O Landgren

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Respiratory tract infections in the pathway to multiple myeloma: a population-based study in Scandinavia
    Ola Landgren
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7236, USA
    Haematologica 91:1697-700. 2006
  2. ncbi request reprint New aspects in descriptive, etiologic, and molecular epidemiology of Hodgkin's lymphoma
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, National Institutes of Health, 6120 Executive Boulevard, Building EPS Room 7110, Bethesda, MD 20892 7236, USA
    Hematol Oncol Clin North Am 21:825-40. 2007
  3. pmc Significant association between polymorphism of the erythropoietin gene promoter and myelodysplastic syndrome
    Wanlong Ma
    Department of Hematology Oncology, Quest Diagnostics Nichols Institute, San Juan Capistrano, CA, USA
    BMC Med Genet 11:163. 2010
  4. ncbi request reprint Risk of multiple myeloma following medication use and medical conditions: a case-control study in Connecticut women
    Ola Landgren
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Building EPS Room 7110, Bethesda, MD 20892 7236, USA
    Cancer Epidemiol Biomarkers Prev 15:2342-7. 2006
  5. pmc Pesticide exposure and risk of monoclonal gammopathy of undetermined significance in the Agricultural Health Study
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 113:6386-91. 2009
  6. ncbi request reprint Autoimmunity and susceptibility to Hodgkin lymphoma: a population-based case-control study in Scandinavia
    Ola Landgren
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7236, USA
    J Natl Cancer Inst 98:1321-30. 2006
  7. pmc Respiratory tract infections and subsequent risk of chronic lymphocytic leukemia
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7236, USA
    Blood 109:2198-201. 2007
  8. ncbi request reprint Risk of second malignant neoplasms among lymphoma patients with a family history of cancer
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
    Int J Cancer 120:1099-102. 2007
  9. pmc Risk factors for lymphoproliferative disorders after allogeneic hematopoietic cell transplantation
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Blood 113:4992-5001. 2009
  10. doi request reprint B-cell clones as early markers for chronic lymphocytic leukemia
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 360:659-67. 2009

Detail Information

Publications93

  1. ncbi request reprint Respiratory tract infections in the pathway to multiple myeloma: a population-based study in Scandinavia
    Ola Landgren
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7236, USA
    Haematologica 91:1697-700. 2006
    ..7-fold (95%CI 1.0-3.0; p=0.05) and a 1.5-fold (95%CI 0.6-3.9) elevated MM risk, respectively. Pneumonia could be a trigger to the development of MM or a manifestation of immune disturbances in late-stage MGUS...
  2. ncbi request reprint New aspects in descriptive, etiologic, and molecular epidemiology of Hodgkin's lymphoma
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, National Institutes of Health, 6120 Executive Boulevard, Building EPS Room 7110, Bethesda, MD 20892 7236, USA
    Hematol Oncol Clin North Am 21:825-40. 2007
    ..These results emphasize an interaction between environmental and genetic risk factors in Hodgkin's lymphoma...
  3. pmc Significant association between polymorphism of the erythropoietin gene promoter and myelodysplastic syndrome
    Wanlong Ma
    Department of Hematology Oncology, Quest Diagnostics Nichols Institute, San Juan Capistrano, CA, USA
    BMC Med Genet 11:163. 2010
    ..The G/G genotype of the single-nucleotide polymorphism (SNP) rs1617640 in the erythropoietin (EPO) promoter has been shown to be associated with decreased EPO expression. We examined the association of rs1617640 genotype with MDS...
  4. ncbi request reprint Risk of multiple myeloma following medication use and medical conditions: a case-control study in Connecticut women
    Ola Landgren
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Building EPS Room 7110, Bethesda, MD 20892 7236, USA
    Cancer Epidemiol Biomarkers Prev 15:2342-7. 2006
    ..We conducted a population-based case-control study to investigate the role of medical history in the etiology of multiple myeloma among Connecticut women...
  5. pmc Pesticide exposure and risk of monoclonal gammopathy of undetermined significance in the Agricultural Health Study
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 113:6386-91. 2009
    ..In summary, the prevalence of MGUS among pesticide applicators was twice that in a population-based sample of men from Minnesota, adding support to the hypothesis that specific pesticides are causatively linked to myelomagenesis...
  6. ncbi request reprint Autoimmunity and susceptibility to Hodgkin lymphoma: a population-based case-control study in Scandinavia
    Ola Landgren
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7236, USA
    J Natl Cancer Inst 98:1321-30. 2006
    ..In contrast, there are limited data on risk of Hodgkin lymphoma following autoimmune diseases and almost no data addressing whether there is a familial association between the conditions...
