Robert Langenbach

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Cyclooxygenase knockout mice: models for elucidating isoform-specific functions
    R Langenbach
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Biochem Pharmacol 58:1237-46. 1999
  2. ncbi request reprint Cyclooxygenase-deficient mice. A summary of their characteristics and susceptibilities to inflammation and carcinogenesis
    R Langenbach
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Ann N Y Acad Sci 889:52-61. 1999
  3. pmc Cyclooxygenase-1-selective inhibition prolongs gestation in mice without adverse effects on the ductus arteriosus
    Charles D Loftin
    Laboratory of Environmental Carcinogenesis and Mutagenesis, National Institutes of Health, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Clin Invest 110:549-57. 2002
  4. ncbi request reprint Contrasting effects of cyclooxygenase-1 (COX-1) and COX-2 deficiency on the host response to influenza A viral infection
    Michelle A Carey
    Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Research Triangle Park, NC 27709, USA
    J Immunol 175:6878-84. 2005
  5. ncbi request reprint Genetic deficiency or pharmacological inhibition of cyclooxygenase-1 or -2 induces mouse keratinocyte differentiation in vitro and in vivo
    Jacqueline K Akunda
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    FASEB J 18:185-7. 2004
  6. pmc Prostaglandin E2 released from activated microglia enhances astrocyte proliferation in vitro
    Dan Zhang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 238:64-70. 2009
  7. pmc Cyclooxygenase-2 inhibits UVB-induced apoptosis in mouse skin by activating the prostaglandin E2 receptors, EP2 and EP4
    Kyung Soo Chun
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences NIH, Research Triangle Park, NC 27709, USA
    Cancer Res 67:2015-21. 2007
  8. pmc The prostaglandin receptor EP2 activates multiple signaling pathways and beta-arrestin1 complex formation during mouse skin papilloma development
    Kyung Soo Chun
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Carcinogenesis 30:1620-7. 2009
  9. pmc Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injury
    Sang Ho Choi
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    FASEB J 22:1491-501. 2008
  10. pmc The prostaglandin E2 receptor, EP2, stimulates keratinocyte proliferation in mouse skin by G protein-dependent and {beta}-arrestin1-dependent signaling pathways
    Kyung Soo Chun
    Laboratory of Toxicology and Pharmacology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 285:39672-81. 2010

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Cyclooxygenase knockout mice: models for elucidating isoform-specific functions
    R Langenbach
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Biochem Pharmacol 58:1237-46. 1999
    ..However, for the maintenance of normal physiology, it appears that deficiency of COX-2 has more profound effects than deficiency of COX-1...
  2. ncbi request reprint Cyclooxygenase-deficient mice. A summary of their characteristics and susceptibilities to inflammation and carcinogenesis
    R Langenbach
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Ann N Y Acad Sci 889:52-61. 1999
    ..Furthermore, data from COX-deficient mice indicate that both isoforms can contribute to the inflammatory response and that both isoforms have significant roles in carcinogenesis...
  3. pmc Cyclooxygenase-1-selective inhibition prolongs gestation in mice without adverse effects on the ductus arteriosus
    Charles D Loftin
    Laboratory of Environmental Carcinogenesis and Mutagenesis, National Institutes of Health, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Clin Invest 110:549-57. 2002
    ..Therefore, COX-1-selective inhibitors may provide effective treatment to delay preterm labor with fewer adverse effects on fetal or neonatal health than nonselective or COX-2-selective inhibitors...
  4. ncbi request reprint Contrasting effects of cyclooxygenase-1 (COX-1) and COX-2 deficiency on the host response to influenza A viral infection
    Michelle A Carey
    Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Research Triangle Park, NC 27709, USA
    J Immunol 175:6878-84. 2005
    ..COX-1 deficiency is detrimental whereas COX-2 deficiency is beneficial to the host during influenza viral infection...
  5. ncbi request reprint Genetic deficiency or pharmacological inhibition of cyclooxygenase-1 or -2 induces mouse keratinocyte differentiation in vitro and in vivo
    Jacqueline K Akunda
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    FASEB J 18:185-7. 2004
    ..Thus, a major effect of COX inhibitors and COX-deficiency is the induction of keratinocyte differentiation...
