Christine A Kozak

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Evolution of different antiviral strategies in wild mouse populations exposed to different gammaretroviruses
    Christine A Kozak
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, United States Electronic address
    Curr Opin Virol 3:657-63. 2013
  2. pmc Moloney murine leukemia virus glyco-gag facilitates xenotropic murine leukemia virus-related virus replication through human APOBEC3-independent mechanisms
    Takayuki Nitta
    Department of Molecular Biology and Biochemistry and Cancer Research Institute, University of California, Irvine, CA 92697 3905, USA
    Retrovirology 9:58. 2012
  3. pmc Viewpoint on Emv2, the onlhy endogenous ecotropic murine leukemia virus of C57BL/6 mice
    Christine A Kozak
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, 4 Center Drive MSC 0460, Bethesda, MD 20892 0460, USA
    Retrovirology 9:25. 2012
  4. pmc Evolution of functional and sequence variants of the mammalian XPR1 receptor for mouse xenotropic gammaretroviruses and the human-derived retrovirus XMRV
    Yuhe Yan
    NIH, NIAID, LMM, Bldg 4, Room 329, 4 Center Drive MSC 0460, Bethesda, MD 20892 0460
    J Virol 84:11970-80. 2010
  5. pmc The mouse "xenotropic" gammaretroviruses and their XPR1 receptor
    Christine A Kozak
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0460, USA
    Retrovirology 7:101. 2010
  6. pmc Rmcf2, a xenotropic provirus in the Asian mouse species Mus castaneus, blocks infection by polytropic mouse gammaretroviruses
    Tiyun Wu
    Laboratory of Molecular Microbiology, National Institute and Allergy and Infectious Diseases, Bethesda, MD 20892 0460, USA
    J Virol 79:9677-84. 2005
  7. pmc Role of receptor polymorphism and glycosylation in syncytium induction and host range variation of ecotropic mouse gammaretroviruses
    Yuhe Yan
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD, 20892 0460, USA
    Retrovirology 5:2. 2008
  8. pmc Removal of either N-glycan site from the envelope receptor binding domain of Moloney and Friend but not AKV mouse ecotropic gammaretroviruses alters receptor usage
    Ryan C Knoper
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0460, USA
    Virology 391:232-9. 2009
  9. pmc Origin, antiviral function and evidence for positive selection of the gammaretrovirus restriction gene Fv1 in the genus Mus
    Yuhe Yan
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0460, USA
    Proc Natl Acad Sci U S A 106:3259-63. 2009
  10. pmc Wild mouse variants of envelope genes of xenotropic/polytropic mouse gammaretroviruses and their XPR1 receptors elucidate receptor determinants of virus entry
    Yuhe Yan
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0460, USA
    J Virol 81:10550-7. 2007