  7. pmc Respiratory tract infections and subsequent risk of chronic lymphocytic leukemia
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7236, USA
    Blood 109:2198-201. 2007
    ..001). None of 9 other respiratory-tract infections was significantly associated with CLL risk. Pneumonia might be a potential CLL trigger or it could represent premalignant immune disruption preceding CLL...
  8. ncbi request reprint Risk of second malignant neoplasms among lymphoma patients with a family history of cancer
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
    Int J Cancer 120:1099-102. 2007
    ..99, 95% CI: 0.73-5.39). Our observations suggest that genetic factors, as measured by positive family history of cancer, may be influential risk-factors for selected second tumors following lymphoproliferative disorders...
  9. pmc Risk factors for lymphoproliferative disorders after allogeneic hematopoietic cell transplantation
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Blood 113:4992-5001. 2009
    ..Our findings identify subgroups of patients who underwent allogeneic HCT at elevated risk of PTLDs for whom prospective monitoring of Epstein-Barr virus activation and early treatment intervention may be particularly beneficial...
  10. doi request reprint B-cell clones as early markers for chronic lymphocytic leukemia
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 360:659-67. 2009
    ..Hospital-based series indicate an excess risk of progression from MBL to chronic lymphocytic leukemia (CLL). In this prospective cohort study, we tested the hypothesis that CLL is always preceded by MBL...
  11. pmc Risk of plasma cell and lymphoproliferative disorders among 14621 first-degree relatives of 4458 patients with monoclonal gammopathy of undetermined significance in Sweden
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, and Center for Cancer Research, Medical Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Blood 114:791-5. 2009
    ..Among first-degree relatives of a nationwide MGUS cohort, we found elevated risks of MGUS, MM, LPL/WM, and CLL, supporting a role for germline susceptibility genes, shared environmental influences, or an interaction between both...
  12. pmc Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 113:5412-7. 2009
    ..In the present study, an asymptomatic MGUS stage consistently preceded MM. Novel molecular markers are needed to better predict progression to MM in patients with MGUS...
  13. ncbi request reprint Risk of malignant disease among 1525 adult male US Veterans with Gaucher disease
    Ola Landgren
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Arch Intern Med 167:1189-94. 2007
    ..The aim of this study was to assess the pattern of Gaucher disease and subsequent malignancies among male veterans admitted to US Veterans Affairs hospitals...
  14. pmc Increased risks of polycythemia vera, essential thrombocythemia, and myelofibrosis among 24,577 first-degree relatives of 11,039 patients with myeloproliferative neoplasms in Sweden
    Ola Landgren
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7236, USA
    Blood 112:2199-204. 2008
    ..9; 0.9-3.8; P = .09). Our findings of 5- to 7-fold elevated risk of MPNs among first-degree relatives of MPN patients support the hypothesis that common, strong, shared susceptibility genes predispose to PV, ET, MF, and possibly CML...
  15. ncbi request reprint Acquired immune-related and inflammatory conditions and subsequent chronic lymphocytic leukaemia
    Ola Landgren
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA
    Br J Haematol 139:791-8. 2007
    ..14-fold (1.03-1.25) and 1.64-fold (1.14-2.37) elevated CLL risk. These association patterns suggest primary focus on infectious agents rather than autoantigens for future aetiologic CLL studies...
  16. ncbi request reprint Prevalence of monoclonal gammopathy of undetermined significance among men in Ghana
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Bldg EPS Room 7110, Bethesda, MD 20892 7236, USA
    Mayo Clin Proc 82:1468-73. 2007
    ....
  17. ncbi request reprint A population-based cohort study on early-stage Hodgkin lymphoma treated with radiotherapy alone: with special reference to older patients
    O Landgren
    Hematology Center, Department of Medicine, Karolinska University Hospital and Institutet, Solna, Stockholm, Sweden
    Ann Oncol 17:1290-5. 2006
    ..We conducted a population-based study to evaluate long-term follow-up outcome in older early-stage HL patients initially treated with radiotherapy (RT) alone...
  18. doi request reprint Patterns of monoclonal gammopathy of undetermined significance and multiple myeloma in various ethnic/racial groups: support for genetic factors in pathogenesis
    O Landgren
    Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Leukemia 23:1691-7. 2009
    ..This review focuses on racial disparity and familial aggregation patterns for MGUS and MM and discusses how these observations provide novel clues with regard to pathogenesis...
  19. ncbi request reprint Myeloma and second primary cancers
    Ola Landgren
    National Cancer Institute, Bethesda, MD
    N Engl J Med 365:2241-2. 2011
    ..However, leukemia is now being seen in patients receiving lenalidomide maintenance therapy. Patients with monoclonal gammopathy of undetermined significance also have an increased risk of leukemia without ever being treated...
  20. doi request reprint From myeloma precursor disease to multiple myeloma: new diagnostic concepts and opportunities for early intervention
    Ola Landgren
    Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 17:1243-52. 2011
    ..In this review, we discuss novel insights from recent studies and propose future directions of relevance for clinical management and research studies...
  21. doi request reprint Monoclonal gammopathy of undetermined significance and smoldering myeloma: new insights into pathophysiology and epidemiology
    Ola Landgren
    Multiple Myeloma Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Hematology Am Soc Hematol Educ Program 2010:295-302. 2010
    ..is MM always preceded by a precursor state, and is there anything that could or should be done to delay or prevent progression?; and iii) why do some individuals develop MM precursor diseases, and is there a reason to screen the family?..
  22. doi request reprint Development of early treatment strategies for high-risk myeloma precursor disease in the future
    Ola Landgren
    Medical Oncology Branch, National Cancer Institute, Bethesda, MD, 20892, USA
    Semin Hematol 48:66-72. 2011
    ..This review discusses how the integration of novel biological markers and clinical monitoring of SMM could facilitate the development of early treatment strategies for high-risk SMM patients in the future...
  23. doi request reprint Multiple myeloma precursor disease
    Ola Landgren
    National Cancer Institute, National Institutes of Health, Center for Cancer Research, Medical Oncology Branch, 9000 Rockville Pike, Bldg 10 Room 13N240, Bethesda, MD 20892, USA
    JAMA 304:2397-404. 2010
    ....
  24. pmc Survival patterns in patients with Hodgkin's lymphoma with a pre-existing hospital discharge diagnosis of autoimmune disease
    Ola Landgren
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Clin Oncol 28:5081-7. 2010
    ..Autoimmune diseases (AIs) are associated with elevated risk for Hodgkin's lymphoma (HL); however, information on the interplay of AIs and HL on survival is sparse...
  25. pmc Obesity is associated with an increased risk of monoclonal gammopathy of undetermined significance among black and white women
    Ola Landgren
    Center for Cancer Research and Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 116:1056-9. 2010
    ..Our findings support the hypothesis that obesity is etiologically linked to myelomagenesis. The 2-fold excess of MGUS among blacks compared with whites of similar socioeconomic status supports a role for susceptibility genes in MGUS...
  26. ncbi request reprint Multiple myeloma, chronic lymphocytic leukaemia and associated precursor diseases
    Ola Landgren
    National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Br J Haematol 139:717-23. 2007
    ..Also, we speculate on the relationship between precursor and malignancy and talk about future directions and gaps in the literature...
  27. pmc Patterns of autoimmunity and subsequent chronic lymphocytic leukemia in Nordic countries
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7236, USA
    Blood 108:292-6. 2006
    ....
  28. ncbi request reprint Familial characteristics of autoimmune and hematologic disorders in 8,406 multiple myeloma patients: a population-based case-control study
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Int J Cancer 118:3095-8. 2006
    ..However, MM itself shows significant familial aggregation, implicating the etiologic importance of this type of hematological neoplasm and perhaps MGUS in germ line genes...
  29. pmc Circulating serum free light chains as predictive markers of AIDS-related lymphoma
    Ola Landgren
    National Cancer Institute, National Institutes of Health, Center for Cancer Research, Medical Oncology Branch, 9000 Rockville Pike, Bldg 10 Room 13N240, Bethesda, MD, 20892, USA
    J Clin Oncol 28:773-9. 2010
    ..CONCLUSION Elevated FLCs may represent sensitive markers of polyclonal B-cell activation and dysfunction and could be useful for identifying HIV-infected persons at increased NHL risk...
  30. pmc Risk of monoclonal gammopathy of undetermined significance (MGUS) and subsequent multiple myeloma among African American and white veterans in the United States
    Ola Landgren
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, Bethesda, MD 20892 7236, USA
    Blood 107:904-6. 2006
    ..In the largest study to date, we suggest that the excess risk of MM in African Americans results from an increase in risk of MGUS rather than an increased risk of progression from MGUS to MM...
  31. doi request reprint Epidemiology, pathology and treatment of non-follicular indolent lymphomas
    Ola Landgren
    National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7236, USA
    Leuk Lymphoma 49:35-42. 2008
    ..Universally accepted therapeutic guidelines do not exist, however, and carefully designed, prospective clinical studies are needed to further assess optimal therapeutic approaches for these indolent NHLs...
