Marika C Kullberg

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Helicobacter hepaticus-induced colitis in interleukin-10-deficient mice: cytokine requirements for the induction and maintenance of intestinal inflammation
    M C Kullberg
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 0425, USA
    Infect Immun 69:4232-41. 2001
  2. pmc Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus-induced colitis
    Marika C Kullberg
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases NIH, Building 50, Room 6146, 50 South Drive, Bethesda, MD 20892, USA
    J Exp Med 196:505-15. 2002
  3. pmc Induction of colitis by a CD4+ T cell clone specific for a bacterial epitope
    Marika C Kullberg
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:15830-5. 2003
  4. pmc Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection
    Dragana Jankovic
    Immunobiology Section and 2Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:273-83. 2007
  5. pmc IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis
    Marika C Kullberg
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:2485-94. 2006
  6. ncbi request reprint TGF-beta1 production by CD4+ CD25+ regulatory T cells is not essential for suppression of intestinal inflammation
    Marika C Kullberg
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Eur J Immunol 35:2886-95. 2005
  7. ncbi request reprint Parasite-induced Th2 polarization is associated with down-regulated dendritic cell responsiveness to Th1 stimuli and a transient delay in T lymphocyte cycling
    Dragana Jankovic
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 173:2419-27. 2004
  8. ncbi request reprint In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting
    Dragana Jankovic
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 16:429-39. 2002
  9. pmc Transgenic mice expressing human interleukin-10 in the antigen-presenting cell compartment show increased susceptibility to infection with Mycobacterium avium associated with decreased macrophage effector function and apoptosis
    Carl G Feng
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Infect Immun 70:6672-9. 2002
  10. ncbi request reprint Mechanisms underlying helminth- induced Th2 polarization: default, negative or positive pathways?
    Dragana Jankovic
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8003, USA
    Chem Immunol Allergy 90:65-81. 2006

Detail Information

Publications12

  1. pmc Helicobacter hepaticus-induced colitis in interleukin-10-deficient mice: cytokine requirements for the induction and maintenance of intestinal inflammation
    M C Kullberg
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 0425, USA
    Infect Immun 69:4232-41. 2001
    ..Taken together, our results demonstrate a crucial role for IL-12 in both inducing and sustaining intestinal inflammation through recruitment and maintenance of a pool of pathogenic Th1 cells...
  2. pmc Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus-induced colitis
    Marika C Kullberg
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases NIH, Building 50, Room 6146, 50 South Drive, Bethesda, MD 20892, USA
    J Exp Med 196:505-15. 2002
    ..The induction of such cells in response to gut flora may be a mechanism protecting normal individuals against inflammatory bowel disease...
  3. pmc Induction of colitis by a CD4+ T cell clone specific for a bacterial epitope
    Marika C Kullberg
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:15830-5. 2003
    ....
  4. pmc Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection
    Dragana Jankovic
    Immunobiology Section and 2Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:273-83. 2007
    ..These findings indicate that IL-10 production by CD4(+) T lymphocytes need not involve a distinct regulatory Th cell subset but can be generated in Th1 cells as part of the effector response to intracellular pathogens...
  5. pmc IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis
    Marika C Kullberg
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:2485-94. 2006
    ....
  6. ncbi request reprint TGF-beta1 production by CD4+ CD25+ regulatory T cells is not essential for suppression of intestinal inflammation
    Marika C Kullberg
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Eur J Immunol 35:2886-95. 2005
    ....
  7. ncbi request reprint Parasite-induced Th2 polarization is associated with down-regulated dendritic cell responsiveness to Th1 stimuli and a transient delay in T lymphocyte cycling
    Dragana Jankovic
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 173:2419-27. 2004
    ..Together, these findings suggest that the emergence of IL-4-producing CD4(+) lymphocytes results from a suppression in DC function leading to a temporary delay in initial T cell cycling...
  8. ncbi request reprint In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting
    Dragana Jankovic
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 16:429-39. 2002
    ....
  9. pmc Transgenic mice expressing human interleukin-10 in the antigen-presenting cell compartment show increased susceptibility to infection with Mycobacterium avium associated with decreased macrophage effector function and apoptosis
    Carl G Feng
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Infect Immun 70:6672-9. 2002
    ..Together, these data indicate that APC-derived IL-10 can exert a major inhibitory effect on control of mycobacterial infection by a mechanism involving the suppression of macrophage effector function and apoptosis...
  10. ncbi request reprint Mechanisms underlying helminth- induced Th2 polarization: default, negative or positive pathways?
    Dragana Jankovic
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8003, USA
    Chem Immunol Allergy 90:65-81. 2006
    ..negative vs. the absence of signals from antigen-presenting cells. In addition, we will discuss the similarities between the pathways involved in parasite- and allergen-induced Th2 differentiation...
  11. pmc Interleukin-23 drives innate and T cell-mediated intestinal inflammation
    Sophie Hue
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, England, UK
    J Exp Med 203:2473-83. 2006
    ..These results newly identify IL-23 as a driver of innate immune pathology in the intestine and suggest that selective targeting of IL-23 represents an attractive therapeutic approach in human IBD...
  12. doi request reprint Immunology: soothing intestinal sugars
    Marika C Kullberg
    Nature 453:602-4. 2008