Research Topics
| M A LaneSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Caloric restriction in primatesM A Lane
Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
Ann N Y Acad Sci 928:287-95. 2001....- Calorie restriction in nonhuman primates: effects on diabetes and cardiovascular disease riskM A Lane
Intramural Research Program, Gerontology Research Center, National Institute on Aging, NIH Baltimore, Maryland 21224, USA
Toxicol Sci 52:41-8. 1999..These and other findings have suggested that CR might have beneficial effects on certain disease risk factors independent of reductions in body weight or prevention of obesity... - Short-term calorie restriction improves disease-related markers in older male rhesus monkeys (Macaca mulatta)M A Lane
Intramural Research Program, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD 21224, USA
Mech Ageing Dev 112:185-96. 2000..Interestingly, the observed glucoregulatory changes emerged prior to any evidence of a change in body composition suggesting that certain effects of CR may not be wholly dependent on changes in body composition in older monkeys... - Nutritional modulation of aging in nonhuman primatesM A Lane
Intramural Research Program, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD 21224, USA
J Nutr Health Aging 3:69-76. 1999..This review summarizes the major findings from the primate CR studies after over a decade of research in this model... - Energy restriction does not alter bone mineral metabolism or reproductive cycling and hormones in female rhesus monkeysM A Lane
Laboratory of Neurosciences, National Institute on Aging, Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
J Nutr 131:820-7. 2001..02) concentrations than did younger monkeys. We conclude that ER does not negatively affect these indices of skeletal or reproductive health and does not alter age-associated changes in the same variables... - Nonhuman primate models in biogerontologyM A Lane
Gerontology Research Center, Intramural Research Program, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Exp Gerontol 35:533-41. 2000.... - Effects of reduced energy intake on the biology of aging: the primate modelG S Roth
National Institute on Aging, Baltimore, MD 21224, USA
Eur J Clin Nutr 54:S15-20. 2000..In summary, nearly all CR effects detected in rodents, which have thus far been examined in primates, exhibit similar phenomenology. Potential applicability of these beneficial effects to humans is discussed... - Caloric restriction in primates and relevance to humansG S Roth
Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
Ann N Y Acad Sci 928:305-15. 2001.... - A nonhuman primate model of age-related bone loss: a longitudinal study in male and premenopausal female rhesus monkeysA Black
Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, Baltimore, MD, USA
Bone 28:295-302. 2001..Changes in markers of bone turnover with age were also observed in male monkeys. The results of this longitudinal study suggest that the rhesus monkey is a potential model for age-related changes in the human skeleton... - Calorie restriction and skeletal mass in rhesus monkeys (Macaca mulatta): evidence for an effect mediated through changes in body sizeA Black
Molecular and Nutritional Physiology Unit, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224, USA
J Gerontol A Biol Sci Med Sci 56:B98-107. 2001..Although osteocalcin concentrations were significantly lower in young restricted males after 1 month on 30% CR in the short-term study, they were no longer different from control values by 6 months on 30% CR... - Aging and caloric restriction in nonhuman primates: behavioral and in vivo brain imaging studiesD K Ingram
Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
Ann N Y Acad Sci 928:316-26. 2001.... - Dehydroepiandrosterone sulfate: a biomarker of primate aging slowed by calorie restrictionM A Lane
Gerontology Research Center, Nathan W Shock Laboratories, National Institutes of Health, Johns Hopkins University Bayview Campus, Baltimore, Maryland 21224, USA
J Clin Endocrinol Metab 82:2093-6. 1997..This represents the first evidence that this nutritional intervention has the potential to alter aspects of postmaturational aging in a long-lived species... - Strategy for identifying biomarkers of aging in long-lived speciesD K Ingram
Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Exp Gerontol 36:1025-34. 2001.... - Effects of dietary caloric restriction and aging on thyroid hormones of rhesus monkeysG S Roth
Laboratory of Neurosciences, National Institute on Aging, Baltimore, Maryland 21224, USA
