Affiliation: National Institutes of Health
- Distinct regulation of osmoprotective genes in yeast and mammals. Aldose reductase osmotic response element is induced independent of p38 and stress-activated protein kinase/Jun N-terminal kinase in rabbit kidney cellsD Kultz
Laboratory of Kidney and Electrolyte Metabolism, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 0951, USA
J Biol Chem 272:13165-70. 1997..This finding stands in contrast to the requirement for the HOG1 pathway for hyperosmotically induced activation of yeast GPD1...
- Phylogenetic and functional classification of mitogen- and stress-activated protein kinasesD Kultz
Laboratory of Kidney and Electrolyte Metabolism, NHLBI, National Institutes of Health, 10 Center Drive, MSC 1603, Building 10 Room 6N260, Bethesda, MD 20892 1603, USA
J Mol Evol 46:571-88. 1998..These unique residues are likely to be crucial for subfamily-specific interactions of MAPKs with substrates, inhibitors, or activators and, therefore, represent excellent targets for site-directed mutagenesis experiments...
- Hyperosmolality causes growth arrest of murine kidney cells. Induction of GADD45 and GADD153 by osmosensing via stress-activated protein kinase 2D Kultz
Laboratory of Kidney and Electrolyte Metabolism, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
J Biol Chem 273:13645-51. 1998....
- Evolution of osmotic stress signaling via MAP kinase cascadesD Kultz
Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA
J Exp Biol 201:3015-21. 1998..The evidence for this conjecture is discussed, and our current knowledge about osmotic stress signaling pathways in yeast, animals and plants is briefly reviewed...
- Protection of renal inner medullary epithelial cells from apoptosis by hypertonic stress-induced p53 activationN Dmitrieva
NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1603 and the Whitney Laboratory, University of Florida, St Augustine, Florida 32086 8623, USA
J Biol Chem 275:18243-7. 2000..We conclude that induction of active p53 in mIMCD3 cells by hypertonic stress contributes to cell survival...