H S Kruth

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Macrophage foam cells and atherosclerosis
    H S Kruth
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1422, USA
    Front Biosci 6:D429-55. 2001
  2. pmc Fluid-phase pinocytosis of native low density lipoprotein promotes murine M-CSF differentiated macrophage foam cell formation
    Manoj K Barthwal
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 8:e58054. 2013
  3. ncbi request reprint Fluid-phase pinocytosis of LDL by macrophages: a novel target to reduce macrophage cholesterol accumulation in atherosclerotic lesions
    Howar S Kruth
    Section of Experimental Atherosclerosis, NHLBI, National Institutes of Health, Building 10, Room 5N 113, 10 Center Drive MSC 1422, Bethesda, MD 20892 1422
    Curr Pharm Des 19:5865-72. 2013
  4. pmc Evaluation of transduction efficiency in macrophage colony-stimulating factor differentiated human macrophages using HIV-1 based lentiviral vectors
    Francisco J Leyva
    Experimental Atherosclerosis Section, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA
    BMC Biotechnol 11:13. 2011
  5. ncbi request reprint Sequestration of aggregated low-density lipoproteins by macrophages
    Howard S Kruth
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute NIH, Buiulding 10, Room 5N113, 10 Center Drive MSC 1422, Bethesda, MD 20892 1422, USA
    Curr Opin Lipidol 13:483-8. 2002
  6. ncbi request reprint Macropinocytosis is the endocytic pathway that mediates macrophage foam cell formation with native low density lipoprotein
    Howard S Kruth
    Section of Experimental Atherosclerosis, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1422, USA
    J Biol Chem 280:2352-60. 2005
  7. ncbi request reprint Macrophage foam cell formation with native low density lipoprotein
    Howard S Kruth
    Section of Experimental Atherosclerosis, NHLBI National Institutes of Health, Bldg 10 Rm 5N 113, 10 Center Drive, MSC 1422, Bethesda, MD 20892, USA
    J Biol Chem 277:34573-80. 2002
  8. ncbi request reprint Lipoprotein cholesterol and atherosclerosis
    H S Kruth
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1422, USA
    Curr Mol Med 1:633-53. 2001
  9. ncbi request reprint Monoclonal antibody detection of plasma membrane cholesterol microdomains responsive to cholesterol trafficking
    H S Kruth
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Lipid Res 42:1492-500. 2001
  10. ncbi request reprint Characterization of patocytosis: endocytosis into macrophage surface-connected compartments
    H S Kruth
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1422, USA
    Eur J Cell Biol 78:91-9. 1999

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Macrophage foam cells and atherosclerosis
    H S Kruth
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1422, USA
    Front Biosci 6:D429-55. 2001
    ..Some cytokines, hormones, and pharmacologic agents show potential to modulate these processes and may be useful in directing macrophage function in atherosclerotic lesions towards beneficial rather than harmful effects...
  2. pmc Fluid-phase pinocytosis of native low density lipoprotein promotes murine M-CSF differentiated macrophage foam cell formation
    Manoj K Barthwal
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 8:e58054. 2013
    ..In conclusion, our findings provide evidence that targeting those components mediating macrophage macropinocytosis with inhibitors may be an effective strategy to limit macrophage accumulation of LDL-derived cholesterol in arteries...
  3. ncbi request reprint Fluid-phase pinocytosis of LDL by macrophages: a novel target to reduce macrophage cholesterol accumulation in atherosclerotic lesions
    Howar S Kruth
    Section of Experimental Atherosclerosis, NHLBI, National Institutes of Health, Building 10, Room 5N 113, 10 Center Drive MSC 1422, Bethesda, MD 20892 1422
    Curr Pharm Des 19:5865-72. 2013
    ....
  4. pmc Evaluation of transduction efficiency in macrophage colony-stimulating factor differentiated human macrophages using HIV-1 based lentiviral vectors
    Francisco J Leyva
    Experimental Atherosclerosis Section, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA
    BMC Biotechnol 11:13. 2011
    ..The objective of this study was to determine transduction efficiency of two HIV-based lentiviral vector configurations as delivery systems for the transduction of primary human blood monocyte-derived macrophages...
  5. ncbi request reprint Sequestration of aggregated low-density lipoproteins by macrophages
    Howard S Kruth
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute NIH, Buiulding 10, Room 5N113, 10 Center Drive MSC 1422, Bethesda, MD 20892 1422, USA
    Curr Opin Lipidol 13:483-8. 2002
    ..This review discusses a novel endocytic pathway by which macrophages process aggregated LDL...
