Zhennan Lai

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Gene transfer into the central nervous system in vivo using a recombinanat lentivirus vector
    Zhennan Lai
    Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci Res 67:363-71. 2002
  2. pmc Design of an HIV-1 lentiviral-based gene-trap vector to detect developmentally regulated genes in mammalian cells
    Zhennan Lai
    Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:3651-6. 2002
  3. ncbi request reprint Expression and secretion of human glucocerebrosidase mediated by recombinant lentivirus vectors in vitro and in vivo: implications for gene therapy of Gaucher disease
    Eun Young Kim
    Division of Genetic Disease, Department of Biomedical Sciences, National Institute of Health, Seoul, Republic of Korea
    Biochem Biophys Res Commun 318:381-90. 2004
  4. ncbi request reprint Long-term expression of the human glucocerebrosidase gene in vivo after transplantation of bone-marrow-derived cells transformed with a lentivirus vector
    Eun Young Kim
    Division of Genetic Disease, Department of Biomedical Sciences, National Institute of Health, Seoul, Korea
    J Gene Med 7:878-87. 2005

Collaborators

Detail Information

Publications4

  1. ncbi request reprint Gene transfer into the central nervous system in vivo using a recombinanat lentivirus vector
    Zhennan Lai
    Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci Res 67:363-71. 2002
    ..The data also demonstrate that up to 90% of the CNS cells transduced by our lentiviral vector under the control of the neuronal promoter are neurons...
  2. pmc Design of an HIV-1 lentiviral-based gene-trap vector to detect developmentally regulated genes in mammalian cells
    Zhennan Lai
    Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:3651-6. 2002
    ..Lentiviral gene-trap vectors appear to offer a wealth of possibilities for the study of cell differentiation and lineage commitment, as well as for the discovery of new genes...
  3. ncbi request reprint Expression and secretion of human glucocerebrosidase mediated by recombinant lentivirus vectors in vitro and in vivo: implications for gene therapy of Gaucher disease
    Eun Young Kim
    Division of Genetic Disease, Department of Biomedical Sciences, National Institute of Health, Seoul, Republic of Korea
    Biochem Biophys Res Commun 318:381-90. 2004
    ..This study represents an initial step toward gene transfer using recombinant lentivirus vectors for treatment of Gaucher disease...
  4. ncbi request reprint Long-term expression of the human glucocerebrosidase gene in vivo after transplantation of bone-marrow-derived cells transformed with a lentivirus vector
    Eun Young Kim
    Division of Genetic Disease, Department of Biomedical Sciences, National Institute of Health, Seoul, Korea
    J Gene Med 7:878-87. 2005
    ..A recombinant lentivirus vector was used to evaluate the transduction of the human GC gene into murine bone-marrow-derived HSCs and its expression in their progeny...