Jeffrey B Kopp

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc TGF-β1 stimulates mitochondrial oxidative phosphorylation and generation of reactive oxygen species in cultured mouse podocytes, mediated in part by the mTOR pathway
    Yoshifusa Abe
    10 Center Drive, NIH, Bethesda, MD 20892 1268
    Am J Physiol Renal Physiol 305:F1477-90. 2013
  2. ncbi request reprint Indinavir-associated interstitial nephritis and urothelial inflammation: clinical and cytologic findings
    Jeffrey B Kopp
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA
    Clin Infect Dis 34:1122-8. 2002
  3. pmc Squirrel monkeys support replication of BK virus more efficiently than simian virus 40: an animal model for human BK virus infection
    Concepcion Zaragoza
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 3N116, Bethesda, MD 20892 1268
    J Virol 79:1320-6. 2005
  4. pmc Glomerular pathology in autosomal dominant MYH9 spectrum disorders: what are the clues telling us about disease mechanism?
    Jeffrey B Kopp
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1268, USA
    Kidney Int 78:130-3. 2010
  5. ncbi request reprint Kidney patient care in disasters: lessons from the hurricanes and earthquake of 2005
    Jeffrey B Kopp
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1268, USA
    Clin J Am Soc Nephrol 2:814-24. 2007
  6. ncbi request reprint Kidney patient care in disasters: emergency planning for patients and dialysis facilities
    Jeffrey B Kopp
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1268, USA
    Clin J Am Soc Nephrol 2:825-38. 2007
  7. pmc MYH9 genetic variants associated with glomerular disease: what is the role for genetic testing?
    Jeffrey B Kopp
    Kidney Disease Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1268, USA
    Semin Nephrol 30:409-17. 2010
  8. pmc Dense mapping of MYH9 localizes the strongest kidney disease associations to the region of introns 13 to 15
    George W Nelson
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD, USA
    Hum Mol Genet 19:1805-15. 2010
  9. pmc Angiotensin II overcomes strain-dependent resistance of rapid CKD progression in a new remnant kidney mouse model
    Asada Leelahavanichkul
    Renal Diagnostics and Therapeutics Unit, Kidney Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1268, USA
    Kidney Int 78:1136-53. 2010
  10. pmc Urinary exosomal transcription factors, a new class of biomarkers for renal disease
    Hua Zhou
    Renal Diagnostics and Therapeutics Unit, National Institutes of Health, Bethesda, Maryland, USA
    Kidney Int 74:613-21. 2008

Detail Information

Publications79

  1. pmc TGF-β1 stimulates mitochondrial oxidative phosphorylation and generation of reactive oxygen species in cultured mouse podocytes, mediated in part by the mTOR pathway
    Yoshifusa Abe
    10 Center Drive, NIH, Bethesda, MD 20892 1268
    Am J Physiol Renal Physiol 305:F1477-90. 2013
    ..Our data suggest that TGF-β1, acting, in part, via mTOR, increases mitochondrial MMP and OCR, resulting in increased ROS generation and that this may contribute to podocyte injury...
  2. ncbi request reprint Indinavir-associated interstitial nephritis and urothelial inflammation: clinical and cytologic findings
    Jeffrey B Kopp
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA
    Clin Infect Dis 34:1122-8. 2002
    ....
  3. pmc Squirrel monkeys support replication of BK virus more efficiently than simian virus 40: an animal model for human BK virus infection
    Concepcion Zaragoza
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 3N116, Bethesda, MD 20892 1268
    J Virol 79:1320-6. 2005
    ..We conclude that the squirrel monkey is a suitable animal for studies of experimental BKV infection and may facilitate studies of viral entry, pathogenesis, and therapy...
  4. pmc Glomerular pathology in autosomal dominant MYH9 spectrum disorders: what are the clues telling us about disease mechanism?
    Jeffrey B Kopp
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1268, USA
    Kidney Int 78:130-3. 2010
    ..A better understanding of the disease mechanisms responsible for glomerular injury in autosomal dominant MYH9 syndromes will lead to fuller appreciation of the role of this gene in glomerular biology...
