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Genomes and Genes | Robert LangenbachSummaryAffiliation: National Institutes of Health Country: USA Publications
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Cyclooxygenase knockout mice: models for elucidating isoform-specific functionsR Langenbach
National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Biochem Pharmacol 58:1237-46. 1999..However, for the maintenance of normal physiology, it appears that deficiency of COX-2 has more profound effects than deficiency of COX-1...- Cyclooxygenase-deficient mice. A summary of their characteristics and susceptibilities to inflammation and carcinogenesisR Langenbach
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Ann N Y Acad Sci 889:52-61. 1999..Furthermore, data from COX-deficient mice indicate that both isoforms can contribute to the inflammatory response and that both isoforms have significant roles in carcinogenesis... 
Cyclooxygenase-1-selective inhibition prolongs gestation in mice without adverse effects on the ductus arteriosusCharles D Loftin
Laboratory of Environmental Carcinogenesis and Mutagenesis, National Institutes of Health, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
J Clin Invest 110:549-57. 2002..Therefore, COX-1-selective inhibitors may provide effective treatment to delay preterm labor with fewer adverse effects on fetal or neonatal health than nonselective or COX-2-selective inhibitors...- Contrasting effects of cyclooxygenase-1 (COX-1) and COX-2 deficiency on the host response to influenza A viral infectionMichelle A Carey
Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Research Triangle Park, NC 27709, USA
J Immunol 175:6878-84. 2005..COX-1 deficiency is detrimental whereas COX-2 deficiency is beneficial to the host during influenza viral infection... - Cyclooxygenase-2 inhibits UVB-induced apoptosis in mouse skin by activating the prostaglandin E2 receptors, EP2 and EP4Kyung Soo Chun
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences NIH, Research Triangle Park, NC 27709, USA
Cancer Res 67:2015-21. 2007..Furthermore, both agonists decreased apoptosis in COX-2-/- mice by 50%. The data suggest that COX-2-generated PGE(2) has antiapoptotic roles in UVB-exposed mouse skin that involves EP2- and EP4-mediated signaling... - Genetic deficiency or pharmacological inhibition of cyclooxygenase-1 or -2 induces mouse keratinocyte differentiation in vitro and in vivoJacqueline K Akunda
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
FASEB J 18:185-7. 2004..Thus, a major effect of COX inhibitors and COX-deficiency is the induction of keratinocyte differentiation... - The prostaglandin receptor EP2 activates multiple signaling pathways and beta-arrestin1 complex formation during mouse skin papilloma developmentKyung Soo Chun
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Carcinogenesis 30:1620-7. 2009..The data indicated that EP2 contributed to tumor formation via activation of PKA and EGFR and that EP2 formed a complex with beta-arrestin1 and Src that contributed to signaling and/or EP2 desensitization... - Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injurySang Ho Choi
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
FASEB J 22:1491-501. 2008..These findings suggest that COX-1 plays a previously unrecognized role in neuroinflammatory damage... - The prostaglandin E2 receptor, EP2, stimulates keratinocyte proliferation in mouse skin by G protein-dependent and {beta}-arrestin1-dependent signaling pathwaysKyung Soo Chun
Laboratory of Toxicology and Pharmacology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Biol Chem 285:39672-81. 2010..Therefore, the results indicate that EP2 contributed to mouse keratinocyte proliferation by G protein-independent, β-arrestin1-dependent activation of EGFR and G protein-dependent activation of PKA... - Cyclooxygenase-2 deficiency increases epidermal apoptosis and impairs recovery following acute UVB exposureJacqueline K Akunda
Laboratory of Molecular Carcinogenesis, NIEHS NIH, Research Triangle Park, North Carolina 27709, USA
Mol Carcinog 46:354-62. 2007..The data indicate that COX-2 induction initially protects against the acute sunburn effects of UVB, but that continuous induction of COX-2 may contribute to skin cancer in chronic UVB exposure... - Prostaglandin E2 released from activated microglia enhances astrocyte proliferation in vitroDan Zhang
Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Toxicol Appl Pharmacol 238:64-70. 2009..These findings are important in elucidating the role of activated microglia and PGE(2) in astrocyte proliferation and in suggesting a potential avenue in the use of anti-inflammatory agents for the therapy of astroglioma... - Phenotypes of the COX-deficient mice indicate physiological and pathophysiological roles for COX-1 and COX-2Charles D Loftin
Laboratory of Environmental Carcinogenesis and Mutagenesis, National Institutes of Health, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Prostaglandins Other Lipid Mediat 68:177-85. 2002..Studies with the COX-deficient mice suggest that in addition to COX-2-selective inhibition, therapeutic advances may also be achieved with COX-1-selective inhibitors which lack gastrointestinal side effects... - MPP+-induced COX-2 activation and subsequent dopaminergic neurodegenerationTongguang Wang
Neuropharmacology Section, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
FASEB J 19:1134-6. 2005..Thus inhibition of microgliosis and COX-2 activity may stop this vicious circle and be valuable strategies in PD therapy... 
