Research Topics
Genomes and Genes
| Hynda K KleinmanSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Role of the extracellular matrix in morphogenesisHynda K Kleinman
Cell Biology Section, CDBRB, National Institute of Dental and Craniofacial Research NIH, 30 Convent Drive, MSC 4370, Bethesda, MD 20892, USA
Curr Opin Biotechnol 14:526-32. 2003..Biologically active extracellular matrix components may have use in tissue repair, regeneration and engineering, and in programming stem cells for tissue replacement...- Matrigel: basement membrane matrix with biological activityHynda K Kleinman
NIH, NIDCR, 30 433, 30 Convent Dr MSC 4370, Bethesda, MD 20892 4370, USA
Semin Cancer Biol 15:378-86. 2005..In vivo, it is used for measuring angiogenic inhibitors and stimulators, to improve graft survival, repair damaged tissues, and increase tumor growth... - Identification of an active site on the laminin alpha5 chain globular domain that binds to CD44 and inhibits malignancySuguru Hibino
Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research/NIH, 30 Convent Drive, Bethesda, MD 20892, USA
Cancer Res 64:4810-6. 2004..Our results suggest that A5G27 binds to the CD44 receptor of B16-F10 melanoma cells via the GAGs on CD44 and, thus, inhibits tumor cell migration, invasion, and angiogenesis in a dominant-negative manner... - Thymosin beta 4 induces hair growth via stem cell migration and differentiationDeborah Philp
Cell Biology Section, NIH, NIDCR, Building 30, Room 433, 30 Convent Dr MSC 4370, Bethesda, MD 20892, USA
Ann N Y Acad Sci 1112:95-103. 2007..We have also determined the mechanism by which thymosin beta 4 acts to promote hair growth by examining its effects on follicle stem cell growth, migration, differentiation, and protease production... - Thymosin beta4 promotes matrix metalloproteinase expression during wound repairDeborah Philp
Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892 4370, USA
J Cell Physiol 208:195-200. 2006..Thus, Tbeta4 may play a pivotal role in extracellular matrix remodeling during wound repair... - Laminin alpha5 chain metastasis- and angiogenesis-inhibiting peptide blocks fibroblast growth factor 2 activity by binding to the heparan sulfate chains of CD44Suguru Hibino
Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892-4370, USA
Cancer Res 65:10494-501. 2005..We conclude that peptide A5G27 inhibits metastasis and angiogenesis by blocking FGF2 binding to the heparan sulfate side chains of CD44 variant 3, thus decreasing FGF2 bioactivity... - Cell-cell and cell-extracellular matrix interactions regulate embryonic stem cell differentiationSilvia S Chen
Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development NIH, Bethesda, MD 20892, USA
Stem Cells 25:553-61. 2007.... 
Angiogenic laminin-derived peptides stimulate wound healingKatherine M Malinda
Review Branch DERA, NHLBI, NIH, Bethesda, MD 20892 1857, USA
Int J Biochem Cell Biol 40:2771-80. 2008..We conclude that small bioactive angiogenic peptides can promote dermal wound healing and may offer a new class of stable and chemically manipulable therapeutics for wound healing...- Inhibition of VEGF receptors significantly impairs mammary cancer growth in C3(1)/Tag transgenic mice through antiangiogenic and non-antiangiogenic mechanismsJung im Huh
Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Oncogene 24:790-800. 2005.... - Endogenous osteonectin/SPARC/BM-40 expression inhibits MDA-MB-231 breast cancer cell metastasisJennifer E Koblinski
Craniofacial Developmental Biology and Regeneration Branch and Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892-4370, USA
Cancer Res 65:7370-7. 2005..These studies suggest that high endogenous expression of osteonectin in breast cancer cells may reduce metastasis via reduced invasive activity and reduced tumor cell-platelet aggregation... - Thymosin beta4 increases hair growth by activation of hair follicle stem cellsDeborah Philp
Cell Biology Section, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA
FASEB J 18:385-7. 2004.... - An angiogenic switch in breast cancer involves estrogen and soluble vascular endothelial growth factor receptor 1Michael Elkin
Cell Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
J Natl Cancer Inst 96:875-8. 2004..Our data suggest that inhibition of soluble VEGFR-1 expression represents a novel mechanism--an estrogen-driven angiogenic switch--possibly responsible for breast carcinoma progression... - Role of thymosin beta4 in tumor metastasis and angiogenesisHee-Jae Cha
Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
J Natl Cancer Inst 95:1674-80. 2003..This induction of angiogenesis by thymosin beta4 was associated with induction of vascular endothelial growth factor expression. CONCLUSION: Thymosin beta4 may stimulate tumor metastasis by activating cell migration and angiogenesis... 