  5. ncbi request reprint Kidney patient care in disasters: lessons from the hurricanes and earthquake of 2005
    Jeffrey B Kopp
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1268, USA
    Clin J Am Soc Nephrol 2:814-24. 2007
    ..With suitable planning, the nephrology community can do much to ensure the continuity of medical care for kidney patients in the face of a wide range of possible natural and human-made disasters...
  6. ncbi request reprint Kidney patient care in disasters: emergency planning for patients and dialysis facilities
    Jeffrey B Kopp
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1268, USA
    Clin J Am Soc Nephrol 2:825-38. 2007
    ..A timeline to safety for dialysis patients can be visualized; if specific tasks are accomplished at each disaster stage, then it is likely that the health of these vulnerable patients can be protected...
  7. pmc MYH9 genetic variants associated with glomerular disease: what is the role for genetic testing?
    Jeffrey B Kopp
    Kidney Disease Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1268, USA
    Semin Nephrol 30:409-17. 2010
    ..Such studies will address critical questions pertaining to MYH9-associated kidney disease, including mechanism, course, and response to therapy...
  8. pmc Dense mapping of MYH9 localizes the strongest kidney disease associations to the region of introns 13 to 15
    George W Nelson
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD, USA
    Hum Mol Genet 19:1805-15. 2010
    ..Rs5750250 combined with rs11912763 had receiver operator characteristic (ROC) C statistics of 0.80, 0.73 and 0.65 for HIVAN, FSGS and H-ESKD, respectively, allowing prediction of genetic risk by typing two SNPs...
  9. pmc Angiotensin II overcomes strain-dependent resistance of rapid CKD progression in a new remnant kidney mouse model
    Asada Leelahavanichkul
    Renal Diagnostics and Therapeutics Unit, Kidney Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1268, USA
    Kidney Int 78:1136-53. 2010
    ..Thus, reducing renal mass in CD-1 or 129S3 mice mimics many features of human CKD. Angiotensin II can convert the C57BL/6 strain from CKD resistant to susceptible in this disease model...
  10. pmc Urinary exosomal transcription factors, a new class of biomarkers for renal disease
    Hua Zhou
    Renal Diagnostics and Therapeutics Unit, National Institutes of Health, Bethesda, Maryland, USA
    Kidney Int 74:613-21. 2008
    ..Measurement of urinary exosomal transcription factors may offer insight into cellular regulatory pathways...
  11. pmc Bioenergetic characterization of mouse podocytes
    Yoshifusa Abe
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1268, USA
    Am J Physiol Cell Physiol 299:C464-76. 2010
    ..Replication of these experiments in primary mouse podocytes yielded similar data. We conclude that mitochondria play the primary role in maintaining podocyte energy homeostasis, while glycolysis makes a lesser contribution...
  12. doi request reprint Urinary exosomal Wilms' tumor-1 as a potential biomarker for podocyte injury
    Hua Zhou
    Renal Diagnostics and Therapeutics Unit, NIDDK, National Institutes of Health, 10 Center Dr, Bldg 10, Rm 3N108, Bethesda, MD 20892 1268
    Am J Physiol Renal Physiol 305:F553-9. 2013
    ..These results warrant longitudinal, prospective studies in a large cohort with a range of podocyte diseases. ..
  13. pmc Chronic kidney disease worsens sepsis and sepsis-induced acute kidney injury by releasing High Mobility Group Box Protein-1
    Asada Leelahavanichkul
    Renal Diagnostics and Therapeutics Unit, National Institutes of Health, Bethesda, Maryland 20892 1268, USA
    Kidney Int 80:1198-211. 2011
    ..Thus, progressive CKD increases the severity of sepsis, in part, by reducing the renal clearance of several cytokines. CKD-induced splenic apoptosis and HMGB1 release could be important common mediators for both CKD and sepsis...
  14. pmc Cell-cell contact regulates gene expression in CDK4-transformed mouse podocytes
    Toru Sakairi
    Kidney Disease Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA
    Am J Physiol Renal Physiol 299:F802-9. 2010
    ..Our findings suggest that CDK4 podocytes are useful tools to study podocyte biology. Furthermore, the role of cell-cell contact in podocyte gene expression may have relevance for podocyte function in vivo...
  15. pmc APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy
    Jeffrey B Kopp
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland, USA
    J Am Soc Nephrol 22:2129-37. 2011
    ..These data add to the evidence base required to determine whether genetic testing for APOL1 has a use in clinical practice...
  16. ncbi request reprint BK virus and SV40 co-infection in polyomavirus nephropathy
    Rui Mei Li
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    Transplantation 74:1497-504. 2002
    ..The simian virus (SV) 40 is PV that was likely introduced into the human population through contaminated vaccines. The purpose of this study was to identify and characterize the PV that is associated with PV nephropathy...
  17. pmc Conditionally immortalized human podocyte cell lines established from urine
    Toru Sakairi
    Kidney Disease Section, Kidney Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1268, USA
    Am J Physiol Renal Physiol 298:F557-67. 2010
    ..Further improvements in the approaches to cell transformation and/or cell culture techniques are needed to allow cultured podocytes to fully reproduce in vivo characteristics...
  18. pmc Pirfenidone: an anti-fibrotic therapy for progressive kidney disease
    Monique E Cho
    National Institutes of Health, Kidney Disease Branch, 10 CRC 5 5750, 9000 Rockville Pike, Bethesda, MD 20892 1268, USA
    Expert Opin Investig Drugs 19:275-83. 2010
    ..Larger studies are needed to better understand long-term efficacy and safety of this medication in various patient populations...
  19. pmc Proteomic analysis identifies insulin-like growth factor-binding protein-related protein-1 as a podocyte product
    Takayuki Matsumoto
    Kidney Disease Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA
    Am J Physiol Renal Physiol 299:F776-84. 2010
    ..We conclude that IGFBP-rP1 may be a product of injured podocytes. Further analysis of the podocyte secretory proteome may identify biomarkers of podocyte injury...
  20. pmc Tetracycline-inducible gene expression in conditionally immortalized mouse podocytes
    Hiroshi Kajiyama
    Kidney Disease Section, Kidney Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, MD 20892 1268, USA
    Am J Nephrol 29:153-63. 2009
    ..Conditionally immortalized podocytes are valuable research tools but are difficult to efficiently transfect and do not provide graded transgene expression...
  21. ncbi request reprint Urinary cytology associated with human polyomavirus and indinavir therapy in HIV-infected patients
    Armando C Filie
    Cytopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Am J Clin Pathol 117:922-6. 2002
    ..Indinavir crystals have a characteristic fan or circular lamellate appearance. Because indinavir crystals may be associated with genitourinary disease, recognizing and reporting them is clinically relevant in HIV+ patients...
  22. pmc The Gne M712T mouse as a model for human glomerulopathy
    Sravan Kakani
    Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 1851, USA
    Am J Pathol 180:1431-40. 2012
    ..Moreover, the partial restoration of glomerular architecture in ManNAc-treated mice highlights ManNAc as a potential treatment for humans affected with disorders of glomerular hyposialylation...
  23. pmc Increased prevalence of albuminuria in HIV-infected adults with diabetes
    Peter S Kim
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e24610. 2011
    ..HIV and type 2 diabetes are known risk factors for albuminuria, but no previous reports have characterized albuminuria in HIV-infected patients with diabetes...
  24. ncbi request reprint Molecular identification of SV40 infection in human subjects and possible association with kidney disease
    Rui Mei Li
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1268, USA
    J Am Soc Nephrol 13:2320-30. 2002
    ..This study demonstrates for the first time that human kidney can serve as a reservoir for SV40 replication and that SV40 may contribute to the pathogenesis of kidney disease, particularly FSGS...
  25. ncbi request reprint Inducible podocyte-specific gene expression in transgenic mice
    Tetsuya Shigehara
    Kidney Disease Section, Metabolic Diseases Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    J Am Soc Nephrol 14:1998-2003. 2003
    ..This transgenic system should aid future investigations of podocyte function...