  32. ncbi request reprint Personal and family history of autoimmune diabetes mellitus and susceptibility to young-adult-onset Hodgkin lymphoma
    Ola Landgren
    Division of Hematology, Karolinska Hospital and Institutet, Stockholm, Sweden
    Int J Cancer 118:449-52. 2006
    ..0) history of diabetes mellitus. These findings suggests that characteristics of the immune system associated with conditions such as diabetes mellitus type I are of importance in the pathogenesis of young-adult-onset HL...
  33. pmc Immune-related and inflammatory conditions and risk of lymphoplasmacytic lymphoma or Waldenstrom macroglobulinemia
    Sigurdur Y Kristinsson
    Department of Medicine, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    J Natl Cancer Inst 102:557-67. 2010
    ..We conducted, to our knowledge, the most comprehensive study to date to evaluate associations between a personal or family history of many immune-related and/or inflammatory disorders and the subsequent risk of LPL-WM...
  34. pmc Risk of multiple myeloma and monoclonal gammopathy of undetermined significance among white and black male United States veterans with prior autoimmune, infectious, inflammatory, and allergic disorders
    Linda Morris Brown
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Blood 111:3388-94. 2008
    ..Risks for MGUS were generally of similar magnitude. Our results indicate that various types of immune-mediated conditions might act as triggers for MM/MGUS development...
  35. ncbi request reprint Biological markers may add to prediction of outcome achieved by the International Prognostic Score in Hodgkin's disease
    U Axdorph
    Department of Medicine, Karolinska Hospital and Institutet, Stockholm, Sweden
    Ann Oncol 11:1405-11. 2000
    ..The IPS is also applicable in limited disease. However, the IPS does not identify patients with a very poor prognosis. The aim of this study was to define biological markers which may add to the IPS in predicting outcome...
  36. pmc Survival patterns among lymphoma patients with a family history of lymphoma
    Lesley A Anderson
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    J Clin Oncol 26:4958-65. 2008
    ..Only a few small studies have assessed clinical characteristics and prognosis for familial patients, with inconsistent findings...
  37. pmc Patterns of hematologic malignancies and solid tumors among 37,838 first-degree relatives of 13,896 patients with multiple myeloma in Sweden
    Sigurdur Y Kristinsson
    Department of Medicine, Division of Hematology, Karolinska University Hospital, Solna and Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 125:2147-50. 2009
    ..0-1.5). No significantly increased risk was found for other hematologic or solid malignancies. Our findings support a role for a shared susceptibility (genetic, environmental or both) that predisposes to MM, MGUS, ALL and bladder cancer...
  38. pmc Risk of lymphoproliferative disorders among first-degree relatives of lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia patients: a population-based study in Sweden
    Sigurdur Y Kristinsson
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
    Blood 112:3052-6. 2008
    ..Our findings of highly increased risks of developing LPL/WM, NHL, CLL, and MGUS support the operation of shared susceptibility genes that predispose to LPL/WM and other lymphoproliferative disorders...
  39. pmc Risk of immune thrombocytopenic purpura and autoimmune hemolytic anemia among 120 908 US veterans with hepatitis C virus infection
    Elizabeth Y Chiao
    Department of Medicine, Baylor College of Medicine, 2002 Holcombe Road, Houston, TX 77030, USA
    Arch Intern Med 169:357-63. 2009
    ..There is emerging evidence that hepatitis C virus (HCV) infection play a role in the etiology of immune thrombocytopenia purpura (ITP) and autoimmune hemolytic anemia (AIHA), both of which are severe autoimmune cytopenias...
  40. ncbi request reprint Patterns of survival in multiple myeloma: a population-based study of patients diagnosed in Sweden from 1973 to 2003
    Sigurdur Yngvi Kristinsson
    Division of Hematology, Department of Medicine, Karolinska Karolinska University Hospital and Institutet, Stockholm, Sweden
    J Clin Oncol 25:1993-9. 2007
    ..To define patterns of survival among all multiple myeloma (MM) patients diagnosed in Sweden during a 30-year period...
  41. ncbi request reprint Risk of non-Hodgkin lymphoma and lymphoproliferative precursor diseases in US veterans with hepatitis C virus
    Thomas P Giordano
    Department of Medicine, Baylor College of Medicine, and The Houston Center for Quality of Care and Utilization Studies, Michael E DeBakey Veterans Affairs Medical Center, Houston, Tex 77030, USA
    JAMA 297:2010-7. 2007
    ..Previous studies have been too small to adequately assess these risks...
  42. pmc Risk of hepatobiliary and pancreatic cancers after hepatitis C virus infection: A population-based study of U.S. veterans
    Hashem B El-Serag
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Hepatology 49:116-23. 2009
    ..Absence of an association with ECC was consistent in adjusted and unadjusted models. A significant association with pancreatic cancer was erased by alcohol use and other variables...