Animal studies with thymosin beta, a multifunctional tissue repair and regeneration peptideDeborah Philp
NIH, NIDCR, Bethesda, Maryland, USA
Ann N Y Acad Sci 1194:81-6. 2010..This paper reviews and discusses the topical and systemic uses of Tbeta(4) in various animal models that demonstrate its potential for clinical use...- The basement membrane matrix in malignancyJean A Engbring
Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health/DHHS, 30 Convent Drive, MSC 4370, Bethesda, MD 20892-4370, USA
J Pathol 200:465-70. 2003..This review will follow the metastatic process with particular attention to the effect of laminin on tumour cells... - The actin binding site on thymosin beta4 promotes angiogenesisDeborah Philp
Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
FASEB J 17:2103-5. 2003..The adhesion and sprouting activity of thymosin beta4 was inhibited with the addition of 5-50 nM soluble actin. These results demonstrate that the actin binding motif of thymosin beta4 is an essential site for its angiogenic activity... - Regulation of heparanase gene expression by estrogen in breast cancerMichael Elkin
Cell Biology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892, USA
Cancer Res 63:8821-6. 2003.... - Matrix cell adhesion activation by non-adhesion proteinsJennifer E Koblinski
Cell Biology Section, Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
J Cell Sci 118:2965-74. 2005..Such findings might explain contradictions in the literature about the activity of 'adhesive proteins'... - Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanismsMatthew P Hoffman
Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, MSC 4370, Bethesda, MD 20892 4370, USA
Development 129:5767-78. 2002..Taken together, our results suggest specific FGFs and BMPs play reciprocal roles in regulating branching morphogenesis and FGFR1 signaling plays a central role by regulating both FGF and BMP expression... - New method for modeling connective-tissue cell migration: improved accuracy on motility parametersMatt J Kipper
National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
Biophys J 93:1797-808. 2007.... - Identification of a potent peptide antagonist to an active laminin-1 sequence that blocks angiogenesis and tumor growthM Lourdes Ponce
Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
Cancer Res 63:5060-4. 2003..These results indicate that we have identified a more potent antiangiogenesis inhibitor peptide that may be used as a therapeutic to treat cancer... - Metallothionein promotes laminin-1-induced acinar differentiation in vitro and reduces tumor growth in vivoDalit Hecht
Center for Information Technology, National Institute of Dental and Craniofacial Research/NIH, 30 Convent Drive, Bethesda, MD 20892, USA
Cancer Res 62:5370-4. 2002..We conclude that MTs are important in acinar cell morphological differentiation and may have novel functions other than metal binding... - The effects of adrenomedullin overexpression in breast tumor cellsAlfredo Martinez
Cell and Cancer Biology Branch and Vascular Biology Faculty, National Cancer Institute, National Institutes of Health NIH, Bethesda, MD 20892, USA
J Natl Cancer Inst 94:1226-37. 2002..Several reports have indicated that adrenomedullin may be involved in tumor survival, but this has not been directly shown. Here we evaluate the in vitro and in vivo effects of adrenomedullin overexpression in human breast cancer cells... - Zyxin is upregulated in the nucleus by thymosin beta4 in SiHa cellsHye Sung Moon
National Institute of Dental and Craniofacial Research, NIH, MSC 4370, Bethesda, MD 20892 4370, USA
Exp Cell Res 312:3425-31. 2006..Both zyxin and thymosin beta4 show increased localization in the nucleus. We conclude that thymosin beta4 may exert some of its migration promoting activity via increased zyxin expression... - Identification of redundant angiogenic sites in laminin alpha1 and gamma1 chainsM Lourdes Ponce
Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
