Qing Lan

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    PLoS ONE 8:e59230. 2013
  2. pmc Method for determination of (-102C>T) single nucleotide polymorphism in the human manganese superoxide dismutase promoter
    Robert C G Martin
    Department of Surgery, University of Louisville School of Medicine, Louisville, KY, USA
    BMC Genet 5:33. 2004
  3. ncbi request reprint Indoor coal combustion emissions, GSTM1 and GSTT1 genotypes, and lung cancer risk: a case-control study in Xuan Wei, China
    Q Lan
    Center for Environmental Medicine and Lung Biology, University of North Carolina, Chapel Hill 27599 7315, USA
    Cancer Epidemiol Biomarkers Prev 9:605-8. 2000
  4. ncbi request reprint Lymphocyte toxicity and T cell receptor excision circles in workers exposed to benzene
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS 8109, Bethesda, MD 20892 7240, USA
    Chem Biol Interact 153:111-5. 2005
  5. pmc Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma
    Qing Lan
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, MSC 7240, 6120 Executive Blvd, EPS 8109, Bethesda, MD 20892 7240, USA
    Blood 107:4101-8. 2006
  6. pmc Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studies
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    Blood 114:264-7. 2009
  7. ncbi request reprint Polymorphisms in cytokine and cellular adhesion molecule genes and susceptibility to hematotoxicity among workers exposed to benzene
    Qing Lan
    Division of Cancer Epidemiology, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892 7240, USA
    Cancer Res 65:9574-81. 2005
  8. ncbi request reprint Smoky coal exposure, NBS1 polymorphisms, p53 protein accumulation, and lung cancer risk in Xuan Wei, China
    Qing Lan
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, MSC 7240, 6120 Executive Blvd, EPS 8109, Bethesda, MD 20892 7240, USA
    Lung Cancer 49:317-23. 2005
  9. pmc A prospective study of telomere length measured by monochrome multiplex quantitative PCR and risk of non-Hodgkin lymphoma
    Qing Lan
    Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, Maryland 20892 7240, USA
    Clin Cancer Res 15:7429-33. 2009
  10. pmc Occupational exposure to trichloroethylene is associated with a decline in lymphocyte subsets and soluble CD27 and CD30 markers
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
    Carcinogenesis 31:1592-6. 2010

Collaborators

Detail Information

Publications107 found, 100 shown here

  1. pmc Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    PLoS ONE 8:e59230. 2013
    ..030). Our findings suggest that individuals with longer telomere length in peripheral white blood cells may have an increased risk of lung cancer, but require replication in additional prospective cohorts and populations...
  2. pmc Method for determination of (-102C>T) single nucleotide polymorphism in the human manganese superoxide dismutase promoter
    Robert C G Martin
    Department of Surgery, University of Louisville School of Medicine, Louisville, KY, USA
    BMC Genet 5:33. 2004
    ..The aim of our study was to develop a method to identify and determine the frequency of this (-102C>T) polymorphism in human tissues...
  3. ncbi request reprint Indoor coal combustion emissions, GSTM1 and GSTT1 genotypes, and lung cancer risk: a case-control study in Xuan Wei, China
    Q Lan
    Center for Environmental Medicine and Lung Biology, University of North Carolina, Chapel Hill 27599 7315, USA
    Cancer Epidemiol Biomarkers Prev 9:605-8. 2000
    ..In contrast, the GSTT1 genotype was not significantly associated with lung cancer risk. Our data suggest that the GSTM1-null genotype may enhance susceptibility to air pollution from indoor coal combustion emissions...
  4. ncbi request reprint Lymphocyte toxicity and T cell receptor excision circles in workers exposed to benzene
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS 8109, Bethesda, MD 20892 7240, USA
    Chem Biol Interact 153:111-5. 2005
    ..Although our study does not rule out counterbalancing alterations of TREC levels in specific T cell subsets, benzene's lymphotoxicity does not appear to be mediated through diminished thymus function...
  5. pmc Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma
    Qing Lan
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, MSC 7240, 6120 Executive Blvd, EPS 8109, Bethesda, MD 20892 7240, USA
    Blood 107:4101-8. 2006
    ..84; 95% CI = 1.79-8.22; P < .001). Further, the IL10 and IL4 SNP associations remained significant after adjusting for multiple comparisons. These results suggest that SNPs in Th2 cytokine genes may be associated with risk of NHL...
  6. pmc Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studies
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    Blood 114:264-7. 2009
    ..It is noteworthy that genetic variants in CASP8 were associated with risk of all major NHL subtypes. Our findings suggest that genetic variation in caspases may play an important role in lymphomagenesis...
