Research Topics
Genomes and Genes
Species | Maria Teresa LandiSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
DNA repair, dysplastic nevi, and sunlight sensitivity in the development of cutaneous malignant melanomaMaria Teresa Landi
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7236, USA
J Natl Cancer Inst 94:94-101. 2002..We designed this case-control study to determine whether DNA repair capacity (DRC) is associated with the risk of CMM and to identify risk factors that may interact biologically with DRC in the development of melanoma...
MicroRNA expression differentiates histology and predicts survival of lung cancerMaria Teresa Landi
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland 20892 7236, USA
Clin Cancer Res 16:430-41. 2010..The molecular drivers that determine histology in lung cancer are largely unknown. We investigated whether microRNA (miR) expression profiles can differentiate histologic subtypes and predict survival for non-small cell lung cancer...- MC1R, ASIP, and DNA repair in sporadic and familial melanoma in a Mediterranean populationMaria Teresa Landi
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7236, USA
J Natl Cancer Inst 97:998-1007. 2005..We examined MC1R and ASIP genotypes in relation to phenotypic characteristics, sporadic and familial melanoma risk, and melanoma thickness as an indicator of disease progression in a Mediterranean population... - Environment And Genetics in Lung cancer Etiology (EAGLE) study: an integrative population-based case-control study of lung cancerMaria Teresa Landi
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA
BMC Public Health 8:203. 2008..A new framework of research is needed to address the challenges offered by this complex disease... - CYP1A1 and CYP1B1 genotypes, haplotypes, and TCDD-induced gene expression in subjects from Seveso, ItalyMaria Teresa Landi
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Blvd, EPS, Bethesda, MD 20892 7236, USA
Toxicology 207:191-202. 2005..Genetic variation in cytochrome P450 induction may identify subjects with variable responsiveness to TCDD and potentially increased risk of disease... - TCDD-mediated alterations in the AhR-dependent pathway in Seveso, Italy, 20 years after the accidentMaria Teresa Landi
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7236, USA
Carcinogenesis 24:673-80. 2003.... - A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinomaMaria Teresa Landi
Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Am J Hum Genet 85:679-91. 2009..In conclusion, a lung cancer GWAS identified a distinct hereditary contribution to adenocarcinoma... - MC1R germline variants confer risk for BRAF-mutant melanomaMaria Teresa Landi
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Science 313:521-2. 2006..In this tumor subtype, the risk for melanoma associated with MC1R is due to an increase in risk of developing melanomas with BRAF mutations... - Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expressionMelissa Rotunno
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS ONE 4:e5652. 2009..Our findings emphasize the necessity of post-GWAS fine mapping and SNP functional assessment to further elucidate cancer risk associations... - Alcohol consumption and lung cancer risk in the Environment and Genetics in Lung Cancer Etiology (EAGLE) studyVincenzo Bagnardi
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 7114, Bethesda, MD 20892 7236, USA
Am J Epidemiol 171:36-44. 2010..Although residual confounding by tobacco smoking cannot be ruled out, this finding may reflect interplay between alcohol and smoking, emphasizing the need for preventive measures... - Aryl-hydrocarbon receptor-dependent pathway and toxic effects of TCDD in humans: a population-based study in Seveso, ItalyAndrea Baccarelli
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7236, USA
Toxicol Lett 149:287-93. 2004..Markers within the AhR pathway were correlated with one another. Our findings suggest the presence of long-term effects in the subjects exposed to TCDD after the Seveso accident... - Family history of cancer and nonmalignant lung diseases as risk factors for lung cancerYing Gao
Division of Cancer Epidemiology and Genetics, Genetic Epidemiology Branch, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7236, USA
Int J Cancer 125:146-52. 2009..23-1.80) and decreased (OR = 0.73, 95% CI = 0.61-0.87) lung cancer risk, respectively. FH of lung cancer and nonmalignant lung diseases affected lung cancer risk independently, and did not appear to be modified by FH of smoking... - Chronic obstructive pulmonary disease and altered risk of lung cancer in a population-based case-control studyJill Koshiol
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
PLoS ONE 4:e7380. 2009..Chronic obstructive pulmonary disease (COPD) has been consistently associated with increased risk of lung cancer. However, previous studies have had limited ability to determine whether the association is due to smoking... - Nucleotide diversity and population differentiation of the melanocortin 1 receptor gene, MC1RSharon A Savage