  26. pmc PPARα and Sirt1 mediate erythropoietin action in increasing metabolic activity and browning of white adipocytes to protect against obesity and metabolic disorders
    Li Wang
    Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland
    Diabetes 62:4122-31. 2013
    ..Collectively, EPO, as a novel regulator of adipose energy homeostasis via these metabolism coregulators, provides a potential therapeutic strategy to protect against obesity and metabolic disorders. ..
  27. pmc TGF-beta1 reduces Wilms' tumor suppressor gene expression in podocytes
    Toru Sakairi
    Kidney Disease Section, Kidney Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    Nephrol Dial Transplant 26:2746-52. 2011
    ..We aimed to address whether TGF-beta affects WT1 expression in podocytes...
  28. pmc MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis
    Jeffrey B Kopp
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 40:1175-84. 2008
    ..2, 95% CI = 1.5-3.4; n = 433), but not type 2 diabetic ESKD (n = 476). Genetic variation at the MYH9 locus substantially explains the increased burden of FSGS and hypertensive ESKD among African Americans...
  29. pmc Genetics of focal segmental glomerulosclerosis and human immunodeficiency virus-associated collapsing glomerulopathy: the role of MYH9 genetic variation
    Cheryl A Winkler
    Scientific Applications International Corporation Frederick, Inc, Laboratory of Genomic Diversity, Center for Cancer Research, National Cancer Institute Frederick, National Institutes of Health, Frederick, MD, USA
    Semin Nephrol 30:111-25. 2010
    ..The strong predicted power of MYH9 variation for disease indicates a clear role for genetic testing for these variants in personalized medicine, for assessment of genetic risk, and potentially for diagnosis...
  30. ncbi request reprint Detection and localization of proteinuria by dynamic contrast-enhanced magnetic resonance imaging using MS325
    Yantian Zhang
    Department of Radiology, Warren Grant Magnuson Clinical Center, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Am Soc Nephrol 16:1752-7. 2005
    ..If this technique can be successfully applied in human patients, it may allow for the localization of proteinuria after kidney transplant and thereby provide a noninvasive way to detect disease affecting the renal allograft...
  31. pmc Human immunodeficiency virus (HIV)-1 viral protein R suppresses transcriptional activity of peroxisome proliferator-activated receptor {gamma} and inhibits adipocyte differentiation: implications for HIV-associated lipodystrophy
    Shashi Shrivastav
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Disease NIH, 10 Center Drive MSC 1268, Bethesda, MD 20892 1268, USA
    Mol Endocrinol 22:234-47. 2008
    ..Vpr may alter sensitivity to insulin and thereby contribute to the development of lipodystrophy and insulin resistance observed in HIV-1-infected patients...
  32. pmc Microalbuminuria in HIV disease
    Colleen Hadigan
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health NIH, Department of Critical Care Medicine, NIH, Bethesda, MD, USA
    Am J Nephrol 37:443-51. 2013
    ....
  33. ncbi request reprint Pirfenidone slows renal function decline in patients with focal segmental glomerulosclerosis
    Monique E Cho
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1268, USA
    Clin J Am Soc Nephrol 2:906-13. 2007
    ..Our objective was to determine whether pirfenidone slows the loss of renal function in focal segmental glomerulosclerosis...
  34. ncbi request reprint Natural history and treatment of renal involvement in Fabry disease
    Mary Branton
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Am Soc Nephrol 13:S139-43. 2002
  35. ncbi request reprint Twenty-one-year trend in ESRD due to focal segmental glomerulosclerosis in the United States
    Chagriya Kitiyakara
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, The National Institutes of Health, Department of Health and Human Services, Bethesda, MD USA
    Am J Kidney Dis 44:815-25. 2004
    ..In the absence of a population-based estimate of FSGS incidence, we wished to obtain a population-based estimate of incident ESRD cases caused by FSGS (FSGS ESRD) and characterize temporal changes in this group...
  36. pmc HIV-1 Vpr enhances PPARβ/δ-mediated transcription, increases PDK4 expression, and reduces PDC activity
    Shashi Shrivastav
    Kidney Disease Section, National Institute of Diabetes and Digestive andKidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1268, USA
    Mol Endocrinol 27:1564-76. 2013
    ..These results support the hypothesis that Vpr contributes to impaired energy metabolism and increased energy expenditure in HIV patients. ..