  43. pmc Hematopoietic malignancies associated with viral and alcoholic hepatitis
    Lesley A Anderson
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 7076 Rockville, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 17:3069-75. 2008
    ..In summary, HCV, but not other causes of hepatitis, was associated with the elevated risk of non-Hodgkin lymphoma and acute myeloid leukemia. HCV may induce lymphoproliferative malignancies through chronic immune stimulation...
  44. pmc Autoimmunity and the risk of myeloproliferative neoplasms
    Sigurdur Y Kristinsson
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    Haematologica 95:1216-20. 2010
    ..Future studies are needed to unravel the effects of these autoimmune diseases themselves, their treatment, or common genetic susceptibility...
  45. pmc Arterial and venous thrombosis in monoclonal gammopathy of undetermined significance and multiple myeloma: a population-based study
    Sigurdur Y Kristinsson
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
    Blood 115:4991-8. 2010
    ..0 g/L) at diagnosis. MGUS patients with (vs without) thrombosis had no excess risk of MM or Waldenström macroglobulinemia. Our findings are of relevance for future studies and for improvement of thrombosis prophylaxis strategies...
  46. doi request reprint Pain and anxiety during bone marrow aspiration/biopsy: Comparison of ratings among patients versus health-care professionals
    Y Lidén
    Department of Physiology and Pharmacology, Section for Anesthesiology and Intensive Care, Karolinska Institutet, Stockholm, Sweden
    Eur J Oncol Nurs 16:323-9. 2012
    ..To assess pain and anxiety during bone marrow aspiration/biopsy (BMA) among patients versus health-care professionals (HCPs)...
  47. pmc Use of hair colouring products and risk of multiple myeloma among US women
    S Koutros
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS 8122, Bethesda, MD 20852, USA
    Occup Environ Med 66:68-70. 2009
    ..To evaluate the association between personal hair dye use and risk of multiple myeloma among women...
  48. doi request reprint Monoclonal B-cell lymphocytosis (MBL): biology, natural history and clinical management
    T D Shanafelt
    Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA
    Leukemia 24:512-20. 2010
    ..In this paper, we provide a state of the art review on the prevalence, nomenclature, biology, natural history and clinical management of MBL...
  49. pmc Highly increased familial risks for specific lymphoma subtypes
    Lynn R Goldin
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7236, USA
    Br J Haematol 146:91-4. 2009
    ..These results imply that germline susceptibility genes are specific to lymphoma subtype...
  50. pmc Cancer incidence among pesticide applicators exposed to permethrin in the Agricultural Health Study
    Jennifer A Rusiecki
    Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
    Environ Health Perspect 117:581-6. 2009
    ..Permethrin is a synthetic pyrethroid insecticide widely used in agriculture, in public health, and in many U.S. homes and gardens...
  51. pmc Timing of births and endometrial cancer risk in Swedish women
    Ruth M Pfeiffer
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd EPS RM 8030, Bethesda, MD 20892 7244, USA
    Cancer Causes Control 20:1441-9. 2009
    ..0001) for women with > or =25 years since a last birth compared to women having given birth within 4 years. Our findings support that clearance of initiated cells during delivery may be important in endometrial carcinogenesis...
  52. pmc Common genetic variants in candidate genes and risk of familial lymphoid malignancies
    Xueying Sharon Liang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7236, USA
    Br J Haematol 146:418-23. 2009
    ..Polymorphisms in TNFSF10 were associated with both CLL and WM. Future replication and functional studies are needed to clarify the role of these genetic variants. Finally, our data further support the close association of WM and CLL...
  53. ncbi request reprint High expression of cyclin B1 predicts a favorable outcome in patients with follicular lymphoma
    Erik Björck
    Department of Molecular Medicine, Division of Hematology, Karolinska University Hospital and Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Blood 105:2908-15. 2005
    ..CCNB1 expression had an independent prognostic value when included in a multivariate analysis together with the 5 parameters of the follicular lymphoma international prognostic index...
  54. pmc Hodgkin lymphoma among US solid organ transplant recipients
    Scott C Quinlan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA
    Transplantation 90:1011-5. 2010
    ..To assess the risk and identify risk factors of Hodgkin lymphoma (HL) in solid organ transplant recipients. Prior research has been limited by the rarity of HL and the requirement for extended follow-up after transplantation...
  55. doi request reprint A case study progression to multiple myeloma
    Mary Ann Yancey
    Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Clin J Oncol Nurs 14:419-22. 2010
    ..This case report illustrates the clinical dilemma of progression from precursor to full malignancy. The article also discusses future directions in management and research focusing on myelomagenesis...
  56. pmc Prior history of non-melanoma skin cancer is associated with increased mortality in patients with chronic lymphocytic leukemia
    Jorge R Toro
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Bldg EPS Room 7012, Bethesda, 20892 7236, USA
    Haematologica 94:1460-4. 2009
    ..0001; log-rank test). Non-melanoma skin cancer may be a novel clinical predictor of worse chronic lymphocytic leukemia outcome...
  57. pmc Immunologic and virologic predictors of AIDS-related non-hodgkin lymphoma in the highly active antiretroviral therapy era
    Eric A Engels
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, DHHS, 6120 Executive Boulevard, EPS 7076 Rockville, MD 20892
    J Acquir Immune Defic Syndr 54:78-84. 2010
    ..The association with high-level viremia could reflect detrimental effects on immune function related to incompletely effective HAART or direct effects on B cells...
  58. pmc Patterns of improved survival in patients with multiple myeloma in the twenty-first century: a population-based study
    Ingemar Turesson
    Department of Medicine, Section of Hematology, Malmo University Hospital, S 2052 Malmö, Sweden
    J Clin Oncol 28:830-4. 2010
    ..Consequently, in the era of novel MM therapies, population-based studies will serve as a necessary complement to randomized trials...
  59. pmc Increased risk for lymphoid and myeloid neoplasms in elderly solid-organ transplant recipients
    Scott C Quinlan
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, 6120 Executive Boulevard, EPS 7076, Rockville, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 19:1229-37. 2010
    ....
  60. pmc Patterns of multiple myeloma during the past 5 decades: stable incidence rates for all age groups in the population but rapidly changing age distribution in the clinic
    Ingemar Turesson
    Department of Medicine, Section of Hematology, Malmo University Hospital, Malmo, Sweden
    Mayo Clin Proc 85:225-30. 2010
    ....
  61. doi request reprint Current insight on trends, causes, and mechanisms of Hodgkin's lymphoma
    Neil E Caporaso
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Cancer J 15:117-23. 2009
    ..These results emphasize an interaction between environmental and genetic risk factors in HL...
  62. pmc Plasmacytoma of bone, extramedullary plasmacytoma, and multiple myeloma: incidence and survival in the United States, 1992-2004
    Graca M Dores
    Department of Veterans Affairs Medical Center, Medical Service, Oklahoma City, OK 73104, USA
    Br J Haematol 144:86-94. 2009
    ..Five-year relative survival for P-bone, P-extramedullary, and MM varied significantly by age (<60/60+ years), supporting age-related differences in disease burden at presentation, disease biology, and/or treatment approaches...
  63. ncbi request reprint Chronic lymphocytic leukaemia: an overview of aetiology in light of recent developments in classification and pathogenesis
    Martha S Linet
    DCEG Radiation Epidemiology Branch, National Cancer Institute, Bethesda, MD, USA
    Br J Haematol 139:672-86. 2007
    ....
  64. pmc Chronic immune stimulation and subsequent Waldenström macroglobulinemia
    Jill Koshiol
    Cancer Prevention Fellowship Program, Office of Preventive Oncology, and Division of Genetic Epidemiology Branch, National Cancer Institute, 6120 Executive Blvd, EPS 7003, MSC 7236, Bethesda, MD 20892 7236, USA
    Arch Intern Med 168:1903-9. 2008
    ..A few previous studies suggest that chronic inflammation may particularly elevate risk of the distinct non-Hodgkin lymphoma subtype Waldenström macroglobulinemia (WM)...
  65. ncbi request reprint Risks of cancer among a cohort of 23,935 men and women with osteoporosis
    Katherine A McGlynn
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, EPS Suite 550, 6120 Executive Boulevard, Rockville, MD 20852 7234, USA
    Int J Cancer 122:1879-84. 2008
    ..Conversely, factors associated with later onset osteoporosis may be related to a decreased risk of cancer...
  66. pmc Increased risk for non-Hodgkin lymphoma in individuals with celiac disease and a potential familial association
    Ying Gao
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 7236, USA
    Gastroenterology 136:91-8. 2009
    ..However, there are only limited data on risk in the current era of serologic testing and human leukocytes antigen typing to screen for CD. There is also no information on the role of family history of CD in relation to lymphoma risk...
  67. pmc Autoimmunity and lymphomagenesis
    Lynn R Goldin
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7236, USA
    Int J Cancer 124:1497-502. 2009
    ..Finally, we discuss the future directions involving a combination of population and molecular studies that are needed to better define underlying biological mechanisms...
  68. ncbi request reprint Chronic lymphocytic leukaemia genetics overview
    Neil Caporaso
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Br J Haematol 139:630-4. 2007
    ..In this summary we highlight selected themes in the genetics of CLL emphasizing the opportunities and challenges of this malignancy...