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, USA
BMC Genet 9:31. 2008..The melanocortin 1 receptor gene (MC1R) is responsible for normal pigment variation in humans and is highly polymorphic with numerous population-specific alleles. Some MC1R variants have been associated with skin cancer risk... - A gene expression signature from peripheral whole blood for stage I lung adenocarcinomaMelissa Rotunno
Division of Cancer Epidemiology and Genetics, NCI, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
Cancer Prev Res (Phila) 4:1599-608. 2011..81, 95% CI = 0.74-0.87). Our finding suggests the use of gene expression from PWB for the identification of early detection markers of lung cancer in the future... - Dietary quercetin, quercetin-gene interaction, metabolic gene expression in lung tissue and lung cancer riskTram Kim Lam
Cancer Prevention Fellowship Program, Office of Preventive Oncology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Carcinogenesis 31:634-42. 2010..Our findings suggest an interplay between quercetin intake, tobacco smoking, and lung cancer risk. Further research on this relationship is warranted... - Genome-wide and candidate gene association study of cigarette smoking behaviorsNeil Caporaso
Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland, United States of America
PLoS ONE 4:e4653. 2009..4x10(-5)), our analysis provides independent replication of the association between the chr15q25.1 region and smoking intensity and data for multiple other loci associated with smoking behavior that merit further follow-up... - A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility lociNathaniel Rothman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Nat Genet 42:978-84. 2010..Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis... - High-risk melanoma susceptibility genes and pancreatic cancer, neural system tumors, and uveal melanoma across GenoMELAlisa M Goldstein
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892 7236, USA
Cancer Res 66:9818-28. 2006..This GenoMEL study provides the most extensive characterization of mutations in high-risk melanoma susceptibility genes in families with three or more melanoma patients yet available... - Genetic variation in innate immunity and inflammation pathways associated with lung cancer riskMeredith S Shiels
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, USA
Cancer 118:5630-6. 2012.... - Inherited variation at chromosome 12p13.33, including RAD52, influences the risk of squamous cell lung carcinomaJianxin Shi
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Cancer Discov 2:131-9. 2012..20, P(combined) = 2.3 × 10(-8)). SIGNIFICANCE: The combination of pathway-based approaches and information on disease-specific subtypes can improve the identification of cancer susceptibility loci in heterogeneous diseases... 
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in AsiaQing Lan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Nat Genet 44:1330-5. 2012..3. We observed no evidence of association for lung cancer at 15q25 in never-smoking women in Asia, providing strong evidence that this locus is not associated with lung cancer independent of smoking...- Mood disorders and risk of lung cancer in the EAGLE case-control study and in the U.S. Veterans Affairs inpatient cohortDavid E Capo-Ramos
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS ONE 7:e42945. 2012..Mood disorders may affect lung cancer risk. We evaluated this hypothesis in two large studies... - Evaluation of normalization methods for two-channel microRNA microarraysYingdong Zhao
Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
J Transl Med 8:69. 2010..Findings from previous studies have sometimes been inconclusive or contradictory. Further studies to determine optimal normalization methods for miR microarrays are needed... - Lower risk of lung cancer after multiple pneumonia diagnosesJill Koshiol
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, MSC 7248, Bethesda, MD 20892 7248, USA
Cancer Epidemiol Biomarkers Prev 19:716-21. 2010..Although pneumonia has been suggested as a risk factor for lung cancer, previous studies have not evaluated the influence of number of pneumonia diagnoses in relation to lung cancer risk... - GSTM1 and GSTT1 copy numbers and mRNA expression in lung cancerMelissa Rotunno
Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 7248, USA
Mol Carcinog 51:E142-50. 2012..A protective effect of the same mutations may be operative in never-smokers and women, possibly because of reduced activity of other genotoxic chemicals... - A flexible Bayesian model for studying gene-environment interactionKai Yu
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
PLoS Genet 8:e1002482. 2012.... - Handling of dioxin measurement data in the presence of non-detectable values: overview of available methods and their application in the Seveso chloracne studyAndrea Baccarelli