  7. ncbi request reprint Polymorphisms in cytokine and cellular adhesion molecule genes and susceptibility to hematotoxicity among workers exposed to benzene
    Qing Lan
    Division of Cancer Epidemiology, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892 7240, USA
    Cancer Res 65:9574-81. 2005
    ..041) and increased (P = 0.076) CFU-GEMM progenitor cell colony formation in 29 benzene-exposed workers. This is the first report to provide evidence that SNPs in genes that regulate hematopoiesis influence benzene-induced hematotoxicity...
  8. ncbi request reprint Smoky coal exposure, NBS1 polymorphisms, p53 protein accumulation, and lung cancer risk in Xuan Wei, China
    Qing Lan
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, MSC 7240, 6120 Executive Blvd, EPS 8109, Bethesda, MD 20892 7240, USA
    Lung Cancer 49:317-23. 2005
    ..However, additional studies in other populations with substantial environmental exposures to PAHs are needed to confirm our findings...
  9. pmc A prospective study of telomere length measured by monochrome multiplex quantitative PCR and risk of non-Hodgkin lymphoma
    Qing Lan
    Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, Maryland 20892 7240, USA
    Clin Cancer Res 15:7429-33. 2009
    ..We hypothesized that telomere length in peripheral WBC DNA obtained from healthy individuals would be a predictor of future risk of developing non-Hodgkin lymphoma...
  10. pmc Occupational exposure to trichloroethylene is associated with a decline in lymphocyte subsets and soluble CD27 and CD30 markers
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
    Carcinogenesis 31:1592-6. 2010
    ..Given that altered immunity is an established risk factor for NHL, these results add to the biologic plausibility that TCE is a possible lymphomagen...
  11. pmc Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
    Eur J Haematol 85:492-5. 2010
    ..5%) lower in the Chinese population compared with Caucasians. These results suggest that variants in three loci may contribute to risk of CLL among Chinese...
  12. pmc Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Carcinogenesis 30:50-8. 2009
    ..Our findings suggest that SNPs involved in DNA repair and genomic maintenance, with particular clustering in the homologous DNA recombination pathway, play an important role in benzene-induced hematotoxicity...
  13. ncbi request reprint p53 gene expression in relation to indoor exposure to unvented coal smoke in Xuan Wei, China
    Q Lan
    University of North Carolina, Chapl Hill, USA
    J Occup Environ Med 43:226-30. 2001
    ..This study suggests that exposure to the combustion products of smoky coal in Xuan Wei is more strongly associated with women who have lung cancer accompanied by p53 protein overexpression in exfoliated tumor cells...
  14. ncbi request reprint Glutathione S-transferase genotypes and stomach cancer in a population-based case-control study in Warsaw, Poland
    Q Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
    Pharmacogenetics 11:655-61. 2001
    ..01). This was due to a shift in the GSTT1 genotype distribution across age groups among stomach cancer patients only. These results suggest that the GSTT1 null genotype may be associated with increased risk of stomach cancer...
  15. ncbi request reprint Genetic polymorphisms in the oxidative stress pathway and susceptibility to non-Hodgkin lymphoma
    Qing Lan
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, EPS 8109, Bethesda, MD 20892 7240, USA
    Hum Genet 121:161-8. 2007
    ..013), but was also associated with non-significant increased risks for each of the common B-cell histologies. These results suggest that SNPs in genes related to the oxidative stress pathway may be associated with increased risk of NHL...
  16. pmc A prospective study of mitochondrial DNA copy number and risk of non-Hodgkin lymphoma
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD, USA
    Blood 112:4247-9. 2008
    ..0; 3.2 [0.7-15.7]; 14.1 [1.9-103.2]; P(trend) = .009). These results suggest that mtDNA copy number could be associated with the risk of NHL, particularly CLL/SLL...
  17. ncbi request reprint Oxidative damage-related genes AKR1C3 and OGG1 modulate risks for lung cancer due to exposure to PAH-rich coal combustion emissions
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
    Carcinogenesis 25:2177-81. 2004
    ..However, due to the small sample size, additional studies are needed to evaluate these associations within Xuan Wei and other populations with substantial exposure to PAHs...
  18. ncbi request reprint No apparent association between NAT1 and NAT2 genotypes and risk of stomach cancer
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland 20892 7240, USA
    Cancer Epidemiol Biomarkers Prev 12:384-6. 2003
  19. ncbi request reprint Genetic variants in caspase genes and susceptibility to non-Hodgkin lymphoma
    Qing Lan
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute NIH, DHHS, Bethesda, MD 20892 7240, USA
    Carcinogenesis 28:823-7. 2007
    ..The striking protective associations observed for polymorphisms in all four genes for NHL and/or one or more subtypes suggest that genetic variation in CASP genes may play an important role in the etiology of NHL...
