Research Topics
| K Kwon-ChungSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Gene disruption to evaluate the role of fungal candidate virulence genesK Kwon-Chung
Molecular Microbiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Building 10, 11C304, National Institutes of Health, Bethesda MD 20892, USA
Curr Opin Microbiol 1:381-9. 1998..In other fungi, such as Histoplasma capsulatum, however, more efficient gene disruption methods need to be developed before such approaches can be regularly used for identifying virulence genes...- Do major species concepts support one, two or more species within Cryptococcus neoformans?Kyung J Kwon-Chung
Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, NIAID NIH Bethesda, MD 20892, USA
FEMS Yeast Res 6:574-87. 2006..In this paper, we review and attest to the validity of the current two-species system in light of the three major species concepts... - TUP1 disruption in Cryptococcus neoformans uncovers a peptide-mediated density-dependent growth phenomenon that mimics quorum sensingHyeseung Lee
Laboratory of Clinical Infectious Diseases, NIAID, NIH, Bethesda, MD 20892, USA
Mol Microbiol 64:591-601. 2007..The identification of an 11-mer peptide as an autoregulatory molecule in C. neoformans suggests that a diverse mechanism of cell-to-cell communication exists in the Kingdom Fungi... - Cobalt chloride, a hypoxia-mimicking agent, targets sterol synthesis in the pathogenic fungus Cryptococcus neoformansHyeseung Lee
Laboratory of Clinical Infectious Diseases, NIAID, NIH, Bethesda, MD 20892, USA
Mol Microbiol 65:1018-33. 2007..This article identifies the Sre1p pathway as a common mechanism by which yeast cells sense and adapt to changes in both CoCl2 concentrations and oxygen levels... 
Cryptococcus neoformans strains and infection in apparently immunocompetent patients, ChinaJianghan Chen
Shanghai Changzheng Hospital, Shanghai, People s Republic of China
Emerg Infect Dis 14:755-62. 2008..Our finding that most cryptococcosis patients in China had no apparent risk factor is in stark contrast with reports from other countries...
A chronological history of the International Conference on Cryptococcus and Cryptococcosis (ICCC), an invaluable forum for growth of the cryptococcal research field and clinical practiceKyung J Kwon-Chung
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Mycopathologia 173:287-93. 2012....- Taxonomy of fungi causing mucormycosis and entomophthoramycosis (zygomycosis) and nomenclature of the disease: molecular mycologic perspectivesKyung J Kwon-Chung
Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Clin Infect Dis 54:S8-S15. 2012..The article also reiterates the reasons why the classic names "mucormycosis" and "entomophthoramycosis" are more appropriate than "zygomycosis.".. - Identification of a Cryptococcus neoformans cytochrome P450 lanosterol 14α-demethylase (Erg11) residue critical for differential susceptibility between fluconazole/voriconazole and itraconazole/posaconazoleEdward Sionov
Laboratory of Clinical Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Antimicrob Agents Chemother 56:1162-9. 2012..It underscores the necessity of in vitro susceptibility testing for each FLC-resistant C. neoformans clinical isolate against different groups of azoles in order to assist patient management... - Cryptococcus neoformans STE12alpha regulates virulence but is not essential for matingY C Chang
Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Office of the Director, National Institutes of Health, Bethesda, Maryland 20892, USA
J Exp Med 191:871-82. 2000..These results demonstrate a clear molecular link between mating type and virulence in C. neoformans... - Hematogenously disseminated skin disease caused by Mucor velutinosus in a patient with acute myeloid leukemiaJanyce A Sugui
Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, National Institutes ofHealth, Bethesda, Maryland 20817 1811, USA
J Clin Microbiol 49:2728-32. 2011..We believe this to be the first published report of a clinical case of mucormycosis due to M. velutinosus, as well as a rare case of dissemination from a deep site to skin... - Sexual reproduction in Aspergillus species of medical or economical importance: why so fastidious?Kyung J Kwon-Chung
Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Trends Microbiol 17:481-7. 2009.... - What do we know about the role of gliotoxin in the pathobiology of Aspergillus fumigatus?Kyung J Kwon-Chung
Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Med Mycol 47:S97-103. 2009..fumigatus. These studies indicate that the neutropenic mice model is inadequate to reveal the pathobiological importance of fungal secondary metabolites in invasive pulmonary aspergillosis... - Cryptococcosis: clinical and biological aspectsK J Kwon-Chung
Laboratory of Clinical Investigation, NIAID, NIH, Bethesda, MD 20892, USA
Med Mycol 38:205-13. 2000..neoformans. This review includes various areas of research interest ranging from pathobiology, biochemistry and immunology, to genomics... - Genes differentially expressed in conidia and hyphae of Aspergillus fumigatus upon exposure to human neutrophilsJanyce A Sugui
Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS ONE 3:e2655. 2008..fumigatus in response to neutrophils from healthy donors as well as from those with chronic granulomatous disease (CGD) which are defective in the production of reactive oxygen species... - Importance of mitochondria in survival of Cryptococcus neoformans under low oxygen conditions and tolerance to cobalt chlorideSusham S Ingavale
Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS Pathog 4:e1000155. 2008..These findings imply that multiple pathways are involved in oxygen sensing in C. neoformans... - Neosartorya udagawae (Aspergillus udagawae), an emerging agent of aspergillosis: how different is it from Aspergillus fumigatus?J A Sugui
Laboratory of Clinical Infectious Diseases, National Institutes of Health, 10 Center Drive, RM 11N234, Bethesda, MD 20892, USA
J Clin Microbiol 48:220-8. 2010..These findings suggest that growth and susceptibility to the host response might account for the reduced virulence of N. udagawae and the subtle distinction in the progression of the disease caused by the two species... - Cas3p belongs to a seven-member family of capsule structure designer proteinsFrédérique Moyrand
Unité de Mycologie Moléculaire, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
Eukaryot Cell 3:1513-24. 2004..Hence, these genes are all involved in assembly of the GXM structure in C. neoformans... - Complementation of a capsule deficient Cryptococcus neoformans with CAP64 restores virulence in a murine lung infectionJulie A Wilder
University of New Mexico School of Medicine, Department of Pathology, Albuquerque, New Mexico 87131-5301, USA
Am J Respir Cell Mol Biol 26:306-14. 2002..In summary, the cryptococcal capsule plays an important role in lung virulence and dissemination to the brain, and intact immunity is required to control lung growth of the encapsulated yeast... - Cryptococcus neoformans with a mutation in the tetratricopeptide repeat-containing gene, CCN1, causes subcutaneous lesions but fails to cause systemic infectionSeyung Chung
Molecular Microbiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Infect Immun 71:1988-94. 2003..CLF1 complemented the Ts phenotype of B-4551. CCN1, however, failed to rescue the clf1 mutant in S. cerevisiae. These results indicate that the Ccn1p may not be as functionally diverse as Clf1p in yeast... - Molecular analysis of CPRalpha, a MATalpha-specific pheromone receptor gene of Cryptococcus neoformansSeyung Chung
Molecular Microbiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 208921, USA
Eukaryot Cell 1:432-9. 2002..The delta cpr alpha cells, however, exhibited only basal levels of MFalpha message with or without pheromone exposure, suggesting that CPRalpha and MFalpha are components of the same signaling pathway... - Cryptococcal yeast cells invade the central nervous system via transcellular penetration of the blood-brain barrierYun C Chang
Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Infect Immun 72:4985-95. 2004..neoformans with the choroid plexus, however, was not detected during up to 10 days of observation. Our findings indicate that C. neoformans cells invade the central nervous system by transcellular crossing of the endothelium of the BBB... - Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells requires protein kinase C-alpha activationAmbrose Jong
Division of Hematology Oncology, Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
Cell Microbiol 10:1854-65. 2008..neoformans invasion. These results suggest a significant role of PKCalpha and downstream actin filament activity during the fungal invasion into HBMEC... - Involvement of human CD44 during Cryptococcus neoformans infection of brain microvascular endothelial cellsAmbrose Jong
Division of Hematology Oncology, The Saban Research Institute, Childrens Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA
Cell Microbiol 10:1313-26. 2008..Our results highlight the interactions between C. neoformans hyaluronic acid and host CD44 and the dynamic results of these interactions, which may represent events during the adhesion and entry of C. neoformans at HBMEC membrane rafts... - Identification and characterization of CPS1 as a hyaluronic acid synthase contributing to the pathogenesis of Cryptococcus neoformans infectionAmbrose Jong
Division of Hematology Oncology, Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
Eukaryot Cell 6:1486-96. 2007..Together, our results support that C. neoformans CPS1 encodes hyaluronic acid synthase and that its product, hyaluronic acid, plays a role as an adhesion molecule during the association of endothelial cells with yeast... - Sre1p, a regulator of oxygen sensing and sterol homeostasis, is required for virulence in Cryptococcus neoformansYun C Chang
National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA
Mol Microbiol 64:614-29. 2007..Animal studies confirm the importance of SRE1 for C. neoformans to adapt to the host environment and to cause fatal meningoencephalitis, thereby identifying the SREBP pathway as a therapeutic target for cryptococcosis... - Identification of a novel gene, URE2, that functionally complements a urease-negative clinical strain of Cryptococcus neoformansAshok Varma
Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Microbiology 152:3723-31. 2006..Furthermore, this study shows that complementation cloning can serve as a useful tool to functionally identify genes such as URE2 that have otherwise been annotated as hypothetical proteins in genomic databases...