David E Kleiner

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Nonalcoholic fatty liver disease: pathologic patterns and biopsy evaluation in clinical research
    David E Kleiner
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Semin Liver Dis 32:3-13. 2012
  2. pmc The association of mast cells and serotonin in children with chronic abdominal pain of unknown etiology
    Tara J Taylor
    National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, USA
    BMC Res Notes 3:265. 2010
  3. ncbi request reprint The liver biopsy in chronic hepatitis C: a view from the other side of the microscope
    David E Kleiner
    Laboratory of Pathology, National Cancer Institute, Bldg 10 Room 2N212, Bethesda, MD 20892, USA
    Semin Liver Dis 25:52-64. 2005
  4. ncbi request reprint Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    David E Kleiner
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Hepatology 41:1313-21. 2005
  5. ncbi request reprint Granulomas in the liver
    David E Kleiner
    Laboratory of Pathology, National Cancer Institute, Building 10, Room 2N212, 10 Center Drive, MSC 1516, Bethesda, MD 20892, USA
    Semin Diagn Pathol 23:161-9. 2006
  6. ncbi request reprint The pathology of drug-induced liver injury
    David E Kleiner
    Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20892, USA
    Semin Liver Dis 29:364-72. 2009
  7. ncbi request reprint Changes in serum adipokine levels during pioglitazone treatment for nonalcoholic steatohepatitis: relationship to histological improvement
    Glen Lutchman
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Clin Gastroenterol Hepatol 4:1048-52. 2006
  8. ncbi request reprint The effects of discontinuing pioglitazone in patients with nonalcoholic steatohepatitis
    Glen Lutchman
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA
    Hepatology 46:424-9. 2007
  9. ncbi request reprint Steatosis and progression of fibrosis in untreated patients with chronic hepatitis C infection
    Ponni Perumalswami
    Liver Diseases Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1800, USA
    Hepatology 43:780-7. 2006
  10. ncbi request reprint The liver diseases of lipodystrophy: the long-term effect of leptin treatment
    Elika Safar Zadeh
    Diabetes Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States
    J Hepatol 59:131-7. 2013

Detail Information

Publications83

  1. doi request reprint Nonalcoholic fatty liver disease: pathologic patterns and biopsy evaluation in clinical research
    David E Kleiner
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Semin Liver Dis 32:3-13. 2012
    ..A current understanding of NAFLD pathologic classification, as well as nuances of grading and staging, is presented in this review...
  2. pmc The association of mast cells and serotonin in children with chronic abdominal pain of unknown etiology
    Tara J Taylor
    National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, USA
    BMC Res Notes 3:265. 2010
    ..This study evaluated the association between interleukin-6 (IL-6), mast cell infiltrates, and serotonin (5-HT) levels in gastrointestinal (GI) biopsies, with perceived abdominal pain in a pediatric cohort...
  3. ncbi request reprint The liver biopsy in chronic hepatitis C: a view from the other side of the microscope
    David E Kleiner
    Laboratory of Pathology, National Cancer Institute, Bldg 10 Room 2N212, Bethesda, MD 20892, USA
    Semin Liver Dis 25:52-64. 2005
    ..Clinicians can then make best use of the information derived from the liver biopsy to help them advise patients on the natural history of their disease and the therapeutic options that are available...
  4. ncbi request reprint Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    David E Kleiner
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Hepatology 41:1313-21. 2005
    ..NAS of > or =5 correlated with a diagnosis of NASH, and biopsies with scores of less than 3 were diagnosed as "not NASH."..
  5. ncbi request reprint Granulomas in the liver
    David E Kleiner
    Laboratory of Pathology, National Cancer Institute, Building 10, Room 2N212, 10 Center Drive, MSC 1516, Bethesda, MD 20892, USA
    Semin Diagn Pathol 23:161-9. 2006
    ..This review surveys both common and unusual granulomatous diseases with emphasis on practical diagnosis...