  20. pmc Variation in lung cancer risk by smoky coal subtype in Xuanwei, China
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Int J Cancer 123:2164-9. 2008
    ..2) coal types and lower for coal from other subtypes. These findings strongly suggest that in Xuanwei and elsewhere, the carcinogenic potential of coal combustion products can exhibit substantial local variation by specific coal source...
  21. ncbi request reprint One-carbon metabolism gene polymorphisms and risk of non-Hodgkin lymphoma in Australia
    Kyoung Mu Lee
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd EPS 8118, Bethesda, MD 20892 7240, USA
    Hum Genet 122:525-33. 2007
    ..01). In conclusion, the results of this study suggest that genetic polymorphisms of one-carbon metabolism genes such as MTHFR and TYMS may influence susceptibility to NHL...
  22. ncbi request reprint Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphoma
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
    Carcinogenesis 27:1828-34. 2006
    ....
  23. pmc Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development
    Lindsay M Morton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 18:1259-70. 2009
    ..Replication of our findings and further study to identify functional SNPs are warranted...
  24. ncbi request reprint Polymorphisms in immunoregulatory genes, smoky coal exposure and lung cancer risk in Xuan Wei, China
    Kyoung Mu Lee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
    Carcinogenesis 28:1437-41. 2007
    ..11, 95% CI = 0.03-0.44; P(interaction) = 0.03). In conclusion, genetic variation in immunoregulatory genes may play an important role in the development of lung cancer in this population...
  25. ncbi request reprint Polymorphisms in folate metabolic genes and lung cancer risk in Xuan Wei, China
    Min Shen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, MSC 7240, 6120 Executive Blvd, Bethesda, MD 20892 7240, USA
    Lung Cancer 49:299-309. 2005
    ..002 and P=0.07, respectively). In summary, three genetic variants in folate metabolism genes are associated with an increased risk of lung cancer in Xuan Wei, China...
  26. ncbi request reprint Genotype frequency and F ST analysis of polymorphisms in immunoregulatory genes in Chinese and Caucasian populations
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Immunogenetics 59:839-52. 2007
    ..25). These results suggest that there is substantial genetic diversity in immune genes and exploration of SNP associations with immune-related diseases that vary in incidence across these two populations may be warranted...
  27. ncbi request reprint Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma among women in Connecticut
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
    Hum Genet 119:659-68. 2006
    ..Further work is needed to extend these findings by carrying out extended haplotype analyses of these and related genes and to replicate the observations in other studies...
  28. ncbi request reprint Polymorphisms in genes involved in DNA double-strand break repair pathway and susceptibility to benzene-induced hematotoxicity
    Min Shen
    Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD 20892, USA
    Carcinogenesis 27:2083-9. 2006
    ..The effect of BRCA2 Ex11 +1487 A > G polymorphism was limited to granulocytes. These results suggest that genetic polymorphisms in WRN, TP53 and BRCA2 that maintain genomic stability impact benzene-induced hematotoxicity...
  29. ncbi request reprint Polymorphisms in the DNA base excision repair genes APEX1 and XRCC1 and lung cancer risk in Xuan Wei, China
    Min Shen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892 7240, USA
    Anticancer Res 25:537-42. 2005
    ..34; 95% CI: 1.16-9.67). We found genetic variants in APEX1 and XRCC1 may alter the risk of lung cancer in a special population in China...
  30. pmc Coal mining is associated with lung cancer risk in Xuanwei, China
    H Dean Hosgood
    Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, Maryland 20892 7240, USA
    Am J Ind Med 55:5-10. 2012
    ..In Xuanwei, coal is typically extracted from underground mines, without ventilation, and transported to the surface using carts powered by manpower or electricity...
  31. pmc Polymorphisms in genes involved in innate immunity and susceptibility to benzene-induced hematotoxicity
    Min Shen
    Division of Cancer Epidemiology and Genetics NCI, NIH, DHHS, Bethesda MD 20892, U S A
    Exp Mol Med 43:374-8. 2011
    ..0008) with WBCs even though the three SNPs were not significant individually. Our study suggests that polymorphisms in innate immunity genes may play a role in benzene-induced hematotoxicity; however, independent replication is necessary...
  32. pmc Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, MSC 7240, 6120 Executive Blvd, Bethesda, Maryland 20892 7240, USA
    Environ Mol Mutagen 50:285-90. 2009
    ..Integrin/receptor and complement pathways as well as IgE regulation are particularly noteworthy...
  33. ncbi request reprint Polymorphisms in DNA repair genes and risk of non-Hodgkin's lymphoma in New South Wales, Australia
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892 7240, USA
    Haematologica 92:1180-5. 2007
    ..We investigated whether putatively functional single-nucleotide polymorphisms (SNP) in DNA repair genes influence susceptibility to NHL in a population-based case-control study conducted in Australia...