  69. ncbi request reprint Chronic lymphocytic leukaemia and small lymphocytic lymphoma: overview of the descriptive epidemiology
    Graca M Dores
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services DHHS, National Cancer Institute NCI, National Institutes of Health NIH, Bethesda, MD, USA
    Br J Haematol 139:809-19. 2007
    ..Avenues of future research include assessment of delayed- and under-reporting to cancer registries and exploration of race, gender, and age effects in epidemiological studies...
  70. doi request reprint Autoimmunity and hematologic malignancies: associations and mechanisms
    Damali N Martin
    Division of Cancer Control and Population Sciences, Center for Cancer Research, National Cancer Institute, Bethesda, Rockville, MD 20852 7324, USA
    Leuk Lymphoma 50:541-50. 2009
    ..Finally, we provide future directions for new research studies aimed to improve our understanding of inflammation and the dysregulated immune system in the development of autoimmunity and hematologic malignancies...
  71. pmc Novel aspects pertaining to the relationship of Waldenström's macroglobulinemia, IgM monoclonal gammopathy of undetermined significance, polyclonal gammopathy, and hypoglobulinemia
    Mary L McMaster
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Clin Lymphoma Myeloma 9:19-22. 2009
    ..Large collaborative studies are needed to confirm these findings, which present an opportunity to define the earliest lesion(s) in the WM oncogenic pathway...
  72. pmc Elevated risk of chronic lymphocytic leukemia and other indolent non-Hodgkin's lymphomas among relatives of patients with chronic lymphocytic leukemia
    Lynn R Goldin
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Bethesda, MD 20892, USA
    Haematologica 94:647-53. 2009
    ....
  73. ncbi request reprint Familial aggregation and heterogeneity of non-Hodgkin lymphoma in population-based samples
    Lynn R Goldin
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, MSC 7236, Bethesda, MD 20892 7236, USA
    Cancer Epidemiol Biomarkers Prev 14:2402-6. 2005
    ..We estimate that the absolute lifetime risk for a first-degree relative of an NHL case to develop NHL is 3.6% (compared with a population risk of 2.1%) and higher if the index case had an aggressive subtype of NHL...
  74. pmc Circulating antibody free light chains and risk of posttransplant lymphoproliferative disorder
    E A Engels
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Am J Transplant 12:1268-74. 2012
    ..2 and 3.2 for monoclonal and polyclonal elevations). FLC elevations are common in transplant recipients and associated with heightened PTLD risk. FLCs likely reflect B-cell dysfunction, perhaps related to EBV-driven lymphoproliferation...
  75. ncbi request reprint A prospective study on antibody response to repeated vaccinations with pneumococcal capsular polysaccharide in splenectomized individuals with special reference to Hodgkin's lymphoma
    O Landgren
    Division of Hematology, Department of Medicine, Karolinska Hospital and Institutet, Stockholm, Sweden
    J Intern Med 255:664-73. 2004
    ....
  76. doi request reprint Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management
    R A Kyle
    Division of Hematology, Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Leukemia 24:1121-7. 2010
    ..Testing should be done 2-3 months after the initial recognition of SMM. If the results are stable, the patient should be followed every 4-6 months for 1 year and, if stable, every 6-12 months...
  77. pmc Plasma cell neoplasms in US solid organ transplant recipients
    Eric A Engels
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Am J Transplant 13:1523-32. 2013
    ..PBC may be another risk factor, perhaps by causing chronic immune activation...
  78. doi request reprint Procedure-related pain among adult patients with hematologic malignancies
    Y Lidén
    Department of Physiology and Pharmacology, Section for Anesthesiology and Intensive Care, Karolinska Institutet, Stockholm, Sweden
    Acta Anaesthesiol Scand 53:354-63. 2009
    ..Cancer patients undergo numerous invasive diagnostic procedures. However, there are only sparse data on the characteristics and determinants for procedure-related pain among adult cancer patients...
  79. ncbi request reprint Immune thrombocytopenic purpura does not exhibit a disparity in prevalence between African American and White veterans
    Ola Landgren
    Blood 108:1111-2. 2006
  80. doi request reprint Autoimmune disease in individuals and close family members and susceptibility to non-Hodgkin's lymphoma
    Lene Mellemkjaer
    Danish Cancer Society, Copenhagen, Denmark
    Arthritis Rheum 58:657-66. 2008
    ..This study was initiated to evaluate the risks of NHL associated with a personal or family history of a wide range of autoimmune diseases...
  81. pmc Hepatitis C virus infection and risk of posttransplantation lymphoproliferative disorder among solid organ transplant recipients
    Lindsay M Morton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA
    Blood 110:4599-605. 2007
    ..14-8.42; P interaction = .007). Our findings suggest that HCV is not a major risk factor for PTLD, which is consistent with the model in which an intact immune system is necessary for development of HCV-related lymphoproliferation...
