Research Topics
| Charles E LandSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Cancer risks attributable to low doses of ionizing radiation: assessing what we really knowDavid J Brenner
Center for Radiological Research, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Proc Natl Acad Sci U S A 100:13761-6. 2003..This linearity assumption is not necessarily the most conservative approach, and it is likely that it will result in an underestimate of some radiation-induced cancer risks and an overestimate of others...
Incidence of female breast cancer among atomic bomb survivors, Hiroshima and Nagasaki, 1950-1990Charles E Land
Radiation Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA
Radiat Res 160:707-17. 2003..ERR(1Sv) was observed to decline with increasing attained age, with by far the largest drop around age 35. Possible explanations for these observations are discussed, along with research approaches that might provide more information...
Projected lifetime cancer risks from exposure to regional radioactive fallout in the Marshall IslandsCharles E Land
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA
Health Phys 99:201-15. 2010....- Radiation doses and cancer risks in the Marshall Islands associated with exposure to radioactive fallout from Bikini and Enewetak nuclear weapons tests: summarySteven L Simon
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA
Health Phys 99:105-23. 2010..The 170 excess cancers are in comparison to about 10,600 cancers that would spontaneously arise, unrelated to radioactive fallout, among the same cohort of Marshallese people... - Thyroid nodules, polymorphic variants in DNA repair and RET-related genes, and interaction with ionizing radiation exposure from nuclear tests in KazakhstanAlice J Sigurdson
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7238, USA
Radiat Res 171:77-88. 2009..Other pathways such as genes in double-strand break repair, apoptosis and genes related to proliferation should also be pursued... - Thyroid cancer in childhood cancer survivors: a detailed evaluation of radiation dose response and its modifiersCécile M Ronckers
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland
Radiat Res 166:618-28. 2006..In summary, we applied models derived from radiobiology to describe the radiation dose-response curve for thyroid cancer in an epidemiological study and found convincing evidence for a downturn in risk at high doses... - Cancer mortality among women frequently exposed to radiographic examinations for spinal disordersCécile M Ronckers
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20852, USA
Radiat Res 174:83-90. 2010..77), cervical (SMR = 0.31), and liver (SMR = 0.17). The excess relative risk (ERR) for breast cancer mortality increased significantly with 10-year lagged radiation dose to the breast (ERR/Gy = 3.9; 95% CI: 1.0-9.3)... - Coronary heart disease after radiotherapy for peptic ulcer diseaseZhanat A Carr
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH/DHHS, 6120 Executive Boulevard, EPS 7038, Rockville, MD 20852, USA
Int J Radiat Oncol Biol Phys 61:842-50. 2005..CONCLUSION: The excess CHD risk in patients undergoing RT for peptic ulcer disease decades previously indicates the need for long-term follow-up for cardiovascular disease after chest RT... - Multiple diagnostic X-rays for spine deformities and risk of breast cancerCécile M Ronckers
Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 7046, 6120 Executive Boulevard, MS 7238, Bethesda, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 17:605-13. 2008..In this historic cohort, 95% of daily dose increments (when exposure to the breast occurred) were under 2.4 cGy, with mean 1.1 cGy... - Low-dose extrapolation of radiation health risks: some implications of uncertainty for radiation protection at low dosesCharles E Land
National Cancer Institute National Institutes of Health, Radiation Epidemiology Branch EPS 7046, 6120 Executive Boulevard, MS7238, Bethesda, MD 20892 7238, USA
Health Phys 97:407-15. 2009.... - Radiation and breast cancer: a review of current evidenceCécile M Ronckers
National Cancer Institute, Division of Cancer Epidemiology and Genetics, NIH, HHS, Bethesda, Maryland, USA
Breast Cancer Res 7:21-32. 2005.... - Late health effects of childhood nasopharyngeal radium irradiation: nonmelanoma skin cancers, benign tumors, and hormonal disordersCécile M Ronckers
Department of Ear, Nose and Throat Medicine, Reinaert Kliniek, Maastricht, The Netherlands
Pediatr Res 52:850-8. 2002..0-2.1). We found no evidence of highly elevated risk of benign head and neck tumors, nonmelanoma skin cancer, thyroid disorders, or indicators of pituitary radiation damage after childhood NRI in The Netherlands... - Cancer incidence after nasopharyngeal radium irradiationCécile M Ronckers
