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Genomes and Genes | Jeffrey B KoppSummaryAffiliation: National Institutes of Health Country: USA Publications
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Squirrel monkeys support replication of BK virus more efficiently than simian virus 40: an animal model for human BK virus infectionConcepcion Zaragoza
Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 3N116, Bethesda, MD 20892 1268
J Virol 79:1320-6. 2005..We conclude that the squirrel monkey is a suitable animal for studies of experimental BKV infection and may facilitate studies of viral entry, pathogenesis, and therapy...- Glomerular pathology in autosomal dominant MYH9 spectrum disorders: what are the clues telling us about disease mechanism?Jeffrey B Kopp
Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1268, USA
Kidney Int 78:130-3. 2010..A better understanding of the disease mechanisms responsible for glomerular injury in autosomal dominant MYH9 syndromes will lead to fuller appreciation of the role of this gene in glomerular biology... 
Indinavir-associated interstitial nephritis and urothelial inflammation: clinical and cytologic findingsJeffrey B Kopp
Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA
Clin Infect Dis 34:1122-8. 2002....- MYH9 genetic variants associated with glomerular disease: what is the role for genetic testing?Jeffrey B Kopp
Kidney Disease Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1268, USA
Semin Nephrol 30:409-17. 2010..Such studies will address critical questions pertaining to MYH9-associated kidney disease, including mechanism, course, and response to therapy... - Kidney patient care in disasters: emergency planning for patients and dialysis facilitiesJeffrey B Kopp
Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1268, USA
Clin J Am Soc Nephrol 2:825-38. 2007..A timeline to safety for dialysis patients can be visualized; if specific tasks are accomplished at each disaster stage, then it is likely that the health of these vulnerable patients can be protected... - Kidney patient care in disasters: lessons from the hurricanes and earthquake of 2005Jeffrey B Kopp
Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1268, USA
Clin J Am Soc Nephrol 2:814-24. 2007..With suitable planning, the nephrology community can do much to ensure the continuity of medical care for kidney patients in the face of a wide range of possible natural and human-made disasters... - Dense mapping of MYH9 localizes the strongest kidney disease associations to the region of introns 13 to 15George W Nelson
Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD, USA
Hum Mol Genet 19:1805-15. 2010..Rs5750250 combined with rs11912763 had receiver operator characteristic (ROC) C statistics of 0.80, 0.73 and 0.65 for HIVAN, FSGS and H-ESKD, respectively, allowing prediction of genetic risk by typing two SNPs... - Angiotensin II overcomes strain-dependent resistance of rapid CKD progression in a new remnant kidney mouse modelAsada Leelahavanichkul
Renal Diagnostics and Therapeutics Unit, Kidney Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1268, USA
Kidney Int 78:1136-53. 2010..Thus, reducing renal mass in CD-1 or 129S3 mice mimics many features of human CKD. Angiotensin II can convert the C57BL/6 strain from CKD resistant to susceptible in this disease model... - Urinary exosomal transcription factors, a new class of biomarkers for renal diseaseHua Zhou
Renal Diagnostics and Therapeutics Unit, National Institutes of Health, Bethesda, Maryland, USA
Kidney Int 74:613-21. 2008..Measurement of urinary exosomal transcription factors may offer insight into cellular regulatory pathways... - Chronic kidney disease worsens sepsis and sepsis-induced acute kidney injury by releasing High Mobility Group Box Protein-1Asada Leelahavanichkul
Renal Diagnostics and Therapeutics Unit, National Institutes of Health, Bethesda, Maryland 20892 1268, USA
Kidney Int 80:1198-211. 2011..Thus, progressive CKD increases the severity of sepsis, in part, by reducing the renal clearance of several cytokines. CKD-induced splenic apoptosis and HMGB1 release could be important common mediators for both CKD and sepsis... - BK virus and SV40 co-infection in polyomavirus nephropathyRui-Mei Li
Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
