Mitchel A Kling

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Sustained low-grade pro-inflammatory state in unmedicated, remitted women with major depressive disorder as evidenced by elevated serum levels of the acute phase proteins C-reactive protein and serum amyloid A
    Mitchel A Kling
    Clinical Neuroendocrinology Branch, Division of Intramural Research Programs, National Institute of Mental Health, Bethesda, MD 20892 1284, USA
    Biol Psychiatry 62:309-13. 2007
  2. doi request reprint Unmedicated, remitted patients with major depression have decreased serum immunoglobulin A
    Philip W Gold
    Clinical Neuroendocrinology Branch, NIH NIMH, 10 Center Drive, Bethesda, MD 20892, USA
    Neurosci Lett 520:1-5. 2012
  3. pmc Acute hydrocortisone treatment increases anxiety but not fear in healthy volunteers: a fear-potentiated startle study
    Christian Grillon
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
    Biol Psychiatry 69:549-55. 2011
  4. pmc Cardiac implications of increased arterial entry and reversible 24-h central and peripheral norepinephrine levels in melancholia
    Philip W Gold
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1284, USA
    Proc Natl Acad Sci U S A 102:8303-8. 2005
  5. pmc Acute stress potentiates anxiety in humans
    Christian Grillon
    Unit of Affective Psychophysiology, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
    Biol Psychiatry 62:1183-6. 2007
  6. pmc CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques
    Christina S Barr
    Laboratory of Clinical Studies, Primate Section, National Institute on Alcohol Abuse Alcoholism, Division of Intramural Clinical and Biological Research, TR 112, PO Box 529, Poolesville, MD 20837, USA
    Arch Gen Psychiatry 65:934-44. 2008
  7. pmc Activation of blood coagulation in patients with major depressive disorder during euglycemic hyperinsulinemia
    McDonald K Horne
    Hematology Service, Department of Laboratory Medicine, W G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20895, United States
    Thromb Res 120:517-21. 2007
  8. ncbi request reprint Major depression is associated with significant diurnal elevations in plasma interleukin-6 levels, a shift of its circadian rhythm, and loss of physiological complexity in its secretion: clinical implications
    Salvatore Alesci
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Building 10, Room 2D46, MSC 1284, Bethesda, Maryland 20892 1284, USA
    J Clin Endocrinol Metab 90:2522-30. 2005
  9. ncbi request reprint Vagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase trial
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Biol Psychiatry 58:347-54. 2005
  10. ncbi request reprint Effect of vagus nerve stimulation on cerebrospinal fluid monoamine metabolites, norepinephrine, and gamma-aminobutyric acid concentrations in depressed patients
    Linda L Carpenter
    Laboratory for Clinical Neuroscience, Butler Hospital, Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, Rhode Island 02906, USA edu
    Biol Psychiatry 56:418-26. 2004