A reciprocal relationship exists between non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) and cyclooxygenase-2Genzo Iguchi
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, RTP, NC 27709, USA
Cancer Lett 282:152-8. 2009..Furthermore, PGE(2) reduces NAG-1 while celebrex induces NAG-1 expression. The results suggest that a possible inverse relationship exists between the expression of NAG-1 and COX-2 in tumor formation of colon tissue...- Cyclooxygenase enzymes in allergic inflammation and asthmaMichelle A Carey
Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive Mail Drop D2-02, Research Triangle Park, NC 27709, USA
Prostaglandins Leukot Essent Fatty Acids 69:157-62. 2003.... - Cyclooxygenase-1 and -2 enzymes differentially regulate the brain upstream NF-kappa B pathway and downstream enzymes involved in prostaglandin biosynthesisSang Ho Choi
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurochem 98:801-11. 2006..Additionally, COX-1 deficiency can affect the expression of reciprocal and coupled enzymes, COX-2, Ca2+ -dependent PLA2, and terminal mPGES-2, to overcome defects in brain AA cascade... - Prostaglandin E2 and microsomal prostaglandin E synthase-2 expression are decreased in the cyclooxygenase-2-deficient mouse brain despite compensatory induction of cyclooxygenase-1 and Ca2+-dependent phospholipase A2Francesca Bosetti
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurochem 91:1389-97. 2004..Overall, the data suggest that compensatory mechanisms exist in COX-2(-/-) mice and that mPGES-2 is functionally coupled with COX-2... - The prostaglandin E2 receptor, EP2, regulates survivin expression via an EGFR/STAT3 pathway in UVB-exposed mouse skinKyung Soo Chun
Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Mol Carcinog 50:439-48. 2011..Therefore, targeting the EP2/survivin pathway may provide a strategy for the chemoprevention/chemotherapy of skin cancer... 
Differential gene expression patterns in cyclooxygenase-1 and cyclooxygenase-2 deficient mouse brainChristopher D Toscano
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
Genome Biol 8:R14. 2007....- A proposed COX-2 and PGE(2) receptor interaction in UV-exposed mouse skinKyung Soo Chun
Laboratory of Molecular Carcinogenesis, NIEHS, NIH, Research Triangle Park, North Carolina 27709, USA
Mol Carcinog 46:699-704. 2007.... - Resting and arecoline-stimulated brain metabolism and signaling involving arachidonic acid are altered in the cyclooxygenase-2 knockout mouseMireille Basselin
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892 0947, USA
J Neurochem 96:669-79. 2006..This response likely reflects selective COX-2-mediated conversion of PLA2-released AA to prostanoids... - Altered brain lipid composition in cyclooxygenase-2 knockout mouseKaizong Ma
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
J Lipid Res 48:848-54. 2007..A lifetime absence of COX-2 produces multiple changes in brain lipid composition. These changes may be related to reported changes in fatty acid kinetics and in resistance to neuroinflammation and excitotoxicity in the COX-2(-/-) mouse... - Role of reactive oxygen species in LPS-induced production of prostaglandin E2 in microgliaTongguang Wang
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, North Carolina 27709, USA
J Neurochem 88:939-47. 2004..These findings suggest a potential therapeutic intervention strategy for the treatment of inflammation-mediated neurodegenerative diseases... - Down-regulation of brain nuclear factor-kappa B pathway in the cyclooxygenase-2 knockout mouseJagadeesh S Rao
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, 9000 Rockville Pike, Building 9, Room 1S 128, Bethesda, MD 20892, USA
Brain Res Mol Brain Res 139:217-24. 2005..Overall, our data indicate that constitutive brain NF-kappaB activity is decreased in COX-2 deficient mice and suggest a reciprocal coupling between NF-kappaB and COX-2... - Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesisJames C Bonner
Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, North Carolina 27709, USA
Am J Pathol 161:459-70. 2002..These findings indicate that the COX-2 enzyme is protective against pulmonary fibrogenesis, and we suggest that COX-2 generation of PGE(2) is an important factor in resolving inflammation... - Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesisHoward F Tiano
Laboratory of Experimental Carcinogenesis and Mutagenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Cancer Res 62:3395-401. 2002..Thus, both COX-1 and COX-2 have roles in keratinocyte differentiation, and we propose that the absence of either isoform causes premature terminal differentiation of initiated keratinocytes and reduced tumor formation... - Genetic ablation of cyclooxygenase-2 in keratinocytes produces a cell-autonomous defect in tumor formationHuei Chen Lao
Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Carcinogenesis 33:2293-300. 2012..Furthermore, the data indicate that deficiency/inhibition of COX-2 in the initiated keratinocyte is an important determinant of papilloma forming ability... - Interleukin-1beta-induced mucin production in human airway epithelium is mediated by cyclooxygenase-2, prostaglandin E2 receptors, and cyclic AMP-protein kinase A signalingThomas Gray
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Mol Pharmacol 66:337-46. 2004..We conclude that the induction of MUC5AC by IL-1beta, TNF-alpha, PAF, and LPS involves COX-2- generated PGE(2), activation of EP2 and/or EP4 receptor(s), and cAMP-PKA-mediated signaling... - Neuroinflammatory response to lipopolysaccharide is exacerbated in mice genetically deficient in cyclooxygenase-2Saba Aid
Brain Physiology and Metabolism Section, National Institute on Aging, NIH, 9000 Memorial Drive, Bldg 9 Room 1S126, Bethesda, MD 20892, USA
J Neuroinflammation 5:17. 2008..Recently, we demonstrated that COX-1 deficient mice show decreased neuroinflammatory response and neuronal damage in response to lipopolysaccharide (LPS)... - Multi-walled carbon nanotubes induce COX-2 and iNOS expression via MAP Kinase-dependent and -independent mechanisms in mouse RAW264.7 macrophagesJong Kwon Lee
Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC, 27709, USA
Part Fibre Toxicol 9:14. 2012..abstract:.. - A novel role for the T-box transcription factor Tbx1 as a negative regulator of tumor cell growth in miceCarol S Trempus
Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Mol Carcinog 50:981-91. 2011..2011 Wiley Periodicals, Inc... - Accentuated T helper type 2 airway response after allergen challenge in cyclooxygenase-1-/- but not cyclooxygenase-2-/- miceMichelle A Carey
National Institute of Environmental Health Sciences/NIH, 111 TW Alexander Drive, Building 101, Research Triangle Park, NC 27709, USA
Am J Respir Crit Care Med 167:1509-15. 2003..These data suggest that genetic deficiency of COX-1 but not COX-2 modulates T cell recruitment, Th2 cytokine secretion, and lung function in the allergic airway... - Mechanism of cyclooxygenase-2 upregulation in late preconditioningYu-Ting Xuan
Experimental Research Laboratory, Division of Cardiology, University of Louisville and the Jewish Hospital Heart and Lung Institute, Louisville, KY 40292, USA
J Mol Cell Cardiol 35:525-37. 2003..To our knowledge, this is the first evidence that myocardial COX-2 is upregulated via a JAK1/2-STAT1/3 pathway... - Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyposisHaruna Takeda
Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
Cancer Res 63:4872-7. 2003.... - Expanding the febrigenic role of cyclooxygenase-2 to the previously overlooked responsesAlexandre A Steiner
Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, 350 W Thomas Rd, Phoenix, Arizona 85013, USA
Am J Physiol Regul Integr Comp Physiol 289:R1253-7. 2005..It also suggests that no product of the COX-1 gene, including the splice variant COX-1b (COX-3), is essential for these responses... - A novel anti-atherogenic role for COX-2--potential mechanism for the cardiovascular side effects of COX-2 inhibitorsAjay Narasimha
