Affiliation: National Institutes of Health
- Gene transfer into the central nervous system in vivo using a recombinanat lentivirus vectorZhennan Lai
Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci Res 67:363-71. 2002..The data also demonstrate that up to 90% of the CNS cells transduced by our lentiviral vector under the control of the neuronal promoter are neurons...
- Design of an HIV-1 lentiviral-based gene-trap vector to detect developmentally regulated genes in mammalian cellsZhennan Lai
Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 99:3651-6. 2002..Lentiviral gene-trap vectors appear to offer a wealth of possibilities for the study of cell differentiation and lineage commitment, as well as for the discovery of new genes...
- Expression and secretion of human glucocerebrosidase mediated by recombinant lentivirus vectors in vitro and in vivo: implications for gene therapy of Gaucher diseaseEun Young Kim
Division of Genetic Disease, Department of Biomedical Sciences, National Institute of Health, Seoul, Republic of Korea
Biochem Biophys Res Commun 318:381-90. 2004..This study represents an initial step toward gene transfer using recombinant lentivirus vectors for treatment of Gaucher disease...
- Long-term expression of the human glucocerebrosidase gene in vivo after transplantation of bone-marrow-derived cells transformed with a lentivirus vectorEun Young Kim
Division of Genetic Disease, Department of Biomedical Sciences, National Institute of Health, Seoul, Korea
J Gene Med 7:878-87. 2005..This approach is potentially useful for the treatment of patents with Gaucher disease and other lysosomal storage disorders...