Collaborators

Detail Information

Publications24

  1. pmc Evolution of different antiviral strategies in wild mouse populations exposed to different gammaretroviruses
    Christine A Kozak
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, United States Electronic address
    Curr Opin Virol 3:657-63. 2013
    ..These different antiviral restrictions in Mus musculus subspecies suggest that the different virus types found in these natural populations may pose different but largely uncharacterized survival risks in their host subspecies. ..
  2. pmc Moloney murine leukemia virus glyco-gag facilitates xenotropic murine leukemia virus-related virus replication through human APOBEC3-independent mechanisms
    Takayuki Nitta
    Department of Molecular Biology and Biochemistry and Cancer Research Institute, University of California, Irvine, CA 92697 3905, USA
    Retrovirology 9:58. 2012
    ..We examined XMRV to determine if its leader sequence contains glyco-gag activity, whether the presence of conventional gPr80Gag affects replication of XMRV, and we describe the evolution of glyco-gag-deficient MuLVs in Mus...
  3. pmc Viewpoint on Emv2, the onlhy endogenous ecotropic murine leukemia virus of C57BL/6 mice
    Christine A Kozak
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, 4 Center Drive MSC 0460, Bethesda, MD 20892 0460, USA
    Retrovirology 9:25. 2012
    ..Here I comment on the articles by Lee and colleagues (Retrovirology 2011, 8:82) and Lee and Cho (Retrovirology 2012, 9:23) dealing with an endogenous ecotropic mouse leukemia virus found in C57BL mice...
  4. pmc Evolution of functional and sequence variants of the mammalian XPR1 receptor for mouse xenotropic gammaretroviruses and the human-derived retrovirus XMRV
    Yuhe Yan
    NIH, NIAID, LMM, Bldg 4, Room 329, 4 Center Drive MSC 0460, Bethesda, MD 20892 0460
    J Virol 84:11970-80. 2010
    ....
  5. pmc The mouse "xenotropic" gammaretroviruses and their XPR1 receptor
    Christine A Kozak
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0460, USA
    Retrovirology 7:101. 2010
    ....
  6. pmc Rmcf2, a xenotropic provirus in the Asian mouse species Mus castaneus, blocks infection by polytropic mouse gammaretroviruses
    Tiyun Wu
    Laboratory of Molecular Microbiology, National Institute and Allergy and Infectious Diseases, Bethesda, MD 20892 0460, USA
    J Virol 79:9677-84. 2005
    ..This type of provirus Env-mediated resistance represents an important defense mechanism in wild mouse populations exposed to endemic infections...
  7. pmc Role of receptor polymorphism and glycosylation in syncytium induction and host range variation of ecotropic mouse gammaretroviruses
    Yuhe Yan
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD, 20892 0460, USA
    Retrovirology 5:2. 2008
    ..Because M. dunni cells carry a variant CAT-1 cell surface virus receptor (dCAT-1), we examined the role of this receptor variant in cytopathicity and host range...
  8. pmc Removal of either N-glycan site from the envelope receptor binding domain of Moloney and Friend but not AKV mouse ecotropic gammaretroviruses alters receptor usage
    Ryan C Knoper
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0460, USA
    Virology 391:232-9. 2009
    ..Virus envelope glycan size or type does not affect infectivity. Thus, host range variation due to N-glycan deletion is receptor variant-specific, cell-specific, virus type-specific, and glycan site-specific...
  9. pmc Origin, antiviral function and evidence for positive selection of the gammaretrovirus restriction gene Fv1 in the genus Mus
    Yuhe Yan
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0460, USA
    Proc Natl Acad Sci U S A 106:3259-63. 2009
    ..This analysis suggests that Fv1 has had an antiviral role throughout Mus evolution predating exposure of mice to the MLVs restricted by laboratory mouse Fv1, and suggests a mechanism for Fv1 restriction...
  10. pmc Wild mouse variants of envelope genes of xenotropic/polytropic mouse gammaretroviruses and their XPR1 receptors elucidate receptor determinants of virus entry
    Yuhe Yan
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0460, USA
    J Virol 81:10550-7. 2007
    ....
  11. pmc Generation of novel syncytium-inducing and host range variants of ecotropic moloney murine leukemia virus in Mus spicilegus
    Yong Tae Jung
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 0460, USA
    J Virol 77:5065-72. 2003
    ..dunni...
  12. pmc Second site mutation in the virus envelope expands the host range of a cytopathic variant of Moloney murine leukemia virus
    John Ferrarone
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0460, USA
    Virology 433:7-11. 2012
    ..Residues at env position 114 are thus important determinants of host range, and E114G suppresses host range restriction due to S82F, but does not affect S82F-governed cytopathicity...