  6. ncbi request reprint The pathology of drug-induced liver injury
    David E Kleiner
    Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20892, USA
    Semin Liver Dis 29:364-72. 2009
    ....
  7. ncbi request reprint Changes in serum adipokine levels during pioglitazone treatment for nonalcoholic steatohepatitis: relationship to histological improvement
    Glen Lutchman
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Clin Gastroenterol Hepatol 4:1048-52. 2006
    ..This study was conducted to assess changes in serum levels of selected adipokines and proinflammatory cytokines and to relate these changes to the improved liver histology resulting from pioglitazone therapy for NASH...
  8. ncbi request reprint The effects of discontinuing pioglitazone in patients with nonalcoholic steatohepatitis
    Glen Lutchman
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA
    Hepatology 46:424-9. 2007
    ....
  9. ncbi request reprint Steatosis and progression of fibrosis in untreated patients with chronic hepatitis C infection
    Ponni Perumalswami
    Liver Diseases Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1800, USA
    Hepatology 43:780-7. 2006
    ..In conclusion, in this cohort of patients with CHC, steatosis was associated with older age, higher BMI, and higher serum ALT levels but not with the presence of or subsequent progression of fibrosis...
  10. ncbi request reprint The liver diseases of lipodystrophy: the long-term effect of leptin treatment
    Elika Safar Zadeh
    Diabetes Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States
    J Hepatol 59:131-7. 2013
    ..Non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) are also features of this condition. We studied the spectrum of liver disease in lipodystrophy and the effects of leptin replacement...
  11. ncbi request reprint Maintenance therapy with ribavirin in patients with chronic hepatitis C who fail to respond to combination therapy with interferon alfa and ribavirin
    Jay H Hoofnagle
    Liver Diseases Section, Digestive Diseases Branch, and Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Hepatology 38:66-74. 2003
    ..Whether these improvements will ultimately result in prevention of progression of hepatitis C requires further study...
  12. pmc Hepatic involvement and portal hypertension predict mortality in chronic granulomatous disease
    Jordan J Feld
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892 1800, USA
    Gastroenterology 134:1917-26. 2008
    ..Liver involvement in CGD includes vascular abnormalities, which may lead to noncirrhotic portal hypertension...
  13. pmc Identification of novel markers for liver fibrosis in HIV/hepatitis C virus coinfected individuals using genomics-based approach
    Daniel L Suzman
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    AIDS 22:1433-9. 2008
    ..Liver biopsy is invasive, risky and costly, but is required to assess fibrosis. This study intended to identify novel noninvasive markers to accurately assess fibrosis in HIV/hepatitis C virus coinfection...
  14. pmc Host response to translocated microbial products predicts outcomes of patients with HBV or HCV infection
    Netanya G Sandler
    Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Gastroenterology 141:1220-30, 1230.e1-3. 2011
    ..We investigated whether the extent and progression of liver disease in patients with chronic HBV or HCV infection are associated with microbial translocation and subsequent activation of monocytes...
  15. pmc The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease
    Yaron Rotman
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1800, USA
    Hepatology 52:894-903. 2010
    ..010). In children, no SNP was associated with histological severity. However, the rs738409 G allele was associated with younger age at the time of biopsy in multivariate analysis (P = 0.045)...
  16. pmc Association of IL28B genotype with fibrosis progression and clinical outcomes in patients with chronic hepatitis C: a longitudinal analysis
    Mazen Noureddin
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD
    Hepatology 58:1548-57. 2013
    ....
  17. pmc Type 1 diabetes associated with acquired generalized lipodystrophy and insulin resistance: the effect of long-term leptin therapy
    Jean Y Park
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 93:26-31. 2008
    ..Acquired generalized lipodystrophy (AGL) is marked by severe insulin resistance and hypertriglyceridemia. Rarely, AGL and type 1 diabetes (T1D) coexist...
  18. pmc Discordance among transient elastography, aspartate aminotransferase to platelet ratio index, and histologic assessments of liver fibrosis in patients with chronic hepatitis C
    Naveen Gara
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Clin Gastroenterol Hepatol 11:303-8.e1. 2013
    ..We evaluated discordance among TE, APRI, and histology diagnoses of cirrhosis...