  6. pmc Prostaglandin E2 released from activated microglia enhances astrocyte proliferation in vitro
    Dan Zhang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 238:64-70. 2009
    ..These findings are important in elucidating the role of activated microglia and PGE(2) in astrocyte proliferation and in suggesting a potential avenue in the use of anti-inflammatory agents for the therapy of astroglioma...
  7. pmc Cyclooxygenase-2 inhibits UVB-induced apoptosis in mouse skin by activating the prostaglandin E2 receptors, EP2 and EP4
    Kyung Soo Chun
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences NIH, Research Triangle Park, NC 27709, USA
    Cancer Res 67:2015-21. 2007
    ..Furthermore, both agonists decreased apoptosis in COX-2-/- mice by 50%. The data suggest that COX-2-generated PGE(2) has antiapoptotic roles in UVB-exposed mouse skin that involves EP2- and EP4-mediated signaling...
  8. pmc The prostaglandin receptor EP2 activates multiple signaling pathways and beta-arrestin1 complex formation during mouse skin papilloma development
    Kyung Soo Chun
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Carcinogenesis 30:1620-7. 2009
    ..The data indicated that EP2 contributed to tumor formation via activation of PKA and EGFR and that EP2 formed a complex with beta-arrestin1 and Src that contributed to signaling and/or EP2 desensitization...
  9. pmc Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injury
    Sang Ho Choi
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    FASEB J 22:1491-501. 2008
    ..These findings suggest that COX-1 plays a previously unrecognized role in neuroinflammatory damage...
  10. pmc The prostaglandin E2 receptor, EP2, stimulates keratinocyte proliferation in mouse skin by G protein-dependent and {beta}-arrestin1-dependent signaling pathways
    Kyung Soo Chun
    Laboratory of Toxicology and Pharmacology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 285:39672-81. 2010
    ..Therefore, the results indicate that EP2 contributed to mouse keratinocyte proliferation by G protein-independent, β-arrestin1-dependent activation of EGFR and G protein-dependent activation of PKA...
  11. ncbi request reprint Phenotypes of the COX-deficient mice indicate physiological and pathophysiological roles for COX-1 and COX-2
    Charles D Loftin
    Laboratory of Environmental Carcinogenesis and Mutagenesis, National Institutes of Health, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Prostaglandins Other Lipid Mediat 68:177-85. 2002
    ..Studies with the COX-deficient mice suggest that in addition to COX-2-selective inhibition, therapeutic advances may also be achieved with COX-1-selective inhibitors which lack gastrointestinal side effects...
  12. ncbi request reprint Cyclooxygenase-2 deficiency increases epidermal apoptosis and impairs recovery following acute UVB exposure
    Jacqueline K Akunda
    Laboratory of Molecular Carcinogenesis, NIEHS NIH, Research Triangle Park, North Carolina 27709, USA
    Mol Carcinog 46:354-62. 2007
    ..The data indicate that COX-2 induction initially protects against the acute sunburn effects of UVB, but that continuous induction of COX-2 may contribute to skin cancer in chronic UVB exposure...
  13. pmc Genetic ablation of cyclooxygenase-2 in keratinocytes produces a cell-autonomous defect in tumor formation
    Huei Chen Lao
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Carcinogenesis 33:2293-300. 2012
    ..Furthermore, the data indicate that deficiency/inhibition of COX-2 in the initiated keratinocyte is an important determinant of papilloma forming ability...
  14. doi request reprint A reciprocal relationship exists between non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) and cyclooxygenase-2
    Genzo Iguchi
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, RTP, NC 27709, USA
    Cancer Lett 282:152-8. 2009
    ..Furthermore, PGE(2) reduces NAG-1 while celebrex induces NAG-1 expression. The results suggest that a possible inverse relationship exists between the expression of NAG-1 and COX-2 in tumor formation of colon tissue...
