Research Topics
Species | Christian P KratzSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
The clinical utility of testicular cancer risk lociChristian P Kratz
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Rockville, MD 20852, USA
Genome Med 3:1. 2011..Here, we discuss the question of whether the newly identified risk polymorphisms can be used to guide patient care...- Cancer in Noonan, Costello, cardiofaciocutaneous and LEOPARD syndromesChristian P Kratz
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Boulevard, EPS 7018, Rockville, MD 20892, USA
Am J Med Genet C Semin Med Genet 157:83-9. 2011..The cancers described in CFCS and NSML overlapped with those reported in NS and CS. Future epidemiologic studies will be required to confirm the described cancer spectrum and to estimate precise cancer risks... - A stratified genetic risk assessment for testicular cancerC P Kratz
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
Int J Androl 34:e98-102. 2011..More research is required before we can utilize testicular cancer-risk loci for clinically meaningful risk prediction... - Variants in or near KITLG, BAK1, DMRT1, and TERT-CLPTM1L predispose to familial testicular germ cell tumourChristian P Kratz
Division of CancerEpidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA
J Med Genet 48:473-6. 2011..Familial testicular germ cell tumours (TGCTs) and bilateral TGCTs comprise 1-2% and 5% of all TGCTs, respectively, but their genetic basis remains largely unknown... - Familial testicular germ cell tumoursChristian P Kratz
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA
Best Pract Res Clin Endocrinol Metab 24:503-13. 2010..Notably, all five loci are involved in the biology of primordial germ cells, representing the cell of origin of TGCT, suggesting that the tumours arise as a result of disturbed testicular development... - Familial testicular germ cell tumors in adults: 2010 summary of genetic risk factors and clinical phenotypeMark H Greene
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852, USA
Endocr Relat Cancer 17:R109-21. 2010..All five loci are involved in normal testicular development and/or male infertility. These genetic data provide a novel insight into the genetic basis of FTGCT, and an invaluable guide to future TGCT research... - Promoter methylation of candidate genes associated with familial testicular cancerLisa Mirabello
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services Bethesda, Maryland, USA
Int J Mol Epidemiol Genet 3:213-27. 2012..Our results suggest that familial TGCT susceptibility may be associated with promoter methylation of previously-identified TGCT risk-modifying genes. Larger studies are warranted... - Detectable clonal mosaicism and its relationship to aging and cancerKevin B Jacobs
Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Rockville, Maryland, USA
Nat Genet 44:651-8. 2012..4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases...