Hynda K Kleinman

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Role of the extracellular matrix in morphogenesis
    Hynda K Kleinman
    Cell Biology Section, CDBRB, National Institute of Dental and Craniofacial Research NIH, 30 Convent Drive, MSC 4370, Bethesda, MD 20892, USA
    Curr Opin Biotechnol 14:526-32. 2003
  2. pmc Laminin-111-derived peptides and cancer
    Yamato Kikkawa
    Laboratory of Clinical Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
    Cell Adh Migr 7:150-256. 2013
  3. ncbi request reprint Matrigel: basement membrane matrix with biological activity
    Hynda K Kleinman
    NIH, NIDCR, 30 433, 30 Convent Dr MSC 4370, Bethesda, MD 20892 4370, USA
    Semin Cancer Biol 15:378-86. 2005
  4. ncbi request reprint Identification of an active site on the laminin alpha5 chain globular domain that binds to CD44 and inhibits malignancy
    Suguru Hibino
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research NIH, 30 Convent Drive, Bethesda, MD 20892, USA
    Cancer Res 64:4810-6. 2004
  5. ncbi request reprint Laminin alpha5 chain metastasis- and angiogenesis-inhibiting peptide blocks fibroblast growth factor 2 activity by binding to the heparan sulfate chains of CD44
    Suguru Hibino
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892 4370, USA
    Cancer Res 65:10494-501. 2005
  6. ncbi request reprint Thymosin beta4 promotes matrix metalloproteinase expression during wound repair
    Deborah Philp
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892 4370, USA
    J Cell Physiol 208:195-200. 2006
  7. ncbi request reprint Cell-cell and cell-extracellular matrix interactions regulate embryonic stem cell differentiation
    Silvia S Chen
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development NIH, Bethesda, MD 20892, USA
    Stem Cells 25:553-61. 2007
  8. ncbi request reprint Thymosin beta 4 induces hair growth via stem cell migration and differentiation
    Deborah Philp
    Cell Biology Section, NIH, NIDCR, Building 30, Room 433, 30 Convent Dr MSC 4370, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 1112:95-103. 2007
  9. pmc Angiogenic laminin-derived peptides stimulate wound healing
    Katherine M Malinda
    Review Branch DERA, NHLBI, NIH, Bethesda, MD 20892 1857, USA
    Int J Biochem Cell Biol 40:2771-80. 2008
  10. ncbi request reprint Inhibition of VEGF receptors significantly impairs mammary cancer growth in C3(1)/Tag transgenic mice through antiangiogenic and non-antiangiogenic mechanisms
    Jung im Huh
    Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Oncogene 24:790-800. 2005

Detail Information

Publications55

  1. ncbi request reprint Role of the extracellular matrix in morphogenesis
    Hynda K Kleinman
    Cell Biology Section, CDBRB, National Institute of Dental and Craniofacial Research NIH, 30 Convent Drive, MSC 4370, Bethesda, MD 20892, USA
    Curr Opin Biotechnol 14:526-32. 2003
    ..Biologically active extracellular matrix components may have use in tissue repair, regeneration and engineering, and in programming stem cells for tissue replacement...
  2. pmc Laminin-111-derived peptides and cancer
    Yamato Kikkawa
    Laboratory of Clinical Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
    Cell Adh Migr 7:150-256. 2013
    ..C16 increases tumor growth and angiogenesis via integrins. Identification of such sites on laminin-111 will have use in defining strategies to develop therapeutics for cancer...
  3. ncbi request reprint Matrigel: basement membrane matrix with biological activity
    Hynda K Kleinman
    NIH, NIDCR, 30 433, 30 Convent Dr MSC 4370, Bethesda, MD 20892 4370, USA
    Semin Cancer Biol 15:378-86. 2005
    ..In vivo, it is used for measuring angiogenic inhibitors and stimulators, to improve graft survival, repair damaged tissues, and increase tumor growth...
  4. ncbi request reprint Identification of an active site on the laminin alpha5 chain globular domain that binds to CD44 and inhibits malignancy
    Suguru Hibino
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research NIH, 30 Convent Drive, Bethesda, MD 20892, USA
    Cancer Res 64:4810-6. 2004
    ..Our results suggest that A5G27 binds to the CD44 receptor of B16-F10 melanoma cells via the GAGs on CD44 and, thus, inhibits tumor cell migration, invasion, and angiogenesis in a dominant-negative manner...
  5. ncbi request reprint Laminin alpha5 chain metastasis- and angiogenesis-inhibiting peptide blocks fibroblast growth factor 2 activity by binding to the heparan sulfate chains of CD44
    Suguru Hibino
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892 4370, USA
    Cancer Res 65:10494-501. 2005
    ..We conclude that peptide A5G27 inhibits metastasis and angiogenesis by blocking FGF2 binding to the heparan sulfate side chains of CD44 variant 3, thus decreasing FGF2 bioactivity...
  6. ncbi request reprint Thymosin beta4 promotes matrix metalloproteinase expression during wound repair
    Deborah Philp
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892 4370, USA
    J Cell Physiol 208:195-200. 2006
    ..Thus, Tbeta4 may play a pivotal role in extracellular matrix remodeling during wound repair...
  7. ncbi request reprint Cell-cell and cell-extracellular matrix interactions regulate embryonic stem cell differentiation
    Silvia S Chen
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development NIH, Bethesda, MD 20892, USA
    Stem Cells 25:553-61. 2007
    ....
  8. ncbi request reprint Thymosin beta 4 induces hair growth via stem cell migration and differentiation
    Deborah Philp
    Cell Biology Section, NIH, NIDCR, Building 30, Room 433, 30 Convent Dr MSC 4370, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 1112:95-103. 2007
    ..We have also determined the mechanism by which thymosin beta 4 acts to promote hair growth by examining its effects on follicle stem cell growth, migration, differentiation, and protease production...
  9. pmc Angiogenic laminin-derived peptides stimulate wound healing
    Katherine M Malinda
    Review Branch DERA, NHLBI, NIH, Bethesda, MD 20892 1857, USA
    Int J Biochem Cell Biol 40:2771-80. 2008
    ..We conclude that small bioactive angiogenic peptides can promote dermal wound healing and may offer a new class of stable and chemically manipulable therapeutics for wound healing...
  10. ncbi request reprint Inhibition of VEGF receptors significantly impairs mammary cancer growth in C3(1)/Tag transgenic mice through antiangiogenic and non-antiangiogenic mechanisms
    Jung im Huh
    Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Oncogene 24:790-800. 2005
    ....
  11. ncbi request reprint Thymosin beta4 increases hair growth by activation of hair follicle stem cells
    Deborah Philp
    Cell Biology Section, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA
    FASEB J 18:385-7. 2004
    ....
  12. ncbi request reprint Integrin-dependent cell behavior on ECM peptide-conjugated chitosan membranes
    Mayumi Mochizuki
    Laboratory of Clinical Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan
    Biopolymers 88:122-30. 2007
    ..These data demonstrate that peptide-chitosan membranes can regulate specific integrin-mediated cell responses and are useful constructs as ECM mimetics...
  13. ncbi request reprint Role of thymosin beta4 in tumor metastasis and angiogenesis
    Hee Jae Cha
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Natl Cancer Inst 95:1674-80. 2003
    ..However, little is known about the mechanism(s) by which thymosin beta4 promotes metastasis...
  14. ncbi request reprint The basement membrane matrix in malignancy
    Jean A Engbring
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health DHHS, 30 Convent Drive, MSC 4370, Bethesda, MD 20892 4370, USA
    J Pathol 200:465-70. 2003
    ..This review will follow the metastatic process with particular attention to the effect of laminin on tumour cells...
  15. ncbi request reprint Identification of a potent peptide antagonist to an active laminin-1 sequence that blocks angiogenesis and tumor growth
    M Lourdes Ponce
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Res 63:5060-4. 2003
    ..These results indicate that we have identified a more potent antiangiogenesis inhibitor peptide that may be used as a therapeutic to treat cancer...
  16. ncbi request reprint Endogenous osteonectin/SPARC/BM-40 expression inhibits MDA-MB-231 breast cancer cell metastasis
    Jennifer E Koblinski
    Craniofacial Developmental Biology and Regeneration Branch and Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892 4370, USA
    Cancer Res 65:7370-7. 2005
    ..These studies suggest that high endogenous expression of osteonectin in breast cancer cells may reduce metastasis via reduced invasive activity and reduced tumor cell-platelet aggregation...
  17. ncbi request reprint Animal studies with thymosin beta, a multifunctional tissue repair and regeneration peptide
    Deborah Philp
    NIH, NIDCR, Bethesda, Maryland, USA
    Ann N Y Acad Sci 1194:81-6. 2010
    ..This paper reviews and discusses the topical and systemic uses of Tbeta(4) in various animal models that demonstrate its potential for clinical use...
  18. ncbi request reprint An angiogenic switch in breast cancer involves estrogen and soluble vascular endothelial growth factor receptor 1
    Michael Elkin
    Cell Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Natl Cancer Inst 96:875-8. 2004
    ..Our data suggest that inhibition of soluble VEGFR-1 expression represents a novel mechanism--an estrogen-driven angiogenic switch--possibly responsible for breast carcinoma progression...
  19. ncbi request reprint Matrix cell adhesion activation by non-adhesion proteins
    Jennifer E Koblinski
    Cell Biology Section, Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
    J Cell Sci 118:2965-74. 2005
    ..Such findings might explain contradictions in the literature about the activity of 'adhesive proteins'...
  20. ncbi request reprint The actin binding site on thymosin beta4 promotes angiogenesis
    Deborah Philp
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    FASEB J 17:2103-5. 2003
    ..The adhesion and sprouting activity of thymosin beta4 was inhibited with the addition of 5-50 nM soluble actin. These results demonstrate that the actin binding motif of thymosin beta4 is an essential site for its angiogenic activity...
  21. ncbi request reprint Regulation of heparanase gene expression by estrogen in breast cancer
    Michael Elkin
    Cell Biology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 63:8821-6. 2003
    ....
  22. pmc New method for modeling connective-tissue cell migration: improved accuracy on motility parameters
    Matt J Kipper
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Biophys J 93:1797-808. 2007
    ....
  23. ncbi request reprint Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanisms
    Matthew P Hoffman
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, MSC 4370, Bethesda, MD 20892 4370, USA
    Development 129:5767-78. 2002
    ..Taken together, our results suggest specific FGFs and BMPs play reciprocal roles in regulating branching morphogenesis and FGFR1 signaling plays a central role by regulating both FGF and BMP expression...
  24. ncbi request reprint Identification of redundant angiogenic sites in laminin alpha1 and gamma1 chains
    M Lourdes Ponce
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Exp Cell Res 285:189-95. 2003
    ..These highly conserved functional sites are likely important mediators of the biological responses of laminins because either one or both of these chains (active sites) are present in almost all laminin isoforms identified to date...
  25. ncbi request reprint Zyxin is upregulated in the nucleus by thymosin beta4 in SiHa cells
    Hye Sung Moon
    National Institute of Dental and Craniofacial Research, NIH, MSC 4370, Bethesda, MD 20892 4370, USA
    Exp Cell Res 312:3425-31. 2006
    ..Both zyxin and thymosin beta4 show increased localization in the nucleus. We conclude that thymosin beta4 may exert some of its migration promoting activity via increased zyxin expression...
  26. ncbi request reprint Metallothionein promotes laminin-1-induced acinar differentiation in vitro and reduces tumor growth in vivo
    Dalit Hecht
    Center for Information Technology, National Institute of Dental and Craniofacial Research NIH, 30 Convent Drive, Bethesda, MD 20892, USA
    Cancer Res 62:5370-4. 2002
    ..We conclude that MTs are important in acinar cell morphological differentiation and may have novel functions other than metal binding...
  27. ncbi request reprint The effects of adrenomedullin overexpression in breast tumor cells
    Alfredo Martinez
    Cell and Cancer Biology Branch and Vascular Biology Faculty, National Cancer Institute, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Natl Cancer Inst 94:1226-37. 2002
    ..Several reports have indicated that adrenomedullin may be involved in tumor survival, but this has not been directly shown. Here we evaluate the in vitro and in vivo effects of adrenomedullin overexpression in human breast cancer cells...
  28. ncbi request reprint The B16F10 cell receptor for a metastasis-promoting site on laminin-1 is a heparan sulfate/chondroitin sulfate-containing proteoglycan
    Jean A Engbring
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892 4370, USA
    Cancer Res 62:3549-54. 2002
    ....
  29. ncbi request reprint Complex extracellular matrices promote tissue-specific stem cell differentiation
    Deborah Philp
    Cell Biology Section, National Institute of Dental and Craniofacial Research, Bethesda, Maryland, USA
    Stem Cells 23:288-96. 2005
    ..Such preprogramming of cell differentiation with extracellular matrices may be useful in targeting stem cells to repair specific damaged organs...
  30. ncbi request reprint Covalent surface chemistry gradients for presenting bioactive peptides
    Matt J Kipper
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Anal Biochem 363:175-84. 2007
    ..Validation with changes in fibroblast cell migration behavior across a bioactive peptide gradient illustrates preservation of peptide function as well as the usefulness of this technique...
  31. ncbi request reprint Thymosin beta 4 and a synthetic peptide containing its actin-binding domain promote dermal wound repair in db/db diabetic mice and in aged mice
    Deborah Philp
    Cell Biology Sectiona, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Wound Repair Regen 11:19-24. 2003
    ..These studies show that thymosin beta 4 is active for wound repair in models of impaired healing and may have efficacy in chronic wounds in humans...
  32. ncbi request reprint The antifungal drug ciclopirox inhibits deoxyhypusine and proline hydroxylation, endothelial cell growth and angiogenesis in vitro
    Paul M J Clement
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Cancer 100:491-8. 2002
    ..The strong antiangiogenic activity of this readily available antifungal drug along with its antiproliferative effects suggests a new potential application for ciclopirox in the treatment of solid tumors...
  33. ncbi request reprint Cyclic peptides from the loop region of the laminin alpha 4 chain LG4 module show enhanced biological activity over linear peptides
    Fumiharu Yokoyama
    Graduate School of Environmental Earth Science, Hokkaido University, Sapporo 060 0810, Japan
    Biochemistry 43:13590-7. 2004
    ..These results indicate that the activity of A4G82 is highly conformation-dependent, suggesting that the E-F loop structure is crucial for its biological activity...
  34. ncbi request reprint Pericytic-like angiotropism of glioma and melanoma cells
    Claire Lugassy
    Department of Dermatology, George Washington University Medical Center, The George Washington University, Washington, District of Columbia 20037, USA
    Am J Dermatopathol 24:473-8. 2002
    ..These similarities between glioma and melanoma support the hypothesis of an extravascular migration of melanoma cells, particularly along the abluminal surface of vessels...
  35. ncbi request reprint Tissue and serum angiogenic activity is associated with low prevalence of ischemic complications in patients with giant-cell arteritis
    Maria C Cid
    Vasculitis Research Unit, Department of Internal Medicine, Hospital Clinic, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Circulation 106:1664-71. 2002
    ..Vascular inflammatory lesions from patients with giant-cell arteritis show a remarkable amount of neovascularization, but its clinical implications have never been investigated...
  36. ncbi request reprint Elevated production of interleukin-6 is associated with a lower incidence of disease-related ischemic events in patients with giant-cell arteritis: angiogenic activity of interleukin-6 as a potential protective mechanism
    José Hernández-Rodríguez
    Department of Internal Medicine, Hospital Clinic, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Circulation 107:2428-34. 2003
    ..Patients with giant-cell arteritis (GCA) who develop a strong acute-phase response are at low risk of disease-related ischemic events...
