Joel E Kleinman

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Genetic neuropathology of schizophrenia: new approaches to an old question and new uses for postmortem human brains
    Joel E Kleinman
    Section on Neuropathology, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Biol Psychiatry 69:140-5. 2011
  2. pmc No effect of a common allelic variant in the reelin gene on intermediate phenotype measures of brain structure, brain function, and gene expression
    Heike Tost
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1379, USA
    Biol Psychiatry 68:105-7. 2010
  3. ncbi request reprint RGS4 mRNA expression in postmortem human cortex is associated with COMT Val158Met genotype and COMT enzyme activity
    Barbara K Lipska
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute for Mental Health, NIH, DHHS, Bethesda, MD 20892 1385, USA
    Hum Mol Genet 15:2804-12. 2006
  4. pmc Transcript-specific associations of SLC12A5 (KCC2) in human prefrontal cortex with development, schizophrenia, and affective disorders
    Ran Tao
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1385, USA
    J Neurosci 32:5216-22. 2012
  5. ncbi request reprint Age-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortex
    Carlo Colantuoni
    Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, MD 20892, USA
    Brain Struct Funct 213:255-71. 2008
  6. ncbi request reprint Alpha7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1
    Shiny V Mathew
    Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, MD 20892 1385, USA
    Hum Mol Genet 16:2921-32. 2007
  7. pmc Variants in the estrogen receptor alpha gene and its mRNA contribute to risk for schizophrenia
    Cynthia Shannon Weickert
    MiNDS Unit, Section on Neuropathology, GCAP, NIMH, NIH, Bethesda, MD 20892, USA
    Hum Mol Genet 17:2293-309. 2008
  8. pmc Expression of GABA signaling molecules KCC2, NKCC1, and GAD1 in cortical development and schizophrenia
    Thomas M Hyde
    Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 31:11088-95. 2011
  9. pmc Genetic variation in CACNA1C affects brain circuitries related to mental illness
    Kristin L Bigos
    Genes, Cognition, and Psychosis Program, Division of Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 67:939-45. 2010
  10. ncbi request reprint Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain
    Cynthia Shannon Weickert
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 61:544-55. 2004

Detail Information

Publications52

  1. doi request reprint Genetic neuropathology of schizophrenia: new approaches to an old question and new uses for postmortem human brains
    Joel E Kleinman
    Section on Neuropathology, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Biol Psychiatry 69:140-5. 2011
    ..Moreover, the data, interpreted judiciously, can strengthen the plausibility of the association itself...
  2. pmc No effect of a common allelic variant in the reelin gene on intermediate phenotype measures of brain structure, brain function, and gene expression
    Heike Tost
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1379, USA
    Biol Psychiatry 68:105-7. 2010
    ..In the largest neuroimaging intermediate phenotype study reported so far, we evaluated the effect of rs7341475 on an extended array of different neuroscientific measures...
  3. ncbi request reprint RGS4 mRNA expression in postmortem human cortex is associated with COMT Val158Met genotype and COMT enzyme activity
    Barbara K Lipska
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute for Mental Health, NIH, DHHS, Bethesda, MD 20892 1385, USA
    Hum Mol Genet 15:2804-12. 2006
    ..These data suggest that RGS4 mRNA expression is associated with cortical dopamine signaling and illustrate the importance of genetic and/or environmental background in gene expression studies in schizophrenia...
  4. pmc Transcript-specific associations of SLC12A5 (KCC2) in human prefrontal cortex with development, schizophrenia, and affective disorders
    Ran Tao
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1385, USA
    J Neurosci 32:5216-22. 2012
    ..Alternate transcripts from KCC2 may participate in the abnormal GABA signaling in the DLPFC associated with schizophrenia...
  5. ncbi request reprint Age-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortex
    Carlo Colantuoni
    Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, MD 20892, USA
    Brain Struct Funct 213:255-71. 2008
    ..All microarray data are available at NCBI's Gene Expression Omnibus: GEO Series accession number GSE11546 (http://www.ncbi.nlm.nih.gov/geo) [corrected]..
  6. ncbi request reprint Alpha7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1
    Shiny V Mathew
    Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, MD 20892 1385, USA
    Hum Mol Genet 16:2921-32. 2007
    ..Together, these results suggest that the molecular mechanism of the association between NRG1 risk alleles and schizophrenia may include down-regulation of nAChR alpha7 expression...