  82. pmc Deep vein thrombosis after monoclonal gammopathy of undetermined significance and multiple myeloma
    Sigurdur Y Kristinsson
    Department of Medicine, Division of Hematology, Karolinska University Hospital and Institutet, Stockholm, Sweden
    Blood 112:3582-6. 2008
    ..5%) that progressed to MM, only one person had a DVT diagnosis before transformation. Our findings suggest the operation of shared underlying mechanisms causing coagulation abnormalities among patients with MGUS and MM...
  83. ncbi request reprint Re: Familial clustering of Hodgkin lymphoma and multiple sclerosis
    Ola Landgren
    J Natl Cancer Inst 97:543-4; author reply 544-5. 2005
  84. ncbi request reprint Familial longevity: the older you are, the older your father may have been
    Ola Landgren
    J Am Geriatr Soc 53:357-8. 2005
  85. ncbi request reprint BCL-6 and rituximab in diffuse large B-cell lymphoma: where are we?
    Kieron Dunleavy
    Blood 109:843-4; discussion 844-5. 2007
  86. ncbi request reprint Response to splenectomy is durable after a certain point in time in adult patients with chronic immune thrombocytopenic purpura
    Eva Johansson
    Department of Medicine, Division of Hematology, Karolinska University Hospital and Institutet, Stockholm, Sweden
    Eur J Haematol 77:61-6. 2006
    ....
  87. ncbi request reprint Parental longevity and survival in elderly patients with Hodgkin's lymphoma
    Ola Landgren
    Division of Hematology, Department of Medicine, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    Haematologica 87:596-601. 2002
    ..The aim of this study was to test the hypothesis that parental longevity alone--an easily accessible and non-disease associated variable--is also associated with improved outcome using an enlarged series of elderly HL patients...
  88. ncbi request reprint Mutated VH genes and preferential VH3-21 use define new subsets of mantle cell lymphoma
    Sarah H Walsh
    Department of Genetics and Pathology, Uppsala University, Sweden
    Blood 101:4047-54. 2003
    ..03), but they tended to be younger at diagnosis. The combined use of V(H)3-21/V(lambda)3-19 suggests a possible role for antigen(s) in the pathogenesis of these tumors and indicates that V(H)3-21(+) patients constitute a new MCL entity...
  89. ncbi request reprint Hodgkin's lymphoma in the elderly with special reference to type and intensity of chemotherapy in relation to prognosis
    Ola Landgren
    Division of Hematology, Department of Medicine, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    Haematologica 88:438-44. 2003
    ..This study was undertaken to evaluate potential clinical factors of importance for prognosis with special reference to relative dose intensity (RDI) of chemotherapy (CT)...
  90. ncbi request reprint Poor antibody response to pneumococcal polysaccharide vaccination suggests increased susceptibility to pneumococcal infection in splenectomized patients with hematological diseases
    Honar Cherif
    Department of Medicine, Division of Hematology, Karolinska University Hospital and Institute, SE 171 76 Stockholm, Sweden
    Vaccine 24:75-81. 2006
    ..Poor responders do not benefit from revaccination, and should be offered other prophylactic measures...
  91. ncbi request reprint Ascertainment and diagnostic accuracy for hematopoietic lymphoproliferative malignancies in Sweden 1964-2003
    Ingemar Turesson
    Section of Hematology, Department of Medicine, Malmo University Hospital, University of Lund, Malmo, Sweden
    Int J Cancer 121:2260-6. 2007
    ..However, we found under-ascertainment of patients with indolent LP tumors, particularly among patients diagnosed at older ages, with early-stage disease and diagnosed in earlier years...
  92. ncbi request reprint Mantle cell lymphomas with clonal immunoglobulin V(H)3-21 gene rearrangements exhibit fewer genomic imbalances than mantle cell lymphomas utilizing other immunoglobulin V(H) genes
    Emma Flordal Thelander
    Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
    Mod Pathol 18:331-9. 2005
    ..The findings presented in this report may explain the tendency for a better clinical outcome for patients whose tumors utilize V(H)3-21...
  93. ncbi request reprint Parental longevity and prognosis in elderly patients with aggressive non-Hodgkin's lymphoma
    Eva Osby
    Division of Hematology, Department of Medicine, Karolinska Hospital and Institutet, Stockholm, Sweden
    Acta Oncol 43:297-301. 2004
    ..Maternal and paternal lifespan may predict survival in NHL, but with opposing effects. At present parental age appears not to be a clinically useful predictor of prognosis in the elderly with aggressive NHL...