Research Topics
Genomes and Genes | Sergei A KuznetsovSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
In vivo formation of bone and haematopoietic territories by transplanted human bone marrow stromal cells generated in medium with and without osteogenic supplementsSergei A Kuznetsov
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4370, USA
J Tissue Eng Regen Med 7:226-35. 2013..Secondary to increased BMSC proliferation, Dex/AscP may stimulate bone formation if BMSCs and/or the transplantation system are less than optimal...- In vivo bone formation by progeny of human embryonic stem cellsSergei A Kuznetsov
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4370, USA
Stem Cells Dev 20:269-87. 2011.... - Enumeration of the colony-forming units-fibroblast from mouse and human bone marrow in normal and pathological conditionsSergei A Kuznetsov
Department of Health and Human Services, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4370, USA
Stem Cell Res 2:83-94. 2009..Our findings indicate that under appropriate culture conditions, CFE values may provide useful insights into bone/bone marrow pathophysiology... - Circulating skeletal stem cellsS A Kuznetsov
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA
J Cell Biol 153:1133-40. 2001..This is the first definitive proof of the existence of circulating skeletal stem cells in mammals... 
Circulating connective tissue precursors: extreme rarity in humans and chondrogenic potential in guinea pigsSergei A Kuznetsov
Craniofacial Research and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4370, USA
Stem Cells 25:1830-9. 2007..Disclosure of potential conflicts of interest is found at the end of this article...- Age-dependent demise of GNAS-mutated skeletal stem cells and "normalization" of fibrous dysplasia of boneSergei A Kuznetsov
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
J Bone Miner Res 23:1731-40. 2008..This suggests that activating GNAS mutations disrupt a pathway that is required for skeletal stem cell self-renewal... - The potential functional interaction of biglycan and WISP-1 in controlling differentiation and proliferation of osteogenic cellsColette A Inkson
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS Bethesda, Bethesda, MD 20892 4320, USA
Cells Tissues Organs 189:153-7. 2009..These preliminary data suggest that WISP-1 and BGN may functionally interact and control each other's activity, thus regulating the differentiation and proliferation of osteogenic cells... - The interplay of osteogenesis and hematopoiesis: expression of a constitutively active PTH/PTHrP receptor in osteogenic cells perturbs the establishment of hematopoiesis in bone and of skeletal stem cells in the bone marrowSergei A Kuznetsov
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
J Cell Biol 167:1113-22. 2004..Thus, PTH/PTHrP signaling is a major regulator of the ontogeny of the bone marrow and its stromal tissue, and of the skeletal stem cell compartment... - The establishment of a bank of stored clinical bone marrow stromal cell productsMarianna Sabatino
Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Building 10, Room 1C711, Bethesda, MD 20892 1184, USA
J Transl Med 10:23. 2012..For many applications a supply of cryopreserved products that can be used for acute therapy is needed. The establishment of a bank of BMSC products from healthy third party donors is described... - Long-term stable canine mandibular augmentation using autologous bone marrow stromal cells and hydroxyapatite/tricalcium phosphateSergei A Kuznetsov
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
Biomaterials 29:4211-6. 2008..In summary, HA/TCP particles alone undergo a high degree of resorption, while autologous cultured BMSC-HA/TCP transplants provide long-term bony augmentation of the mandible... - Wnt/β-catenin signaling is differentially regulated by Gα proteins and contributes to fibrous dysplasiaJean B Regard
National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 108:20101-6. 2011..Our data suggest that activated Gα proteins are playing physiologically significant roles during both skeletal development and disease by modulating Wnt/β-catenin signaling strength... - Global transcriptome analysis of human bone marrow stromal cells (BMSC) reveals proliferative, mobile and interactive cells that produce abundant extracellular matrix proteins, some of which may affect BMSC potencyJiaqiang Ren
Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1288, USA
Cytotherapy 13:661-74. 2011..Human BMSC were characterized to identify factors that might be responsible for their clinical effects and biomarkers for assessing their quality... - Skeletal ("mesenchymal") stem cells for tissue engineeringPamela Gehron Robey
Department of Health and Human Services, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
Methods Mol Med 140:83-99. 2007..The multipotency of SSCs is probed by in vivo transplantation assays. The ability of SSCs to generate a cell strain competent to form significant amounts of bone in vivo has led to the formulation of preclinical models of bone repair... - TGF-beta1 and WISP-1/CCN-4 can regulate each other's activity to cooperatively control osteoblast functionColette A Inkson
Craniofacial and Skeletal Diseases Branch, National Institutes of Craniofacial and Dental Research, National Institutes of Heath, DHHS, Bethesda, Maryland 20892, USA
J Cell Biochem 104:1865-78. 2008..Our data indicates that full-length WISP-1 and its variant WISP-1va are modulators of proliferation and osteogenic differentiation, and may be novel regulators of TGF-beta1 signaling in osteoblast-like cells... - A novel technique based on a PNA hybridization probe and FRET principle for quantification of mutant genotype in fibrous dysplasia/McCune-Albright syndromeAbdullah Karadag
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 4320, USA
Nucleic Acids Res 32:e63. 2004.... - A mosaic activating mutation in AKT1 associated with the Proteus syndromeMarjorie J Lindhurst
National Human Genome Research Institute, Bethesda, Maryland, USA
N Engl J Med 365:611-9. 2011..The Proteus syndrome is characterized by the overgrowth of skin, connective tissue, brain, and other tissues. It has been hypothesized that the syndrome is caused by somatic mosaicism for a mutation that is lethal in the nonmosaic state... - Cytotoxicity mediated by the Fas ligand (FasL)-activated apoptotic pathway in stem cellsJulia Mazar
Program on Physical Biology, NICHD, National Institutes of Health, Bethesda, MD 20892, USA
J Biol Chem 284:22022-8. 2009.... - Sensitive and specific method for detecting G protein-coupled receptor mRNAsArne Hansen
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institute of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Nat Methods 4:35-7. 2007..We present a method based on multiplex PCR and array detection of amplicons to assay GPCR gene expression with as little as 1 mug of total RNA, and using it, we profiled three human bone marrow stromal cell (BMSC) lines... - MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnoverK Holmbeck
MMP Unit, National Institute of Dental and Craniofacial Research, Bethesda, Maryland 20892, USA
Cell 99:81-92. 1999.... - Differential display of human marrow stromal cells reveals unique mRNA expression patterns in response to dexamethasoneS C Dieudonné
Craniofacial and Skeletal Diseases Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA
J Cell Biochem 76:231-43. 1999..J. Cell. Biochem. 76:231-243, 1999. Published 1999 Wiley-Liss, Inc... - In vivo bone formation by human bone marrow stromal cells: effect of carrier particle size and shapeM H Mankani
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
Biotechnol Bioeng 72:96-107. 2001..These findings provide necessary information for the successful clinical application of BMSC transplantation techniques... - Receptor tyrosine kinase expression in human bone marrow stromal cellsK Satomura
Craniofacial and Skeletal Diseases Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA
J Cell Physiol 177:426-38. 1998....