Howard S Kruth

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Receptor-independent fluid-phase pinocytosis mechanisms for induction of foam cell formation with native low-density lipoprotein particles
    Howard S Kruth
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 20892 1422, USA
    Curr Opin Lipidol 22:386-93. 2011
  2. ncbi request reprint Macropinocytosis is the endocytic pathway that mediates macrophage foam cell formation with native low density lipoprotein
    Howard S Kruth
    Section of Experimental Atherosclerosis, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1422, USA
    J Biol Chem 280:2352-60. 2005
  3. ncbi request reprint Protein kinase C beta and delta isoenzymes mediate cholesterol accumulation in PMA-activated macrophages
    Hong Tao Ma
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1422, USA
    Biochem Biophys Res Commun 349:214-20. 2006
  4. pmc Fluid-phase pinocytosis of native low density lipoprotein promotes murine M-CSF differentiated macrophage foam cell formation
    Manoj K Barthwal
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 8:e58054. 2013
  5. pmc Native low-density lipoprotein uptake by macrophage colony-stimulating factor-differentiated human macrophages is mediated by macropinocytosis and micropinocytosis
    Joshua J Anzinger
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1422, USA
    Arterioscler Thromb Vasc Biol 30:2022-31. 2010
  6. pmc Heterogeneity of human macrophages in culture and in atherosclerotic plaques
    Stephen W Waldo
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892 1422, USA
    Am J Pathol 172:1112-26. 2008
  7. pmc Extracellular cholesterol-rich microdomains generated by human macrophages and their potential function in reverse cholesterol transport
    Daniel S Ong
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1422, USA
    J Lipid Res 51:2303-13. 2010
  8. ncbi request reprint Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL
    Chiara Buono
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892 1422, USA
    J Lipid Res 48:2411-8. 2007
  9. pmc Murine bone marrow-derived macrophages differentiated with GM-CSF become foam cells by PI3Kγ-dependent fluid-phase pinocytosis of native LDL
    Joshua J Anzinger
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    J Lipid Res 53:34-42. 2012
  10. ncbi request reprint PMA activation of macrophages alters macrophage metabolism of aggregated LDL
    Wei Huang
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10, Room 5N 113, 10 Center Drive MSC 1422, Bethesda, MD 20892, USA
    J Lipid Res 43:1275-82. 2002