  37. pmc Off the beaten renin-angiotensin-aldosterone system pathway: new perspectives on antiproteinuric therapy
    Judit Gordon
    Division of Nephrology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Adv Chronic Kidney Dis 18:300-11. 2011
    ..It is hoped that recent advances in the basic science of kidney injury will prompt development of more effective pharmaceutical and biologic therapies for proteinuria...
  38. pmc Longitudinal assessment of metabolic abnormalities in adolescents and young adults with HIV-infection acquired perinatally or in early childhood
    David Dimock
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
    Metabolism 60:874-80. 2011
    ..002). Impaired glucose tolerance, insulin resistance, dyslipidemia, and microalbuminuria are common among young adults with HIV. Long-term exposure to therapy may translate into substantial persistent metabolic risk...
  39. ncbi request reprint Images in clinical medicine. Fabry's disease
    Jeffrey B Kopp
    National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 349:e20. 2003
  40. ncbi request reprint HIV and the kidney: a status report after 20 years
    Monique E Cho
    Kidney Disease Section, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health DHHS, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Curr HIV/AIDS Rep 1:109-15. 2004
    ..Appropriate screening for renal dysfunction can minimize the likelihood of progressive renal injury in all patients with HIV-1 infection...
  41. ncbi request reprint Parvovirus-B19-associated complications in renal transplant recipients
    Meryl Waldman
    Kidney Disease Section, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20814 9692, USA
    Nat Clin Pract Nephrol 3:540-50. 2007
    ..Most patients benefit from intravenous immunoglobulin therapy and/or alteration or reduction of immunosuppressive therapy. Conservative therapy might be sufficient in some cases...
  42. ncbi request reprint Fabry disease in the era of enzyme replacement therapy: a renal perspective
    Monique E Cho
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1268, USA
    Pediatr Nephrol 19:583-93. 2004
    ..Further research is required to determine optimal dosing protocols for treatment and to establish whether therapy can retard the progression of organ dysfunction, or even prevent these complications altogether...
  43. ncbi request reprint Sirolimus therapy of focal segmental glomerulosclerosis is associated with nephrotoxicity
    Monique E Cho
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1268, USA
    Am J Kidney Dis 49:310-7. 2007
    ..We conclude that sirolimus may be associated with nephrotoxicity in some patients with FSGS, particularly those with prolonged disease duration and prior cyclosporine therapy...
  44. ncbi request reprint In vitro models of TGF-beta-induced fibrosis suitable for high-throughput screening of antifibrotic agents
    Qihe Xu
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Disases, National Institutes of Health, Bethesda, MD 20892 1268, USA
    Am J Physiol Renal Physiol 293:F631-40. 2007
    ..As a proof of principle, chemical inhibitors of Alk5 and the antifibrotic compound tranilast were shown to have inhibitory activities in both assays...
  45. ncbi request reprint Parapelvic kidney cysts: a distinguishing feature with high prevalence in Fabry disease
    Markus Ries
    Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1260, USA
    Kidney Int 66:978-82. 2004
    ..In order to identify key novel renal diagnostic imaging features of Fabry disease, we conducted a cross sectional case-control study of kidney involvement in patients with Fabry disease...
  46. doi request reprint Systemic diagnostic testing in patients with apparently isolated uveal coloboma
    Nancy Huynh
    Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, Maryland
    Am J Ophthalmol 156:1159-1168.e4. 2013
    ..To investigate the frequency and types of systemic findings in patients with apparently isolated uveal coloboma...
  47. ncbi request reprint Anti-mouse mesangial cell serum induces acute glomerulonephropathy in mice
    Yoshikage Yo
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892 1268, USA
    Nephron Exp Nephrol 93:e92-106. 2003
    ..Anti-mouse mesangial cell serum induces glomerulopathy characterized by mesangiolysis and mesangial cell apoptosis, and followed by cellular proliferation...