Horm Metab Res 34:378-82. 2002..In the light of the effects of the thyroid axis on overall metabolism, these results suggest a possible mechanism by which CR diets may elicit their well-known beneficial 'anti-aging' effects in mammals... - Dietary caloric restriction prevents the age-related decline in plasma melatonin levels of rhesus monkeysG S Roth
Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224, USA
J Clin Endocrinol Metab 86:3292-5. 2001..Moreover, this index of age-associated physiological decrement seems to be inhibited by dietary CR... - Accuracy and precision of dual-energy X-ray absorptiometry for body composition measurements in rhesus monkeysA Black
Nutritional and Molecular Physiology Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
J Med Primatol 30:94-9. 2001..DXA also accurately measured lumbar spine BMC but underestimated total body BMC as compared with carcass ash determinations... - Age-related decline in striatal volume in monkeys as measured by magnetic resonance imagingJ A Matochik
Brain Imaging Center, Neuroimaging Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Neurobiol Aging 21:591-8. 2000..The current results provide normative data to assess potential interventions (e.g. caloric restriction) in the aging process... - Effect of age and caloric restriction on cutaneous wound closure in rats and monkeysG S Roth
Laboratory of Cellular and Molecular Biology, National Institute on Aging, Baltimore, USA
J Gerontol A Biol Sci Med Sci 52:B98-102. 1997..Thus, impaired wound healing appears to be a generalized physiological manifestation of aging, but its possible amelioration by "anti-aging" interventions remains to be established... - Nonhuman primate models of skeletal and reproductive agingA Black
Nutritional and Molecular Physiology Unit, Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Gerontology 48:72-80. 2002..The significance of these changes underscores the need for developing appropriate animal models to study aging of bone and the reproductive system... - Age-related changes in cytokine production by leukocytes in rhesus monkeysP Mascarucci
Laboratories of Neurosciences, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD 21224, USA
Aging (Milano) 13:85-94. 2001..We believe that such age-related alterations in cytokine production may play a role in the reduced immune responses observed in elderly human populations... - Calorie restriction attenuates age-related alterations in the plasma membrane antioxidant system in rat liverR de Cabo
Laboratory of Experimental Gerontology, National Institute on Aging, NIH, Gerontology Research Center, Box 10, 5600 Nathan Shock Drive, Baltimore, MD 21224 6825, USA
Exp Gerontol 39:297-304. 2004..Thus, our results suggest that CR induces a higher capacity to oxidize NAD(P)H in the PM of old rat livers and as a result, a higher resistance to oxidative stress-induced damage... - Changes in blood chemistry and hematology variables during aging in captive rhesus macaques (Macaca mulatta)D A Smucny
Wisconsin Regional Primate Research Center, Madison, USA
J Med Primatol 30:161-73. 2001..Here we present the first phase of a project that will: a) identify changes with age in physiological variables among adult captive rhesus macaques; and b) characterize normative values for the aging rhesus population... - Developmental changes in ketogenic enzyme gene expression during sheep rumen developmentM A Lane
Department of Animal Sciences, Rutgers--The State University of New Jersey, New Brunswick 08903, USA
J Anim Sci 80:1538-44. 2002..Thus, the expression of the genes encoding the ketogenic enzymes are not affected by the presence of VFA in the ruminal lumen... - Changes in blood chemistry and hematology variables during aging in captive rhesus macaques (Macaca mulatta). J Med Primatol 30:161-173, 2001D A Smucny
Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
J Med Primatol 33:48-54. 2004..These data were collected from several research colonies and have been submitted to rigorous statistical analyses to identify relationships with chronological age... - Effect of caloric restriction on the 24-hour plasma DHEAS and cortisol profiles of young and old male rhesus macaquesH F Urbanski
Division of Neuroscience, Oregon National Primate Research Center, 505 N W 185 th Avenue, Beaverton, OR 97006, USA
Ann N Y Acad Sci 1019:443-7. 2004..These data fail to support the hypothesis that CR can attenuate the aging-related decline in plasma DHEAS concentrations, at least not when initiated after puberty...