Transplantation 74:1497-504. 2002..CONCLUSION: The authors report molecular evidence that co-infection with BKV and SV40 occurs in renal transplant patients with PVN, suggesting that SV40 may contribute to PVN after renal transplant... - APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathyJeffrey B Kopp
Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland, USA
J Am Soc Nephrol 22:2129-37. 2011..These data add to the evidence base required to determine whether genetic testing for APOL1 has a use in clinical practice... - Cell-cell contact regulates gene expression in CDK4-transformed mouse podocytesToru Sakairi
Kidney Disease Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA
Am J Physiol Renal Physiol 299:F802-9. 2010..Our findings suggest that CDK4 podocytes are useful tools to study podocyte biology. Furthermore, the role of cell-cell contact in podocyte gene expression may have relevance for podocyte function in vivo... - Bioenergetic characterization of mouse podocytesYoshifusa Abe
Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1268, USA
Am J Physiol Cell Physiol 299:C464-76. 2010..Replication of these experiments in primary mouse podocytes yielded similar data. We conclude that mitochondria play the primary role in maintaining podocyte energy homeostasis, while glycolysis makes a lesser contribution... - Pirfenidone: an anti-fibrotic therapy for progressive kidney diseaseMonique E Cho
National Institutes of Health, Kidney Disease Branch, 10 CRC 5 5750, 9000 Rockville Pike, Bethesda, MD 20892 1268, USA
Expert Opin Investig Drugs 19:275-83. 2010..Larger studies are needed to better understand long-term efficacy and safety of this medication in various patient populations... - Proteomic analysis identifies insulin-like growth factor-binding protein-related protein-1 as a podocyte productTakayuki Matsumoto
Kidney Disease Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA
Am J Physiol Renal Physiol 299:F776-84. 2010..We conclude that IGFBP-rP1 may be a product of injured podocytes. Further analysis of the podocyte secretory proteome may identify biomarkers of podocyte injury... - Urinary cytology associated with human polyomavirus and indinavir therapy in HIV-infected patientsArmando C Filie
Cytopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
Am J Clin Pathol 117:922-6. 2002..Indinavir crystals have a characteristic fan or circular lamellate appearance. Because indinavir crystals may be associated with genitourinary disease, recognizing and reporting them is clinically relevant in HIV+ patients... - The Gne M712T mouse as a model for human glomerulopathySravan Kakani
Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 1851, USA
Am J Pathol 180:1431-40. 2012..Moreover, the partial restoration of glomerular architecture in ManNAc-treated mice highlights ManNAc as a potential treatment for humans affected with disorders of glomerular hyposialylation... - Increased prevalence of albuminuria in HIV-infected adults with diabetesPeter S Kim
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS ONE 6:e24610. 2011..HIV and type 2 diabetes are known risk factors for albuminuria, but no previous reports have characterized albuminuria in HIV-infected patients with diabetes... - Conditionally immortalized human podocyte cell lines established from urineToru Sakairi
Kidney Disease Section, Kidney Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1268, USA
Am J Physiol Renal Physiol 298:F557-67. 2010..Further improvements in the approaches to cell transformation and/or cell culture techniques are needed to allow cultured podocytes to fully reproduce in vivo characteristics... - Molecular identification of SV40 infection in human subjects and possible association with kidney diseaseRui-Mei Li
Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-1268, USA
J Am Soc Nephrol 13:2320-30. 2002..This study demonstrates for the first time that human kidney can serve as a reservoir for SV40 replication and that SV40 may contribute to the pathogenesis of kidney disease, particularly FSGS... - Inducible podocyte-specific gene expression in transgenic miceTetsuya Shigehara
Kidney Disease Section, Metabolic Diseases Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
J Am Soc Nephrol 14:1998-2003. 2003..This transgenic system should aid future investigations of podocyte function... - TGF-beta1 reduces Wilms' tumor suppressor gene expression in podocytesToru Sakairi
Kidney Disease Section, Kidney Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