  48. pmc Solid-phase synthesis and screening of N-acylated polyamine (NAPA) combinatorial libraries for protein binding
    Jaclyn A Iera
    Laboratory of Bioorganic Chemistry and Kidney Disease Section, NIDDK, NIH, DHHS, Bethesda, MD 20892, United States
    Bioorg Med Chem Lett 20:6500-3. 2010
    ..Screens of the library identified a member with favorable binding properties to the HIV viral protein R (Vpr), a regulatory protein from HIV, that is involved in numerous interactions with other proteins critical for viral replication...
  49. pmc Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A
    Yingfan Zhang
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1583, USA
    Blood 119:238-50. 2012
    ..Our results show that heterozygous mice with mutations in the myosin motor or filament-forming domain manifest similar hematologic, eye, and kidney phenotypes to humans with MYH9-related disease...
  50. pmc Description of familial keloids in five pedigrees: evidence for autosomal dominant inheritance and phenotypic heterogeneity
    Jason A Clark
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    BMC Dermatol 9:8. 2009
    ..We wished to determine the inheritance pattern and phenotype of keloids among multigenerational families, as a prelude to a positional mapping strategy to identify candidate genes...
  51. pmc Viruses and kidney disease: beyond HIV
    Meryl Waldman
    Kidney Disease Section, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1268, USA
    Semin Nephrol 28:595-607. 2008
    ..We also discuss an approach to the identification of new viral renal pathogens, using a viral gene chip to identify viral DNA or RNA...
  52. ncbi request reprint Parvovirus B19 and the kidney
    Meryl Waldman
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1268, USA
    Clin J Am Soc Nephrol 2:S47-56. 2007
    ..Allograft rejection and dysfunction have been reported in association with infection, but a cause-effect relationship has not been proved. Further investigation of the relationship between B19 and kidney disease is warranted...
  53. doi request reprint Renal growth in isolated methylmalonic acidemia
    Paul S Kruszka
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
    Genet Med 15:990-6. 2013
    ..Genet Med 15 12, 990-996.Genetics in Medicine (2013); 15 12, 990-996. doi:10.1038/gim.2013.42. ..
  54. doi request reprint Glomerular disease in 2012: more mechanistic insights, but translational progress is slow
    Jeffrey B Kopp
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1268, USA
    Nat Rev Nephrol 9:67-8. 2013
    ..Progress in glomerular disease has continued, although our understanding of disease processes continues to extend much further than our ability to intervene effectively...
  55. pmc HIV-associated nephropathy patients with and without apolipoprotein L1 gene variants have similar clinical and pathological characteristics
    Mohamed G Atta
    Department of Medicine, Johns Hopkins Medical Center, Baltimore, MD 21205, USA
    Kidney Int 82:338-43. 2012
    ....
  56. ncbi request reprint Natural history of Fabry renal disease: influence of alpha-galactosidase A activity and genetic mutations on clinical course
    Mary H Branton
    Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland 20892 1268, USA
    Medicine (Baltimore) 81:122-38. 2002
  57. pmc Lack of A1 adenosine receptors augments diabetic hyperfiltration and glomerular injury
    Robert Faulhaber-Walter
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 4D51, 10 Center Drive, MSC 1370, Bethesda, MD 20892, USA
    J Am Soc Nephrol 19:722-30. 2008
    ..Rather, an A1AR-dependent mechanism, possibly TGF, limits the degree of diabetic hyperfiltration and nephropathy...
  58. ncbi request reprint Trends in the epidemiology of focal segmental glomerulosclerosis
    Chagriya Kitiyakara
    Kidney Disease Section, Epidemiology Research Program, National Institute for Diabetes and Digestive and Kidney Diseases, NIH, DHHS, Bethesda, MD, USA
    Semin Nephrol 23:172-82. 2003
    ..The reasons for the recent increase in idiopathic FSGS and FSGS incident ESRD cases are complex, but these trends are likely caused, at least in part, by a real increase in the incidence of FSGS over the past 10 to 20 years...
  59. pmc Rapid isolation of urinary exosomal biomarkers using a nanomembrane ultrafiltration concentrator
    Anita Cheruvanky
    Renal Diagnostics and Therapeutics Unit, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1268, USA
    Am J Physiol Renal Physiol 292:F1657-61. 2007
    ..This enhanced method may accelerate the translation of urinary exosomal biomarkers from bench to bedside for the diagnosis, classification, and prognostication of renal diseases...
