S Kottilil

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Innate immunity in human immunodeficiency virus infection: effect of viremia on natural killer cell function
    Shyam Kottilil
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases NIH, 9000 Wiscoinsin Avenue, Building 10, Room 6A08A, Bethesda, MD 20892, USA
    J Infect Dis 187:1038-45. 2003
  2. pmc Cytokine/chemokine patterns connect host and viral characteristics with clinics during chronic hepatitis C
    Antonios Katsounas
    Department of Gastroenterology and Hepatology, University Hospital of Essen, Germany
    Eur J Med Res 17:9. 2012
  3. ncbi request reprint Natural killer cells in HIV-1 infection: role of NK cell-mediated non-cytolytic mechanisms in pathogenesis of HIV-1 infection
    Shyam Kottilil
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institute of Health, Building 10, Room 6AI 1, 10 Center Drive, Bethesda, MD 20892, USA
    Indian J Exp Biol 41:1219-25. 2003
  4. ncbi request reprint Innate immune dysfunction in HIV infection: effect of HIV envelope-NK cell interactions
    Shyam Kottilil
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 176:1107-14. 2006
  5. pmc Human immunodeficiency virus and hepatitis C infections induce distinct immunologic imprints in peripheral mononuclear cells
    Shyam Kottilil
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Hepatology 50:34-45. 2009
  6. ncbi request reprint Expression of chemokine and inhibitory receptors on natural killer cells: effect of immune activation and HIV viremia
    S Kottilil
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 189:1193-8. 2004
  7. ncbi request reprint Changes in hepatitis C viral response after initiation of highly active antiretroviral therapy and control of HIV viremia in chronically co-infected individuals
    Shyam Kottilil
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    HIV Clin Trials 5:25-32. 2004
  8. ncbi request reprint Innate immunity in HIV infection: enhanced susceptibility to CD95-mediated natural killer cell death and turnover induced by HIV viremia
    Shyam Kottilil
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Acquir Immune Defic Syndr 46:151-9. 2007
  9. ncbi request reprint Hepatitis B & hepatitis C in HIV-infection
    Shyam Kottilil
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Rm 11N204, 9000 Wisconsin Avenue, Bethesda, MD 20892, USA
    Indian J Med Res 121:424-50. 2005
  10. pmc Defective plasmacytoid dendritic cell-NK cell cross-talk in HIV infection
    K N Reitano
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health DHHS, SAIC Frederick, NCI, Frederick, MD 21702, USA
    AIDS Res Hum Retroviruses 25:1029-37. 2009

Detail Information

Publications41

  1. ncbi request reprint Innate immunity in human immunodeficiency virus infection: effect of viremia on natural killer cell function
    Shyam Kottilil
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases NIH, 9000 Wiscoinsin Avenue, Building 10, Room 6A08A, Bethesda, MD 20892, USA
    J Infect Dis 187:1038-45. 2003
    ....
  2. pmc Cytokine/chemokine patterns connect host and viral characteristics with clinics during chronic hepatitis C
    Antonios Katsounas
    Department of Gastroenterology and Hepatology, University Hospital of Essen, Germany
    Eur J Med Res 17:9. 2012
    ....
  3. ncbi request reprint Natural killer cells in HIV-1 infection: role of NK cell-mediated non-cytolytic mechanisms in pathogenesis of HIV-1 infection
    Shyam Kottilil
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institute of Health, Building 10, Room 6AI 1, 10 Center Drive, Bethesda, MD 20892, USA
    Indian J Exp Biol 41:1219-25. 2003
    ..Better understanding of the mechanisms involved in HIV-1-NK cell interactions would be helpful in delineating novel therapeutic strategics against HIV-1...
  4. ncbi request reprint Innate immune dysfunction in HIV infection: effect of HIV envelope-NK cell interactions
    Shyam Kottilil
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 176:1107-14. 2006
    ..Identification of specific surface receptors on NK cells that interact with HIV envelope proteins might explain how HIV is capable of circumventing innate immune defense mechanisms and establishing infection in susceptible individuals...
  5. pmc Human immunodeficiency virus and hepatitis C infections induce distinct immunologic imprints in peripheral mononuclear cells
    Shyam Kottilil
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Hepatology 50:34-45. 2009
    ....
  6. ncbi request reprint Expression of chemokine and inhibitory receptors on natural killer cells: effect of immune activation and HIV viremia
    S Kottilil
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 189:1193-8. 2004
    ....
