Jens H Kuhn

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Clarification and guidance on the proper usage of virus and virus species names
    Jens H Kuhn
    Integrated Research Facility at Fort Detrick IRF Frederick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, B 8200 Research Plaza, Fort Detrick, Frederick, MD 21702, USA
    Arch Virol 155:445-53. 2010
  2. pmc Nyamiviridae: proposal for a new family in the order Mononegavirales
    Jens H Kuhn
    Integrated Research Facility at Fort Detrick IRF Frederick, Division of Clinical Research DCR, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, B 8200 Research Plaza, Fort Detrick, Frederick, MD, 21702, USA
    Arch Virol 158:2209-26. 2013
  3. pmc The International Code of Virus Classification and Nomenclature (ICVCN): proposal for text changes for improved differentiation of viral taxa and viruses
    Jens H Kuhn
    Integrated Research Facility at Fort Detrick IRF Frederick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases NIH, B 8200 Research Plaza, Fort Detrick, Frederick, MD 21702, USA
    Arch Virol 158:1621-9. 2013
  4. pmc Virus nomenclature below the species level: a standardized nomenclature for laboratory animal-adapted strains and variants of viruses assigned to the family Filoviridae
    Jens H Kuhn
    Integrated Research Facility at Fort Detrick IRF Frederick, Division of Clinical Research DCR, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, B 8200 Research Plaza, Fort Detrick, Frederick, MD, 21702, USA
    Arch Virol 158:1425-32. 2013
  5. pmc Virus nomenclature below the species level: a standardized nomenclature for natural variants of viruses assigned to the family Filoviridae
    Jens H Kuhn
    Integrated Research Facility at Fort Detrick IRF Frederick, Division of Clinical Research DCR, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, B 8200 Research Plaza, Fort Detrick, Frederick, MD, 21702, USA
    Arch Virol 158:301-11. 2013
  6. pmc The International Code of Virus Classification and Nomenclature (ICVCN): proposal to delete Rule 3.41
    Jens H Kuhn
    Integrated Research Facility at Fort Detrick IRF Frederick, Division of Clinical Research DCR, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Fort Detrick, Frederick, MD, USA
    Arch Virol 158:297-9. 2013
  7. pmc Induction of ebolavirus cross-species immunity using retrovirus-like particles bearing the Ebola virus glycoprotein lacking the mucin-like domain
    Wu Ou
    Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Bldg, 29B, Room 5NN22, 8800 Rockville Pike, Bethesda, MD 20892, USA
    Virol J 9:32. 2012
  8. pmc Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations
    Jens H Kuhn
    Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, National Interagency Biodefense Campus, B 8200 Research Plaza, Fort Detrick, Frederick, MD 21702, USA
    Arch Virol 155:2083-103. 2010
  9. pmc Evaluation of perceived threat differences posed by filovirus variants
    Jens H Kuhn
    National Institutes of Health, National Institute of Allergy and Infectious Diseases, Division of Clinical Research, Integrated Research Facility at Fort Detrick, Frederick, Maryland, USA
    Biosecur Bioterror 9:361-71. 2011
  10. pmc Drug discovery technologies and strategies for Machupo virus and other New World arenaviruses
    Sheli R Radoshitzky
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA
    Expert Opin Drug Discov 7:613-32. 2012