  60. ncbi request reprint Progressive glomerulonephritis and histiocytic sarcoma associated with macrophage functional defects in CYP1B1-deficient mice
    Jerrold M Ward
    The National Institute of Allergy and Infectious Diseases, NIH and SoBran, Inc, Twinbrook 3, Room 2W 01A, Bethesda, Maryland 20892 8135, USA
    Toxicol Pathol 32:710-8. 2004
    ..The function of CYP1B1 in histiocytes and macrophages may involve both self-tolerance and tumor suppression...
  61. ncbi request reprint Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome
    Jesus M Salvador
    Gene Response Section, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Immunity 16:499-508. 2002
    ....
  62. ncbi request reprint The cyclin-dependent kinase inhibitor p21 limits murine mesangial proliferative glomerulonephritis
    Toshiaki Monkawa
    Division of Nephrology, University of Washington, Seattle, Washington, USA
    Nephron Exp Nephrol 102:e8-18. 2006
    ..However, the role of p21 in acute mesangial proliferative GN is not known. This study was conducted to test the hypothesis that p21 regulates MC proliferation and apoptosis in anti-MC serum-induced GN...
  63. ncbi request reprint Update in podocyte biology: putting one's best foot forward
    Laura Barisoni
    The Johns Hopkins University, Baltimore, Maryland, USA
    Curr Opin Nephrol Hypertens 12:251-8. 2003
    ..The rapidly developing field of podocyte cell biology is reviewed, focusing on papers published in the last 12 months...
  64. ncbi request reprint Hepatocyte growth factor counteracts transforming growth factor-beta1, through attenuation of connective tissue growth factor induction, and prevents renal fibrogenesis in 5/6 nephrectomized mice
    Tsutomu Inoue
    Department of Nephrology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    FASEB J 17:268-70. 2003
    ..In conclusion, HGF can block, at least partially, renal fibrogenesis promoted by TGF-beta1 in the remnant kidney, via attenuation of CTGF induction...
  65. ncbi request reprint Renal pathology in Fabry disease
    Joseph Alroy
    Department of Pathology, Tufts University Schools of Veterinary Medicine and Medicine, New England Medical Center, Boston, Massachusetts, USA
    J Am Soc Nephrol 13:S134-8. 2002
  66. ncbi request reprint Modulation of podocyte phenotype in collapsing glomerulopathies
    Laura Barisoni
    Department of Pathology, The Johns Hopkins University, Baltimore, Maryland
    Microsc Res Tech 57:254-62. 2002
    ..Finally, is it important to mention that collapsing glomerulopathies have a high prevalence in black patients, suggesting a link between racial background and the virus-related podocyte injury...
  67. ncbi request reprint CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility
    Jeong M Kim
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 300:1298-300. 2003
    ..Two human patients with focal segmental glomerulosclerosis had a mutation predicted to ablate expression of one CD2AP allele, implicating CD2AP as a determinant of human susceptibility to glomerular disease...
  68. ncbi request reprint Pathogenesis and treatment of HIV-associated renal diseases: lessons from clinical and animal studies, molecular pathologic correlations, and genetic investigations
    Paul L Kimmel
    Division of Renal Diseases and Hypertension, Department of Medicine, George Washington University Medical Center, 2150 Pennsylvania Avenue NW, Washington, DC 20037, USA
    Ann Intern Med 139:214-26. 2003
    ..Outcomes in patients undergoing hemodialysis and peritoneal dialysis have improved, and current research focuses on renal transplantation for treatment of HIV-infected patients...
  69. ncbi request reprint Effects of transgenic expression of HIV-1 Vpr on lipid and energy metabolism in mice
    Ashok Balasubramanyam
    Translational Metabolism Unit, Division of Diabetes, Endocrinology and Metabolism, BCM 700B, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Am J Physiol Endocrinol Metab 292:E40-8. 2007
    ....