  19. pmc Liver stiffness increases acutely during sickle cell vaso-occlusive crisis
    Christopher Koh
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland
    Am J Hematol 88:E250-4. 2013
    ..Increase in TE may reflect both hepatic passive congestion and hepatic involvement during VOC. TE may serve as a physiological biomarker for hepatic features of VOC...
  20. ncbi request reprint Results from a human renal allograft tolerance trial evaluating T-cell depletion with alemtuzumab combined with deoxyspergualin
    Allan D Kirk
    Transplantation Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Transplantation 80:1051-9. 2005
    ..We therefore performed a trial to determine if lymphocyte depletion with alemtuzumab combined with DSG would induce tolerance in humans...
  21. ncbi request reprint A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis
    Kittichai Promrat
    Liver Diseases Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    Hepatology 39:188-96. 2004
    ..The long-term safety and benefits of pioglitazone require further study...
  22. pmc A 25-year study of the clinical and histologic outcomes of hepatitis C virus infection and its modes of transmission in a cohort of initially asymptomatic blood donors
    Robert D Allison
    Department of Transfusion Medicine, National Institutes of Health, Bethesda, MD, USA
    J Infect Dis 206:654-61. 2012
    ..A total of 738 volunteer blood donors who were positive for anti-hepatitis C virus (HCV) were assessed for risk factors and outcomes for up to 15 years within the study and up to 54 years from the estimated onset of infection...
  23. ncbi request reprint Hepatic abnormalities in patients with chronic granulomatous disease
    Nadeem Hussain
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892 1800, USA
    Hepatology 45:675-83. 2007
    ..Vascular lesions such as venopathy and--to a lesser extent--NRH are common. The cause and clinical consequences of venopathy await prospective evaluation...
  24. pmc Evaluation of tacrolimus abbreviated area-under-the-curve monitoring in renal transplant patients who are potentially at risk for adverse events
    Yuen Yi Hon
    Pharmacy Department, Clinical Center, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Transplant 24:557-63. 2010
    ..Lower C0 and AUC appeared to be associated with biopsy-proven AR>6 months post-transplant. Further prospective evaluation of TAC AUC and C0 monitoring in a larger cohort of patients is warranted...
  25. ncbi request reprint Hepatic histological findings in suspected drug-induced liver injury: systematic evaluation and clinical associations
    David E Kleiner
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD
    Hepatology 59:661-70. 2014
    ....
  26. doi request reprint Early changes in hepatitis C virus (HCV) levels in response to peginterferon and ribavirin treatment in patients with chronic HCV genotype 1 infection
    Jay H Hoofnagle
    Liver Disease Research Branch, Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda 20817, USA
    J Infect Dis 199:1112-20. 2009
    ..Trial registration. ClinicalTrials.gov identifier: NCT00038974 ...
  27. pmc Reactivation of hepatitis B with reappearance of hepatitis B surface antigen after chemotherapy and immunosuppression
    Tara N Palmore
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, MSC 1888, Bethesda, Maryland 20892 1888, USA
    Clin Gastroenterol Hepatol 7:1130-7. 2009
    ..We report 6 patients who experienced loss of serologic markers of hepatitis B immunity and reappearance of HBsAg in the serum as a result of a variety of acquired immune deficiencies...
  28. pmc Placebo in nonalcoholic steatohepatitis: insight into natural history and implications for future clinical trials
    Rohit Loomba
    Liver Diseases Branch, National Institute of Diabetes and Digestive Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Clin Gastroenterol Hepatol 6:1243-8. 2008
    ..The aim of our study was to assess the biochemical and histologic changes seen in the placebo arm of the randomized, placebo-controlled trials in adult patients with NASH...