Nephrol Dial Transplant 26:2746-52. 2011..We aimed to address whether TGF-beta affects WT1 expression in podocytes... - Genetics of focal segmental glomerulosclerosis and human immunodeficiency virus-associated collapsing glomerulopathy: the role of MYH9 genetic variationCheryl A Winkler
Scientific Applications International Corporation Frederick, Inc, Laboratory of Genomic Diversity, Center for Cancer Research, National Cancer Institute Frederick, National Institutes of Health, Frederick, MD, USA
Semin Nephrol 30:111-25. 2010..The strong predicted power of MYH9 variation for disease indicates a clear role for genetic testing for these variants in personalized medicine, for assessment of genetic risk, and potentially for diagnosis... - Tetracycline-inducible gene expression in conditionally immortalized mouse podocytesHiroshi Kajiyama
Kidney Disease Section, Kidney Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, MD 20892 1268, USA
Am J Nephrol 29:153-63. 2009..Conditionally immortalized podocytes are valuable research tools but are difficult to efficiently transfect and do not provide graded transgene expression... - Detection and localization of proteinuria by dynamic contrast-enhanced magnetic resonance imaging using MS325Yantian Zhang
Department of Radiology, Warren Grant Magnuson Clinical Center, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
J Am Soc Nephrol 16:1752-7. 2005..If this technique can be successfully applied in human patients, it may allow for the localization of proteinuria after kidney transplant and thereby provide a noninvasive way to detect disease affecting the renal allograft... - MYH9 is a major-effect risk gene for focal segmental glomerulosclerosisJeffrey B Kopp
Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Genet 40:1175-84. 2008..2, 95% CI = 1.5-3.4; n = 433), but not type 2 diabetic ESKD (n = 476). Genetic variation at the MYH9 locus substantially explains the increased burden of FSGS and hypertensive ESKD among African Americans... - Natural history and treatment of renal involvement in Fabry diseaseMary Branton
Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Am Soc Nephrol 13:S139-43. 2002 - Human immunodeficiency virus (HIV)-1 viral protein R suppresses transcriptional activity of peroxisome proliferator-activated receptor {gamma} and inhibits adipocyte differentiation: implications for HIV-associated lipodystrophyShashi Shrivastav
Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Disease NIH, 10 Center Drive MSC 1268, Bethesda, MD 20892 1268, USA
Mol Endocrinol 22:234-47. 2008..Vpr may alter sensitivity to insulin and thereby contribute to the development of lipodystrophy and insulin resistance observed in HIV-1-infected patients... - Twenty-one-year trend in ESRD due to focal segmental glomerulosclerosis in the United StatesChagriya Kitiyakara
Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, The National Institutes of Health, Department of Health and Human Services, Bethesda, MD USA
Am J Kidney Dis 44:815-25. 2004..Idiopathic FSGS now is the most common cause of ESRD caused by primary glomerular disease in the United States in both the black and white populations... - Pirfenidone slows renal function decline in patients with focal segmental glomerulosclerosisMonique E Cho
Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1268, USA
Clin J Am Soc Nephrol 2:906-13. 2007..Our objective was to determine whether pirfenidone slows the loss of renal function in focal segmental glomerulosclerosis... - Parvovirus-B19-associated complications in renal transplant recipientsMeryl Waldman
Kidney Disease Section, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20814 9692, USA
Nat Clin Pract Nephrol 3:540-50. 2007..Most patients benefit from intravenous immunoglobulin therapy and/or alteration or reduction of immunosuppressive therapy. Conservative therapy might be sufficient in some cases... - Off the beaten renin-angiotensin-aldosterone system pathway: new perspectives on antiproteinuric therapyJudit Gordon
Division of Nephrology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Adv Chronic Kidney Dis 18:300-11. 2011..It is hoped that recent advances in the basic science of kidney injury will prompt development of more effective pharmaceutical and biologic therapies for proteinuria... - Longitudinal assessment of metabolic abnormalities in adolescents and young adults with HIV-infection acquired perinatally or in early childhoodDavid Dimock
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
Metabolism 60:874-80. 2011..002). Impaired glucose tolerance, insulin resistance, dyslipidemia, and microalbuminuria are common among young adults with HIV. Long-term exposure to therapy may translate into substantial persistent metabolic risk... - In vitro models of TGF-beta-induced fibrosis suitable for high-throughput screening of antifibrotic agentsQihe Xu
Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Disases, National Institutes of Health, Bethesda, MD 20892 1268, USA
Am J Physiol Renal Physiol 293:F631-40. 2007..As a proof of principle, chemical inhibitors of Alk5 and the antifibrotic compound tranilast were shown to have inhibitory activities in both assays... - Sirolimus therapy of focal segmental glomerulosclerosis is associated with nephrotoxicityMonique E Cho
Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1268, USA
Am J Kidney Dis 49:310-7. 2007..We conclude that sirolimus may be associated with nephrotoxicity in some patients with FSGS, particularly those with prolonged disease duration and prior cyclosporine therapy... - Images in clinical medicine. Fabry's diseaseJeffrey B Kopp
National Institutes of Health, Bethesda, MD 20892, USA
N Engl J Med 349:e20. 2003 - Fabry disease in the era of enzyme replacement therapy: a renal perspectiveMonique E Cho
Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-1268, USA
Pediatr Nephrol 19:583-93. 2004..Further research is required to determine optimal dosing protocols for treatment and to establish whether therapy can retard the progression of organ dysfunction, or even prevent these complications altogether... - Parapelvic kidney cysts: a distinguishing feature with high prevalence in Fabry diseaseMarkus Ries
Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1260, USA
Kidney Int 66:978-82. 2004..In order to identify key novel renal diagnostic imaging features of Fabry disease, we conducted a cross sectional case-control study of kidney involvement in patients with Fabry disease... - HIV and the kidney: a status report after 20 yearsMonique E Cho
Kidney Disease Section, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health/DHHS, 9000 Rockville Pike, Bethesda, MD 20892, USA
Curr HIV/AIDS Rep 1:109-15. 2004..Appropriate screening for renal dysfunction can minimize the likelihood of progressive renal injury in all patients with HIV-1 infection... - Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-AYingfan Zhang
National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1583, USA
Blood 119:238-50. 2012..Our results show that heterozygous mice with mutations in the myosin motor or filament-forming domain manifest similar hematologic, eye, and kidney phenotypes to humans with MYH9-related disease... - Description of familial keloids in five pedigrees: evidence for autosomal dominant inheritance and phenotypic heterogeneityJason A Clark
Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
BMC Dermatol 9:8. 2009..We wished to determine the inheritance pattern and phenotype of keloids among multigenerational families, as a prelude to a positional mapping strategy to identify candidate genes... - Viruses and kidney disease: beyond HIVMeryl Waldman
Kidney Disease Section, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1268, USA
Semin Nephrol 28:595-607. 2008..We also discuss an approach to the identification of new viral renal pathogens, using a viral gene chip to identify viral DNA or RNA... - Anti-mouse mesangial cell serum induces acute glomerulonephropathy in miceYoshikage Yo
Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892-1268, USA
Nephron Exp Nephrol 93:e92-106. 2003..Anti-mouse mesangial cell serum induces glomerulopathy characterized by mesangiolysis and mesangial cell apoptosis, and followed by cellular proliferation... - Parvovirus B19 and the kidneyMeryl Waldman
Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1268, USA
Clin J Am Soc Nephrol 2:S47-56. 2007..Allograft rejection and dysfunction have been reported in association with infection, but a cause-effect relationship has not been proved. Further investigation of the relationship between B19 and kidney disease is warranted... - HIV-associated nephropathy patients with and without apolipoprotein L1 gene variants have similar clinical and pathological characteristicsMohamed G Atta
Department of Medicine, Johns Hopkins Medical Center, Baltimore, MD 21205, USA
Kidney Int 82:338-43. 2012.... - Trends in the epidemiology of focal segmental glomerulosclerosisChagriya Kitiyakara
Kidney Disease Section, Epidemiology Research Program, National Institute for Diabetes and Digestive and Kidney Diseases, NIH, DHHS, Bethesda, MD, USA
Semin Nephrol 23:172-82. 2003..The reasons for the recent increase in idiopathic FSGS and FSGS incident ESRD cases are complex, but these trends are likely caused, at least in part, by a real increase in the incidence of FSGS over the past 10 to 20 years... - Natural history of Fabry renal disease: influence of alpha-galactosidase A activity and genetic mutations on clinical courseMary H Branton
Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland 20892-1268, USA
Medicine (Baltimore) 81:122-38. 2002 - Rapid isolation of urinary exosomal biomarkers using a nanomembrane ultrafiltration concentratorAnita Cheruvanky
Renal Diagnostics and Therapeutics Unit, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1268, USA
Am J Physiol Renal Physiol 292:F1657-61. 2007..This enhanced method may accelerate the translation of urinary exosomal biomarkers from bench to bedside for the diagnosis, classification, and prognostication of renal diseases... - Progressive glomerulonephritis and histiocytic sarcoma associated with macrophage functional defects in CYP1B1-deficient miceJerrold M Ward
The National Institute of Allergy and Infectious Diseases, NIH and SoBran, Inc, Twinbrook 3, Room 2W 01A, Bethesda, Maryland 20892 8135, USA
Toxicol Pathol 32:710-8. 2004..The function of CYP1B1 in histiocytes and macrophages may involve both self-tolerance and tumor suppression... - Lack of A1 adenosine receptors augments diabetic hyperfiltration and glomerular injuryRobert Faulhaber-Walter
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 4D51, 10 Center Drive, MSC 1370, Bethesda, MD 20892, USA
J Am Soc Nephrol 19:722-30. 2008..Rather, an A1AR-dependent mechanism, possibly TGF, limits the degree of diabetic hyperfiltration and nephropathy... - Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndromeJesus M Salvador
Gene Response Section, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
Immunity 16:499-508. 2002.... - The cyclin-dependent kinase inhibitor p21 limits murine mesangial proliferative glomerulonephritisToshiaki Monkawa
Division of Nephrology, University of Washington, Seattle, Washington, USA
Nephron Exp Nephrol 102:e8-18. 2006..However, the role of p21 in acute mesangial proliferative GN is not known. This study was conducted to test the hypothesis that p21 regulates MC proliferation and apoptosis in anti-MC serum-induced GN... - Interstitial fibroblast-like cells express renin-angiotensin system components in a fibrosing murine kidneyHirokazu Okada
Department of Nephrology, Saitama Medical College, Saitama, Japan
Am J Pathol 160:765-72. 2002..These data provide strong evidence for a tubulointerstitial RAS within the fibrosing kidney, and a linkage between the RAS and renal fibrogenesis... - Angiotensin II provokes podocyte injury in murine model of HIV-associated nephropathyHiroshi Ideura
Department of Medicine and Clinical Science, Gunma University Graduste School of Medicine, Maebashi, Gunma, Japan
Am J Physiol Renal Physiol 293:F1214-21. 2007..ANG II infusion alone without doxycycline resulted in a lower level of albuminuria and minimal histological changes. These data demonstrate that excessive ANG II accelerates vpr-induced podocyte injury in a mouse model of HIVAN... - Hepatocyte growth factor counteracts transforming growth factor-beta1, through attenuation of connective tissue growth factor induction, and prevents renal fibrogenesis in 5/6 nephrectomized miceTsutomu Inoue
Department of Nephrology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
FASEB J 17:268-70. 2003..In conclusion, HGF can block, at least partially, renal fibrogenesis promoted by TGF-beta1 in the remnant kidney, via attenuation of CTGF induction... - Renal fibrosisH William Schnaper
Division of Pediatric Nephrology, Northwestern University, Medical School, Chicago, IL, USA
Front Biosci 8:e68-86. 2003..Other proteins and small molecules may have anti-fibrotic effects. Manipulation of these opposing systems holds the promise of effective treatments for chronic progressive kidney disease... - Renal pathology in Fabry diseaseJoseph Alroy
Department of Pathology, Tufts University Schools of Veterinary Medicine and Medicine, New England Medical Center, Boston, Massachusetts, USA
J Am Soc Nephrol 13:S134-8. 2002 - Modulation of podocyte phenotype in collapsing glomerulopathiesLaura Barisoni