  13. pmc Six host range variants of the xenotropic/polytropic gammaretroviruses define determinants for entry in the XPR1 cell surface receptor
    Yuhe Yan
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0460, USA
    Retrovirology 6:87. 2009
    ..The mouse xenotropic/polytropic (X/PMV) gammaretroviruses rely on the XPR1 cell surface receptor for entry into host cells, and polymorphic variants of this receptor have been identified in different rodent species...
  14. pmc Common inbred strains of the laboratory mouse that are susceptible to infection by mouse xenotropic gammaretroviruses and the human-derived retrovirus XMRV
    Surendranath Baliji
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    J Virol 84:12841-9. 2010
    ..Several strains with Xpr1(sxv) lack the active Bxv1 provirus or other endogenous X-MLVs and may provide a useful model system to evaluate the in vivo spread of these gammaretroviruses and their disease potential in their natural host...
  15. pmc Novel postentry resistance to AKV ecotropic mouse gammaretroviruses in the African pygmy mouse, Mus minutoides
    Yuhe Yan
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 0460, USA
    J Virol 82:6120-9. 2008
    ..M. minutoides cells thus have a novel postentry resistance to AKV MLVs...
  16. pmc Endogenous gammaretrovirus acquisition in Mus musculus subspecies carrying functional variants of the XPR1 virus receptor
    Devinka Bamunusinghe
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA
    J Virol 87:9845-55. 2013
    ..Thus, P-MLV ERVs show more insertional polymorphism than X-MLVs, and these differences in ERV acquisition and fixation are linked to subspecies-specific and functionally distinct XPR1 receptor variants. ..
  17. pmc Adaptive evolution of Mus Apobec3 includes retroviral insertion and positive selection at two clusters of residues flanking the substrate groove
    Bradley Sanville
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America
    PLoS Pathog 6:e1000974. 2010
    ....
  18. pmc Novel host range and cytopathic variant of ecotropic Friend murine leukemia virus
    Yong Tae Jung
    Labotratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases NIH, Bldg 4, Room 329, 4 Center Drive, MSC 0460, Bethesda, MD 20892 0460, USA
    J Virol 78:12189-97. 2004
    ..dunni and hamster cells have variant CAT-1 receptors, these results suggest that syncytium formation as well as altered host range may be a consequence of altered interaction between virus and receptor...
  19. pmc Characterization of a polytropic murine leukemia virus proviral sequence associated with the virus resistance gene Rmcf of DBA/2 mice
    Yong Tae Jung
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 0460, USA
    J Virol 76:8218-24. 2002
    ..This study identifies an Rmcf-linked MCF provirus and indicates that, like the ecotropic virus resistance gene Fv4, Rmcf may mediate resistance through an interference mechanism...
  20. pmc Characterization of recombinant nonecotropic murine leukemia viruses from the wild mouse species Mus spretus
    Yong Tae Jung
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 0460, USA
    J Virol 77:12773-81. 2003
    ..We conclude that the M. spretus proviruses are likely to be recent germ line acquisitions and that they contain functional genes that can contribute to the production of replication-competent virus...
  21. pmc The avian XPR1 gammaretrovirus receptor is under positive selection and is disabled in bird species in contact with virus-infected wild mice
    Carrie Martin
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA
    J Virol 87:10094-104. 2013
    ....
  22. pmc Genetic control of a mouse serum lipoprotein factor that inactivates murine leukemia viruses: evaluation of apolipoprotein F as a candidate
    Tiyun Wu
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Building 4, Room 329, 4 Center Drive, Bethesda, MD 20892 0460, USA
    J Virol 76:2279-86. 2002
    ....
  23. pmc Naturally Occurring Polymorphisms of the Mouse Gammaretrovirus Receptors CAT-1 and XPR1 Alter Virus Tropism and Pathogenicity
    Christine A Kozak
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0460, USA
    Adv Virol 2011:975801. 2011
    ....
  24. pmc Xenotropic murine leukemia virus-related virus is not associated with chronic fatigue syndrome in patients from different areas of the us in the 1990s
    Mir A Ali
    Medical Virology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Virol J 8:450. 2011
    ..Since then numerous reports failed to detect XMRV in other cohorts of CFS patients, and some studies suggested that XMRV sequences in human samples might be due to contamination of these samples with mouse DNA...