  37. ncbi request reprint Biological activities of homologous loop regions in the laminin alpha chain G domains
    Nobuharu Suzuki
    Graduate School of Environmental Earth Science, Hokkaido University, Sapporo 060 0810, Japan
    J Biol Chem 278:45697-705. 2003
    ..The homologous peptides, which promote either integrin- or syndecan-mediated cell attachment, may be useful for understanding the cell type- and chain-specific biological activities of the laminins...
  38. ncbi request reprint Extracellular membrane vesicles from tumor cells promote angiogenesis via sphingomyelin
    Chan Woo Kim
    Department of Oncology, Graduate School of East West Medical Science, Kyung Hee University, Yong In, 449 701, Korea
    Cancer Res 62:6312-7. 2002
    ..Together with previously reported results, our data demonstrate that shed tumor vesicles play multiple roles in tumor growth and metastasis by promoting angiogenesis, tumor invasion, and immune escape...
  39. ncbi request reprint Bifunctional peptides derived from homologous loop regions in the laminin alpha chain LG4 modules interact with both alpha 2 beta 1 integrin and syndecan-2
    Fumiharu Yokoyama
    Graduate School of Environmental Earth Science, Hokkaido University, Sapporo 060 0810, Japan
    Biochemistry 44:9581-9. 2005
    ..We conclude that the approach utilizing chimeric peptides is useful for examining cellular mechanisms in dual-receptor systems...
  40. ncbi request reprint Angiogenic activity of human CC chemokine CCL15 in vitro and in vivo
    Jungsu Hwang
    Graduate School of Biotechnology and Institute of Life Sciences and Resources, Kyung Hee University, Yongin 449 701, South Korea
    FEBS Lett 570:47-51. 2004
    ..Our findings demonstrate that CCL15(25-92) has in vitro and in vivo angiogenic activity, and suggest roles of the chemokine in angiogenesis...
  41. pmc Pericyte-like location of GFP-tagged melanoma cells: ex vivo and in vivo studies of extravascular migratory metastasis
    Claire Lugassy
    Department of Dermatology, The George Washington University Medical Center, Washington, District of Columbia, USA
    Am J Pathol 164:1191-8. 2004
    ..This study also demonstrates that these models can provide quantitation analysis that may prove useful in elucidating the molecular interactions involved in extravascular migratory metastasis...
  42. ncbi request reprint A truncated plasminogen activator inhibitor-1 protein blocks the availability of heparin-binding vascular endothelial growth factor A isoforms
    Mary Jo Mulligan-Kehoe
    Department of Surgery, Vascular Surgery Section, Dartmouth Medical School, Dartmouth College, Hanover, New Hampshire 03756, USA
    J Biol Chem 277:49077-89. 2002
    ..This insight into anti-angiogenic functions related to PAI-1 conformational changes could provide potential intervention points in angiogenesis associated with atherosclerotic plaques and cancer...
  43. ncbi request reprint Laminin-1-derived scrambled peptide AG73T disaggregates laminin-1-induced ovarian cancer cell spheroids and improves the efficacy of cisplatin
    Yoshio Yoshida
    Department of Obstetrics and Gynecology, Faculty of Medical Science, University of Fukui, Matuoka, Eiheiji cho, Yoshida gun, Fukui ken 910 1103, Japan
    Int J Oncol 32:673-81. 2008
    ..These findings suggest a novel function of AG73T in ovarian cancer and help to define mechanisms important in ovarian cancer spheroid formation and spread...
  44. ncbi request reprint Estrogens and the vascular endothelium
    Maria C Cid
    Department of Internal Medicine, Hospital Clinic, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Ann N Y Acad Sci 966:143-57. 2002
    ..The mechanisms through which estrogen regulates endothelial cell functions are complex and involve both genomic and nongenomic mechanisms...
  45. ncbi request reprint Ile-Lys-Val-Ala-Val (IKVAV)-containing laminin alpha1 chain peptides form amyloid-like fibrils
    Masanori Yamada
    Division of Bioscience, Graduate School of Environmental Earth Science, Hokkaido University, Kita 10 Nishi 5, Kita ku, Sapporo 060 0810, Japan
    FEBS Lett 530:48-52. 2002
    ..We also examined amyloid-like fibril formation of LAM-L analogs. The neurite outgrowth activity of the LAM-L analogs was closely related to their amyloid-like fibril formation...