Department of Pathology, The Johns Hopkins University, Baltimore, Maryland
Microsc Res Tech 57:254-62. 2002..Finally, is it important to mention that collapsing glomerulopathies have a high prevalence in black patients, suggesting a link between racial background and the virus-related podocyte injury... - Update in podocyte biology: putting one's best foot forwardLaura Barisoni
The Johns Hopkins University, Baltimore, Maryland, USA
Curr Opin Nephrol Hypertens 12:251-8. 2003..Nevertheless, we do understand the consequences that arise when the podocyte cannot put its best foot (processes) forward... - CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibilityJeong M Kim
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
Science 300:1298-300. 2003..Two human patients with focal segmental glomerulosclerosis had a mutation predicted to ablate expression of one CD2AP allele, implicating CD2AP as a determinant of human susceptibility to glomerular disease... - Why kidneys fail: report from an American Society of Nephrology Advances in Research ConferenceH William Schnaper
Department of Pediatrics, Northwestern University Medical School, Illinois, USA
J Am Soc Nephrol 17:1777-81. 2006..In this article, the conference organizers summarize the conference presentations... - NPHS2 gene, nephrotic syndrome and focal segmental glomerulosclerosis: a HuGE reviewNora Franceschini
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27514 3628, USA
Genet Med 8:63-75. 2006..Nevertheless, the available data suggest that large epidemiological case-control studies to examine the association between NPHS2 variants and nephrotic syndrome are warranted... - NPHS2 variation in sporadic focal segmental glomerulosclerosisLouise M McKenzie
Laboratory of Genomic Diversity, SAIC Frederick, National Cancer Institute, NCI Frederick, Frederick, Maryland, USA
J Am Soc Nephrol 18:2987-95. 2007..5, P = 0.001). These results indicate that genetic variation or mutation of NPHS2 may play a role in late-onset sporadic FSGS... - VEGF inhibition and renal thrombotic microangiopathyVera Eremina
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
N Engl J Med 358:1129-36. 2008..These observations provide evidence that glomerular injury in patients who are treated with bevacizumab is probably due to direct targeting of VEGF by antiangiogenic therapy... - Connective tissue growth factor expressed in tubular epithelium plays a pivotal role in renal fibrogenesisHirokazu Okada
Department of Nephrology, Saitama Medical College, 38 Morohongo, Moroyama machi, Irumagun, Saitama 350 0495, Japan
J Am Soc Nephrol 16:133-43. 2005..In conclusion, tubular CTGF acts as a downstream mediator of the profibrotic effects of TGF-beta1 in the remnant kidney, which is a promising target for antifibrotic drugs designed to treat TGF-beta1-dependent interstitial fibrosis... - Angiotensin II type 1 receptor blockade inhibits the development and progression of HIV-associated nephropathy in a mouse modelNoriyuki Hiramatsu
Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, 3 39 22 Showa, Maebashi, Gunma 371 8511, Japan
J Am Soc Nephrol 18:515-27. 2007..AT1R blockade could be beneficial in the treatment of HIVAN by ameliorating podocyte injury by avoiding the vicious cycle of nephron reduction and glomerular hypertension... - A proposed taxonomy for the podocytopathies: a reassessment of the primary nephrotic diseasesLaura Barisoni
Department of Pathology, New York University School of Medicine, New York, New York, USA
Clin J Am Soc Nephrol 2:529-42. 2007.... - Pathogenesis and treatment of HIV-associated renal diseases: lessons from clinical and animal studies, molecular pathologic correlations, and genetic investigationsPaul L Kimmel
Division of Renal Diseases and Hypertension, Department of Medicine, George Washington University Medical Center, 2150 Pennsylvania Avenue NW, Washington, DC 20037, USA
Ann Intern Med 139:214-26. 2003..Outcomes in patients undergoing hemodialysis and peritoneal dialysis have improved, and current research focuses on renal transplantation for treatment of HIV-infected patients... - Effects of transgenic expression of HIV-1 Vpr on lipid and energy metabolism in miceAshok Balasubramanyam
Translational Metabolism Unit, Division of Diabetes, Endocrinology and Metabolism, BCM 700B, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Am J Physiol Endocrinol Metab 292:E40-8. 2007....