  70. pmc VEGF inhibition and renal thrombotic microangiopathy
    Vera Eremina
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    N Engl J Med 358:1129-36. 2008
    ..These observations provide evidence that glomerular injury in patients who are treated with bevacizumab is probably due to direct targeting of VEGF by antiangiogenic therapy...
  71. ncbi request reprint NPHS2 variation in sporadic focal segmental glomerulosclerosis
    Louise M McKenzie
    Laboratory of Genomic Diversity, SAIC Frederick, National Cancer Institute, NCI Frederick, Frederick, Maryland, USA
    J Am Soc Nephrol 18:2987-95. 2007
    ..5, P = 0.001). These results indicate that genetic variation or mutation of NPHS2 may play a role in late-onset sporadic FSGS...
  72. ncbi request reprint A proposed taxonomy for the podocytopathies: a reassessment of the primary nephrotic diseases
    Laura Barisoni
    Department of Pathology, New York University School of Medicine, New York, New York, USA
    Clin J Am Soc Nephrol 2:529-42. 2007
    ....
  73. ncbi request reprint Angiotensin II provokes podocyte injury in murine model of HIV-associated nephropathy
    Hiroshi Ideura
    Department of Medicine and Clinical Science, Gunma University Graduste School of Medicine, Maebashi, Gunma, Japan
    Am J Physiol Renal Physiol 293:F1214-21. 2007
    ..ANG II infusion alone without doxycycline resulted in a lower level of albuminuria and minimal histological changes. These data demonstrate that excessive ANG II accelerates vpr-induced podocyte injury in a mouse model of HIVAN...
  74. ncbi request reprint Angiotensin II type 1 receptor blockade inhibits the development and progression of HIV-associated nephropathy in a mouse model
    Noriyuki Hiramatsu
    Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, 3 39 22 Showa, Maebashi, Gunma 371 8511, Japan
    J Am Soc Nephrol 18:515-27. 2007
    ..AT1R blockade could be beneficial in the treatment of HIVAN by ameliorating podocyte injury by avoiding the vicious cycle of nephron reduction and glomerular hypertension...
  75. ncbi request reprint Why kidneys fail: report from an American Society of Nephrology Advances in Research Conference
    H William Schnaper
    Department of Pediatrics, Northwestern University Medical School, Illinois, USA
    J Am Soc Nephrol 17:1777-81. 2006
    ..In this article, the conference organizers summarize the conference presentations...
  76. ncbi request reprint NPHS2 gene, nephrotic syndrome and focal segmental glomerulosclerosis: a HuGE review
    Nora Franceschini
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27514 3628, USA
    Genet Med 8:63-75. 2006
    ..Nevertheless, the available data suggest that large epidemiological case-control studies to examine the association between NPHS2 variants and nephrotic syndrome are warranted...
  77. ncbi request reprint Connective tissue growth factor expressed in tubular epithelium plays a pivotal role in renal fibrogenesis
    Hirokazu Okada
    Department of Nephrology, Saitama Medical College, 38 Morohongo, Moroyama machi, Irumagun, Saitama 350 0495, Japan
    J Am Soc Nephrol 16:133-43. 2005
    ..In conclusion, tubular CTGF acts as a downstream mediator of the profibrotic effects of TGF-beta1 in the remnant kidney, which is a promising target for antifibrotic drugs designed to treat TGF-beta1-dependent interstitial fibrosis...
  78. ncbi request reprint Renal fibrosis
    H William Schnaper
    Division of Pediatric Nephrology, Northwestern University, Medical School, Chicago, IL, USA
    Front Biosci 8:e68-86. 2003
    ..Other proteins and small molecules may have anti-fibrotic effects. Manipulation of these opposing systems holds the promise of effective treatments for chronic progressive kidney disease...
  79. pmc Interstitial fibroblast-like cells express renin-angiotensin system components in a fibrosing murine kidney
    Hirokazu Okada
    Department of Nephrology, Saitama Medical College, Saitama, Japan
    Am J Pathol 160:765-72. 2002
    ..These data provide strong evidence for a tubulointerstitial RAS within the fibrosing kidney, and a linkage between the RAS and renal fibrogenesis...