G M Lacourciere

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Escherichia coli NifS-like proteins provide selenium in the pathway for the biosynthesis of selenophosphate
    G M Lacourciere
    Laboratory of Biochemistry, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 275:23769-73. 2000
  2. ncbi request reprint Utilization of selenocysteine as a source of selenium for selenophosphate biosynthesis
    G M Lacourciere
    Laboratory of Biochemistry, National Institutes of Health, NHLBI, 50 South Drive, Room 2126, Bethesda, MD 20892, USA
    Biofactors 14:69-74. 2001
  3. ncbi request reprint Biosynthesis of selenophosphate
    G M Lacourciere
    Laboratory of Biochemistry, National Heart, Lung, Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biofactors 10:237-44. 1999
  4. pmc Catalytic properties of selenophosphate synthetases: comparison of the selenocysteine-containing enzyme from Haemophilus influenzae with the corresponding cysteine-containing enzyme from Escherichia coli
    G M Lacourciere
    Laboratory of Biochemistry, National Heart, Lung, Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 96:44-8. 1999
  5. ncbi request reprint Responsiveness of selenoproteins to dietary selenium
    C B Allan
    NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Nutr 19:1-16. 1999

Collaborators

  • C B Allan
  • T C Stadtman

Detail Information

Publications5

  1. ncbi request reprint Escherichia coli NifS-like proteins provide selenium in the pathway for the biosynthesis of selenophosphate
    G M Lacourciere
    Laboratory of Biochemistry, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 275:23769-73. 2000
    ..Taken together the ability of the NifS-like proteins to generate a selenium substrate for SPS and the activation of the SPS (C17S) mutant suggest a selenium delivery function for the proteins in vivo...
  2. ncbi request reprint Utilization of selenocysteine as a source of selenium for selenophosphate biosynthesis
    G M Lacourciere
    Laboratory of Biochemistry, National Institutes of Health, NHLBI, 50 South Drive, Room 2126, Bethesda, MD 20892, USA
    Biofactors 14:69-74. 2001
    ..All three proteins exhibit lyase activity on L-cysteine and L-selenocysteine and produce sulfane sulfur, S(0), or Se(0) respectively. Each lyase can effectively mobilize Se(0) from L-selenocysteine for selenophosphate biosynthesis...
  3. ncbi request reprint Biosynthesis of selenophosphate
    G M Lacourciere
    Laboratory of Biochemistry, National Heart, Lung, Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biofactors 10:237-44. 1999
    ..The inactive purified human enzyme together with the very low determined specific activity of the E. coli enzyme (83 nmol/min/mg) suggest an essential component for the formation of selenophosphate has not been identified...
  4. pmc Catalytic properties of selenophosphate synthetases: comparison of the selenocysteine-containing enzyme from Haemophilus influenzae with the corresponding cysteine-containing enzyme from Escherichia coli
    G M Lacourciere
    Laboratory of Biochemistry, National Heart, Lung, Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 96:44-8. 1999
    ..However, the selenocysteine-containing enzyme did not exhibit the expected higher catalytic activity. Based on these results we suggest a role of selenocysteine in H. influenzae that is not catalytic...
  5. ncbi request reprint Responsiveness of selenoproteins to dietary selenium
    C B Allan
    NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Nutr 19:1-16. 1999
    ..In general, selenoprotein levels in brain are less sensitive to dietary selenium fluctuation than the corresponding selenoprotein levels in other tissues...