  7. pmc Variants in the estrogen receptor alpha gene and its mRNA contribute to risk for schizophrenia
    Cynthia Shannon Weickert
    MiNDS Unit, Section on Neuropathology, GCAP, NIMH, NIH, Bethesda, MD 20892, USA
    Hum Mol Genet 17:2293-309. 2008
    ..Thus, the variation in the ESR1 gene is associated with schizophrenia and the mechanism of this association may involve alternative gene regulation and transcript processing...
  8. pmc Expression of GABA signaling molecules KCC2, NKCC1, and GAD1 in cortical development and schizophrenia
    Thomas M Hyde
    Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 31:11088-95. 2011
    ..These findings suggest that abnormalities in GABA signaling critical to brain development contribute to genetic risk for schizophrenia...
  9. pmc Genetic variation in CACNA1C affects brain circuitries related to mental illness
    Kristin L Bigos
    Genes, Cognition, and Psychosis Program, Division of Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 67:939-45. 2010
    ..The CACNA1C gene (alpha-1C subunit of the L-type voltage-gated calcium channel) has been identified as a risk gene for bipolar disorder and schizophrenia, but the mechanism of association has not been explored...
  10. ncbi request reprint Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain
    Cynthia Shannon Weickert
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 61:544-55. 2004
    ..3) encodes a neuronal protein that binds to beta-dystrobrevin and may be part of the dystrophin protein complex. Little is known about dysbindin expression in normal or schizophrenic brain...
  11. ncbi request reprint A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain
    Mitsuyuki Matsumoto
    Clinical Brain Disorders Branch, NIMH, NIH, Bethesda, MD 20892, USA
    Brain Res Mol Brain Res 138:58-69. 2005
    ..Together, these data suggest a possible link between SREB family and neural plasticity, which may explain its extremely high conservation throughout vertebrate evolution...
  12. pmc Characteristics of the cation cotransporter NKCC1 in human brain: alternate transcripts, expression in development, and potential relationships to brain function and schizophrenia
    Yukitaka Morita
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, Department of Psychiatry, Hiroshima City Hospital, Hiroshima City, Hiroshima Prefecture, 730 8518, Japan, Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, Maryland 21205, Neurodevelopmental and Neuropsychiatric Genetics Laboratory, Departments of Psychiatry and Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, Colorado 80045, and Departments of Psychiatry, Neurology, Neuroscience and the McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Neurosci 34:4929-40. 2014
    ....
  13. pmc DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms
    Kenji Nakata
    Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1385, USA
    Proc Natl Acad Sci U S A 106:15873-8. 2009
    ..Our results implicate a molecular mechanism of genetic risk associated with DISC1 involving specific alterations in gene processing...
  14. pmc Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients
    Cynthia Shannon Weickert
    MiNDS Unit of the Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20892, USA
    Schizophr Res 98:105-10. 2008
    ..Our results indicate that previously reported dysbindin-1 protein reductions may be due in part to decreased dysbindin-1 mRNA and that reduced dysbindin-1 may contribute to hippocampal formation synaptic pathology in schizophrenia...
  15. ncbi request reprint Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs
    Barbara K Lipska
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Hum Mol Genet 15:1245-58. 2006
    ..Although, many other DISC1 binding partners still need to be investigated, these data implicate genetically linked abnormalities in the DISC1 molecular pathway in the pathophysiology of schizophrenia...
  16. ncbi request reprint Alteration in estrogen receptor alpha mRNA levels in frontal cortex and hippocampus of patients with major mental illness
    William R Perlman
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, MD 20892 1385, USA
    Biol Psychiatry 58:812-24. 2005
    ..We hypothesized that gender-specific alterations in DLPFC and hippocampus estrogen receptor alpha (ERalpha) mRNA levels may exist in MMI patients...
  17. doi request reprint Evidence of sex-modulated association of ZNF804A with schizophrenia
    Fengyu Zhang
    Genes, Cognition and Psychosis Program and Clinical, Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 69:914-7. 2011
    ..A recent candidate gene study, which replicated the positive association with rs1344706, identified another positive SNP (rs7597593) in ZNF804A associated with schizophrenia...