  34. pmc Common gene variants in the tumor necrosis factor (TNF) and TNF receptor superfamilies and NF-kB transcription factors and non-Hodgkin lymphoma risk
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, United States of America
    PLoS ONE 4:e5360. 2009
    ..We hypothesized that the TNF and NF-kappaB pathways are important for NHL and that gene variations across the pathways may alter NHL risk...
  35. ncbi request reprint Green tea consumption, genetic susceptibility, PAH-rich smoky coal, and the risk of lung cancer
    Matthew R Bonner
    Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS 8121, MSC 7240, Bethesda, MD 20892 7240, USA
    Mutat Res 582:53-60. 2005
    ..The chemopreventive effects of green tea in this population may be restricted to individuals who are particularly susceptible to oxidative stress and oxidative DNA damage...
  36. pmc A report of cytokine polymorphisms and COPD risk in Xuan Wei, China
    Min Shen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, MSC 7240, 6120 Executive Blvd, Bethesda, MD 20892 7240, USA
    Int J Hyg Environ Health 211:352-6. 2008
    ..However, in view of our relatively small sample size, this study should be replicated in other populations with substantial exposure to indoor air pollutants such as polycyclic aromatic hydrocarbons (PAH) and particulate matter...
  37. ncbi request reprint Polymorphisms in the DNA nucleotide excision repair genes and lung cancer risk in Xuan Wei, China
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Int J Cancer 116:768-73. 2005
    ..However, due to the small sample size, additional studies are needed to evaluate these associations within Xuan Wei and in other populations with substantial environmental exposure to PAHs...
  38. pmc A prospective study of telomere length measured by monochrome multiplex quantitative PCR and risk of lung cancer
    Min Shen
    Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD 20892, United States
    Lung Cancer 73:133-7. 2011
    ..Telomere length plays an important role in chromosomal stability and tumorigenesis, and its measurement in peripheral white blood cell DNA may be a predictor of the development of lung cancer...
  39. pmc Genetic variation in metabolic genes, occupational solvent exposure, and risk of non-hodgkin lymphoma
    Kathryn Hughes Barry
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Epidemiol 173:404-13. 2011
    ..77, 95% CI: 1.06, 2.97; P(interaction) = 0.06). In contrast, no effect was observed among AG/GG women. Additional studies with larger sample size are needed to replicate these findings...
  40. ncbi request reprint Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrations
    Sungkyoon Kim
    School of Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
    Pharmacogenet Genomics 17:789-801. 2007
    ....
  41. pmc Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studies
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Br J Haematol 151:239-44. 2010
    ..These results support the hypothesis that common genetic polymorphisms in human DNA repair genes may modify the risk of NHL...
  42. pmc Hematotoxicity in workers exposed to low levels of benzene
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD 20892, USA
    Science 306:1774-6. 2004
    ..Thus, hematotoxicity from exposure to benzene occurred at air levels of 1 ppm or less and may be particularly evident among genetically susceptible subpopulations...
  43. pmc Mitochondrial DNA copy number and lung cancer risk in a prospective cohort study
    H Dean Hosgood
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 8118, MCS 7240, Bethesda, MD 20892 7240, USA
    Carcinogenesis 31:847-9. 2010
    ....
  44. pmc PTEN identified as important risk factor of chronic obstructive pulmonary disease
    H Dean Hosgood
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Respir Med 103:1866-70. 2009
    ..However, due to the small sample size, additional studies are needed to evaluate these associations within Xuanwei and other populations with coal smoke exposures...
  45. pmc Caspase polymorphisms and genetic susceptibility to multiple myeloma
    H Dean Hosgood
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Hematol Oncol 26:148-51. 2008
    ..The protective associations observed in two key caspase genes suggest that genetic variation in CASP genes may play an important role in the aetiology of multiple myeloma...
  46. pmc Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut
    Kyoung Mu Lee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Am J Hematol 85:560-3. 2010
    ..Additional studies are needed to replicate these findings and, more generally, to explore the manner in which genes and receptors may influence the pathogenesis of this poorly understood malignancy...
  47. doi request reprint Dietary factors, food contamination and lung cancer risk in Xuanwei, China
    Min Shen
    Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD, United States
    Lung Cancer 61:275-82. 2008
    ..Thus, residents could be exposed to carcinogenic coal emissions not only via inhalation but also via ingestion of these foodstuffs...
  48. pmc Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Bethesda, Maryland, USA
    Nat Genet 45:868-76. 2013
    ..3 (ODF1, P=5.40×10(-8)) and 5p15.33 (TERT, P=1.92×10(-7)). Although further studies are required, the proximity of several of these loci to genes involved in apoptosis suggests a plausible underlying biological mechanism...