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, Bethesda, MD 20852, USA
Chemosphere 60:898-906. 2005..6% of plasma TCDD measurements were non-detects. We suggest that distribution-based multiple imputation be the preferred method to analyze environmental data when substantial proportions of observations are non-detects... - Genome-wide association studies of pigmentation and skin cancer: a review and meta-analysisMeg R Gerstenblith
Genetic Epidemiology Branch Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Pigment Cell Melanoma Res 23:587-606. 2010..As with any GWAS, the identified loci may not include the causal variants and may need confirmation by direct genome sequencing... - Influence of quercetin-rich food intake on microRNA expression in lung cancer tissuesTram K Lam
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 21:2176-84. 2012..A quercetin-rich diet might modulate microRNA (miR) expression; however, this mechanism has not been fully examined... - Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in AsiaH Dean Hosgood
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 8118, MCS 7240, Bethesda, MD 20892 7240, USA
Hum Genet 131:1197-203. 2012..037; allelic risk = 0.82, 95% CI = 0.67-0.99). Our findings provide strong evidence that genetic variation in TP63 is associated with the risk of lung adenocarcinoma among Asian females in the absence of tobacco smoking... - Large-scale pathway-based analysis of bladder cancer genome-wide association data from five studies of European backgroundIdan Menashe
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
PLoS ONE 7:e29396. 2012..Identification of the aromatic amine metabolism pathway provides support for the ability of this approach to identify pathways with established relevance to bladder carcinogenesis... 
Immunologic effects of dioxin: new results from Seveso and comparison with other studiesAndrea Baccarelli
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
Environ Health Perspect 110:1169-73. 2002..The possible long-term immunologic effects of TCDD exhibited by the participants of the present study, coupled with the increased incidence of lymphatic tumors in the area of the accident, warrant further investigation...- Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survivalMaria Teresa Landi
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, Maryland, USA
PLoS ONE 3:e1651. 2008..Tobacco smoking is responsible for over 90% of lung cancer cases, and yet the precise molecular alterations induced by smoking in lung that develop into cancer and impact survival have remained obscure... - Intakes of red meat, processed meat, and meat mutagens increase lung cancer riskTram Kim Lam
Cancer Prevention Fellowship Program, Office of Preventive Oncology, National Cancer Institute, NIH, Department of Health and Human Services, corrected Bethesda, Maryland 20892 7236, USA
Cancer Res 69:932-9. 2009..In summary, red meat, processed meat, and meat mutagens were independently associated with increased risk of lung cancer... - Instrumental measurements of skin color and skin ultraviolet light sensitivity and risk of cutaneous malignant melanoma: a case-control study in an Italian populationAlina V Brenner
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7362, USA
Am J Epidemiol 156:353-62. 2002..Epidemiologic studies of CMM may benefit from the inclusion of colorimetric and MED measurements along with traditional risk factors to obtain more accurate, quantitative, and objective information... - A genome-wide association study of bladder cancer identifies a new susceptibility locus within SLC14A1, a urea transporter gene on chromosome 18q12.3Montserrat Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Hum Mol Genet 20:4282-9. 2011..Our findings suggest that genetic variation in SLC14A1 could provide new etiological insights into bladder carcinogenesis... - [Risk factors of malignant skin melanoma in Italian population: review of results of a case-control study]Andrea Baccarelli
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute NIH 6120 Executive Blvd, EPS 7110, Bethesda, MD 20892 7236, USA
Epidemiol Prev 26:293-9. 2002..7; 95% CI: 2.4-18.6) than those lacking dysplastic nevi and with high DRC. These results may help identify high-risk subjects in the Mediterranean populations who would the benefit from preventive measures... - Association of MC1R variants and risk of melanoma in melanoma-prone families with CDKN2A mutationsAlisa M Goldstein
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7236, USA
Cancer Epidemiol Biomarkers Prev 14:2208-12. 2005..Additional studies are needed to confirm these findings and to explore the mechanisms that may contribute to this relationship... - Assessment of human papillomavirus in lung tumor tissueJill Koshiol
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7248, USA
J Natl Cancer Inst 103:501-7. 2011..Lung cancer kills more than 1 million people worldwide each year. Whereas several human papillomavirus (HPV)-associated cancers have been identified, the role of HPV in lung carcinogenesis remains controversial... - Impact of occupational carcinogens on lung cancer risk in a general populationSara De Matteis