Department of Ear Nose and Throat Medicine, Reinaert Kliniek, Maastricht, The Netherlands
Epidemiology 13:552-60. 2002..From 1940 until 1970, nasopharyngeal radium irradiation was used to treat children and military personnel suffering from Eustachian tube failure attributable to local lymphoid hyperplasia... - Health effects from falloutEthel S Gilbert
Division of Cancer Epidemiotogy and Genetics, National Cancer Institute, NIH, Rockville, MD 20852, USA
Health Phys 82:726-35. 2002..Very preliminary estimates of cancer risks from fallout doses received by the United States population are presented... - Site-specific cancer incidence and mortality after cerebral angiography with radioactive thorotrastLois B Travis
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892, USA
Radiat Res 160:691-706. 2003..Nonetheless, the substantial risks associated with liver cancer and leukemia indicate that unique and prolonged exposure to alpha-particle-emitting Thorotrast increased carcinogenic risks... - Behavior and food consumption pattern of the population exposed in 1949-1962 to fallout from Semipalatinsk nuclear test site in KazakhstanVladimir Drozdovitch
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, Bethesda, MD, 20892 7238, USA
Radiat Environ Biophys 50:91-103. 2011..The response data collected are useful for improving estimates of thyroid radiation dose estimates for the subjects of an ongoing epidemiological study... - External dose estimates for Dolon village: application of the U.S./Russian joint methodologySteven L Simon
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
J Radiat Res 47:A143-7. 2006..This report presents the basic elements of the joint methodology model for estimation of external dose received from SNTS fallout... - Incidence of carcinoma of the major salivary glands according to the WHO classification, 1992 to 2006: a population-based study in the United StatesHouda Boukheris
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute NIH, Bethesda, Maryland, USA
Cancer Epidemiol Biomarkers Prev 18:2899-906. 2009..Carcinomas of the major salivary glands (M-SGC) comprise a morphologically diverse group of rare tumors of largely unknown cause. To gain insight into etiology, we evaluated incidence of M-SGC using the WHO classification schema (WHO-2005)... - Uncertainty, low-dose extrapolation and the threshold hypothesisCharles E Land
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
J Radiol Prot 22:A129-35. 2002..Allowing for the possibility of a threshold would, however, remove very little of the regulatory burden associated with the so-called linear, no-threshold hypothesis, unless that possibility were a virtual certainty... - Malignant neoplasms after radiation therapy for peptic ulcerZhanat A Carr
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Radiat Res 157:668-77. 2002..Our excess relative risk per gray estimate of 0.20 at doses <or=10 Gy (95% CI 0, 0.73) is consistent with the estimate of 0.24 (95% CI 0.10, 0.40) obtained from the LSS study with the linear model... - Breast cancerCécile M Ronckers
Lancet 366:1605-6; author reply 1606. 2005 - Interactive RadioEpidemiological Program (IREP): a web-based tool for estimating probability of causation/assigned share of radiogenic cancersDavid C Kocher
SENES Oak Ridge, Inc, 102 Donner Drive, Oak Ridge, TN 37830, USA
Health Phys 95:119-47. 2008.... - Improving the efficiency of nested case-control studies of interaction by selecting controls using counter matching on exposureJohn B Cologne
Departments of Radiobiology Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan
Int J Epidemiol 33:485-92. 2004.... - Heterozygous individuals bearing a founder mutation in the XPA DNA repair gene comprise nearly 1% of the Japanese populationYuko Hirai
Department of Genetics, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Hiroshima, Japan
Mutat Res 601:171-8. 2006..88%. This rate, if representative, implies that there are about 1 million carriers of the XPA founder mutation in the Japanese population. Thus, investigation of their cancer risk may be warranted... - A pathology study of malignant and benign ovarian tumors among atomic-bomb survivors--case series reportKouki Inai
Department of Pathology, Division of Medical Intelligence and Informatics, Graduate School of Biomedical Sciences, Hiroshima University, Japan
J Radiat Res (Tokyo) 47:49-59. 2006..Variations in histological types of ovarian tumors in response to radiation dose, suggested by the case series data need to be followed up by population-based incidence analysis...