Qing Lan

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. request reprint
    Lan Q, Shen M, Berndt S, Bonner M, He X, Yeager M, et al. Smoky coal exposure, NBS1 polymorphisms, p53 protein accumulation, and lung cancer risk in Xuan Wei, China. Lung Cancer. 2005;49:317-23 pubmed
    ..However, additional studies in other populations with substantial environmental exposures to PAHs are needed to confirm our findings. ..
  2. Lan Q, Lim U, Liu C, Weinstein S, Chanock S, Bonner M, et al. A prospective study of mitochondrial DNA copy number and risk of non-Hodgkin lymphoma. Blood. 2008;112:4247-9 pubmed publisher
    ..0; 3.2 [0.7-15.7]; 14.1 [1.9-103.2]; P(trend) = .009). These results suggest that mtDNA copy number could be associated with the risk of NHL, particularly CLL/SLL. ..
  3. Josyula S, Lin J, Xue X, Rothman N, Lan Q, Rohan T, et al. Household air pollution and cancers other than lung: a meta-analysis. Environ Health. 2015;14:24 pubmed publisher
    ..Further research is needed to confirm these associations in prospective studies. ..
  4. Dai Y, Niu Y, Duan H, Bassig B, Ye M, Zhang X, et al. Effects of occupational exposure to carbon black on peripheral white blood cell counts and lymphocyte subsets. Environ Mol Mutagen. 2016;57:615-622 pubmed publisher
    ..Environ. Mol. Mutagen. 57:589-604, 2016. © 2016 Wiley Periodicals, Inc. ..
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    Lan Q, Chow W, Lissowska J, Hein D, Buetow K, Engel L, et al. Glutathione S-transferase genotypes and stomach cancer in a population-based case-control study in Warsaw, Poland. Pharmacogenetics. 2001;11:655-61 pubmed
    ..01). This was due to a shift in the GSTT1 genotype distribution across age groups among stomach cancer patients only. These results suggest that the GSTT1 null genotype may be associated with increased risk of stomach cancer. ..
  6. request reprint
    Lan Q, Mumford J, Shen M, DeMarini D, Bonner M, He X, et al. Oxidative damage-related genes AKR1C3 and OGG1 modulate risks for lung cancer due to exposure to PAH-rich coal combustion emissions. Carcinogenesis. 2004;25:2177-81 pubmed
    ..However, due to the small sample size, additional studies are needed to evaluate these associations within Xuan Wei and other populations with substantial exposure to PAHs. ..
  7. request reprint
    Lan Q, Zhang L, Shen M, Smith M, Li G, Vermeulen R, et al. Polymorphisms in cytokine and cellular adhesion molecule genes and susceptibility to hematotoxicity among workers exposed to benzene. Cancer Res. 2005;65:9574-81 pubmed
    ..041) and increased (P = 0.076) CFU-GEMM progenitor cell colony formation in 29 benzene-exposed workers. This is the first report to provide evidence that SNPs in genes that regulate hematopoiesis influence benzene-induced hematotoxicity. ..
  8. Lan Q, Zheng T, Rothman N, Zhang Y, Wang S, Shen M, et al. Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma. Blood. 2006;107:4101-8 pubmed
    ..84; 95% CI = 1.79-8.22; P < .001). Further, the IL10 and IL4 SNP associations remained significant after adjusting for multiple comparisons. These results suggest that SNPs in Th2 cytokine genes may be associated with risk of NHL. ..
  9. request reprint
    Lan Q, Zheng T, Chanock S, Zhang Y, Shen M, Wang S, et al. Genetic variants in caspase genes and susceptibility to non-Hodgkin lymphoma. Carcinogenesis. 2007;28:823-7 pubmed
    ..The striking protective associations observed for polymorphisms in all four genes for NHL and/or one or more subtypes suggest that genetic variation in CASP genes may play an important role in the etiology of NHL. ..

More Information

Publications16

  1. request reprint
    Lan Q, Zheng T, Shen M, Zhang Y, Wang S, Zahm S, et al. Genetic polymorphisms in the oxidative stress pathway and susceptibility to non-Hodgkin lymphoma. Hum Genet. 2007;121:161-8 pubmed
    ..013), but was also associated with non-significant increased risks for each of the common B-cell histologies. These results suggest that SNPs in genes related to the oxidative stress pathway may be associated with increased risk of NHL. ..
  2. Lan Q, Zhang L, Shen M, Jo W, Vermeulen R, Li G, et al. Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity. Carcinogenesis. 2009;30:50-8 pubmed publisher
    ..Our findings suggest that SNPs involved in DNA repair and genomic maintenance, with particular clustering in the homologous DNA recombination pathway, play an important role in benzene-induced hematotoxicity. ..
  3. Lan Q, Morton L, Armstrong B, Hartge P, Menashe I, Zheng T, et al. Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studies. Blood. 2009;114:264-7 pubmed publisher
    ..It is noteworthy that genetic variants in CASP8 were associated with risk of all major NHL subtypes. Our findings suggest that genetic variation in caspases may play an important role in lymphomagenesis. ..
  4. Lan Q, Cawthon R, Shen M, Weinstein S, Virtamo J, Lim U, et al. A prospective study of telomere length measured by monochrome multiplex quantitative PCR and risk of non-Hodgkin lymphoma. Clin Cancer Res. 2009;15:7429-33 pubmed publisher
    ..003], and this association was similar across the most common non-Hodgkin lymphoma subtypes present in this study. These results suggest that longer telomere length may be a potential predictor for future risk of non-Hodgkin lymphoma. ..
  5. Lan Q, Zhang L, Tang X, Shen M, Smith M, Qiu C, et al. Occupational exposure to trichloroethylene is associated with a decline in lymphocyte subsets and soluble CD27 and CD30 markers. Carcinogenesis. 2010;31:1592-6 pubmed publisher
    ..Given that altered immunity is an established risk factor for NHL, these results add to the biologic plausibility that TCE is a possible lymphomagen...
  6. Lan Q, Au W, Chanock S, Tse J, Wong K, Shen M, et al. Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong. Eur J Haematol. 2010;85:492-5 pubmed publisher
    ..5%) lower in the Chinese population compared with Caucasians. These results suggest that variants in three loci may contribute to risk of CLL among Chinese. ..
  7. Lan Q, Cawthon R, Gao Y, Hu W, Hosgood H, Barone Adesi F, et al. Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China. PLoS ONE. 2013;8:e59230 pubmed publisher
    ..030). Our findings suggest that individuals with longer telomere length in peripheral white blood cells may have an increased risk of lung cancer, but require replication in additional prospective cohorts and populations. ..