  15. ncbi request reprint MPP+-induced COX-2 activation and subsequent dopaminergic neurodegeneration
    Tongguang Wang
    Neuropharmacology Section, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    FASEB J 19:1134-6. 2005
    ..Thus inhibition of microgliosis and COX-2 activity may stop this vicious circle and be valuable strategies in PD therapy...
  16. pmc β-Arrestin-2 deficiency attenuates abdominal aortic aneurysm formation in mice
    Darshini B Trivedi
    Laboratory of Toxicology and Pharmacology, Comparative Medicine Branch, and Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Circ Res 112:1219-29. 2013
    ..However, a role for βarr2 in AngII-induced AAA formation is currently unknown...
  17. pmc Cyclooxygenase-1 and -2 enzymes differentially regulate the brain upstream NF-kappa B pathway and downstream enzymes involved in prostaglandin biosynthesis
    Sang Ho Choi
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurochem 98:801-11. 2006
    ..Additionally, COX-1 deficiency can affect the expression of reciprocal and coupled enzymes, COX-2, Ca2+ -dependent PLA2, and terminal mPGES-2, to overcome defects in brain AA cascade...
  18. ncbi request reprint Prostaglandin E2 and microsomal prostaglandin E synthase-2 expression are decreased in the cyclooxygenase-2-deficient mouse brain despite compensatory induction of cyclooxygenase-1 and Ca2+-dependent phospholipase A2
    Francesca Bosetti
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurochem 91:1389-97. 2004
    ..Overall, the data suggest that compensatory mechanisms exist in COX-2(-/-) mice and that mPGES-2 is functionally coupled with COX-2...
  19. ncbi request reprint Cyclooxygenase enzymes in allergic inflammation and asthma
    Michelle A Carey
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive Mail Drop D2 02, Research Triangle Park, NC 27709, USA
    Prostaglandins Leukot Essent Fatty Acids 69:157-62. 2003
    ....
  20. pmc Multi-walled carbon nanotubes induce COX-2 and iNOS expression via MAP kinase-dependent and -independent mechanisms in mouse RAW264.7 macrophages
    Jong Kwon Lee
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709, USA
    Part Fibre Toxicol 9:14. 2012
    ....
  21. doi request reprint The prostaglandin E2 receptor, EP2, regulates survivin expression via an EGFR/STAT3 pathway in UVB-exposed mouse skin
    Kyung Soo Chun
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Mol Carcinog 50:439-48. 2011
    ..Therefore, targeting the EP2/survivin pathway may provide a strategy for the chemoprevention/chemotherapy of skin cancer...
  22. ncbi request reprint Role of reactive oxygen species in LPS-induced production of prostaglandin E2 in microglia
    Tongguang Wang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, North Carolina 27709, USA
    J Neurochem 88:939-47. 2004
    ..These findings suggest a potential therapeutic intervention strategy for the treatment of inflammation-mediated neurodegenerative diseases...
  23. pmc Differential gene expression patterns in cyclooxygenase-1 and cyclooxygenase-2 deficient mouse brain
    Christopher D Toscano
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Biol 8:R14. 2007
    ....
  24. pmc Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis
    James C Bonner
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Pathol 161:459-70. 2002
    ..These findings indicate that the COX-2 enzyme is protective against pulmonary fibrogenesis, and we suggest that COX-2 generation of PGE(2) is an important factor in resolving inflammation...
  25. ncbi request reprint Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis
    Howard F Tiano
    Laboratory of Experimental Carcinogenesis and Mutagenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 62:3395-401. 2002
    ..Thus, both COX-1 and COX-2 have roles in keratinocyte differentiation, and we propose that the absence of either isoform causes premature terminal differentiation of initiated keratinocytes and reduced tumor formation...
  26. ncbi request reprint Resting and arecoline-stimulated brain metabolism and signaling involving arachidonic acid are altered in the cyclooxygenase-2 knockout mouse
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892 0947, USA
    J Neurochem 96:669-79. 2006
    ..This response likely reflects selective COX-2-mediated conversion of PLA2-released AA to prostanoids...
