Genomes and Genes
Mitchel A Kling
Affiliation: National Institutes of Health
- Sustained low-grade pro-inflammatory state in unmedicated, remitted women with major depressive disorder as evidenced by elevated serum levels of the acute phase proteins C-reactive protein and serum amyloid AMitchel A Kling
Clinical Neuroendocrinology Branch, Division of Intramural Research Programs, National Institute of Mental Health, Bethesda, MD 20892 1284, USA
Biol Psychiatry 62:309-13. 2007..Elevations of the inflammatory markers C-reactive protein (CRP) and serum amyloid A (SAA) predict increased CAD risk in populations; few data on these markers exist in MDD, particularly in remitted patients...
- Unmedicated, remitted patients with major depression have decreased serum immunoglobulin APhilip W Gold
Clinical Neuroendocrinology Branch, NIH NIMH, 10 Center Drive, Bethesda, MD 20892, USA
Neurosci Lett 520:1-5. 2012..In the light of the fact that IgA serves many immunomodulatory, anti-inflammatory roles, this finding supports the concept that major depressive illness represents a proinflammatory state...
- Acute hydrocortisone treatment increases anxiety but not fear in healthy volunteers: a fear-potentiated startle studyChristian Grillon
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
Biol Psychiatry 69:549-55. 2011..The current study examines these effects, as instantiated with short- and long-duration threats...
- Cardiac implications of increased arterial entry and reversible 24-h central and peripheral norepinephrine levels in melancholiaPhilip W Gold
Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1284, USA
Proc Natl Acad Sci U S A 102:8303-8. 2005..Even mildly-to-moderately depressed melancholic patients had clinically relevant increases in the arterial NE-appearance rate. These findings will not apply to all clinical subtypes of major depression...
- Acute stress potentiates anxiety in humansChristian Grillon
Unit of Affective Psychophysiology, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
Biol Psychiatry 62:1183-6. 2007..Stress is an important factor in the development and maintenance of anxiety disorders. Stress also potentiates anxiety-like response in animals, but empirical evidence for a similar effect in humans is still lacking...
- CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaquesChristina S Barr
Laboratory of Clinical Studies, Primate Section, National Institute on Alcohol Abuse Alcoholism, Division of Intramural Clinical and Biological Research, TR 112, PO Box 529, Poolesville, MD 20837, USA
Arch Gen Psychiatry 65:934-44. 2008..As such, CRH gene variation may influence risk for alcohol use and dependence...
- Activation of blood coagulation in patients with major depressive disorder during euglycemic hyperinsulinemiaMcDonald K Horne
Hematology Service, Department of Laboratory Medicine, W G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20895, United States
Thromb Res 120:517-21. 2007
- Major depression is associated with significant diurnal elevations in plasma interleukin-6 levels, a shift of its circadian rhythm, and loss of physiological complexity in its secretion: clinical implicationsSalvatore Alesci
Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Building 10, Room 2D46, MSC 1284, Bethesda, Maryland 20892 1284, USA
J Clin Endocrinol Metab 90:2522-30. 2005..Given the activating role of IL-6 on the hypothalamic-pituitary-adrenal (HPA) axis, and the relevance of its dysregulation in MDD, we also analyzed the relations between IL-6 and cortisol levels...
- Vagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase trialA John Rush
Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Biol Psychiatry 58:347-54. 2005..Vagus nerve stimulation (VNS) alters both concentrations of neurotransmitters or their metabolites and functional activity of central nervous system regions dysregulated in mood disorders. An open trial has suggested efficacy...
- Effect of vagus nerve stimulation on cerebrospinal fluid monoamine metabolites, norepinephrine, and gamma-aminobutyric acid concentrations in depressed patientsLinda L Carpenter
Laboratory for Clinical Neuroscience, Butler Hospital, Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, Rhode Island 02906, USA edu
Biol Psychiatry 56:418-26. 2004..Cerebrospinal fluid (CSF) studies in epilepsy patients show that VNS alters concentrations of monamines and gamma-aminobutyric acid (GABA), neurotransmitter systems possibly involved in the pathogenesis of depression...
- VNS and depression: current status and future directionsSally P Walsh
Department of Neurology, Georgetown University Medical Center, Washington, DC 20057, USA
Expert Rev Med Devices 1:155-60. 2004..Results from the long-term phase of this trial may be more significant, however published data are awaited...
- A one-year comparison of vagus nerve stimulation with treatment as usual for treatment-resistant depressionMark S George
Department of Psychiatry, Medical University of South Carolina, 67 President Street 502 N, Charleston, SC 29425, USA
Biol Psychiatry 58:364-73. 2005..To better understand these effects on long-term outcome, we compared 12-month VNS+TAU outcomes with those of a comparable TRD group...
- Decreased cerebrospinal fluid concentrations of substance P in treatment-resistant depression and lack of alteration after acute adjunct vagus nerve stimulation therapyLinda L Carpenter
Mood Disorders Research Program, Butler Hospital, Brown University, Providence, RI, USA
Psychiatry Res 157:123-9. 2008..Low CSF SP may reflect a biological marker of the subtype of severe and chronic depression that is resistant to standard therapies...