  18. pmc Expression of oligodendrocyte-associated genes in dorsolateral prefrontal cortex of patients with schizophrenia
    Shruti N Mitkus
    Clinical Brain Disorders Branch, Section on Neuropathology, DIRP NIMH NIH, Bethesda, MD, 20892 1385, USA
    Schizophr Res 98:129-38. 2008
    ..These data illustrate the importance of genetic background in gene expression studies in schizophrenia...
  19. ncbi request reprint Critical factors in gene expression in postmortem human brain: Focus on studies in schizophrenia
    Barbara K Lipska
    Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1385, USA
    Biol Psychiatry 60:650-8. 2006
    ..They are, however, confounded by pre- and postmortem factors. The purpose of this study was to identify sources of variation that will enable a better design of gene expression studies and higher reliability of gene expression data...
  20. pmc Genetic variation in FGF20 modulates hippocampal biology
    Herve Lemaitre
    Clinical Brain Disorder Branch, Genes, Cognition, and Psychosis Program, National Institutes of Health National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Neurosci 30:5992-7. 2010
    ..These associations, from mRNA expression to brain morphology to cognition and an interaction with aging, confirm a role of FGF20 in human brain structure and function during development and aging...
  21. pmc Metabotropic glutamate receptor 2 and 3 gene expression in the human prefrontal cortex and mesencephalon in schizophrenia
    Subroto Ghose
    Clinical Brain Disorders Branch, NIMH, NIH, Bethesda, Maryland, USA
    Int J Neurosci 118:1609-27. 2008
    ..The expression of mGluR2, 3 in DA cells provide a mechanism for glutamate to modulate dopamine release in the human brain and this species-specific difference may be critical to understanding rodent models in schizophrenia...
  22. pmc DNA methylation signatures in development and aging of the human prefrontal cortex
    Shusuke Numata
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Hum Genet 90:260-72. 2012
    ..Additional discovery is made possible with a stand-alone application, BrainCloudMethyl...
  23. pmc Common genetic variation in Neuregulin 3 (NRG3) influences risk for schizophrenia and impacts NRG3 expression in human brain
    Wee Tin Kao
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1385, USA
    Proc Natl Acad Sci U S A 107:15619-24. 2010
    ..Our observations strengthen the evidence that NRG3 is a schizophrenia susceptibility gene, provide quantitative insight into NRG3 transcription traits in the human brain, and reveal a probable mechanistic basis for disease association...
  24. pmc Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition
    Andreas Meyer-Lindenberg
    Unit for Systems Neuroscience in Psychiatry, Neuroimaging Core Facility, and Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute for Mental Health NIMH, NIH, Bethesda, MD 20892, USA
    J Clin Invest 117:672-82. 2007
    ..Our convergent results identify a prefrontal-neostriatal system affected by variation in PPP1R1B and suggest that DARPP-32 plays a pivotal role in cognitive function and possibly in the pathogenesis of schizophrenia...
  25. doi request reprint Expression of a GRM3 splice variant is increased in the dorsolateral prefrontal cortex of individuals carrying a schizophrenia risk SNP
    Leah J Sartorius
    Genes Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropsychopharmacology 33:2626-34. 2008
    ..Our results suggest that rs2228595, or a neighboring SNP in linkage disequilibrium with it, may contribute to risk for schizophrenia by modulating GRM3 splicing...
  26. pmc Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain
    Jingshan Chen
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Hum Genet 75:807-21. 2004
    ....
  27. pmc Temporal dynamics and genetic control of transcription in the human prefrontal cortex
    Carlo Colantuoni
    Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, Maryland 20892, USA
    Nature 478:519-23. 2011
    ..v1.p1) and can also be interrogated via a biologist-friendly stand-alone application (http://www.libd.org/braincloud)...
  28. pmc Increased lactate levels and reduced pH in postmortem brains of schizophrenics: medication confounds
    Nader D Halim
    Graduate Program in Molecular and Cell Biology, Bethesda, MD 20814, USA
    J Neurosci Methods 169:208-13. 2008
    ....