  49. pmc Albumin adducts of electrophilic benzene metabolites in benzene-exposed and control workers
    Yu Sheng Lin
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7431, USA
    Environ Health Perspect 115:28-34. 2007
    ..Metabolism of benzene produces reactive electrophiles, including benzene oxide (BO), 1,4-benzoquinone (1,4-BQ), and 1,2-benzoquinone (1,2-BQ), that are capable of reacting with blood proteins to produce adducts...
  50. pmc Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA
    Carcinogenesis 29:1955-62. 2008
    ..These results indicate that genetic variation in carcinogen-metabolizing genes, particularly AKR1C3, could be associated with bladder cancer risk...
  51. pmc Genetic variation in N-acetyltransferases 1 and 2, cigarette smoking, and risk of non-Hodgkin lymphoma
    Briseis A Kilfoy
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    Cancer Causes Control 21:127-33. 2010
    ..We conclude that these findings require replication in larger studies and ultimately in pooled analyses...
  52. pmc A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphoma
    Mark P Purdue
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892, USA
    Carcinogenesis 30:275-81. 2009
    ..No associations with TLR4 variants were observed. This pooled analysis provides strong evidence that variation in the TLR10-TLR1-TLR6 region is associated with NHL risk and suggests that TLR2 variants may influence susceptibility to MZL...
  53. pmc Association between mitochondrial DNA copy number, blood cell counts, and occupational benzene exposure
    Min Shen
    Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, Maryland 20892 7240, USA
    Environ Mol Mutagen 49:453-7. 2008
    ..Benzene exposure may induce mtDNA amplification, possibly in response to oxidative stress caused by benzene. The finding needs to be replicated by other studies...
  54. pmc Genetic variation in Th1/Th2 pathway genes and risk of non-Hodgkin lymphoma: a pooled analysis of three population-based case-control studies
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD, USA
    Br J Haematol 153:341-50. 2011
    ..This SNP was also associated specifically with risk of follicular lymphoma (allele risk OR= 1·26; P(trend)= 0·0012). These findings suggest that genetic variation in Th1/Th2 cytokine genes may contribute to lymphomagenesis...
  55. ncbi request reprint Detailed exposure assessment for a molecular epidemiology study of benzene in two shoe factories in China
    Roel Vermeulen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, Rockville, MD 20892, USA
    Ann Occup Hyg 48:105-16. 2004
    ..Our goal was to identify workers with a broad range of benzene exposures, for an epidemiologic study relating exposure to early biologic effects...
  56. pmc History of lung disease and risk of lung cancer in a population with high household fuel combustion exposures in rural China
    H Dean Hosgoodiii
    Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD, USA
    Lung Cancer 81:343-6. 2013
    ..3; 95%CI = 1.7-6.4) were associated with increased risks. These findings suggest that history of chronic lung diseases may also increase risk of lung cancer in populations with indoor coal smoke exposures...
  57. ncbi request reprint Assessment of dermal exposure to benzene and toluene in shoe manufacturing by activated carbon cloth patches
    Roel Vermeulen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20892, USA
    J Environ Monit 8:1143-8. 2006
    ..The aim of this investigation was to use activated carbon cloth (ACC) patches to study the probability and extent of dermal exposure to benzene and toluene in a shoe factory...
  58. doi request reprint Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Nat Genet 44:1330-5. 2012
    ..3. We observed no evidence of association for lung cancer at 15q25 in never-smoking women in Asia, providing strong evidence that this locus is not associated with lung cancer independent of smoking...
  59. pmc Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway
    H Dean Hosgood
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 29:1938-43. 2008
    ..These results should be viewed as exploratory until they are replicated in a larger study...
  60. ncbi request reprint Common variants in genes that mediate immunity and risk of multiple myeloma
    Elizabeth E Brown
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    Int J Cancer 120:2715-22. 2007
    ..Our findings provide preliminary evidence that common genetic variants in specific immune-mediated pathways could influence the risk of MM...
  61. doi request reprint Occupational exposure to trichloroethylene and serum concentrations of IL-6, IL-10, and TNF-alpha
    Bryan A Bassig
    Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Environ Mol Mutagen 54:450-4. 2013
    ..Given that IL-10 plays an important role in immunologic processes, including mediating the Th1/Th2 balance, our findings provide additional evidence that TCE is immunotoxic in humans...
  62. doi request reprint Occupational trichloroethylene exposure and risk of lymphatic and haematopoietic cancers: a meta-analysis
    Sara Karami
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20852, USA
    Occup Environ Med 70:591-9. 2013
    ..Our updated meta-analysis of NHL, which incorporates new analytical results from three cohort and four case-control studies, supports an association between occupational TCE exposure and NHL. ..
  63. pmc Occupational exposure to formaldehyde and alterations in lymphocyte subsets
    H Dean Hosgood
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7240, USA
    Am J Ind Med 56:252-7. 2013
    ..Formaldehyde is used in many occupational settings, most notably in manufacturing, health care, and embalming. Formaldehyde has been classified as a human carcinogen, but its mechanism of action remains uncertain...