  7. ncbi request reprint Changes in hepatitis C viral response after initiation of highly active antiretroviral therapy and control of HIV viremia in chronically co-infected individuals
    Shyam Kottilil
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    HIV Clin Trials 5:25-32. 2004
    ..We examined the long-term effect of controlling HIV infection with highly active antiretroviral therapy (HAART) on HCV viremia among co-infected patients...
  8. ncbi request reprint Innate immunity in HIV infection: enhanced susceptibility to CD95-mediated natural killer cell death and turnover induced by HIV viremia
    Shyam Kottilil
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Acquir Immune Defic Syndr 46:151-9. 2007
    ..In addition, these NK cells, particularly the CD56(dim) CD16(bright) subset, undergo enhanced cell turnover in vivo, as demonstrated by intracellular Ki67 expression...
  9. ncbi request reprint Hepatitis B & hepatitis C in HIV-infection
    Shyam Kottilil
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Rm 11N204, 9000 Wisconsin Avenue, Bethesda, MD 20892, USA
    Indian J Med Res 121:424-50. 2005
    ..This review discusses the current trends in the understanding of the biology of co-infection and implications for treating these viruses effectively...
  10. pmc Defective plasmacytoid dendritic cell-NK cell cross-talk in HIV infection
    K N Reitano
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health DHHS, SAIC Frederick, NCI, Frederick, MD 21702, USA
    AIDS Res Hum Retroviruses 25:1029-37. 2009
    ..These findings suggest a novel mechanism by which HIV is capable of suppressing an innate immune function in infected individuals...
  11. pmc HIV/Hepatitis C virus-coinfected virologic responders to pegylated interferon and ribavirin therapy more frequently incur interferon-related adverse events than nonresponders do
    Anu Osinusi
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Acquir Immune Defic Syndr 53:357-63. 2010
    ..This study aimed to assess the relationship between interferon (IFN)-related adverse effects and Hepatitis C virus (HCV) virologic response in HIV/HCV-coinfected individuals treated with pegylated interferon and ribavirin...
  12. ncbi request reprint HIV Infection, hepatitis C infection, and HAART: hard clinical choices
    Shyam Kottilil
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    JAMA 292:243-50. 2004
    ..Although coinfection with HCV and HIV has become a common clinical problem, optimal treatment of such patients remains to be defined and must be individualized to maximize benefit and tolerance...
  13. pmc Human immunodeficiency virus viremia induces plasmacytoid dendritic cell activation in vivo and diminished alpha interferon production in vitro
    John C Tilton
    LIR, NIAID, NIH, Bldg 10, Rm 11B 09, 10 Center Dr, MSC 1876, Bethesda, MD 20892 1876, USA
    J Virol 82:3997-4006. 2008
    ..Rather, diminished function in vitro is likely a consequence of prior activation via type I interferons or HIV virions in vivo...
  14. ncbi request reprint Gene expression profiles in hepatitis C virus (HCV) and HIV coinfection: class prediction analyses before treatment predict the outcome of anti-HCV therapy among HIV-coinfected persons
    R A Lempicki
    Science Applications International Program SAIC Frederick, Inc, National Cancer Institute Frederick, National Institutes of Health, Frederick, Maryland, USA
    J Infect Dis 193:1172-7. 2006
    ..Failure of anti-HCV therapy was associated with elevated expression of interferon-stimulated genes. Gene expression patterns may provide a tool to predict anti-HCV therapeutic response...
  15. pmc Distinct and overlapping genomic profiles and antiviral effects of Interferon-λ and -α on HCV-infected and noninfected hepatoma cells
    A Kohli
    Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD 20892, USA
    J Viral Hepat 19:843-53. 2012
    ..The findings from our comparative analysis of IFN-α and IFN-λ in HCV-infected and noninfected cells support the clinical use of IFN-λ as a potential alternative to IFN-α in the treatment of chronic hepatitis C...
  16. ncbi request reprint Immunodeficiency and intrinsic IFN resistance are associated with viral breakthrough to HCV therapy in HIV-coinfected patients
    Veronique Nussenblatt
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    AIDS Res Hum Retroviruses 23:1354-9. 2007
    ..HIV/HCV-coinfected patients have a high rate of VB on PEG-IFN/RBV therapy characterized by higher levels of IFIG expression, immunodeficiency, and hepatic inflammation. Novel strategies are required for the treatment of persons with VB...