  29. pmc Association of interleukin-15-induced peripheral immune activation with hepatic stellate cell activation in persons coinfected with hepatitis C virus and HIV
    Robert D Allison
    Department of Transfusion Medicine, National Institutes of Health, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 1876, USA
    J Infect Dis 200:619-23. 2009
    ..Future strategies that reduce immune activation and HSC activation may delay progression of liver fibrosis...
  30. pmc Increased caffeine consumption is associated with reduced hepatic fibrosis
    Apurva A Modi
    Liver Diseases Branch, National Institutes of Diabetes and Digestive and Kidney Diseases NIDDK, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Hepatology 51:201-9. 2010
    ....
  31. pmc Nodular regenerative hyperplasia in common variable immunodeficiency
    Ivan J Fuss
    Mucosal Immunity Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Clin Immunol 33:748-58. 2013
    ..The purpose of this study was to define the characteristics and course of this complication of CVID...
  32. ncbi request reprint Hepatic histologic response (HR) to combination therapy among HCV/HIV-coinfected individuals: interferon induces HR independent of sustained virologic response (SVR)
    Lynne Wu
    Laboratory of Immunoregulation, NIAID, NIH, DHHS, Bethesda, Maryland, USA
    AIDS Res Hum Retroviruses 22:1091-8. 2006
    ..Combination therapy resulted in an HR for most of the patients, however, further follow-up of these patients will determine the durability of such an HR...
  33. pmc Liver regeneration signature in hepatitis B virus (HBV)-associated acute liver failure identified by gene expression profiling
    Oriel Nissim
    Hepatic Pathogenesis Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 7:e49611. 2012
    ..We investigated the molecular mechanisms of liver regeneration in 4 patients who underwent liver transplantation for hepatitis B virus (HBV)-associated ALF...
  34. pmc Prognostic value of Ishak fibrosis stage: findings from the hepatitis C antiviral long-term treatment against cirrhosis trial
    James E Everhart
    Division of Digestive Diseases and Nutrition, Department of Health and Human Services, National Institutes of Health, Bethesda, MD 20892 5450, USA
    Hepatology 51:585-94. 2010
    ..Similar results were observed with liver transplantation or liver-related death as the outcome...
  35. ncbi request reprint Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophy
    Edward D Javor
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Hepatology 41:753-60. 2005
    ..These reductions were associated with significant reductions in steatosis and the hepatocellular ballooning injury seen in NASH...
  36. ncbi request reprint Composite tissue allotransplantation: classification of clinical acute skin rejection
    Linda C Cendales
    Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health, Department of Health and Human Resources, Bethesda, MD 20892 1102, USA
    Transplantation 80:1676-80. 2005
    ..However, a systematic examination of this process has not been performed, and there are no standardized criteria for the description of severity or type of rejection..
  37. pmc Lung manifestations in an autopsy-based series of pulmonary or disseminated nontuberculous mycobacterial disease
    Meghan L O'Connell
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1888, USA
    Chest 141:1203-9. 2012
    ..The clinical, histopathologic, and radiologic disease manifestations of primary pulmonary or disseminated nontuberculous mycobacterial disease were compared in an autopsy series...
  38. ncbi request reprint Hepatoportal venopathy due to disseminated Mycobacterium avium complex infection in a child with IFN-gamma receptor 2 deficiency
    Amy V Rapkiewicz
    Laboratory of Pathology, National Cancer Institute, National Institute of Health, Bethesda, MD, USA
    Virchows Arch 451:95-100. 2007
    ..We herein report a case of a child with autosomal recessive IFN-gamma receptor 2 (IFN-gammaR2) deficiency who developed hepatic venopathy secondary to disseminated Mycobacterium avium complex (MAC) infection...
  39. ncbi request reprint Associations of chemokine system polymorphisms with clinical outcomes and treatment responses of chronic hepatitis C
    Kittichai Promrat
    The Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Gastroenterology 124:352-60. 2003
    ..The roles of other disease-associated chemokine system polymorphisms have not been evaluated in hepatitis C virus infection...
