Alexander Kuzin

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Nerfin-1 is required for early axon guidance decisions in the developing Drosophila CNS
    Alexander Kuzin
    Neural Cell Fate Determinants Section, NINDS, NIH, Bethesda MD 20892 4160, USA
    Dev Biol 277:347-65. 2005
  2. ncbi The Drosophila nerfin-1 mRNA requires multiple microRNAs to regulate its spatial and temporal translation dynamics in the developing nervous system
    Alexander Kuzin
    Neural Cell Fate Determinants Section, NINDS, NIH, Bethesda, MD, USA
    Dev Biol 310:35-43. 2007
  3. ncbi Functional analysis of conserved sequences within a temporally restricted neural precursor cell enhancer
    Alexander Kuzin
    Neural Cell Fate Determinants Section, NINDS, NIH Bethesda, MD, USA
    Mech Dev 128:165-77. 2011
  4. ncbi Conserved sequence block clustering and flanking inter-cluster flexibility delineate enhancers that regulate nerfin-1 expression during Drosophila CNS development
    Alexander Kuzin
    Neural Cell Fate Determinants Section, NINDS, NIH, Bethesda, MD, USA
    Gene Expr Patterns 9:65-72. 2009
  5. ncbi Sequence conservation and combinatorial complexity of Drosophila neural precursor cell enhancers
    Thomas Brody
    Neural Cell Fate Determinants Section, NINDS, NIH, Bethesda, Maryland, USA
    BMC Genomics 9:371. 2008
  6. ncbi cis-Decoder discovers constellations of conserved DNA sequences shared among tissue-specific enhancers
    Thomas Brody
    Neural Cell Fate Determinants Section, NINDS, NIH, Bethesda, MD 20892, USA
    Genome Biol 8:R75. 2007
  7. ncbi Use of a Drosophila genome-wide conserved sequence database to identify functionally related cis-regulatory enhancers
    Thomas Brody
    Neural Cell Fate Determinants Section, NINDS, NIH, Bethesda, Maryland 20892, USA
    Dev Dyn 241:169-89. 2012
  8. ncbi EVOPRINTER, a multigenomic comparative tool for rapid identification of functionally important DNA
    Ward F Odenwald
    Neural Cell Fate Determinants Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:14700-5. 2005
  9. ncbi The cis-regulatory dynamics of the Drosophila CNS determinant castor are controlled by multiple sub-pattern enhancers
    Alexander Kuzin
    Neural Cell Fate Determinants Section, NINDS, NIH 9000 Rockville Pike, Bethesda, MD 20892, USA
    Gene Expr Patterns 12:261-72. 2012
  10. ncbi Horizontal gene transfers link a human MRSA pathogen to contagious bovine mastitis bacteria
    Thomas Brody
    The Neural Cell Fate Determinants Section, National Institutes of Health NIH, Bethesda, Maryland, USA
    PLoS ONE 3:e3074. 2008

Detail Information

Publications11

  1. ncbi Nerfin-1 is required for early axon guidance decisions in the developing Drosophila CNS
    Alexander Kuzin
    Neural Cell Fate Determinants Section, NINDS, NIH, Bethesda MD 20892 4160, USA
    Dev Biol 277:347-65. 2005
    ..Our studies also show that Nerfin-1 is essential for the proper expression of robo2, wnt5, derailed, G-oalpha47A, Lar, and futsch, genes whose encoded proteins participate in these early navigational events...
  2. ncbi The Drosophila nerfin-1 mRNA requires multiple microRNAs to regulate its spatial and temporal translation dynamics in the developing nervous system
    Alexander Kuzin
    Neural Cell Fate Determinants Section, NINDS, NIH, Bethesda, MD, USA
    Dev Biol 310:35-43. 2007
    ....
  3. ncbi Functional analysis of conserved sequences within a temporally restricted neural precursor cell enhancer
    Alexander Kuzin
    Neural Cell Fate Determinants Section, NINDS, NIH Bethesda, MD, USA
    Mech Dev 128:165-77. 2011
    ..Our work also points to an unexpectedly large number of TFs required for optimal enhancer function - mutant TF analysis has identified at least four that are required for full enhancer regulation...
  4. ncbi Conserved sequence block clustering and flanking inter-cluster flexibility delineate enhancers that regulate nerfin-1 expression during Drosophila CNS development
    Alexander Kuzin
    Neural Cell Fate Determinants Section, NINDS, NIH, Bethesda, MD, USA
    Gene Expr Patterns 9:65-72. 2009
    ..In summary, EvoPrinter facilitates the discovery and analysis of enhancers that control crucial aspects of nerfin-1 expression...
  5. ncbi Sequence conservation and combinatorial complexity of Drosophila neural precursor cell enhancers
    Thomas Brody
    Neural Cell Fate Determinants Section, NINDS, NIH, Bethesda, Maryland, USA
    BMC Genomics 9:371. 2008
    ..We describe the use of EvoPrinter and cis-Decoder, a suite of interrelated phylogenetic footprinting and alignment programs, to characterize highly conserved sequences that are shared among co-regulating enhancers...
  6. ncbi cis-Decoder discovers constellations of conserved DNA sequences shared among tissue-specific enhancers
    Thomas Brody
    Neural Cell Fate Determinants Section, NINDS, NIH, Bethesda, MD 20892, USA
    Genome Biol 8:R75. 2007
    ..Our findings suggest that enhancers employ overlapping repertoires of highly conserved core elements...
  7. ncbi Use of a Drosophila genome-wide conserved sequence database to identify functionally related cis-regulatory enhancers
    Thomas Brody
    Neural Cell Fate Determinants Section, NINDS, NIH, Bethesda, Maryland 20892, USA
    Dev Dyn 241:169-89. 2012
    ..Currently, there is no systematic approach for enhancer discovery and analysis that takes full-advantage of the sequence information within enhancer CSCs...
  8. ncbi EVOPRINTER, a multigenomic comparative tool for rapid identification of functionally important DNA
    Ward F Odenwald
    Neural Cell Fate Determinants Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:14700-5. 2005
    ..Also, evoprinter allows one to assess the degree of evolutionary divergence between orthologous DNAs by highlighting differences between a selected species and the other test species...
  9. ncbi The cis-regulatory dynamics of the Drosophila CNS determinant castor are controlled by multiple sub-pattern enhancers
    Alexander Kuzin
    Neural Cell Fate Determinants Section, NINDS, NIH 9000 Rockville Pike, Bethesda, MD 20892, USA
    Gene Expr Patterns 12:261-72. 2012
    ..Cas limits the expression of one enhancer while two others require cas function for full expression. These studies represent a starting point for the further analysis of cas gene expression and the TFs that regulate it...
  10. ncbi Horizontal gene transfers link a human MRSA pathogen to contagious bovine mastitis bacteria
    Thomas Brody
    The Neural Cell Fate Determinants Section, National Institutes of Health NIH, Bethesda, Maryland, USA
    PLoS ONE 3:e3074. 2008
    ..We have adapted the multi-genome alignment tool EvoPrinter to facilitate discovery of HGT DNA sequences within bacterial genomes and within their mobile genetic elements...
  11. ncbi Drosophila homeodomain protein Nkx6 coordinates motoneuron subtype identity and axonogenesis
    Heather T Broihier
    Department of Genetics, Washington University School of Medicine, 4566 Scott Avenue, St Louis, MO 63110, USA
    Development 131:5233-42. 2004
    ..Thus, this work demonstrates that Nkx6 acts in a specific neuronal population to link neuronal subtype identity to neuronal morphology and connectivity...