  27. ncbi request reprint Altered brain lipid composition in cyclooxygenase-2 knockout mouse
    Kaizong Ma
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    J Lipid Res 48:848-54. 2007
    ..A lifetime absence of COX-2 produces multiple changes in brain lipid composition. These changes may be related to reported changes in fatty acid kinetics and in resistance to neuroinflammation and excitotoxicity in the COX-2(-/-) mouse...
  28. ncbi request reprint Down-regulation of brain nuclear factor-kappa B pathway in the cyclooxygenase-2 knockout mouse
    Jagadeesh S Rao
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, 9000 Rockville Pike, Building 9, Room 1S 128, Bethesda, MD 20892, USA
    Brain Res Mol Brain Res 139:217-24. 2005
    ..Overall, our data indicate that constitutive brain NF-kappaB activity is decreased in COX-2 deficient mice and suggest a reciprocal coupling between NF-kappaB and COX-2...
  29. ncbi request reprint A proposed COX-2 and PGE(2) receptor interaction in UV-exposed mouse skin
    Kyung Soo Chun
    Laboratory of Molecular Carcinogenesis, NIEHS, NIH, Research Triangle Park, North Carolina 27709, USA
    Mol Carcinog 46:699-704. 2007
    ....
  30. ncbi request reprint Interleukin-1beta-induced mucin production in human airway epithelium is mediated by cyclooxygenase-2, prostaglandin E2 receptors, and cyclic AMP-protein kinase A signaling
    Thomas Gray
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Mol Pharmacol 66:337-46. 2004
    ..We conclude that the induction of MUC5AC by IL-1beta, TNF-alpha, PAF, and LPS involves COX-2- generated PGE(2), activation of EP2 and/or EP4 receptor(s), and cAMP-PKA-mediated signaling...
  31. pmc Neuroinflammatory response to lipopolysaccharide is exacerbated in mice genetically deficient in cyclooxygenase-2
    Saba Aid
    Brain Physiology and Metabolism Section, National Institute on Aging, NIH, 9000 Memorial Drive, Bldg 9 Room 1S126, Bethesda, MD 20892, USA
    J Neuroinflammation 5:17. 2008
    ..Recently, we demonstrated that COX-1 deficient mice show decreased neuroinflammatory response and neuronal damage in response to lipopolysaccharide (LPS)...
  32. ncbi request reprint Accentuated T helper type 2 airway response after allergen challenge in cyclooxygenase-1-/- but not cyclooxygenase-2-/- mice
    Michelle A Carey
    National Institute of Environmental Health Sciences NIH, 111 TW Alexander Drive, Building 101, Research Triangle Park, NC 27709, USA
    Am J Respir Crit Care Med 167:1509-15. 2003
    ..These data suggest that genetic deficiency of COX-1 but not COX-2 modulates T cell recruitment, Th2 cytokine secretion, and lung function in the allergic airway...
  33. pmc A novel role for the T-box transcription factor Tbx1 as a negative regulator of tumor cell growth in mice
    Carol S Trempus
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Mol Carcinog 50:981-91. 2011
    ..2011 Wiley Periodicals, Inc...
  34. ncbi request reprint Generation of a conditional allele of the mouse prostaglandin EP4 receptor
    Andre Schneider
    Division of Nephrology and Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 2372, USA
    Genesis 40:7-14. 2004
    ..The EP4(flox) mouse should provide a useful reagent with which to examine the physiologic roles of the EP4 receptor...
  35. ncbi request reprint E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation
    Jennifer L Goulet
    Division of Nephrology, Department of Medicine, Duke University and Durham Veterans Affairs Medical Centers, Durham, NC 27705, USA
    J Immunol 173:1321-6. 2004
    ..These studies demonstrate that PGE(2) promotes acute inflammation by activating EP3 receptors and suggest that EP3 receptors may be useful targets for anti-inflammatory therapy...
  36. ncbi request reprint Prostaglandin I(2) and E(2) mediate the protective effects of cyclooxygenase-2 in a mouse model of immune-mediated liver injury
    Hao Yin
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Hepatology 45:159-69. 2007
    ..These findings suggest that COX-2-derived PGs may have great therapeutic potentials in treating patients with inflammatory liver diseases...