  40. ncbi request reprint Composite tissue allotransplantation: development of a preclinical model in nonhuman primates
    Linda C Cendales
    Orthopedic Section, Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1102, USA
    Transplantation 80:1447-54. 2005
    ..However, the optimal strategies to prevent CTA rejection remain undefined. Presently, no CTA model exists to evaluate human-specific immunosuppressants or the relative immunogenicity of all CTA tissues...
  41. ncbi request reprint Composite tissue allotransplantation: classification of clinical acute skin rejection
    Linda C Cendales
    Office of the Clinical Director, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Disease, NIH, Department of Health and Human Resources, Bethesda, MD 20892 1102, USA
    Transplantation 81:418-22. 2006
    ..However, a systematic examination of this process has not been performed, and there are no standardized criteria for the description of severity or type of rejection...
  42. ncbi request reprint Histological classification of liver and intrahepatic bile duct cancers in SEER registries
    Sean F Altekruse
    National Cancer Institute, Division of Cancer Control and Population Sciences, Rockville, MD, USA
    J Registry Manag 38:201-5. 2011
    ....
  43. ncbi request reprint Progression of fibrosis in chronic hepatitis C
    Marc G Ghany
    Liver Diseases Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIH, Building 10, Room 9B 06, 10 Center Drive, MSC 1800, Bethesda, MD 20892 1800, USA
    Gastroenterology 124:97-104. 2003
    ..We evaluated a large cohort of patients with chronic hepatitis C (CHC) using liver histology to assess the rate and predictors of progression of fibrosis...
  44. ncbi request reprint Nodular regenerative hyperplasia: not all nodules are created equal
    Preeti A Reshamwala
    Liver Diseases Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892 1800, USA
    Hepatology 44:7-14. 2006
  45. ncbi request reprint Molecular and immunohistochemical characterization of the onset and resolution of human renal allograft ischemia-reperfusion injury
    Steven C Hoffmann
    National Institute of Diabetes and Digestive and Kidney Diseases and Navy Transplantation and Autoimmunity Branch, Bethesda, MD 20892, USA
    Transplantation 74:916-23. 2002
    ..This gives way to a T-cell dominant milieu even in grafts selected for their stable function and absence of rejection. These data have implications for understanding the fundamental link between I/R injury and alloimmunity...
  46. ncbi request reprint Results from a human renal allograft tolerance trial evaluating the humanized CD52-specific monoclonal antibody alemtuzumab (CAMPATH-1H)
    Allan D Kirk
    Transplantation and Autoimmunity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Transplantation 76:120-9. 2003
    ..We therefore performed a study to determine if pretransplant T-cell depletion with alemtuzumab would induce tolerance in human renal allografts and to evaluate the nature of the alloimmune response in the setting of T-cell depletion...
  47. pmc MKS3-related ciliopathy with features of autosomal recessive polycystic kidney disease, nephronophthisis, and Joubert Syndrome
    Meral Gunay-Aygun
    Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    J Pediatr 155:386-92.e1. 2009
    ..To describe 3 children with mutations in a Meckel syndrome gene (MKS3), with features of autosomal recessive polycystic kidney disease (ARPKD), nephronophthisis, and Joubert syndrome (JS)...
  48. pmc Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques
    Thomas A Waldmann
    Center for Cancer Research, National Cancer Institute, Frederick, MD, USA
    Blood 117:4787-95. 2011
    ....
  49. pmc Cigarette smoking, body mass index, gastro-esophageal reflux disease, and non-steroidal anti-inflammatory drug use and risk of subtypes of esophageal and gastric cancers by P53 overexpression
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Cancer Causes Control 20:361-8. 2009
    ..Further research on these tumors is needed to identify molecular markers associated with variations in the risk factor profiles...
  50. pmc Salivary gland involvement in chronic graft-versus-host disease: prevalence, clinical significance, and recommendations for evaluation
    Matin M Imanguli
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biol Blood Marrow Transplant 16:1362-9. 2010
    ..Formal evaluation of salivary function using standardized criteria is needed, and this could be incorporated as an outcome measure in clinical trials of cGVHD...