Unit of Epidemiology, Department of Preventive Medicine, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico and EPOCA Research Centre, Department of Occupational and Environmental Health, Universita degli Studi di Milano, Milan, Italy
Int J Epidemiol 41:711-21. 2012..Most of the previous studies were in highly exposed industrial cohorts. Our aim was to quantify lung cancer burden attributable to occupational carcinogens in a general population... - Comprehensive evaluation of allele frequency differences of MC1R variants across populationsMeg R Gerstenblith
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 7236, USA
Hum Mutat 28:495-505. 2007.... - Strengths and limitations of laboratory procedures for microRNA detectionJill Koshiol
Infections and Immunepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 7070, Rockville, MD 20852 7248, USA
Cancer Epidemiol Biomarkers Prev 19:907-11. 2010..MicroRNAs (miR) are endogenous, noncoding RNAs involved in many cellular processes and have been associated with the development and progression of cancer. There are many different ways to evaluate miRs... - On the interplay of telomeres, nevi and the risk of melanomaClara Bodelon
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
PLoS ONE 7:e52466. 2012..Larger studies across different populations are necessary to clarify these associations... - Mutations in the tyrosine kinase domain of the epidermal growth factor receptor in non-small cell lung cancerSei Hoon Yang
Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute NIH, 41 Library Drive, Bethesda, MD 20892, USA
Clin Cancer Res 11:2106-10. 2005..Screening subjects with EGFR mutations may identify patients whose tumors could respond to targeted therapy using tyrosine kinase inhibitors... - Detectable clonal mosaicism and its relationship to aging and cancerKevin B Jacobs
Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Rockville, Maryland, USA
Nat Genet 44:651-8. 2012..4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases... - Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continentsAlisa M Goldstein
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892 7236, USA
J Med Genet 44:99-106. 2007.... - Genetic variation and willingness to participate in epidemiologic research: data from three studiesParveen Bhatti
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS 7091, MSC 7238, Bethesda, MD 20892 7238, USA
Cancer Epidemiol Biomarkers Prev 14:2449-53. 2005..To the extent possible, investigators should evaluate their own genetic data for bias in response categories... - A comparison of CDKN2A mutation detection within the Melanoma Genetics Consortium (GenoMEL)Mark Harland
Division of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Cancer Centre at Leeds, St James s University Hospital, Leeds, UK
Eur J Cancer 44:1269-74. 2008..The relatively low rate of CDKN2A mutation detection is not due to failure to detect mutations and implies the existence of other high penetrance melanoma susceptibility genes... - Correspondence re: K. Toide et al., Aryl hydrocarbon hydroxylase represents CYP1B1, and not CYP1A1, in human freshly isolated white cells: trimodal distribution of Japanese population according to induction of CYP1B1 mRNA by environmental dioxins. 12: 219Maria Teresa Landi
Cancer Epidemiol Biomarkers Prev 12:1116-7; author reply 1118. 2003 - Neonatal thyroid function in Seveso 25 years after maternal exposure to dioxinAndrea Baccarelli
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America
PLoS Med 5:e161. 2008.... - Microarray analysis of gene expression in peripheral blood mononuclear cells from dioxin-exposed human subjectsCliona M McHale
School of Public Health, University of California, Berkeley, CA 94720 7360, USA
Toxicology 229:101-13. 2007..Further examination of the role of these genes in dioxin induced-toxicity is warranted... - Identification of 14-3-3 theta as an antigen that induces a humoral response in lung cancerSandra R Pereira-Faca
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Cancer Res 67:12000-6. 2007..5 proteins previously identified as associated with autoantibodies in lung cancer, gave a sensitivity of 55% at 95% specificity (area under the curve, 0.838) in discriminating lung cancer at the preclinical stage from matched controls... - t(14;18) translocations in lymphocytes of healthy dioxin-exposed individuals from Seveso, ItalyAndrea Baccarelli
EPOCA Research Center for Occupational, Clinical and Environmental Epidemiology, Department of Occupational and Environmental Health, University of Milan, IRCCS Ospedale Maggiore Policlinico Mangiagalli e Regina Elena, Milan, Italy
Carcinogenesis 27:2001-7. 2006..Whether this change in t(14;18) frequency is an indicator of elevated lymphoma risk remains speculative and needs further investigation for its potential impact on public health...