  37. ncbi request reprint Reduced sulfur mustard-induced skin toxicity in cyclooxygenase-2 knockout and celecoxib-treated mice
    Uri Wormser
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    Toxicol Appl Pharmacol 200:40-7. 2004
    ..These findings may indicate that COX-2 participates in the early stages of sulfur mustard-induced acute skin toxicity and that COX-1 might exert some protective function against this chemical insult...
  38. pmc Cyclooxygenase-2 expression is critical for chronic UV-induced murine skin carcinogenesis
    Susan M Fischer
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    Mol Carcinog 46:363-71. 2007
    ..UV-induced apoptosis, however, was greater in COX-2 heterozygous mice. Collectively, these results clearly establish the requirement for COX-2 in the development of skin tumors...
  39. ncbi request reprint Effects of cyclooxygenase-1 and -2 gene disruption on Helicobacter pylori-induced gastric inflammation
    Guo Qing Li
    Department of Medicine, Queen Mary Hospital, Hong Kong, People s Republic of China
    J Infect Dis 193:1037-46. 2006
    ..Cyclooxygenases (COXs) play important roles in inflammation and carcinogenesis. The present study aimed to determine the effects of COX-1 and COX-2 gene disruption on Helicobacter pylori-induced gastric inflammation...
  40. ncbi request reprint Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyposis
    Haruna Takeda
    Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Cancer Res 63:4872-7. 2003
    ....
  41. ncbi request reprint Expanding the febrigenic role of cyclooxygenase-2 to the previously overlooked responses
    Alexandre A Steiner
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, 350 W Thomas Rd, Phoenix, Arizona 85013, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1253-7. 2005
    ..It also suggests that no product of the COX-1 gene, including the splice variant COX-1b (COX-3), is essential for these responses...
  42. pmc Mechanism of cyclooxygenase-2 upregulation in late preconditioning
    Yu Ting Xuan
    Experimental Research Laboratory, Division of Cardiology, University of Louisville and the Jewish Hospital Heart and Lung Institute, Louisville, KY 40292, USA
    J Mol Cell Cardiol 35:525-37. 2003
    ..To our knowledge, this is the first evidence that myocardial COX-2 is upregulated via a JAK1/2-STAT1/3 pathway...
  43. pmc A novel anti-atherogenic role for COX-2--potential mechanism for the cardiovascular side effects of COX-2 inhibitors
    Ajay Narasimha
    Department of Molecular and Medical Pharmacology, University of California Los Angeles, CA, United States
    Prostaglandins Other Lipid Mediat 84:24-33. 2007
    ..Our results suggest, for the first time, that COX-2 deficiency contributes to the pro-atherogenic properties of HDL in mice...
  44. ncbi request reprint Cyclooxygenase-1-deficient mice have high sleep-to-wake blood pressure ratios and renal vasoconstriction
    Noritaka Kawada
    Cardiovascular Kidney Institute, Division of Nephrology and Hypertension, Georgetown University, Washington, DC 20007 2197, USA
    Hypertension 45:1131-8. 2005
    ..COX-1 contributes to the normal nocturnal BP dipping phenomenon...
  45. ncbi request reprint Genetic deficiency of cyclooxygenase-2 attenuates abdominal aortic aneurysm formation in mice
    Jonathan M Gitlin
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Cardiovasc Res 73:227-36. 2007
    ..The aim of the current study was to define the role of COX-2 expression in the development of AAAs, using a model of the disease...
  46. ncbi request reprint The effects of aspirin on gastric mucosal integrity, surface hydrophobicity, and prostaglandin metabolism in cyclooxygenase knockout mice
    Rebecca L Darling
    Department of Integrative Biology and Pharmacology, The University of Texas Medical School, Houston, Texas 77030, USA
    Gastroenterology 127:94-104. 2004
    ....
  47. pmc Atherogenic diet causes lethal ileo-ceco-colitis in cyclooxygenase-2 deficient mice
    James A Lin
    Department of Pediatrics, University of California Los Angeles, Los Angeles, CA 90095 1679, USA
    Prostaglandins Other Lipid Mediat 84:98-107. 2007
    ....