Department of Molecular and Medical Pharmacology, University of California Los Angeles, CA, United States
Prostaglandins Other Lipid Mediat 84:24-33. 2007..Our results suggest, for the first time, that COX-2 deficiency contributes to the pro-atherogenic properties of HDL in mice... - Effects of cyclooxygenase-1 and -2 gene disruption on Helicobacter pylori-induced gastric inflammationGuo Qing Li
Department of Medicine, Queen Mary Hospital, Hong Kong, People s Republic of China
J Infect Dis 193:1037-46. 2006..Cyclooxygenases (COXs) play important roles in inflammation and carcinogenesis. The present study aimed to determine the effects of COX-1 and COX-2 gene disruption on Helicobacter pylori-induced gastric inflammation... - Prostaglandin I(2) and E(2) mediate the protective effects of cyclooxygenase-2 in a mouse model of immune-mediated liver injuryHao Yin
Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Hepatology 45:159-69. 2007..These findings suggest that COX-2-derived PGs may have great therapeutic potentials in treating patients with inflammatory liver diseases... - Reduced sulfur mustard-induced skin toxicity in cyclooxygenase-2 knockout and celecoxib-treated miceUri Wormser
Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
Toxicol Appl Pharmacol 200:40-7. 2004..These findings may indicate that COX-2 participates in the early stages of sulfur mustard-induced acute skin toxicity and that COX-1 might exert some protective function against this chemical insult... - Cyclooxygenase-2 expression is critical for chronic UV-induced murine skin carcinogenesisSusan M Fischer
The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
Mol Carcinog 46:363-71. 2007..UV-induced apoptosis, however, was greater in COX-2 heterozygous mice. Collectively, these results clearly establish the requirement for COX-2 in the development of skin tumors... - Generation of a conditional allele of the mouse prostaglandin EP4 receptorAndre Schneider
Division of Nephrology and Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 2372, USA
Genesis 40:7-14. 2004..The EP4(flox) mouse should provide a useful reagent with which to examine the physiologic roles of the EP4 receptor... - E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammationJennifer L Goulet
Division of Nephrology, Department of Medicine, Duke University and Durham Veterans Affairs Medical Centers, Durham, NC 27705, USA
J Immunol 173:1321-6. 2004..These studies demonstrate that PGE(2) promotes acute inflammation by activating EP3 receptors and suggest that EP3 receptors may be useful targets for anti-inflammatory therapy... - Genetic deficiency of cyclooxygenase-2 attenuates abdominal aortic aneurysm formation in miceJonathan M Gitlin
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
Cardiovasc Res 73:227-36. 2007..The aim of the current study was to define the role of COX-2 expression in the development of AAAs, using a model of the disease... - Cyclooxygenase-1-deficient mice have high sleep-to-wake blood pressure ratios and renal vasoconstrictionNoritaka Kawada
Cardiovascular Kidney Institute, Division of Nephrology and Hypertension, Georgetown University, Washington, DC 20007 2197, USA
Hypertension 45:1131-8. 2005..COX-1 contributes to the normal nocturnal BP dipping phenomenon... - The effects of aspirin on gastric mucosal integrity, surface hydrophobicity, and prostaglandin metabolism in cyclooxygenase knockout miceRebecca L Darling
Department of Integrative Biology and Pharmacology, The University of Texas Medical School, Houston, Texas 77030, USA
Gastroenterology 127:94-104. 2004..Aspirin seems to paradoxically increase the gastric mucosal prostaglandin E(2) concentration in cyclooxygenase-1 knockout mice, possibly by the induction of cyclooxygenase-2... - Atherogenic diet causes lethal ileo-ceco-colitis in cyclooxygenase-2 deficient miceJames A Lin
Department of Pediatrics, University of California Los Angeles, Los Angeles, CA 90095 1679, USA
Prostaglandins Other Lipid Mediat 84:98-107. 2007....