  46. ncbi request reprint Human melanoma cell migration along capillary-like structures in vitro: a new dynamic model for studying extravascular migratory metastasis
    Claire Lugassy
    J Invest Dermatol 119:703-4. 2002
  47. ncbi request reprint Angiogenic activity of syndecan-binding laminin peptide AG73 (RKRLQVQLSIRT)
    Mayumi Mochizuki
    Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Arch Biochem Biophys 459:249-55. 2007
    ..These results indicate that the AG73 peptide is a potent syndecan-binding angiogenesis stimulator and may be useful for therapeutic application to treat ischemic injuries...
  48. ncbi request reprint Neuropeptide Y induces migration, proliferation, and tube formation of endothelial cells bimodally via Y1, Y2, and Y5 receptors
    Sharareh Movafagh
    Department of Physiology and Biophysics, Georgetown University Medical Center, Washington, DC 20057, USA
    FASEB J 20:1924-6. 2006
    ..We propose that these receptors form heteromeric complexes, and the Y1/Y2/Y5 receptor oligomer may be the uncloned Y3 receptor...
  49. ncbi request reprint Suradista NSC 651016 inhibits the angiogenic activity of CXCL12-stromal cell-derived factor 1alpha
    Gregory P Schneider
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, Intramural Research Support Program, National Cancer Institute Frederick, Frederick, Maryland 21702, USA
    Clin Cancer Res 8:3955-60. 2002
    ..c. assay. These data indicate that suradista NSC 651016 possesses in vitro and in vivo antiangiogenic activity and has the potential to interfere with neovacularization of tumors and their metastases...
  50. ncbi request reprint Selective side-chain modification of cysteine and arginine residues blocks pathogenic activity of HIV-1-Tat functional peptides
    Krishnakumar Devadas
    Immunopathogenesis Section, Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike HFM 315, Rockville, MD 20852 1448, USA
    Peptides 27:611-21. 2006
    ....
  51. ncbi request reprint Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues
    Allan L Goldstein
    Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine and Health Sciences, 2300 I Street, NW, Washington, DC 20037, USA
    Trends Mol Med 11:421-9. 2005
    ..It might also have important repair functions in the pathophysiologic sequelae that are associated with actin toxicity and with septic shock, such as respiratory distress syndrome, multi-organ failure and severe tissue trauma...
  52. ncbi request reprint A simplified laminin nomenclature
    Monique Aumailley
    Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany
    Matrix Biol 24:326-32. 2005
    ..The chain origin of a domain is specified by the chain nomenclature, such as alpha1L4a. The abbreviation LM is suggested for laminin. Otherwise, the nomenclature remains unaltered...
  53. ncbi request reprint Thymosin beta 4 stimulates laminin-5 production independent of TGF-beta
    Gabriel Sosne
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Exp Cell Res 293:175-83. 2004
    ..Tbeta(4) and TGFbeta-1 increase LM-5 gamma2 chain expression by independent pathways. Suppression of TGFbeta-1 further increases LM-5 gamma2 chain expression...
  54. pmc Heparanase regulates murine hair growth
    Eyal Zcharia
    Department of Oncology, Hadassah Hebrew University of Medical Center, Jerusalem, Israel
    Am J Pathol 166:999-1008. 2005
    ....
  55. pmc Angiotropism of human melanoma: studies involving in transit and other cutaneous metastases and the chicken chorioallantoic membrane: implications for extravascular melanoma invasion and metastasis
    Claire Lugassy
    Department of Pathology, University of Miami School of Medicine Jackson Memorial Hospital, Miami, FL, USA
    Am J Dermatopathol 28:187-93. 2006
    ..Taken together, these data suggest that the CAM is a relevant model for studying tumor cell dissemination, and that EVMM may be a mechanism by which some melanoma cells spread to nearby and even distant sites...