Sergei A Kuznetsov

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc In vivo formation of bone and haematopoietic territories by transplanted human bone marrow stromal cells generated in medium with and without osteogenic supplements
    Sergei A Kuznetsov
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4370, USA
    J Tissue Eng Regen Med 7:226-35. 2013
  2. pmc Enumeration of the colony-forming units-fibroblast from mouse and human bone marrow in normal and pathological conditions
    Sergei A Kuznetsov
    Department of Health and Human Services, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4370, USA
    Stem Cell Res 2:83-94. 2009
  3. pmc In vivo bone formation by progeny of human embryonic stem cells
    Sergei A Kuznetsov
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4370, USA
    Stem Cells Dev 20:269-87. 2011
  4. pmc Circulating skeletal stem cells
    S A Kuznetsov
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA
    J Cell Biol 153:1133-40. 2001
  5. ncbi request reprint Circulating connective tissue precursors: extreme rarity in humans and chondrogenic potential in guinea pigs
    Sergei A Kuznetsov
    Craniofacial Research and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4370, USA
    Stem Cells 25:1830-9. 2007
  6. pmc Age-dependent demise of GNAS-mutated skeletal stem cells and "normalization" of fibrous dysplasia of bone
    Sergei A Kuznetsov
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Bone Miner Res 23:1731-40. 2008
  7. pmc The interplay of osteogenesis and hematopoiesis: expression of a constitutively active PTH/PTHrP receptor in osteogenic cells perturbs the establishment of hematopoiesis in bone and of skeletal stem cells in the bone marrow
    Sergei A Kuznetsov
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 167:1113-22. 2004
  8. pmc The potential functional interaction of biglycan and WISP-1 in controlling differentiation and proliferation of osteogenic cells
    Colette A Inkson
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS Bethesda, Bethesda, MD 20892 4320, USA
    Cells Tissues Organs 189:153-7. 2009
  9. pmc The establishment of a bank of stored clinical bone marrow stromal cell products
    Marianna Sabatino
    Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Building 10, Room 1C711, Bethesda, MD 20892 1184, USA
    J Transl Med 10:23. 2012
  10. pmc Long-term stable canine mandibular augmentation using autologous bone marrow stromal cells and hydroxyapatite/tricalcium phosphate
    Sergei A Kuznetsov
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
    Biomaterials 29:4211-6. 2008