  17. pmc Proteome-wide anti-hepatitis C virus (HCV) and anti-HIV antibody profiling for predicting and monitoring the response to HCV therapy in HIV-coinfected patients
    Peter D Burbelo
    Neurobiology and Pain Therapeutics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 202:894-8. 2010
    ..These results suggest that profiling anti-HCV antibody is useful for monitoring HCV therapy, especially in discriminating between those who experience relapse and those who have SVRs at 48 weeks...
  18. pmc LIPS arrays for simultaneous detection of antibodies against partial and whole proteomes of HCV, HIV and EBV
    Peter D Burbelo
    Neurobiology and Pain Therapeutics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Biosyst 7:1453-62. 2011
    ..These results suggest that LIPS arrays offer a highly discriminating platform for simultaneously profiling a wide spectrum of antibodies associated with many infectious agents...
  19. doi request reprint HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells
    James Arthos
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 9:301-9. 2008
    ..On CD4+ T cells, engagement of alpha4beta7 by gp120 resulted in rapid activation of LFA-1, the central integrin involved in the establishment of virological synapses, which facilitate efficient cell-to-cell spreading of HIV-1...
  20. doi request reprint Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapy
    Tae Wook Chun
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 197:714-20. 2008
    ....
  21. ncbi request reprint Predictors for hematopoietic growth factors use in HIV/HCV-coinfected patients treated with peginterferon alfa 2b and ribavirin
    Alice K Pau
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    AIDS Patient Care STDS 20:612-9. 2006
    ..Larger clinical trials will be needed to address the cost effectiveness of supplemental growth factor use in the HIV/HCV-coinfected patients...
  22. doi request reprint Normalization of B cell counts and subpopulations after antiretroviral therapy in chronic HIV disease
    Susan Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 197:572-9. 2008
    ..However, little is known regarding the effect of antiretroviral therapy (ART)-induced decrease in HIV viremia on B cell numbers and subpopulations...
  23. pmc Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals
    Susan Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 205:1797-805. 2008
    ..These data suggest that HIV-associated premature exhaustion of B cells may contribute to poor antibody responses against HIV in infected individuals...
  24. ncbi request reprint NK cells in HIV infection: paradigm for protection or targets for ambush
    Anthony S Fauci
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 31, Room 7A04, 31 Center Drive, MSC 2520, Bethesda, Maryland 20892 2520, USA
    Nat Rev Immunol 5:835-43. 2005
    ..This Review focuses on the role of natural killer cells in controlling HIV infection and on the impact of HIV and HIV-viraemia-induced immune activation on natural-killer-cell function...
  25. pmc Natural killer cells in HIV-1 infection: dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates
    Domenico Mavilio
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:15011-6. 2003
    ..This phenomenon is not attributed to a direct HIV-1 infection of NK cells; thus, this study may provide insight into the mechanisms of impaired host defenses in HIV-1 viremic patients...
  26. pmc Comparison of the abbott 7000 and bayer 340 systems for measurement of hepatitis C virus load
    Helene C Highbarger
    Virus Isolation and Serology Laboratory, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    J Clin Microbiol 45:2808-12. 2007
    ....
  27. ncbi request reprint Hepatic histologic response (HR) to combination therapy among HCV/HIV-coinfected individuals: interferon induces HR independent of sustained virologic response (SVR)
    Lynne Wu
    Laboratory of Immunoregulation, NIAID, NIH, DHHS, Bethesda, Maryland, USA
    AIDS Res Hum Retroviruses 22:1091-8. 2006
    ..Combination therapy resulted in an HR for most of the patients, however, further follow-up of these patients will determine the durability of such an HR...
  28. pmc Relationship between the frequency of HIV-specific CD8+ T cells and the level of CD38+CD8+ T cells in untreated HIV-infected individuals
    Tae Wook Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:2464-9. 2004
    ....
  29. ncbi request reprint Targeted lysis of HIV-infected cells by natural killer cells armed and triggered by a recombinant immunoglobulin fusion protein: implications for immunotherapy
    Neil Gupta
    Laboratory of Immunoregulation, NIAID, NIH Bldg 10 6A08, 9000 Rockville Pike, Bethesda MD 20892, USA
    Virology 332:491-7. 2005
    ..NK cells pre-armed in this manner retain the capacity to kill targets over an extended period of time. This strategy may have application to other disease states including various viral infections and cancers...