  64. doi request reprint Polymorphisms in pattern-recognition genes in the innate immunity system and risk of non-Hodgkin lymphoma
    Wei Hu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892 7240, USA
    Environ Mol Mutagen 54:72-7. 2013
    ..39, P-trend = 0.033). Our results suggest that genetic variation in pattern-recognition genes is associated with the risk of NHL or specific NHL subtypes, but these preliminary findings require replication in larger studies...
  65. pmc Genetic variation in cell cycle and apoptosis related genes and multiple myeloma risk
    H Dean Hosgood
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, United States
    Leuk Res 33:1609-14. 2009
    ..005). Haplotype analyses supported the SNP findings. These findings suggest that genetic variation in cell cycle and apoptosis genes may play a key role in multiple myeloma and warrant further investigation through replication studies...
  66. pmc Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER case-control study
    Unhee Lim
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health NIH, Department of Health and Human Services DHHS, Rockville, MD 20852, USA
    Blood 109:3050-9. 2007
    ..04-0.39), and MTRR Ex5+136T>CTT (OR = 0.67; 95% CI = 0.47-0.97) genotypes. Warranting replication, our finding of gene-nutrient interactions in one-carbon metabolism supports their etiologic involvement in lymphomagenesis...
  67. pmc GST genotypes and lung cancer susceptibility in Asian populations with indoor air pollution exposures: a meta-analysis
    H Dean Hosgood
    National Cancer Institute, Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, Bethesda, MD 20892 7240, USA
    Mutat Res 636:134-43. 2007
    ..Our results suggest that the GSTM1 null genotype may be associated with a more substantial risk of lung cancer in populations with coal exposure...
  68. pmc Polymorphisms in integrin genes and lymphoma risk
    Min Shen
    Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7240, USA
    Leuk Res 35:968-70. 2011
    ..01 level. While our results suggest that genetic polymorphisms in integrin genes may play a role in the genesis of lymphoma in women, they should be viewed as exploratory until they are replicated in additional populations...
  69. ncbi request reprint Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Lancet Oncol 7:27-38. 2006
    ..We aimed to test this hypothesis using previously unpublished data from eight European, Canadian, and US case-control studies of the International Lymphoma Epidemiology Consortium (InterLymph)...
  70. pmc Polymorphisms in complement system genes and risk of non-Hodgkin lymphoma
    Bryan A Bassig
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892 7240, USA
    Environ Mol Mutagen 53:145-51. 2012
    ..Our results suggest a potential role of the complement system in susceptibility to NHL; however, our results should be viewed as exploratory and further replication is needed to clarify these preliminary findings...
  71. ncbi request reprint Using urinary biomarkers to elucidate dose-related patterns of human benzene metabolism
    Sungkyoon Kim
    School of Public Health, University of North Carolina, Chapel Hill, NC 27599, and National Cancer Institute NCI, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD 20892, USA
    Carcinogenesis 27:772-81. 2006
    ..027 and 15.4 p.p.m. Reductions in metabolite production were most pronounced for CA and PH<1 p.p.m., indicating that metabolism favored production of the toxic metabolites, HQ and MA, at low exposures...
  72. pmc Variation in innate immunity genes and risk of multiple myeloma
    Mark P Purdue
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, Bethesda, MD, USA
    Hematol Oncol 29:42-6. 2011
    ..0 × 10(-5) , P(permutation)  = 0.07). Our findings suggest that genetic variants in SERPINE1 and HGF, and possibly CCR7, are associated with MM risk, and warrant further investigation in other studies...
  73. pmc Coal use, stove improvement, and adult pneumonia mortality in Xuanwei, China: a retrospective cohort study
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, U S Department of Health and Human Services, Bethesda, Maryland 20892 7240, USA
    Environ Health Perspect 117:261-6. 2009
    ..However, the impact of coal burning and stove improvement on risk of pneumonia is not clear...
  74. ncbi request reprint Radon, secondhand smoke, glutathione-S-transferase M1 and lung cancer among women
    Matthew R Bonner
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Rockville, MD, USA
    Int J Cancer 119:1462-7. 2006
    ..Additionally, these findings support the hypothesis that radon and SHS promote neoplasia through shared elements of a common pathway...
  75. ncbi request reprint Polymorphisms in immune function genes and risk of non-Hodgkin lymphoma: findings from the New South Wales non-Hodgkin Lymphoma Study
    Mark P Purdue
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892 7240, USA
    Carcinogenesis 28:704-12. 2007
    ..06, 95% CI=0.88-4.83; trend test, P=0.02). Our findings offer further evidence that variation in the IL10 and TNF loci influences NHL risk. Additional studies are needed to clarify the genetic and biologic basis for these relationships...