  6. ncbi request reprint Macropinocytosis is the endocytic pathway that mediates macrophage foam cell formation with native low density lipoprotein
    Howard S Kruth
    Section of Experimental Atherosclerosis, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1422, USA
    J Biol Chem 280:2352-60. 2005
    ..Macropinocytosis in macrophages and possibly other vascular cells is a new pathway to target for modulating foam cell formation in atherosclerosis...
  7. ncbi request reprint Macrophage foam cell formation with native low density lipoprotein
    Howard S Kruth
    Section of Experimental Atherosclerosis, NHLBI National Institutes of Health, Bldg 10 Rm 5N 113, 10 Center Drive, MSC 1422, Bethesda, MD 20892, USA
    J Biol Chem 277:34573-80. 2002
    ..In addition, the findings direct attention to macrophage fluid phase endocytosis as a relevant pathway to target for modulating macrophage cholesterol accumulation in atherosclerosis...
  8. ncbi request reprint Lipoprotein cholesterol and atherosclerosis
    H S Kruth
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1422, USA
    Curr Mol Med 1:633-53. 2001
    ..How these processes are believed to contribute to cholesterol buildup in atherosclerotic plaques is discussed...
  9. ncbi request reprint Monoclonal antibody detection of plasma membrane cholesterol microdomains responsive to cholesterol trafficking
    H S Kruth
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Lipid Res 42:1492-500. 2001
    ..For the first time, cholesterol microdomains have been visualized that function in cholesterol trafficking to and from the plasma membrane...
  10. ncbi request reprint Characterization of patocytosis: endocytosis into macrophage surface-connected compartments
    H S Kruth
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1422, USA
    Eur J Cell Biol 78:91-9. 1999
    ..Patocytosis is a unique endocytic process in macrophages triggered by small hydrophobic particles that provides a mechanism to sequester large amounts of these materials within a labyrinth of SCC...
  11. ncbi request reprint Apolipoprotein B stimulates formation of monocyte-macrophage surface-connected compartments and mediates uptake of low density lipoprotein-derived liposomes into these compartments
    H S Kruth
    Section of Experimental Atherosclerosis, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 274:7495-500. 1999
    ....
  12. ncbi request reprint PMA activation of macrophages alters macrophage metabolism of aggregated LDL
    Wei Huang
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10, Room 5N 113, 10 Center Drive MSC 1422, Bethesda, MD 20892, USA
    J Lipid Res 43:1275-82. 2002
    ..This results in more cholesterol to be stored in macrophages and less aggregated LDL to be available for plasmin-mediated release from macrophage SCCs...
  13. ncbi request reprint Cholesterol accumulation in human cornea: evidence that extracellular cholesteryl ester-rich lipid particles deposit independently of foam cells
    P M Gaynor
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Lipid Res 37:1849-61. 1996
    ....
  14. pmc UBIAD1 mutation alters a mitochondrial prenyltransferase to cause Schnyder corneal dystrophy
    Michael L Nickerson
    Cancer and Inflammation Program, National Cancer Institute, National Institutes of Health, Frederick, Maryland, USA
    PLoS ONE 5:e10760. 2010
    ..We characterized lesions in the UBIAD1 gene in new SCD families and examined protein homology, localization, and structure...
  15. ncbi request reprint Protein kinase C beta and delta isoenzymes mediate cholesterol accumulation in PMA-activated macrophages
    Hong Tao Ma
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1422, USA
    Biochem Biophys Res Commun 349:214-20. 2006
    ..Thus, our findings show that beta and some other PKC isoenzyme, most likely delta, mediate cholesterol accumulation when macropinocytosis of LDL is stimulated in PMA-activated human monocyte-derived macrophages...
  16. pmc Fluorescent pegylated nanoparticles demonstrate fluid-phase pinocytosis by macrophages in mouse atherosclerotic lesions
    Chiara Buono
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute NHLBI, NIH, Bethesda, Maryland 20892 1422, USA
    J Clin Invest 119:1373-81. 2009
    ..These results show that macrophages within atherosclerotic lesions can take up LDL-sized nanoparticles by fluid-phase pinocytosis and indicate that fluid-phase pinocytosis of LDL is a mechanism for macrophage foam cell formation in vivo...
  17. ncbi request reprint Apolipoprotein A-I and B distribution in the human cornea
    F Ashraf
    Clinical Branch, National Eye Institute, National Institutes of Health, Bethesda, MD 20892
    Invest Ophthalmol Vis Sci 34:3574-8. 1993
    ....
