Arnold S Kristof

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Mitogen-activated protein kinases mediate activator protein-1-dependent human inducible nitric-oxide synthase promoter activation
    A S Kristof
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1434, USA
    J Biol Chem 276:8445-52. 2001
  2. ncbi request reprint Stimulation of signal transducer and activator of transcription-1 (STAT1)-dependent gene transcription by lipopolysaccharide and interferon-gamma is regulated by mammalian target of rapamycin
    Arnold S Kristof
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:33637-44. 2003
  3. ncbi request reprint LY303511 (2-piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of rapamycin (mTOR)- and non-mTOR-dependent mechanisms
    Arnold S Kristof
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Pharmacol Exp Ther 314:1134-43. 2005
  4. ncbi request reprint Phosphatidylinositol 3-kinase-dependent suppression of the human inducible nitric-oxide synthase promoter is mediated by FKHRL1
    Arnold S Kristof
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:23958-68. 2006
  5. pmc Paradoxical effects of rapamycin on experimental house dust mite-induced asthma
    Karin Fredriksson
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 7:e33984. 2012
  6. ncbi request reprint Maximal oxygen uptake and severity of disease in lymphangioleiomyomatosis
    Angelo M Taveira-Dasilva
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1590, USA
    Am J Respir Crit Care Med 168:1427-31. 2003
  7. ncbi request reprint Giles F. Filley Lecture. Genetics and gene expression in lymphangioleiomyomatosis
    Gustavo Pacheco-Rodriguez
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1590, USA
    Chest 121:56S-60S. 2002
  8. doi request reprint Angiopoietin-1 promotes endothelial cell proliferation and migration through AP-1-dependent autocrine production of interleukin-8
    Nelly A Abdel-Malak
    Critical Care and Respiratory Divisions and Meakins Christie Laboratories, Department of Medicine, McGill University Health Centre, McGill University, Montreal, QC, Canada
    Blood 111:4145-54. 2008

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Mitogen-activated protein kinases mediate activator protein-1-dependent human inducible nitric-oxide synthase promoter activation
    A S Kristof
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1434, USA
    J Biol Chem 276:8445-52. 2001
    ..Thus, p38- and ERK-dependent pathways, through effects on the AP-1 complex, activate the hiNOS promoter in cells stimulated with CM or LPS/IFN-gamma...
  2. ncbi request reprint Stimulation of signal transducer and activator of transcription-1 (STAT1)-dependent gene transcription by lipopolysaccharide and interferon-gamma is regulated by mammalian target of rapamycin
    Arnold S Kristof
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:33637-44. 2003
    ..Thus, LPS and IFN-gamma activate the PI3K and mTOR pathways, which converge to regulate STAT1-dependent transcription of pro-apoptotic and pro-inflammatory genes in a rapamycin-insensitive manner...
  3. ncbi request reprint LY303511 (2-piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of rapamycin (mTOR)- and non-mTOR-dependent mechanisms
    Arnold S Kristof
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Pharmacol Exp Ther 314:1134-43. 2005
    ..Given its inhibition of cell proliferation via mTOR-dependent and independent mechanisms, LY303511 has therapeutic potential with antineoplastic actions that are independent of PI3K inhibition...
  4. ncbi request reprint Phosphatidylinositol 3-kinase-dependent suppression of the human inducible nitric-oxide synthase promoter is mediated by FKHRL1
    Arnold S Kristof
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:23958-68. 2006
    ..Regulation of the hiNOS promoter by FKHRL1 represents a potentially important molecular mechanism by which the PI3K pathway might suppress pro-inflammatory and proapoptotic responses to cytokines and bacterial products...
  5. pmc Paradoxical effects of rapamycin on experimental house dust mite-induced asthma
    Karin Fredriksson
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 7:e33984. 2012
    ..Thus, consistent with the context-dependent effects of rapamycin on inflammation, the timing of mTOR inhibition may be an important determinant of efficacy and toxicity in HDM-induced asthma...
  6. ncbi request reprint Maximal oxygen uptake and severity of disease in lymphangioleiomyomatosis
    Angelo M Taveira-Dasilva
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1590, USA
    Am J Respir Crit Care Med 168:1427-31. 2003
    ..We conclude that CPET uncovers the presence of exercise-induced hypoxemia and assists in grading the severity of disease and determining supplemental oxygen requirements in patients with LAM...
  7. ncbi request reprint Giles F. Filley Lecture. Genetics and gene expression in lymphangioleiomyomatosis
    Gustavo Pacheco-Rodriguez
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1590, USA
    Chest 121:56S-60S. 2002
    ....
  8. doi request reprint Angiopoietin-1 promotes endothelial cell proliferation and migration through AP-1-dependent autocrine production of interleukin-8
    Nelly A Abdel-Malak
    Critical Care and Respiratory Divisions and Meakins Christie Laboratories, Department of Medicine, McGill University Health Centre, McGill University, Montreal, QC, Canada
    Blood 111:4145-54. 2008
    ....