Collaborators

Detail Information

Publications24

  1. pmc In vivo formation of bone and haematopoietic territories by transplanted human bone marrow stromal cells generated in medium with and without osteogenic supplements
    Sergei A Kuznetsov
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4370, USA
    J Tissue Eng Regen Med 7:226-35. 2013
    ..Published 2011. This article is a U.S. Government work and is in the public domain in the USA...
  2. pmc Enumeration of the colony-forming units-fibroblast from mouse and human bone marrow in normal and pathological conditions
    Sergei A Kuznetsov
    Department of Health and Human Services, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4370, USA
    Stem Cell Res 2:83-94. 2009
    ..Our findings indicate that under appropriate culture conditions, CFE values may provide useful insights into bone/bone marrow pathophysiology...
  3. pmc In vivo bone formation by progeny of human embryonic stem cells
    Sergei A Kuznetsov
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4370, USA
    Stem Cells Dev 20:269-87. 2011
    ....
  4. pmc Circulating skeletal stem cells
    S A Kuznetsov
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA
    J Cell Biol 153:1133-40. 2001
    ..This is the first definitive proof of the existence of circulating skeletal stem cells in mammals...
  5. ncbi request reprint Circulating connective tissue precursors: extreme rarity in humans and chondrogenic potential in guinea pigs
    Sergei A Kuznetsov
    Craniofacial Research and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4370, USA
    Stem Cells 25:1830-9. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  6. pmc Age-dependent demise of GNAS-mutated skeletal stem cells and "normalization" of fibrous dysplasia of bone
    Sergei A Kuznetsov
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Bone Miner Res 23:1731-40. 2008
    ..This suggests that activating GNAS mutations disrupt a pathway that is required for skeletal stem cell self-renewal...
  7. pmc The interplay of osteogenesis and hematopoiesis: expression of a constitutively active PTH/PTHrP receptor in osteogenic cells perturbs the establishment of hematopoiesis in bone and of skeletal stem cells in the bone marrow
    Sergei A Kuznetsov
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 167:1113-22. 2004
    ..Thus, PTH/PTHrP signaling is a major regulator of the ontogeny of the bone marrow and its stromal tissue, and of the skeletal stem cell compartment...
  8. pmc The potential functional interaction of biglycan and WISP-1 in controlling differentiation and proliferation of osteogenic cells
    Colette A Inkson
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS Bethesda, Bethesda, MD 20892 4320, USA
    Cells Tissues Organs 189:153-7. 2009
    ..These preliminary data suggest that WISP-1 and BGN may functionally interact and control each other's activity, thus regulating the differentiation and proliferation of osteogenic cells...
  9. pmc The establishment of a bank of stored clinical bone marrow stromal cell products
    Marianna Sabatino
    Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Building 10, Room 1C711, Bethesda, MD 20892 1184, USA
    J Transl Med 10:23. 2012
    ..For many applications a supply of cryopreserved products that can be used for acute therapy is needed. The establishment of a bank of BMSC products from healthy third party donors is described...
  10. pmc Long-term stable canine mandibular augmentation using autologous bone marrow stromal cells and hydroxyapatite/tricalcium phosphate
    Sergei A Kuznetsov
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
    Biomaterials 29:4211-6. 2008
    ..In summary, HA/TCP particles alone undergo a high degree of resorption, while autologous cultured BMSC-HA/TCP transplants provide long-term bony augmentation of the mandible...
  11. pmc Wnt/β-catenin signaling is differentially regulated by Gα proteins and contributes to fibrous dysplasia
    Jean B Regard
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:20101-6. 2011
    ..Our data suggest that activated Gα proteins are playing physiologically significant roles during both skeletal development and disease by modulating Wnt/β-catenin signaling strength...
  12. pmc Global transcriptome analysis of human bone marrow stromal cells (BMSC) reveals proliferative, mobile and interactive cells that produce abundant extracellular matrix proteins, some of which may affect BMSC potency
    Jiaqiang Ren
    Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1288, USA
    Cytotherapy 13:661-74. 2011
    ..Human BMSC were characterized to identify factors that might be responsible for their clinical effects and biomarkers for assessing their quality...
  13. pmc TGF-beta1 and WISP-1/CCN-4 can regulate each other's activity to cooperatively control osteoblast function
    Colette A Inkson
    Craniofacial and Skeletal Diseases Branch, National Institutes of Craniofacial and Dental Research, National Institutes of Heath, DHHS, Bethesda, Maryland 20892, USA
    J Cell Biochem 104:1865-78. 2008
    ..Our data indicates that full-length WISP-1 and its variant WISP-1va are modulators of proliferation and osteogenic differentiation, and may be novel regulators of TGF-beta1 signaling in osteoblast-like cells...
  14. ncbi request reprint Skeletal ("mesenchymal") stem cells for tissue engineering
    Pamela Gehron Robey
    Department of Health and Human Services, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
    Methods Mol Med 140:83-99. 2007
    ..The multipotency of SSCs is probed by in vivo transplantation assays. The ability of SSCs to generate a cell strain competent to form significant amounts of bone in vivo has led to the formulation of preclinical models of bone repair...
  15. pmc Intra-subject variability in human bone marrow stromal cell (BMSC) replicative senescence: molecular changes associated with BMSC senescence
    Jiaqiang Ren
    Department of Transfusion Medicine, Clinical Center, National Institutes of Health, 10 Center Dr, Bethesda, MD 20892, USA Electronic address
    Stem Cell Res 11:1060-73. 2013
    ..The 24 BMSC age predictive genes will be useful in assessing the quality of clinical BMSC products. ..
  16. doi request reprint Bone marrow stromal cell assays: in vitro and in vivo
    Pamela Gehron Robey
    National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, USA
    Methods Mol Biol 1130:279-93. 2014
    ..Application of these assays in an appropriate fashion provides a great deal of information on the role of BMSCs, and the subset of SSCs, in health and in disease...
  17. ncbi request reprint Sensitive and specific method for detecting G protein-coupled receptor mRNAs
    Arne Hansen
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institute of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Nat Methods 4:35-7. 2007
    ..We present a method based on multiplex PCR and array detection of amplicons to assay GPCR gene expression with as little as 1 mug of total RNA, and using it, we profiled three human bone marrow stromal cell (BMSC) lines...
  18. pmc A novel technique based on a PNA hybridization probe and FRET principle for quantification of mutant genotype in fibrous dysplasia/McCune-Albright syndrome
    Abdullah Karadag
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 4320, USA
    Nucleic Acids Res 32:e63. 2004
    ....
  19. pmc Cytotoxicity mediated by the Fas ligand (FasL)-activated apoptotic pathway in stem cells
    Julia Mazar
    Program on Physical Biology, NICHD, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 284:22022-8. 2009
    ....
  20. pmc A mosaic activating mutation in AKT1 associated with the Proteus syndrome
    Marjorie J Lindhurst
    National Human Genome Research Institute, Bethesda, Maryland, USA
    N Engl J Med 365:611-9. 2011
    ..The Proteus syndrome is characterized by the overgrowth of skin, connective tissue, brain, and other tissues. It has been hypothesized that the syndrome is caused by somatic mosaicism for a mutation that is lethal in the nonmosaic state...
  21. ncbi request reprint MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover
    K Holmbeck
    MMP Unit, National Institute of Dental and Craniofacial Research, Bethesda, Maryland 20892, USA
    Cell 99:81-92. 1999
    ....
  22. ncbi request reprint In vivo bone formation by human bone marrow stromal cells: effect of carrier particle size and shape
    M H Mankani
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    Biotechnol Bioeng 72:96-107. 2001
    ..These findings provide necessary information for the successful clinical application of BMSC transplantation techniques...
  23. ncbi request reprint Differential display of human marrow stromal cells reveals unique mRNA expression patterns in response to dexamethasone
    S C Dieudonné
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Biochem 76:231-43. 1999
    ..J. Cell. Biochem. 76:231-243, 1999. Published 1999 Wiley-Liss, Inc...
  24. ncbi request reprint Receptor tyrosine kinase expression in human bone marrow stromal cells
    K Satomura
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Physiol 177:426-38. 1998
    ....