  18. ncbi request reprint Constitutive receptor-independent low density lipoprotein uptake and cholesterol accumulation by macrophages differentiated from human monocytes with macrophage-colony-stimulating factor (M-CSF)
    Bin Zhao
    Section of Experimental Atherosclerosis, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1422, USA
    J Biol Chem 281:15757-62. 2006
    ..This mechanism of macrophage foam cell formation does not depend on LDL modification or macrophage receptors...
  19. ncbi request reprint Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL
    Chiara Buono
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892 1422, USA
    J Lipid Res 48:2411-8. 2007
    ..The findings reveal an additional new mechanism by which LXR agonists may inhibit macrophage cholesterol accumulation and atherosclerosis, namely, by inhibiting macrophage uptake of LDL...
  20. pmc Native low-density lipoprotein uptake by macrophage colony-stimulating factor-differentiated human macrophages is mediated by macropinocytosis and micropinocytosis
    Joshua J Anzinger
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1422, USA
    Arterioscler Thromb Vasc Biol 30:2022-31. 2010
    ..To examine the pinocytotic pathways mediating native low-density lipoprotein (LDL) uptake by human macrophage colony-stimulating factor-differentiated macrophages (the predominant macrophage phenotype in human atherosclerotic plaques)...
  21. ncbi request reprint Retention of aggregated LDL by cultured human coronary artery endothelial cells
    Bin Zhao
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 321:728-35. 2004
    ..Thus, it is unlikely that endothelial cells can transport AgLDL out of atherosclerotic lesions, but it is likely that retention of AgLDL affects endothelial function...
  22. pmc Heterogeneity of human macrophages in culture and in atherosclerotic plaques
    Stephen W Waldo
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892 1422, USA
    Am J Pathol 172:1112-26. 2008
    ....
  23. pmc Extracellular cholesterol-rich microdomains generated by human macrophages and their potential function in reverse cholesterol transport
    Daniel S Ong
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1422, USA
    J Lipid Res 51:2303-13. 2010
    ....
  24. ncbi request reprint Histopathology and regression of retinal hard exudates in diabetic retinopathy after reduction of elevated serum lipid levels
    Michael Cusick
    Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ophthalmology 110:2126-33. 2003
    ..To describe a regression of retinal hard exudates in 2 patients with diabetic maculopathy, and to report immunohistologic findings reflecting lipid deposition in the retina...
  25. ncbi request reprint Accumulation of cholesterol in the lesions of focal segmental glomerulosclerosis
    Hyun Soon Lee
    Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
    Nephrology (Carlton) 8:224-3. 2003
    ..These results suggest that both EC and UC accumulate in the sclerotic glomerular segments as the glomerular lesions are advanced, and that these EC and UC appear to be derived from altered LDL with progressive loss of apo B...
  26. ncbi request reprint Lipoprotein-like particles and cholesteryl esters in human Bruch's membrane: initial characterization
    Chuan ming Li
    Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, AL 35294 009, USA
    Invest Ophthalmol Vis Sci 46:2576-86. 2005
    ..To isolate and characterize cholesteryl ester-containing, lipoprotein-like particles (LLPs) from normal aged human Bruch's membrane (BrM)/choroid (Ch)...
  27. ncbi request reprint Intraplaque hemorrhage and progression of coronary atheroma
    Frank D Kolodgie
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    N Engl J Med 349:2316-25. 2003
    ..Intraplaque hemorrhage is common in advanced coronary atherosclerotic lesions. The relation between hemorrhage and the vulnerability of plaque to disruption may involve the accumulation of free cholesterol from erythrocyte membranes...
  28. ncbi request reprint Esterified and unesterified cholesterol in drusen and basal deposits of eyes with age-related maculopathy
    Christine A Curcio
    Department of Ophthalmology, Callahan Eye Foundation Hospital, University of Alabama School of Medicine, 700 South 18th Street, Room H020, Birmingham AL 35294 0009, USA
    Exp Eye Res 81:731-41. 2005
    ..UC in sub-RPE deposits cannot be derived directly from OS without considerable intracellular processing within RPE, additional cholesterol sources, or both...
  29. ncbi request reprint Structural information about organized cholesterol domains from specific antibody recognition
    Lia Addadi
    Department of Structural Biology, Weizmann Institute of Science, 76100 Rehovot, Israel
    Biochim Biophys Acta 1610:208-16. 2003
    ..The information that such antibodies could provide in cells is finally examined together with a proof of application...