Exp Cell Res 285:189-95. 2003..These highly conserved functional sites are likely important mediators of the biological responses of laminins because either one or both of these chains (active sites) are present in almost all laminin isoforms identified to date... - Complex extracellular matrices promote tissue-specific stem cell differentiationDeborah Philp
Cell Biology Section, National Institute of Dental and Craniofacial Research, Bethesda, Maryland, USA
Stem Cells 23:288-96. 2005..Such preprogramming of cell differentiation with extracellular matrices may be useful in targeting stem cells to repair specific damaged organs... - Covalent surface chemistry gradients for presenting bioactive peptidesMatt J Kipper
National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
Anal Biochem 363:175-84. 2007..Validation with changes in fibroblast cell migration behavior across a bioactive peptide gradient illustrates preservation of peptide function as well as the usefulness of this technique... - The B16F10 cell receptor for a metastasis-promoting site on laminin-1 is a heparan sulfate/chondroitin sulfate-containing proteoglycanJean A Engbring
Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892-4370, USA
Cancer Res 62:3549-54. 2002.... - The antifungal drug ciclopirox inhibits deoxyhypusine and proline hydroxylation, endothelial cell growth and angiogenesis in vitroPaul M J Clement
Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
Int J Cancer 100:491-8. 2002..The strong antiangiogenic activity of this readily available antifungal drug along with its antiproliferative effects suggests a new potential application for ciclopirox in the treatment of solid tumors... - Thymosin beta 4 and a synthetic peptide containing its actin-binding domain promote dermal wound repair in db/db diabetic mice and in aged miceDeborah Philp
Cell Biology Sectiona, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
Wound Repair Regen 11:19-24. 2003..These studies show that thymosin beta 4 is active for wound repair in models of impaired healing and may have efficacy in chronic wounds in humans... - Elevated production of interleukin-6 is associated with a lower incidence of disease-related ischemic events in patients with giant-cell arteritis: angiogenic activity of interleukin-6 as a potential protective mechanismJosé Hernández-Rodríguez
Department of Internal Medicine, Hospital Clinic, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
Circulation 107:2428-34. 2003..Patients with giant-cell arteritis (GCA) who develop a strong acute-phase response are at low risk of disease-related ischemic events... - Biological activities of homologous loop regions in the laminin alpha chain G domainsNobuharu Suzuki
Graduate School of Environmental Earth Science, Hokkaido University, Sapporo 060-0810, Japan
J Biol Chem 278:45697-705. 2003..The homologous peptides, which promote either integrin- or syndecan-mediated cell attachment, may be useful for understanding the cell type- and chain-specific biological activities of the laminins... - Tissue and serum angiogenic activity is associated with low prevalence of ischemic complications in patients with giant-cell arteritisMaria C Cid
Vasculitis Research Unit, Department of Internal Medicine, Hospital Clinic, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
Circulation 106:1664-71. 2002..Vascular inflammatory lesions from patients with giant-cell arteritis show a remarkable amount of neovascularization, but its clinical implications have never been investigated... - Pericytic-like angiotropism of glioma and melanoma cellsClaire Lugassy
Department of Dermatology, George Washington University Medical Center, The George Washington University, Washington, District of Columbia 20037, USA
Am J Dermatopathol 24:473-8. 2002..These similarities between glioma and melanoma support the hypothesis of an extravascular migration of melanoma cells, particularly along the abluminal surface of vessels... - Bifunctional peptides derived from homologous loop regions in the laminin alpha chain LG4 modules interact with both alpha 2 beta 1 integrin and syndecan-2Fumiharu Yokoyama
Graduate School of Environmental Earth Science, Hokkaido University, Sapporo 060-0810, Japan
Biochemistry 44:9581-9. 2005..We conclude that the approach utilizing chimeric peptides is useful for examining cellular mechanisms in dual-receptor systems... - Pericyte-like location of GFP-tagged melanoma cells: ex vivo and in vivo studies of extravascular migratory metastasisClaire Lugassy
Department of Dermatology, The George Washington University Medical Center, Washington, District of Columbia, USA
Am J Pathol 164:1191-8. 2004..This study also demonstrates that these models can provide quantitation analysis that may prove useful in elucidating the molecular interactions involved in extravascular migratory metastasis... - Extracellular membrane vesicles from tumor cells promote angiogenesis via sphingomyelinChan Woo Kim
Department of Oncology, Graduate School of East-West Medical Science, Kyung Hee University, Yong In, 449-701, Korea
Cancer Res 62:6312-7. 2002..Together with previously reported results, our data demonstrate that shed tumor vesicles play multiple roles in tumor growth and metastasis by promoting angiogenesis, tumor invasion, and immune escape... - Cyclic peptides from the loop region of the laminin alpha 4 chain LG4 module show enhanced biological activity over linear peptidesFumiharu Yokoyama
Graduate School of Environmental Earth Science, Hokkaido University, Sapporo 060 0810, Japan
Biochemistry 43:13590-7. 2004..These results indicate that the activity of A4G82 is highly conformation-dependent, suggesting that the E-F loop structure is crucial for its biological activity... - Angiogenic activity of human CC chemokine CCL15 in vitro and in vivoJungsu Hwang
Graduate School of Biotechnology and Institute of Life Sciences and Resources, Kyung Hee University, Yongin 449 701, South Korea
FEBS Lett 570:47-51. 2004..Our findings demonstrate that CCL15(25-92) has in vitro and in vivo angiogenic activity, and suggest roles of the chemokine in angiogenesis... - A simplified laminin nomenclatureMonique Aumailley
Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany
Matrix Biol 24:326-32. 2005..The chain origin of a domain is specified by the chain nomenclature, such as alpha1L4a. The abbreviation LM is suggested for laminin. Otherwise, the nomenclature remains unaltered... - Heparanase regulates murine hair growthEyal Zcharia
Department of Oncology, Hadassah Hebrew University of Medical Center, Jerusalem, Israel
Am J Pathol 166:999-1008. 2005.... - A truncated plasminogen activator inhibitor-1 protein blocks the availability of heparin-binding vascular endothelial growth factor A isoformsMary Jo Mulligan-Kehoe
Department of Surgery, Vascular Surgery Section, Dartmouth Medical School, Dartmouth College, Hanover, New Hampshire 03756, USA
J Biol Chem 277:49077-89. 2002..This insight into anti-angiogenic functions related to PAI-1 conformational changes could provide potential intervention points in angiogenesis associated with atherosclerotic plaques and cancer... - Laminin-1-derived scrambled peptide AG73T disaggregates laminin-1-induced ovarian cancer cell spheroids and improves the efficacy of cisplatinYoshio Yoshida
Department of Obstetrics and Gynecology, Faculty of Medical Science, University of Fukui, Matuoka, Eiheiji cho, Yoshida gun, Fukui ken 910 1103, Japan
Int J Oncol 32:673-81. 2008..These findings suggest a novel function of AG73T in ovarian cancer and help to define mechanisms important in ovarian cancer spheroid formation and spread... - Estrogens and the vascular endotheliumMaria C Cid
Department of Internal Medicine, Hospital Clinic, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
Ann N Y Acad Sci 966:143-57. 2002..The mechanisms through which estrogen regulates endothelial cell functions are complex and involve both genomic and nongenomic mechanisms... - Angiogenic activity of syndecan-binding laminin peptide AG73 (RKRLQVQLSIRT)Mayumi Mochizuki
Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
Arch Biochem Biophys 459:249-55. 2007..These results indicate that the AG73 peptide is a potent syndecan-binding angiogenesis stimulator and may be useful for therapeutic application to treat ischemic injuries... - Integrin-dependent cell behavior on ECM peptide-conjugated chitosan membranesMayumi Mochizuki
Laboratory of Clinical Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan
Biopolymers 88:122-30. 2007..These data demonstrate that peptide-chitosan membranes can regulate specific integrin-mediated cell responses and are useful constructs as ECM mimetics... - Suradista NSC 651016 inhibits the angiogenic activity of CXCL12-stromal cell-derived factor 1alphaGregory P Schneider
Laboratory of Molecular Immunoregulation, Center for Cancer Research, Intramural Research Support Program, National Cancer Institute-Frederick, Frederick, Maryland 21702, USA
Clin Cancer Res 8:3955-60. 2002..c. assay. These data indicate that suradista NSC 651016 possesses in vitro and in vivo antiangiogenic activity and has the potential to interfere with neovacularization of tumors and their metastases... - Neuropeptide Y induces migration, proliferation, and tube formation of endothelial cells bimodally via Y1, Y2, and Y5 receptorsSharareh Movafagh
Department of Physiology and Biophysics, Georgetown University Medical Center, Washington, DC 20057, USA
FASEB J 20:1924-6. 2006..We propose that these receptors form heteromeric complexes, and the Y1/Y2/Y5 receptor oligomer may be the uncloned Y3 receptor... - Angiotropism of human melanoma: studies involving in transit and other cutaneous metastases and the chicken chorioallantoic membrane: implications for extravascular melanoma invasion and metastasisClaire Lugassy
Department of Pathology, University of Miami School of Medicine/Jackson Memorial Hospital, Miami, FL, USA
Am J Dermatopathol 28:187-93. 2006..Taken together, these data suggest that the CAM is a relevant model for studying tumor cell dissemination, and that EVMM may be a mechanism by which some melanoma cells spread to nearby and even distant sites... - Human melanoma cell migration along capillary-like structures in vitro: a new dynamic model for studying extravascular migratory metastasisClaire Lugassy
J Invest Dermatol 119:703-4. 2002 - Selective side-chain modification of cysteine and arginine residues blocks pathogenic activity of HIV-1-Tat functional peptidesKrishnakumar Devadas
Immunopathogenesis Section, Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike (HFM-315, Rockville, MD 20852-1448, USA
Peptides 27:611-21. 2006.... - Thymosin beta 4 stimulates laminin-5 production independent of TGF-betaGabriel Sosne
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Exp Cell Res 293:175-83. 2004..Tbeta(4) and TGFbeta-1 increase LM-5 gamma2 chain expression by independent pathways. Suppression of TGFbeta-1 further increases LM-5 gamma2 chain expression... - Thymosin beta4: actin-sequestering protein moonlights to repair injured tissuesAllan L Goldstein
Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine and Health Sciences, 2300 I Street, NW, Washington, DC 20037, USA
Trends Mol Med 11:421-9. 2005..It might also have important repair functions in the pathophysiologic sequelae that are associated with actin toxicity and with septic shock, such as respiratory distress syndrome, multi-organ failure and severe tissue trauma... - Ile-Lys-Val-Ala-Val (IKVAV)-containing laminin alpha1 chain peptides form amyloid-like fibrilsMasanori Yamada
Division of Bioscience, Graduate School of Environmental Earth Science, Hokkaido University, Kita 10 Nishi 5, Kita-ku, Sapporo 060-0810, Japan
FEBS Lett 530:48-52. 2002..We also examined amyloid-like fibril formation of LAM-L analogs. The neurite outgrowth activity of the LAM-L analogs was closely related to their amyloid-like fibril formation...