Collaborators

Detail Information

Publications20

  1. pmc Clarification and guidance on the proper usage of virus and virus species names
    Jens H Kuhn
    Integrated Research Facility at Fort Detrick IRF Frederick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, B 8200 Research Plaza, Fort Detrick, Frederick, MD 21702, USA
    Arch Virol 155:445-53. 2010
    ....
  2. pmc Nyamiviridae: proposal for a new family in the order Mononegavirales
    Jens H Kuhn
    Integrated Research Facility at Fort Detrick IRF Frederick, Division of Clinical Research DCR, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, B 8200 Research Plaza, Fort Detrick, Frederick, MD, 21702, USA
    Arch Virol 158:2209-26. 2013
    ..Here, we review the current knowledge about all three viruses and propose classifying them as members of a new mononegaviral family, Nyamiviridae. ..
  3. pmc The International Code of Virus Classification and Nomenclature (ICVCN): proposal for text changes for improved differentiation of viral taxa and viruses
    Jens H Kuhn
    Integrated Research Facility at Fort Detrick IRF Frederick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases NIH, B 8200 Research Plaza, Fort Detrick, Frederick, MD 21702, USA
    Arch Virol 158:1621-9. 2013
    ..Here, Code text changes are proposed to address this problem. ..
  4. pmc Virus nomenclature below the species level: a standardized nomenclature for laboratory animal-adapted strains and variants of viruses assigned to the family Filoviridae
    Jens H Kuhn
    Integrated Research Facility at Fort Detrick IRF Frederick, Division of Clinical Research DCR, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, B 8200 Research Plaza, Fort Detrick, Frederick, MD, 21702, USA
    Arch Virol 158:1425-32. 2013
    ..EBOV" would suffice if only one EBOV strain/variant/isolate is addressed...
  5. pmc Virus nomenclature below the species level: a standardized nomenclature for natural variants of viruses assigned to the family Filoviridae
    Jens H Kuhn
    Integrated Research Facility at Fort Detrick IRF Frederick, Division of Clinical Research DCR, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, B 8200 Research Plaza, Fort Detrick, Frederick, MD, 21702, USA
    Arch Virol 158:301-11. 2013
    ..Most importantly, it would counter the increasing confusion in genetic variant naming due to the identification of ever more sequences through technological breakthroughs in high-throughput sequencing and environmental sampling...
  6. pmc The International Code of Virus Classification and Nomenclature (ICVCN): proposal to delete Rule 3.41
    Jens H Kuhn
    Integrated Research Facility at Fort Detrick IRF Frederick, Division of Clinical Research DCR, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Fort Detrick, Frederick, MD, USA
    Arch Virol 158:297-9. 2013
    ..It is proposed to delete Rule 3.41 of the International Code of Virus Classification and Nomenclature, which requires the name of a virus taxon to precede the term for the taxonomic unit...
  7. pmc Induction of ebolavirus cross-species immunity using retrovirus-like particles bearing the Ebola virus glycoprotein lacking the mucin-like domain
    Wu Ou
    Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Bldg, 29B, Room 5NN22, 8800 Rockville Pike, Bethesda, MD 20892, USA
    Virol J 9:32. 2012
    ..We hypothesized that immunization with MLD-deleted GP1,2 (GPΔMLD) would induce cross-species immunity by making more conserved regions accessible to the immune system...
  8. pmc Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations
    Jens H Kuhn
    Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, National Interagency Biodefense Campus, B 8200 Research Plaza, Fort Detrick, Frederick, MD 21702, USA
    Arch Virol 155:2083-103. 2010
    ..Furthermore, we explain the etymological derivation of individual names, their pronunciation, and their correct use, and we elaborate on demarcation criteria for each taxon and virus...
  9. pmc Evaluation of perceived threat differences posed by filovirus variants
    Jens H Kuhn
    National Institutes of Health, National Institute of Allergy and Infectious Diseases, Division of Clinical Research, Integrated Research Facility at Fort Detrick, Frederick, Maryland, USA
    Biosecur Bioterror 9:361-71. 2011
    ....
  10. pmc Drug discovery technologies and strategies for Machupo virus and other New World arenaviruses
    Sheli R Radoshitzky
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA
    Expert Opin Drug Discov 7:613-32. 2012
    ..All of these viruses are Risk Group 4 biosafety pathogens. MACV causes human disease outbreak with high case-fatality rates. To date, at least 1,200 cases with ≈200 fatalities have been recorded...
  11. pmc Ebolavirus delta-peptide immunoadhesins inhibit marburgvirus and ebolavirus cell entry
    Sheli R Radoshitzky
    U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702, USA
    J Virol 85:8502-13. 2011
    ..They join cathepsins and integrins as novel modulators of filovirus cell entry, might play important roles in pathogenesis, and could be exploited for the synthesis of powerful new antivirals...
  12. pmc Nonhuman transferrin receptor 1 is an efficient cell entry receptor for Ocozocoautla de Espinosa virus
    Yingyun Cai
    Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, Maryland, USA
    J Virol 87:13930-5. 2013
    ..Interestingly, OCEV and Tacaribe virus could use bat, but not human, TfR1. Replacing three human TfR1 amino acids with their bat ortholog counterparts transformed human TfR1 into an efficient OCEV and Tacaribe virus receptor. ..
  13. pmc Development and characterization of rabbit and mouse antibodies against ebolavirus envelope glycoproteins
    Wu Ou
    Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, FDA, Bethesda, MD, USA
    J Virol Methods 174:99-109. 2011
    ..Together, our results suggest that this panel of antibodies may prove useful for both in vitro analyses of ebolavirus GP₁,₂, as well as analysis of clinically relevant samples...
  14. doi request reprint Crimean-Congo hemorrhagic fever virus utilizes a clathrin- and early endosome-dependent entry pathway
    Aura R Garrison
    United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Maryland, USA
    Virology 444:45-54. 2013
    ..These results indicate that CCHFV likely enters cells through the early endosomal compartment. ..
  15. doi request reprint ABSL-4 aerobiology biosafety and technology at the NIH/NIAID integrated research facility at Fort Detrick
    Matthew G Lackemeyer
    Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, MD 21702, USA
    Viruses 6:137-50. 2014
    ..Here, we provide a brief overview of the animal biosafety level 4 Aerobiology Core at the NIH/NIAID Integrated Research Facility at Fort Detrick, Maryland, USA. ..
  16. pmc Minigenomes, transcription and replication competent virus-like particles and beyond: reverse genetics systems for filoviruses and other negative stranded hemorrhagic fever viruses
    Thomas Hoenen
    Laboratory of Virology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA Department of Virology, Philipps University Marburg, Marburg, Germany
    Antiviral Res 91:195-208. 2011
    ....
  17. pmc IFITM-2 and IFITM-3 but not IFITM-1 restrict Rift Valley fever virus
    Rajini Mudhasani
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland USA
    J Virol 87:8451-64. 2013
    ..Collectively, our data provide new insights into the possible mechanisms by which the IFITM family members restrict distinct viruses. ..
  18. doi request reprint Crimean-Congo hemorrhagic fever: current and future prospects of vaccines and therapies
    Maryam Keshtkar-Jahromi
    Union Memorial Hospital, University of Maryland, Baltimore, MD, USA
    Antiviral Res 90:85-92. 2011
    ..CCHF-immunoglobulin is also in use, but without clear evidence of efficacy. In this article, we review the development of prophylaxis and therapy for CCHF and discuss future prospects for vaccine and drug development...
  19. pmc Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin
    Sheli R Radoshitzky
    U S Army Medical Research Institute of Infectious Diseases, 1425 Porter St, Fort Detrick, Frederick, MD 21702, USA
    J Virol 84:10569-80. 2010
    ..Our results demonstrate that BST-2 might be a broad antiviral factor with the ability to restrict release of a wide variety of human pathogens. However, at least filoviruses, RVFV, and CPXV are immune to its inhibitory effect...
  20. pmc Ebola virion attachment and entry into human macrophages profoundly effects early cellular gene expression
    Victoria Wahl-Jensen
    Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Maryland, United States of America
    PLoS Negl Trop Dis 5:e1359. 2011
    ..In contrast, VLP(VP40) (particles lacking GP(1,2)) caused an aberrant response. This suggests that GP(1,2) binding to macrophages plays an important role in the immediate cellular response...