin Cardiol 30:505-10. 2007
    ..The objective of this study was to determine the importance of chest pain during ETT in predicting future nonfatal cardiac hospitalizations...
  84. doi request reprint Task force 2: training in electrocardiography, ambulatory electrocardiography, and exercise testing
    Robert J Myerburg
    J Am Coll Cardiol 51:348-54. 2008
  85. ncbi request reprint Can the ST segment be saved?
    Michael S Lauer
    J Nucl Cardiol 12:622-4. 2005
  86. ncbi request reprint The prognostic value of a nomogram for exercise capacity in women
    Martha Gulati
    Department of Preventive Medicine, Rush University Medical Center, Chicago, USA
    N Engl J Med 353:468-75. 2005
    ..Our objectives were to construct a nomogram to permit determination of predicted exercise capacity for age in women and to assess the predictive value of the nomogram with respect to survival...
  87. ncbi request reprint ST-segment resolution 60 minutes after combination treatment of abciximab with reteplase or reteplase alone for acute myocardial infarction (30-day mortality results from the resolution of ST-segment after reperfusion therapy substudy)
    Fernando A Cura
    Department of Cardiology, Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina
    Am J Cardiol 94:859-63. 2004
    ..Patients with >70% ST-segment resolution within 60 minutes had markedly decreased mortality rates, irrespective of treatment...
  88. ncbi request reprint Electrocardiographic left ventricular hypertrophy in GUSTO IV ACS: an important risk marker of mortality in women
    Cynthia M Westerhout
    Canadian VIGOUR Centre Research Group, 214 Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Eur Heart J 28:2064-9. 2007
    ..To examine the association of left ventricular hypertrophy (LVH) on admission electrocardiography with adverse outcomes in acute coronary syndrome (ACS) patients...
  89. ncbi request reprint Usefulness of plasma brain natriuretic peptide levels in predicting dobutamine-induced myocardial ischemia
    Junko Asada
    Cardiovascular Center, Kansai Medical University, Moriguchi, Japan
    Am J Cardiol 93:702-4. 2004
    ..0, 95% confidence interval 1.3 to 3.0, p = 0.002). In this pilot study, resting BNP was predictive of dobutamine-induced ischemia. Future work is needed to confirm these findings...
  90. ncbi request reprint In-hospital initiation of lipid-lowering therapy after coronary intervention as a predictor of long-term utilization: a propensity analysis
    Herbert D Aronow
    Division of Cardiovascular Medicine, Department of Internal Medicine, University of Pennsylvania Medical Center and Philadelphia Veterans Administration Medical Center, Philadelphia, PA, USA
    Arch Intern Med 163:2576-82. 2003
    ..Few studies have examined the relationship between predischarge initiation of lipid-lowering therapy and long-term use...
  91. doi request reprint Association of exercise capacity on treadmill with future cardiac events in patients referred for exercise testing
    Pamela N Peterson
    Division of Cardiology, Department of Medicine, Denver Health Medical Center, Denver, Colorado 80204, USA
    Arch Intern Med 168:174-9. 2008
    ..Our objective was to determine the prognostic importance of exercise capacity for nonfatal cardiac events in a clinical population...