  30. pmc Impact of HIV on cell survival and antiviral activity of plasmacytoid dendritic cells
    Jennifer Hartt Meyers
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health NIH, Bethesda, Maryland, United States of America
    PLoS ONE 2:e458. 2007
    ..Elucidation of the mechanism by which pDCs suppress HIV replication in vivo may have clinically relevant implications for future therapeutic strategies...
  31. pmc Identification of novel markers for liver fibrosis in HIV/hepatitis C virus coinfected individuals using genomics-based approach
    Daniel L Suzman
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    AIDS 22:1433-9. 2008
    ..Liver biopsy is invasive, risky and costly, but is required to assess fibrosis. This study intended to identify novel noninvasive markers to accurately assess fibrosis in HIV/hepatitis C virus coinfection...
  32. pmc Functional genomics of innate host defense molecules in normal human monocytes in response to Aspergillus fumigatus
    Karoll J Cortez
    Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, NIH, 10 Center Drive, CRC Rm 1 5250, Bethesda, MD 20892 1882, USA
    Infect Immun 74:2353-65. 2006
    ..Thus, A. fumigatus conidia induced a coordinated expression of genes important in host defense and immunomodulation...
  33. doi request reprint Increased regulatory T cells and impaired functions of circulating CD8 T lymphocytes is associated with viral persistence in Hepatitis B virus-positive newborns
    S Shrivastava
    Institute of Liver and Biliary Sciences, New Delhi, India Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD, USA
    J Viral Hepat 20:582-91. 2013
    ..An expansion of regulatory T cells and impaired TCR signalling may represent the immune tolerant state of the adaptive immune system in response to chronic HBV infection...
  34. pmc Effect of HIV on liver fibrosis among HCV-infected African Americans
    D Silver
    Critical Care MedicineDepartment, National Institutes of Health, 1101 Highland Dr, Silver Spring, MD 20910, USA
    Clin Infect Dis 56:1280-3. 2013
    ..HIV was associated with the early fibrosis group. These results indicate that a large proportion of patients with HCV infection, including those with HIV, could possibly await more-effective and better-tolerated treatment...
  35. pmc Association of interleukin-15-induced peripheral immune activation with hepatic stellate cell activation in persons coinfected with hepatitis C virus and HIV
    Robert D Allison
    Department of Transfusion Medicine, National Institutes of Health, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 1876, USA
    J Infect Dis 200:619-23. 2009
    ..Future strategies that reduce immune activation and HSC activation may delay progression of liver fibrosis...
  36. ncbi request reprint Serious ophthalmic pathology compromising vision in HCV/HIV co-infected patients treated with peginterferon alpha-2b and ribavirin
    Claire Farel
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    AIDS 18:1805-9. 2004
    ..To characterize the ocular changes associated with peginterferon alpha 2b (peg-IFN alpha-2b) and ribavirin therapy for chronic hepatitis C infection in HIV co-infected individuals...
  37. ncbi request reprint Control, immunoregulation, and expression of innate pulmonary host defenses against Aspergillus fumigatus
    T J Walsh
    Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bldg 10, Rm 13N 240, 10 Center Drive, Bethesda, MD 20892, USA
    Med Mycol 43:S165-72. 2005
    ....
  38. doi request reprint CCL5 mRNA is a marker for early fibrosis in chronic hepatitis C and is regulated by interferon-α therapy and toll-like receptor 3 signalling
    A Katsounas
    Dept of Gastroenterology and Hepatology, University Hospital of Essen, Essen, Germany
    J Viral Hepat 19:128-37. 2012
    ....
  39. pmc Idiopathic CD4+ T lymphocytopenia is associated with increases in immature/transitional B cells and serum levels of IL-7
    Angela Malaspina
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD 20892, USA
    Blood 109:2086-8. 2007
    ....
  40. pmc Infections caused by Scedosporium spp
    Karoll J Cortez
    Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA
    Clin Microbiol Rev 21:157-97. 2008
    ..By comparison, infections caused by S. prolificans seldom respond to medical therapy alone. Surgery and reversal of immunosuppression may be the only effective therapeutic options for infections caused by S. prolificans...
  41. ncbi request reprint Differential antiviral effect of PEG-interferon-alpha-2b on HIV and HCV in the treatment of HIV/HCV co-infected patients
    Au Neumann
    Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    AIDS 21:1855-65. 2007
    ..The major antiviral effect of interferon (IFN)-alpha on hepatitis C virus (HCV) is blocking of virion production from infected cells. We now investigate the previously unknown mechanism of action of IFN-alpha against HIV...