  29. ncbi request reprint Discordant changes in cortical TrkC mRNA and protein during the human lifespan
    Senda Beltaifa
    Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20892, USA
    Eur J Neurosci 21:2433-44. 2005
    ..Our results suggest that truncated trkC is prevalent in the human PFC and that neurons and glia may be responsive to NT-3 in the PFC throughout life...
  30. ncbi request reprint Catechol O-methyltransferase (COMT) mRNA expression in the dorsolateral prefrontal cortex of patients with schizophrenia
    Mitsuyuki Matsumoto
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA
    Neuropsychopharmacology 28:1521-30. 2003
    ..The disease-related laminar difference of COMT expression may be involved in dysregulation of dopamine signaling circuits in the DLPFC of patients with schizophrenia...
  31. ncbi request reprint Age-related differences in glucocorticoid receptor mRNA levels in the human brain
    William R Perlman
    MiNDS Unit, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD 20892 1385, USA
    Neurobiol Aging 28:447-58. 2007
    ..Increased GR mRNA in prefrontal cortex during adolescence and adulthood suggests that human GR-mediated forebrain regulation of cognition and the neuroendocrine stress response may be more salient during late maturation and at maturity...
  32. pmc Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110δ inhibition as a potential therapeutic strategy
    Amanda J Law
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:12165-70. 2012
    ....
  33. pmc Psychiatric brain banking: three perspectives on current trends and future directions
    Amy Deep-Soboslay
    Section on Neuropathology, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 69:104-12. 2011
    ....
  34. pmc A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia
    Stephen J Huffaker
    Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, Maryland, USA
    Nat Med 15:509-18. 2009
    ..These results identify a previously undescribed KCNH2 channel isoform involved in cortical physiology, cognition and psychosis, providing a potential new therapeutic drug target...
  35. pmc Evaluation of tissue collection for postmortem studies of bipolar disorder
    Amy Deep-Soboslay
    Division of Intramural Research Programs, Section on Neuropathology, Clinical Brain Disorders Branch, NIMH, NIH, Bethesda, MD 20892, USA
    Bipolar Disord 10:822-8. 2008
    ..We set out to evaluate BPD postmortem brain collections in order to identify both successful methods as well as barriers to collection...
  36. pmc Postmortem investigations of the pathophysiology of schizophrenia: the role of susceptibility genes
    William R Perlman
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD 20892 1384, USA
    J Psychiatry Neurosci 29:287-93. 2004
    ....
  37. ncbi request reprint Reduced glucocorticoid and estrogen receptor alpha messenger ribonucleic acid levels in the amygdala of patients with major mental illness
    William R Perlman
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, Maryland, USA
    Biol Psychiatry 56:844-52. 2004
    ..We also hypothesized that estrogen receptor alpha (ERalpha) mRNA expression might be altered in the amygdala, on the basis of observed gender differences in mental illness...
  38. pmc Binding of a tritiated inverse agonist to cannabinoid CB1 receptors is increased in patients with schizophrenia
    Kimberly J Jenko
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1003, USA
    Schizophr Res 141:185-8. 2012
    ..05)...
  39. pmc Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia
    Michael F Egan
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health NIH DHHS, Building 10, Center Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:12604-9. 2004
    ..These convergent data point to a specific molecular pathway by which GRM3 genotype alters glutamate neurotransmission, prefrontal and hippocampal physiology and cognition, and thereby increased risk for schizophrenia...
  40. ncbi request reprint Glutamate carboxypeptidase II gene expression in the human frontal and temporal lobe in schizophrenia
    Subroto Ghose
    Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 29:117-25. 2004
    ..Our findings support the notion that the hydrolysis of NAAG is disrupted in schizophrenia and that specific anatomical regions may show discrete abnormalities in GCP II synthesis...
  41. ncbi request reprint Catechol-O-methyltransferase genotype and dopamine regulation in the human brain
    Mayada Akil
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 23:2008-13. 2003
    ..This indicates that COMT genotype is a heritable aspect of dopamine regulation and it further explicates the mechanism by which the COMT valine allele increases susceptibility for psychosis...
  42. pmc Use of postmortem human dura mater and scalp for deriving human fibroblast cultures
    Lindsay A Bliss
    Section on Neuropathology, Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 7:e45282. 2012
    ..These tissues may be accessible through existing brain tissue collections, which is critical for studying disorders such as neuropsychiatric diseases...