Collaborators

Detail Information

Publications19

  1. doi request reprint Receptor-independent fluid-phase pinocytosis mechanisms for induction of foam cell formation with native low-density lipoprotein particles
    Howard S Kruth
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 20892 1422, USA
    Curr Opin Lipidol 22:386-93. 2011
    ..The purpose of this review is to discuss recent findings showing that native unmodified LDL can induce massive macrophage cholesterol accumulation mimicking macrophage foam cell formation that occurs within atherosclerotic plaques...
  2. ncbi request reprint Macropinocytosis is the endocytic pathway that mediates macrophage foam cell formation with native low density lipoprotein
    Howard S Kruth
    Section of Experimental Atherosclerosis, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1422, USA
    J Biol Chem 280:2352-60. 2005
    ..Macropinocytosis in macrophages and possibly other vascular cells is a new pathway to target for modulating foam cell formation in atherosclerosis...
  3. ncbi request reprint Protein kinase C beta and delta isoenzymes mediate cholesterol accumulation in PMA-activated macrophages
    Hong Tao Ma
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1422, USA
    Biochem Biophys Res Commun 349:214-20. 2006
    ..Thus, our findings show that beta and some other PKC isoenzyme, most likely delta, mediate cholesterol accumulation when macropinocytosis of LDL is stimulated in PMA-activated human monocyte-derived macrophages...
  4. pmc Fluid-phase pinocytosis of native low density lipoprotein promotes murine M-CSF differentiated macrophage foam cell formation
    Manoj K Barthwal
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 8:e58054. 2013
    ..In conclusion, our findings provide evidence that targeting those components mediating macrophage macropinocytosis with inhibitors may be an effective strategy to limit macrophage accumulation of LDL-derived cholesterol in arteries...
  5. pmc Native low-density lipoprotein uptake by macrophage colony-stimulating factor-differentiated human macrophages is mediated by macropinocytosis and micropinocytosis
    Joshua J Anzinger
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1422, USA
    Arterioscler Thromb Vasc Biol 30:2022-31. 2010
    ..To examine the pinocytotic pathways mediating native low-density lipoprotein (LDL) uptake by human macrophage colony-stimulating factor-differentiated macrophages (the predominant macrophage phenotype in human atherosclerotic plaques)...
  6. pmc Heterogeneity of human macrophages in culture and in atherosclerotic plaques
    Stephen W Waldo
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892 1422, USA
    Am J Pathol 172:1112-26. 2008
    ....
  7. pmc Extracellular cholesterol-rich microdomains generated by human macrophages and their potential function in reverse cholesterol transport
    Daniel S Ong
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1422, USA
    J Lipid Res 51:2303-13. 2010
    ....
  8. ncbi request reprint Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL
    Chiara Buono
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892 1422, USA
    J Lipid Res 48:2411-8. 2007
    ..The findings reveal an additional new mechanism by which LXR agonists may inhibit macrophage cholesterol accumulation and atherosclerosis, namely, by inhibiting macrophage uptake of LDL...
  9. pmc Murine bone marrow-derived macrophages differentiated with GM-CSF become foam cells by PI3Kγ-dependent fluid-phase pinocytosis of native LDL
    Joshua J Anzinger
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    J Lipid Res 53:34-42. 2012
    ..These results show that GM-CSF-differentiated murine macrophages become foam cells by fluid-phase pinocytosis of LDL and identify PI3Kγ as contributing to this process...
  10. ncbi request reprint PMA activation of macrophages alters macrophage metabolism of aggregated LDL
    Wei Huang
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10, Room 5N 113, 10 Center Drive MSC 1422, Bethesda, MD 20892, USA
    J Lipid Res 43:1275-82. 2002
    ..This results in more cholesterol to be stored in macrophages and less aggregated LDL to be available for plasmin-mediated release from macrophage SCCs...
  11. ncbi request reprint Constitutive receptor-independent low density lipoprotein uptake and cholesterol accumulation by macrophages differentiated from human monocytes with macrophage-colony-stimulating factor (M-CSF)
    Bin Zhao
    Section of Experimental Atherosclerosis, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1422, USA
    J Biol Chem 281:15757-62. 2006
    ..This mechanism of macrophage foam cell formation does not depend on LDL modification or macrophage receptors...
  12. ncbi request reprint Retention of aggregated LDL by cultured human coronary artery endothelial cells
    Bin Zhao
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 321:728-35. 2004
    ..Thus, it is unlikely that endothelial cells can transport AgLDL out of atherosclerotic lesions, but it is likely that retention of AgLDL affects endothelial function...
  13. pmc Fluorescent pegylated nanoparticles demonstrate fluid-phase pinocytosis by macrophages in mouse atherosclerotic lesions
    Chiara Buono
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute NHLBI, NIH, Bethesda, Maryland 20892 1422, USA
    J Clin Invest 119:1373-81. 2009
    ..These results show that macrophages within atherosclerotic lesions can take up LDL-sized nanoparticles by fluid-phase pinocytosis and indicate that fluid-phase pinocytosis of LDL is a mechanism for macrophage foam cell formation in vivo...
  14. pmc Evaluation of transduction efficiency in macrophage colony-stimulating factor differentiated human macrophages using HIV-1 based lentiviral vectors
    Francisco J Leyva
    Experimental Atherosclerosis Section, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA
    BMC Biotechnol 11:13. 2011
    ..The objective of this study was to determine transduction efficiency of two HIV-based lentiviral vector configurations as delivery systems for the transduction of primary human blood monocyte-derived macrophages...
  15. pmc UBIAD1 mutation alters a mitochondrial prenyltransferase to cause Schnyder corneal dystrophy
    Michael L Nickerson
    Cancer and Inflammation Program, National Cancer Institute, National Institutes of Health, Frederick, Maryland, USA
    PLoS ONE 5:e10760. 2010
    ..We characterized lesions in the UBIAD1 gene in new SCD families and examined protein homology, localization, and structure...
  16. doi request reprint ABCG1-mediated generation of extracellular cholesterol microdomains
    Sebastian R Freeman
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
    J Lipid Res 55:115-27. 2014
    ..Our findings show that generation of extracellular cholesterol microdomains is mediated by ABCG1 and that reverse cholesterol transport occurs not only at the cell surface but also within the extracellular space. ..
  17. ncbi request reprint Sequestration of aggregated low-density lipoproteins by macrophages
    Howard S Kruth
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute NIH, Buiulding 10, Room 5N113, 10 Center Drive MSC 1422, Bethesda, MD 20892 1422, USA
    Curr Opin Lipidol 13:483-8. 2002
    ..This review discusses a novel endocytic pathway by which macrophages process aggregated LDL...
  18. ncbi request reprint Macrophage foam cell formation with native low density lipoprotein
    Howard S Kruth
    Section of Experimental Atherosclerosis, NHLBI National Institutes of Health, Bldg 10 Rm 5N 113, 10 Center Drive, MSC 1422, Bethesda, MD 20892, USA
    J Biol Chem 277:34573-80. 2002
    ..In addition, the findings direct attention to macrophage fluid phase endocytosis as a relevant pathway to target for modulating macrophage cholesterol accumulation in atherosclerosis...
  19. ncbi request reprint Histopathology and regression of retinal hard exudates in diabetic retinopathy after reduction of elevated serum lipid levels
    Michael Cusick
    Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ophthalmology 110:2126-33. 2003
    ..To describe a regression of retinal hard exudates in 2 patients with diabetic maculopathy, and to report immunohistologic findings reflecting lipid deposition in the retina...