  76. pmc A prospective study of serum soluble CD30 concentration and risk of non-Hodgkin lymphoma
    Mark P Purdue
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
    Blood 114:2730-2. 2009
    ....
  77. pmc A pooled analysis of three studies evaluating genetic variation in innate immunity genes and non-Hodgkin lymphoma risk
    H Dean Hosgood
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD, USA
    Br J Haematol 152:721-6. 2011
    ....
  78. pmc Decreased levels of CXC-chemokines in serum of benzene-exposed workers identified by array-based proteomics
    Roel Vermeulen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 102:17041-6. 2005
    ....
  79. pmc Predictors of 2,4-dichlorophenoxyacetic acid exposure among herbicide applicators
    Parveen Bhatti
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892 7238, USA
    J Expo Sci Environ Epidemiol 20:160-8. 2010
    ..As a large proportion of the variance remained unexplained, further studies should be conducted to try to systematically assess other exposure determinants...
  80. pmc Genetic variation in telomere maintenance genes, telomere length, and lung cancer susceptibility
    H Dean Hosgood
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, United States
    Lung Cancer 66:157-61. 2009
    ..05). Our findings provide evidence that telomere length and genetic variation in telomere maintenance genes may be associated with risk of lung cancer susceptibility and warrant replication in larger studies...
  81. pmc Tuberculosis and subsequent risk of lung cancer in Xuanwei, China
    Eric A Engels
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Int J Cancer 124:1183-7. 2009
    ..The increased lung cancer risk, persisting years after a tuberculosis diagnosis, could reflect the effects of chronic pulmonary inflammation and scarring arising from tuberculosis...
  82. ncbi request reprint Pooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: a HuGE review
    Lawrence S Engel
    Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Am J Epidemiol 156:95-109. 2002
    ..45, 95% CI: -0.03, 0.93). These results indicate that, among populations studied to date, GSTM1 null status is associated with a modest increase in the risk of bladder cancer...
  83. pmc Household coal use and lung cancer: systematic review and meta-analysis of case-control studies, with an emphasis on geographic variation
    H Dean Hosgood
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Int J Epidemiol 40:719-28. 2011
    ..Although coal emissions are a known human carcinogen, there is still uncertainty about the level of risk for lung and other cancers...
  84. pmc Prediagnostic serum levels of cytokines and other immune markers and risk of non-hodgkin lymphoma
    Mark P Purdue
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
    Cancer Res 71:4898-907. 2011
    ..Our findings for sTNF-R1 and sCD27, possible markers for inflammatory and B-cell stimulatory states, respectively, support a role for subclinical inflammation and chronic B-cell stimulation in lymphomagenesis...
  85. pmc In-home coal and wood use and lung cancer risk: a pooled analysis of the International Lung Cancer Consortium
    H Dean Hosgood
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7240, USA
    Environ Health Perspect 118:1743-7. 2010
    ..Recently, the International Agency for Research on Cancer classified indoor emissions from household coal combustion as a human carcinogen (group 1) and from biomass fuel (primarily wood) as a probable human carcinogen (group 2A)...
  86. ncbi request reprint Detection of p53 and K-ras mutations in sputum of individuals exposed to smoky coal emissions in Xuan Wei County, China
    Phouthone Keohavong
    Department of Environmental and Occupational Health and Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Carcinogenesis 26:303-8. 2005
    ....
  87. doi request reprint CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations
    Kyoung Mu Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
    Cancer Epidemiol Biomarkers Prev 17:1120-6. 2008
    ..However, further investigation is warranted considering the relatively small sample size when subgroup analyses were done and the lack of environmental exposure data other than smoking...
  88. ncbi request reprint Household stove improvement and risk of lung cancer in Xuanwei, China
    Qing Lan
    Institute of Environmental Health and Engineering, Chinese Academy of Preventive Medicine, Beijing, China
    J Natl Cancer Inst 94:826-35. 2002
    ..Since the 1970s, most residents have changed from firepits to stoves with chimneys. This study assessed whether lung cancer incidence decreased after this stove improvement...
  89. ncbi request reprint Detection of K-ras and p53 mutations in sputum samples of lung cancer patients using laser capture microdissection microscope and mutation analysis
    Phouthone Keohavong
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Anal Biochem 324:92-9. 2004
    ..This method may be applicable to the analysis of epithelial cells from clinically normal sputum or BAL samples from individuals with a high risk for developing lung cancer...
  90. ncbi request reprint Diet and nutrient intakes and risk of non-Hodgkin's lymphoma in Connecticut women
    Tongzhang Zheng
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    Am J Epidemiol 159:454-66. 2004
    ..The antioxidant or inhibiting nitrosation reaction properties of vegetables and fruits may result in a reduced risk. Further investigation of the role of dietary intakes on the risk of NHL is warranted...