Detail Information

Publications13

  1. pmc Sustained low-grade pro-inflammatory state in unmedicated, remitted women with major depressive disorder as evidenced by elevated serum levels of the acute phase proteins C-reactive protein and serum amyloid A
    Mitchel A Kling
    Clinical Neuroendocrinology Branch, Division of Intramural Research Programs, National Institute of Mental Health, Bethesda, MD 20892 1284, USA
    Biol Psychiatry 62:309-13. 2007
    ..Elevations of the inflammatory markers C-reactive protein (CRP) and serum amyloid A (SAA) predict increased CAD risk in populations; few data on these markers exist in MDD, particularly in remitted patients...
  2. doi request reprint Unmedicated, remitted patients with major depression have decreased serum immunoglobulin A
    Philip W Gold
    Clinical Neuroendocrinology Branch, NIH NIMH, 10 Center Drive, Bethesda, MD 20892, USA
    Neurosci Lett 520:1-5. 2012
    ..In the light of the fact that IgA serves many immunomodulatory, anti-inflammatory roles, this finding supports the concept that major depressive illness represents a proinflammatory state...
  3. pmc Acute hydrocortisone treatment increases anxiety but not fear in healthy volunteers: a fear-potentiated startle study
    Christian Grillon
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
    Biol Psychiatry 69:549-55. 2011
    ..The current study examines these effects, as instantiated with short- and long-duration threats...
  4. pmc Cardiac implications of increased arterial entry and reversible 24-h central and peripheral norepinephrine levels in melancholia
    Philip W Gold
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1284, USA
    Proc Natl Acad Sci U S A 102:8303-8. 2005
    ..Even mildly-to-moderately depressed melancholic patients had clinically relevant increases in the arterial NE-appearance rate. These findings will not apply to all clinical subtypes of major depression...
  5. pmc Acute stress potentiates anxiety in humans
    Christian Grillon
    Unit of Affective Psychophysiology, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
    Biol Psychiatry 62:1183-6. 2007
    ..Stress is an important factor in the development and maintenance of anxiety disorders. Stress also potentiates anxiety-like response in animals, but empirical evidence for a similar effect in humans is still lacking...
  6. pmc CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques
    Christina S Barr
    Laboratory of Clinical Studies, Primate Section, National Institute on Alcohol Abuse Alcoholism, Division of Intramural Clinical and Biological Research, TR 112, PO Box 529, Poolesville, MD 20837, USA
    Arch Gen Psychiatry 65:934-44. 2008
    ..As such, CRH gene variation may influence risk for alcohol use and dependence...
  7. pmc Activation of blood coagulation in patients with major depressive disorder during euglycemic hyperinsulinemia
    McDonald K Horne
    Hematology Service, Department of Laboratory Medicine, W G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20895, United States
    Thromb Res 120:517-21. 2007
  8. ncbi request reprint Major depression is associated with significant diurnal elevations in plasma interleukin-6 levels, a shift of its circadian rhythm, and loss of physiological complexity in its secretion: clinical implications
    Salvatore Alesci
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Building 10, Room 2D46, MSC 1284, Bethesda, Maryland 20892 1284, USA
    J Clin Endocrinol Metab 90:2522-30. 2005
    ..Given the activating role of IL-6 on the hypothalamic-pituitary-adrenal (HPA) axis, and the relevance of its dysregulation in MDD, we also analyzed the relations between IL-6 and cortisol levels...
  9. ncbi request reprint Vagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase trial
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Biol Psychiatry 58:347-54. 2005
    ..Vagus nerve stimulation (VNS) alters both concentrations of neurotransmitters or their metabolites and functional activity of central nervous system regions dysregulated in mood disorders. An open trial has suggested efficacy...
  10. ncbi request reprint Effect of vagus nerve stimulation on cerebrospinal fluid monoamine metabolites, norepinephrine, and gamma-aminobutyric acid concentrations in depressed patients
    Linda L Carpenter
    Laboratory for Clinical Neuroscience, Butler Hospital, Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, Rhode Island 02906, USA edu
    Biol Psychiatry 56:418-26. 2004
    ..Cerebrospinal fluid (CSF) studies in epilepsy patients show that VNS alters concentrations of monamines and gamma-aminobutyric acid (GABA), neurotransmitter systems possibly involved in the pathogenesis of depression...
  11. ncbi request reprint VNS and depression: current status and future directions
    Sally P Walsh
    Department of Neurology, Georgetown University Medical Center, Washington, DC 20057, USA
    Expert Rev Med Devices 1:155-60. 2004
    ..Results from the long-term phase of this trial may be more significant, however published data are awaited...
  12. ncbi request reprint A one-year comparison of vagus nerve stimulation with treatment as usual for treatment-resistant depression
    Mark S George
    Department of Psychiatry, Medical University of South Carolina, 67 President Street 502 N, Charleston, SC 29425, USA
    Biol Psychiatry 58:364-73. 2005
    ..To better understand these effects on long-term outcome, we compared 12-month VNS+TAU outcomes with those of a comparable TRD group...
  13. ncbi request reprint Decreased cerebrospinal fluid concentrations of substance P in treatment-resistant depression and lack of alteration after acute adjunct vagus nerve stimulation therapy
    Linda L Carpenter
    Mood Disorders Research Program, Butler Hospital, Brown University, Providence, RI, USA
    Psychiatry Res 157:123-9. 2008
    ..Low CSF SP may reflect a biological marker of the subtype of severe and chronic depression that is resistant to standard therapies...