  51. ncbi request reprint Malignant insulinoma: spectrum of unusual clinical features
    Boaz Hirshberg
    Division of Intramural Research, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer 104:264-72. 2005
    ..The aims of the current study were to summarize the National Institutes of Health experience during the last two decades and to conduct a critical review of the current literature...
  52. pmc Compartmental analysis of plasma and liver n-3 essential fatty acids in alcohol-dependent men during withdrawal
    Robert J Pawlosky
    Laboratory of Metabolic Control, National Cancer Institute NIH, Bethesda, MD, USA
    J Lipid Res 50:154-61. 2009
    ....
  53. ncbi request reprint Cellular and tissue localization of globotriaosylceramide in Fabry disease
    Hasan Askari
    Developmental and Metabolic Neurology Branch, NINDS, National Institutes of Health, Building 10, Room 3D03, 9000 Rockville Pike, Bethesda, MD 20892 1260, USA
    Virchows Arch 451:823-34. 2007
    ..These findings are crucial for the understanding of the disease mechanism and suggest the usefulness of immunostaining for globotriaosylceramide as a means to assess response to novel, specific therapies...
  54. ncbi request reprint Nodular regenerative hyperplasia and severe portal hypertension in cystinosis
    Kevin O'Brien
    Section on Human Biochemical Genetics, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 1851, USA
    Clin Gastroenterol Hepatol 4:387-94. 2006
    ..We report the case histories of 2 young men with poorly treated nephropathic cystinosis who developed noncirrhotic portal hypertension with evidence of nodular regenerative hyperplasia (NRH)...
  55. pmc Late-onset gastrointestinal pain in juvenile dermatomyositis as a manifestation of ischemic ulceration from chronic endarteropathy
    Gulnara Mamyrova
    Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, Bethesda, Maryland 20892 1301, USA
    Arthritis Rheum 57:881-4. 2007
  56. ncbi request reprint Modeling pathogenesis of primary liver cancer in lineage-specific mouse cell types
    Agnes Holczbauer
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Gastroenterology 145:221-31. 2013
    ..Liver cancer stem cells (CSCs) have been recently described. We investigated the ability of distinct lineages of hepatic cells to become liver CSCs and the phenotypic and genetic heterogeneity of primary liver cancer...
  57. pmc A spectrum of severe familial liver disorders associate with telomerase mutations
    Rodrigo T Calado
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 4:e7926. 2009
    ..Here, we sought to determine the spectrum of clinical manifestations associated with telomerase loss-of-function mutations...
  58. pmc Hepatocellular carcinoma confirmation, treatment, and survival in surveillance, epidemiology, and end results registries, 1992-2008
    Sean F Altekruse
    Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, MD 20852, USA
    Hepatology 55:476-82. 2012
    ..Asian or Pacific Islander cases had significantly better 5-year survival (23%) than white (18%), Hispanic (15%), or black cases (12%)...
  59. pmc Update on fatty liver disease and steatohepatitis
    Fatima Zahra Aly
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Adv Anat Pathol 18:294-300. 2011
    ....
  60. ncbi request reprint Cancers as wounds that do not heal: differences and similarities between renal regeneration/repair and renal cell carcinoma
    Joseph Riss
    Laboratory of Biosystems and Cancer, Comparative Oncology Program, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 66:7216-24. 2006
    ..The observations reported here provide a conceptual framework for further efforts to understand the biology and to develop more effective diagnostic biomarkers and therapeutic strategies for renal tumors and renal ischemia...
  61. doi request reprint Liver biopsy findings in chronic hepatitis B
    Haresh Mani
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Hepatology 49:S61-71. 2009
    ..Thus, liver biopsy can play an important role in staging and grading chronic hepatitis B and should be more widely used in assessing the need for therapy...
  62. ncbi request reprint Causes of death in hyper-IgE syndrome
    Alexandra F Freeman
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1684, USA
    J Allergy Clin Immunol 119:1234-40. 2007
    ..Little has been published regarding the causes of death in these patients or pathologic findings...
  63. ncbi request reprint Functionally significant renal allograft rejection is defined by transcriptional criteria
    Steven C Hoffmann
    Transplantation Branch, NIDDK, NIH, DHHS, Bethesda, Maryland 20892, USA
    Am J Transplant 5:573-81. 2005
    ..Quantitative analysis of selected gene transcripts may enhance the clinical assessment of allografts...
  64. ncbi request reprint Cyclical Cushing syndrome presenting in infancy: an early form of primary pigmented nodular adrenocortical disease, or a new entity?
    Daniel F Gunther
    Section on Endocrinology and Genetics, Developmental Endocrinology Branch, National Institute of Child Health and Human Development NIH, Building 10, Room 10N262, 10 Center Drive MSC 1862, Bethesda, MD 20892 1862, USA
    J Clin Endocrinol Metab 89:3173-82. 2004
    ....
  65. ncbi request reprint Peripheral CD4(+)CD8(+) T cells are differentiated effector memory cells with antiviral functions
    Michelina Nascimbeni
    Liver Diseases Section, DDB, NIDDK, National Institutes of Health, DHHS 10 Center Drive, Bldg 10, Room 9B16, Bethesda, MD 20892 1800, USA
    Blood 104:478-86. 2004
    ....
  66. ncbi request reprint Analysis of factors associated with outcome in patients with malignant peritoneal mesothelioma undergoing surgical debulking and intraperitoneal chemotherapy
    Andrew L Feldman
    Surgical Metabolism Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Clin Oncol 21:4560-7. 2003
    ..We evaluated the peritoneal progression-free and overall survival (PFS and OS, respectively) for patients with peritoneal MM after surgical resection and regional chemotherapy...
  67. pmc A novel bacterium associated with lymphadenitis in a patient with chronic granulomatous disease
    David E Greenberg
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Pathog 2:e28. 2006
    ..This is the first reported case of invasive human disease caused by any of the Acetobacteraceae. Polyphasic taxonomic analysis shows this organism to be a new genus and species for which we propose the name Granulobacter bethesdensis...
  68. ncbi request reprint Host-dependent patterns of tissue injury in invasive pulmonary aspergillosis
    Theodouli Stergiopoulou
    Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Am J Clin Pathol 127:349-55. 2007
    ..Thus, the status of innate host defenses contributes significantly to the histologic patterns observed in IPA...
  69. pmc Antitumor effects in mice of the intravenous injection of attenuated Salmonella typhimurium
    Steven A Rosenberg
    Surgery Branch and Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Building 10, Room 2B42, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Immunother 25:218-25. 2002
    ....
  70. ncbi request reprint Semiquantitation of polycyclic aromatic hydrocarbon-DNA adducts in human esophagus by immunohistochemistry and the automated cellular imaging system
    Hilde E van Gijssel
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 11:1622-9. 2002
    ..These results appear to support the hypothesis that high PAH exposure levels may be etiologically associated with the development of esophageal cancer in Linxian...
  71. ncbi request reprint Prevalence and clinical significance of lymphocytic foci in minor salivary glands of healthy volunteers
    Lida Radfar
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    Arthritis Rheum 47:520-4. 2002
    ..To determine the prevalence and severity of focal lymphocytic sialadenitis in minor salivary glands of healthy, asymptomatic individuals, in whom Sjögren's syndrome (SS) has been excluded...
  72. pmc Hepatic abscess in patients with chronic granulomatous disease
    Matthew Lublin
    Surgery Branch, National Cancer Institute, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ann Surg 235:383-91. 2002
    ..To evaluate the clinical presentation, diagnostic procedures, and surgical management of hepatic abscesses in patients with chronic granulomatous disease (CGD)...
  73. ncbi request reprint Modeling hepatic fibrosis in African American and Caucasian American patients with chronic hepatitis C virus infection
    Robert J Fontana
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Hepatology 44:925-35. 2006
    ..The excellent performance of the Virahep-C model in an external validation cohort suggests the findings are replicable and potentially generalizable...
  74. ncbi request reprint Peginterferon and ribavirin treatment in African American and Caucasian American patients with hepatitis C genotype 1
    Hari S Conjeevaram
    Division of Gastroenterology, The University of Michigan, Ann Arbor, Michigan 48109 0362, USA
    Gastroenterology 131:470-7. 2006
    ..Compared with Caucasian Americans (CA), African Americans (AA) with chronic hepatitis C are less likely to respond to interferon-based antiviral therapy...
  75. ncbi request reprint Kidney transplantation with rabbit antithymocyte globulin induction and sirolimus monotherapy
    S John Swanson
    Organ Transplant Service, Walter Reed Army Medical Center, Washington, DC, USA
    Lancet 360:1662-4. 2002
    ..Rejection was typically correlated with low concentrations of sirolimus, indicating continued dependence on maintenance immunosuppression...
  76. ncbi request reprint Pathologic features associated with fibrosis in nonalcoholic fatty liver disease
    Terry Gramlich
    Cleveland Clinic Foundation, OH, USA
    Hum Pathol 35:196-9. 2004
    ..We conclude that the presence of hepatocyte injury in NAFLD is associated with fibrosis. These pathological features can be used to establish the pathological criteria for diagnosis of the progressive form of NAFLD or NASH...
  77. ncbi request reprint Pathologic assessment of non-alcoholic fatty liver disease
    Silvia Bondini
    Center for Liver Diseases at Inova Fairfax Hospital, 3300 Gallows Road, Falls Church, VA 22042, USA
    Clin Liver Dis 11:17-23, vii. 2007
    ..This article reviews some of the studies dealing with the histopathology of NAFLD, with attempts to develop a standardized pathologic scoring system for NASH...
  78. ncbi request reprint Myxovirus-1 and protein kinase haplotypes and fibrosis in chronic hepatitis C virus
    Leland J Yee
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Hepatology 46:74-83. 2007
    ..Although we observed a similar protective trend for the Mx1-CAGT haplotype in the validation set, the association was not statistically significant...
  79. pmc Clinical spectrum and histopathologic features of chronic hepatitis C infection in children
    Parvathi Mohan
    Department of Gastroenterology and Nutrition, Children s National Medical Center, Washington, DC 20010, USA
    J Pediatr 150:168-74, 174.e1. 2007
    ..To define the natural history and outcomes of children infected with hepatitis C virus (HCV) at birth or in early childhood...
  80. ncbi request reprint Race, insulin resistance and hepatic steatosis in chronic hepatitis C
    Hari S Conjeevaram
    Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109 0362, USA
    Hepatology 45:80-7. 2007
    ..32-0.91, P = 0.02). Insulin resistance but not steatosis was associated with a lower rate of sustained virological response when adjusted for known factors that predict response (relative risk 0.87, 95% CI 0.77-0.99, P = 0.028)...
  81. pmc Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease
    Naga Chalasani
    Indiana University School of Medicine, 1050 Wishard Boulevard, Indianapolis, IN 46202, USA
    J Hepatol 48:829-34. 2008
    ..The relationship between severity and zonal location of steatosis and the presence of steatohepatitis and various histological features that define NASH has not been formally studied...
  82. doi request reprint Cutaneous sarcoidosis and primary biliary cirrhosis: A chance association or related diseases?
    Sowmya Kishor
    Department of Dermatology, Eastern Virginia Medical School, Norfolk, Virginia, USA
    J Am Acad Dermatol 58:326-35. 2008
    ..Although the pathogenesis of both sarcoidosis and PBC remains elusive, the simultaneous occurrence of these uncommon diseases suggests a common pathway may contribute to granuloma formation in both disorders...
  83. ncbi request reprint E1 therapeutic vaccination for chronic hepatitis C: all that glitters is not gold
    Marc G Ghany
    Hepatology 38:1092-4. 2003