  91. ncbi request reprint Molecular epidemiological studies on the relationship between indoor coal burning and lung cancer in Xuan Wei, China
    Qing Lan
    Chinese Center for Disease Control and Prevention, Institute of Environmental Health, Beijing, PR China
    Toxicology 198:301-5. 2004
    ..It is likely that the lung cancer excess in Xuan Wei County results from the complex interaction of genetic and environmental factors that will require further research to be understood...
  92. ncbi request reprint Impact of interleukin-10 polymorphisms (-1082 and -3575) on the survival of patients with lymphoid neoplasms
    Eva Domingo-Domenech
    Department of Hematology, Institut Catala d Oncologia, Avda Gran Via s n, Km 2 7, 08907 L Hospitalet de Llobregat, Barcelona, Spain
    Haematologica 92:1475-81. 2007
    ..The aim of this study was to explore the association between polymorphisms of IL-10-(1082A>G) and IL-10-(3575T>A) with the overall survival in patients with lymphoid neoplasms...
  93. pmc Exogenous and endogenous determinants of blood trihalomethane levels after showering
    Lorraine C Backer
    National Center for Environmental Health, Centers for Disease Control and Prevention, Chamblee, GA 30341, USA
    Environ Health Perspect 116:57-63. 2008
    ..Increases in blood THM levels among subjects who showered or bathed were variable, with increased levels tending to cluster in two groups...
  94. ncbi request reprint Modeling human metabolism of benzene following occupational and environmental exposures
    Sungkyoon Kim
    School of Public Health, University of North Carolina, CB 7431, Chapel Hill, NC 27599
    Cancer Epidemiol Biomarkers Prev 15:2246-52. 2006
    ..Our results also suggest that GLM + NS models are ideal for evaluating nonlinear relationships between environmental exposures and levels of human biomarkers...
  95. pmc Aberrant gene promoter methylation in sputum from individuals exposed to smoky coal emissions
    Yang Liu
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Anticancer Res 28:2061-6. 2008
    ..Here, the promoter methylation of p16, MGMT, RASSF1A and DAPK genes was investigated in sputum of individuals exposed to smoky coal emissions in Xuan Wei, China, where the lung cancer rate more than 6 times the Chinese national average...
  96. pmc Aberrant promoter methylation of p16 and MGMT genes in lung tumors from smoking and never-smoking lung cancer patients
    Yang Liu
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Neoplasia 8:46-51. 2006
    ..Our results suggest an association between tobacco smoking and an increased incidence of aberrant promoter methylation of the p16 and MGMT genes in non-small cell lung cancer...
  97. ncbi request reprint A putative exonic splicing polymorphism in the BCL6 gene and the risk of non-Hodgkin lymphoma
    Yawei Zhang
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 06520 8034, USA
    J Natl Cancer Inst 97:1616-8. 2005
    ..2, 95% CI = 2.0 to 13.3). Our results support the hypothesis that a genetic variant that could alter mRNA transcripts of BCL6 may contribute to the etiology of NHL and suggest that this variant warrants further investigation...
  98. pmc Improvement in household stoves and risk of chronic obstructive pulmonary disease in Xuanwei, China: retrospective cohort study
    Robert S Chapman
    College of Public Health, Chulalongkorn University, Institute Building 3, 10th Floor, Soi Chulalongkorn 62, Phyathai Road, Patumwan, Bangkok 10330, Thailand
    BMJ 331:1050. 2005
    ..To test whether improvement in household coal stoves affected the incidence of chronic obstructive pulmonary disease (COPD) in Xuanwei County, China...
  99. ncbi request reprint Metabolic gene polymorphisms and lung cancer risk in non-smokers. An update of the GSEC study
    Sara Raimondi
    Fondazione Policlinico IRCCS, Molecular and Genetic Epidemiology Unit, Via Pace 9, 20122 Milano, Italy
    Mutat Res 592:45-57. 2005
    ..Since genetic factors may play an important role in lung cancer development at low dose carcinogen exposure, non-smokers are a good model to study genetic susceptibility and its interaction with environmental factors...
  100. ncbi request reprint Use of 'Omic' technologies to study humans exposed to benzene
    Martyn T Smith
    School of Public Health, 140 Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Chem Biol Interact 153:123-7. 2005
    ..Omic technologies therefore have significant potential in generating novel biomarkers of exposure, susceptibility and response to benzene...
  101. ncbi request reprint Use of OctoChrome fluorescence in situ hybridization to detect specific aneuploidy among all 24 chromosomes in benzene-exposed workers
    Luoping Zhang
    School of Public Health, 140 Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Chem Biol Interact 153:117-22. 2005
    ..We are currently investigating potential mechanisms for this induction of selective aneuploidy...