  43. ncbi request reprint Reliability of psychiatric diagnosis in postmortem research
    Amy Deep-Soboslay
    Section on Neuropathology, Clinical Brain Disorders Branch, National Institute of Mental Health NIH, 10 Center Drive, Bethesda, MD 20892, USA
    Biol Psychiatry 57:96-101. 2005
    ..Finding reliable methods for assessing lifetime psychiatric diagnoses in subjects after death is extremely challenging...
  44. pmc Functional genomics in postmortem human brain: abnormalities in a DISC1 molecular pathway in schizophrenia
    Barbara K Lipska
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Dialogues Clin Neurosci 8:353-7. 2006
    ..These data suggest involvement of genetically linked abnormalities in the DISC1 molecular pathway in the pathophysiology of schizophrenia...
  45. pmc A genetic polymorphism for translocator protein 18 kDa affects both in vitro and in vivo radioligand binding in human brain to this putative biomarker of neuroinflammation
    William C Kreisl
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892 1026, USA
    J Cereb Blood Flow Metab 33:53-8. 2013
    ..011). Our results show that TSPO genotype influences PBR28 binding in vitro and in vivo. Correcting for this genotype increased statistical power in our postmortem study and is recommended for in vivo positron emission tomography studies...
  46. pmc A comparison of human brain dissection by drill versus saw on nucleic acid quality
    Ross C Buerlein
    National Institutes of Mental Health, Clinical Brain Disorders Branch, Bethesda, MD 20892, USA
    J Neurosci Methods 179:68-70. 2009
    ..Therefore, these results support the use of a high-speed hand-held electric dental drill as an efficient and anatomically precise means of human brain dissection without compromising tissue quality...
  47. pmc Transcriptional changes common to human cocaine, cannabis and phencyclidine abuse
    Elin Lehrmann
    Cellular Neurobiology Research Branch and Chemistry and Drug Metabolism Section, National Institute on Drug Abuse NIDA Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, United States of America
    PLoS ONE 1:e114. 2006
    ..These changes represent common molecular features of drug abuse, which may underlie changes in synaptic function and plasticity that could have important ramifications for decision-making capabilities in drug abusers...
  48. pmc Postmortem diagnosis and toxicological validation of illicit substance use
    Elin Lehrmann
    Cellular Neurobiology Research Branch, National Institute on Drug Abuse NIDA IRP, National Institutes of Health, Baltimore, MD 21224, USA
    Addict Biol 13:105-17. 2008
    ....
  49. ncbi request reprint Differential Effects of Common Variants in SCN2A on General Cognitive Ability, Brain Physiology, and messenger RNA Expression in Schizophrenia Cases and Control Individuals
    Dwight Dickinson
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
    JAMA Psychiatry 71:647-56. 2014
    ..CONCLUSIONS AND RELEVANCE The findings implicate SCN2A and sodium channel biology in cognitive impairment in schizophrenia cases and unaffected relatives and may facilitate development of cognition-enhancing treatments. ..
  50. ncbi request reprint The development of a posttraumatic stress disorder brain collection
    Amy Deep-Soboslay
    Section on Neuropathology, Clinical Brain Disorders Branch, NIMH NIH, Bethesda, Maryland 20892, USA
    Psychiatry 67:416-8. 2004
  51. ncbi request reprint Neurotensin receptor binding abnormalities in the entorhinal cortex in schizophrenia and affective disorders
    Emad H Hamid
    Clinical Brain Disorders Branch IRP, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Building 10 Room 4S237A, MSC 1379, Bethesda, MD 20892, USA
    Biol Psychiatry 51:795-800. 2002
    ..We have previously reported decreased neurotensin receptor density in layer II of the intermediate entorhinal cortex (ERC) in schizophrenia, a finding seen elsewhere but not seen in more caudal ERC...
  52. ncbi request reprint BDNF mRNA expression during postnatal development, maturation and aging of the human prefrontal cortex
    Maree J Webster
    Stanley Laboratory of Brain Research, Department of Psychiatry, Uniformed Services University for the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814 4799, USA
    Brain Res Dev Brain Res 139:139-50. 2002
    ..The increase in BDNF at this critical time in human development may have important implications for the etiology and treatment of the severe mental disorders that tend to present during this time...