Christian P Kratz

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Variants in or near KITLG, BAK1, DMRT1, and TERT-CLPTM1L predispose to familial testicular germ cell tumour
    Christian P Kratz
    Division of CancerEpidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA
    J Med Genet 48:473-6. 2011
  2. pmc The clinical utility of testicular cancer risk loci
    Christian P Kratz
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Genome Med 3:1. 2011
  3. pmc Cancer in Noonan, Costello, cardiofaciocutaneous and LEOPARD syndromes
    Christian P Kratz
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Boulevard, EPS 7018, Rockville, MD 20892, USA
    Am J Med Genet C Semin Med Genet 157:83-9. 2011
  4. pmc A stratified genetic risk assessment for testicular cancer
    C P Kratz
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
    Int J Androl 34:e98-102. 2011
  5. pmc Meta-analysis identifies four new loci associated with testicular germ cell tumor
    Charles C Chung
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, US National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA
    Nat Genet 45:680-5. 2013
  6. pmc Cyclic AMP and c-KIT signaling in familial testicular germ cell tumor predisposition
    Monalisa F Azevedo
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 98:E1393-400. 2013
  7. pmc Familial testicular germ cell tumours
    Christian P Kratz
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA
    Best Pract Res Clin Endocrinol Metab 24:503-13. 2010
  8. pmc Familial testicular germ cell tumors in adults: 2010 summary of genetic risk factors and clinical phenotype
    Mark H Greene
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852, USA
    Endocr Relat Cancer 17:R109-21. 2010
  9. pmc Erythrocyte adenosine deaminase: diagnostic value for Diamond-Blackfan anaemia
    John H Fargo
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Br J Haematol 160:547-54. 2013
  10. pmc Promoter methylation of candidate genes associated with familial testicular cancer
    Lisa Mirabello
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services Bethesda, Maryland, USA
    Int J Mol Epidemiol Genet 3:213-27. 2012

Detail Information

Publications11

  1. pmc Variants in or near KITLG, BAK1, DMRT1, and TERT-CLPTM1L predispose to familial testicular germ cell tumour
    Christian P Kratz
    Division of CancerEpidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA
    J Med Genet 48:473-6. 2011
    ..Familial testicular germ cell tumours (TGCTs) and bilateral TGCTs comprise 1-2% and 5% of all TGCTs, respectively, but their genetic basis remains largely unknown...
  2. pmc The clinical utility of testicular cancer risk loci
    Christian P Kratz
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Genome Med 3:1. 2011
    ..Here, we discuss the question of whether the newly identified risk polymorphisms can be used to guide patient care...
  3. pmc Cancer in Noonan, Costello, cardiofaciocutaneous and LEOPARD syndromes
    Christian P Kratz
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Boulevard, EPS 7018, Rockville, MD 20892, USA
    Am J Med Genet C Semin Med Genet 157:83-9. 2011
    ..The cancers described in CFCS and NSML overlapped with those reported in NS and CS. Future epidemiologic studies will be required to confirm the described cancer spectrum and to estimate precise cancer risks...
  4. pmc A stratified genetic risk assessment for testicular cancer
    C P Kratz
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
    Int J Androl 34:e98-102. 2011
    ..More research is required before we can utilize testicular cancer-risk loci for clinically meaningful risk prediction...
  5. pmc Meta-analysis identifies four new loci associated with testicular germ cell tumor
    Charles C Chung
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, US National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA
    Nat Genet 45:680-5. 2013
    ..These new TGCT susceptibility loci contain biologically plausible genes encoding proteins important for male germ cell development, chromosomal segregation and the DNA damage response...
  6. pmc Cyclic AMP and c-KIT signaling in familial testicular germ cell tumor predisposition
    Monalisa F Azevedo
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 98:E1393-400. 2013
    ....
  7. pmc Familial testicular germ cell tumours
    Christian P Kratz
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA
    Best Pract Res Clin Endocrinol Metab 24:503-13. 2010
    ..Notably, all five loci are involved in the biology of primordial germ cells, representing the cell of origin of TGCT, suggesting that the tumours arise as a result of disturbed testicular development...
  8. pmc Familial testicular germ cell tumors in adults: 2010 summary of genetic risk factors and clinical phenotype
    Mark H Greene
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852, USA
    Endocr Relat Cancer 17:R109-21. 2010
    ..All five loci are involved in normal testicular development and/or male infertility. These genetic data provide a novel insight into the genetic basis of FTGCT, and an invaluable guide to future TGCT research...
  9. pmc Erythrocyte adenosine deaminase: diagnostic value for Diamond-Blackfan anaemia
    John H Fargo
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Br J Haematol 160:547-54. 2013
    ..Erythrocyte ADA segregated with, as well as independent of, known DBA gene mutations. While eADA was an excellent confirmatory test for DBA, 16% of patients with classical clinical DBA had a normal eADA...
  10. pmc Promoter methylation of candidate genes associated with familial testicular cancer
    Lisa Mirabello
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services Bethesda, Maryland, USA
    Int J Mol Epidemiol Genet 3:213-27. 2012
    ..Our results suggest that familial TGCT susceptibility may be associated with promoter methylation of previously-identified TGCT risk-modifying genes. Larger studies are warranted...
  11. pmc Detectable clonal mosaicism and its relationship to aging and cancer
    Kevin B Jacobs
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Rockville, Maryland, USA
    Nat Genet 44:651-8. 2012
    ..4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases...