Research Topics
Genomes and GenesSpecies | David E KleinerSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Nonalcoholic fatty liver disease: pathologic patterns and biopsy evaluation in clinical researchDavid E Kleiner
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Semin Liver Dis 32:3-13. 2012..A current understanding of NAFLD pathologic classification, as well as nuances of grading and staging, is presented in this review...
The association of mast cells and serotonin in children with chronic abdominal pain of unknown etiologyTara J Taylor
National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, USA
BMC Res Notes 3:265. 2010..This study evaluated the association between interleukin-6 (IL-6), mast cell infiltrates, and serotonin (5-HT) levels in gastrointestinal (GI) biopsies, with perceived abdominal pain in a pediatric cohort...
Granulomas in the liverDavid E Kleiner
Laboratory of Pathology, National Cancer Institute, Building 10, Room 2N212, 10 Center Drive, MSC 1516, Bethesda, MD 20892, USA
Semin Diagn Pathol 23:161-9. 2006..This review surveys both common and unusual granulomatous diseases with emphasis on practical diagnosis...- The pathology of drug-induced liver injuryDavid E Kleiner
Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20892, USA
Semin Liver Dis 29:364-72. 2009.... - Design and validation of a histological scoring system for nonalcoholic fatty liver diseaseDavid E Kleiner
Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
Hepatology 41:1313-21. 2005..NAS of > or =5 correlated with a diagnosis of NASH, and biopsies with scores of less than 3 were diagnosed as "not NASH.".. - The liver biopsy in chronic hepatitis C: a view from the other side of the microscopeDavid E Kleiner
Laboratory of Pathology, National Cancer Institute, Bldg 10 Room 2N212, Bethesda, MD 20892, USA
Semin Liver Dis 25:52-64. 2005..Clinicians can then make best use of the information derived from the liver biopsy to help them advise patients on the natural history of their disease and the therapeutic options that are available... - Changes in serum adipokine levels during pioglitazone treatment for nonalcoholic steatohepatitis: relationship to histological improvementGlen Lutchman
Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Clin Gastroenterol Hepatol 4:1048-52. 2006..CONCLUSIONS: Improvements in liver histology during TZD therapy may be modulated by an adiponectin-mediated effect on insulin sensitivity and hepatic fatty acid metabolism rather than by changes in proinflammatory cytokines... - Steatosis and progression of fibrosis in untreated patients with chronic hepatitis C infectionPonni Perumalswami
Liver Diseases Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-1800, USA
Hepatology 43:780-7. 2006..In conclusion, in this cohort of patients with CHC, steatosis was associated with older age, higher BMI, and higher serum ALT levels but not with the presence of or subsequent progression of fibrosis... - The effects of discontinuing pioglitazone in patients with nonalcoholic steatohepatitisGlen Lutchman
Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA
Hepatology 46:424-9. 2007.... - Maintenance therapy with ribavirin in patients with chronic hepatitis C who fail to respond to combination therapy with interferon alfa and ribavirinJay H Hoofnagle
Liver Diseases Section, Digestive Diseases Branch, and Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Hepatology 38:66-74. 2003..Whether these improvements will ultimately result in prevention of progression of hepatitis C requires further study... - Identification of novel markers for liver fibrosis in HIV/hepatitis C virus coinfected individuals using genomics-based approachDaniel L Suzman
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
AIDS 22:1433-9. 2008..Liver biopsy is invasive, risky and costly, but is required to assess fibrosis. This study intended to identify novel noninvasive markers to accurately assess fibrosis in HIV/hepatitis C virus coinfection... - Hepatic involvement and portal hypertension predict mortality in chronic granulomatous diseaseJordan J Feld
Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892 1800, USA
Gastroenterology 134:1917-26. 2008..Liver involvement in CGD includes vascular abnormalities, which may lead to noncirrhotic portal hypertension... - The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver diseaseYaron Rotman
Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1800, USA
Hepatology 52:894-903. 2010..In pediatric patients, the high-risk rs738409 G allele is associated with an earlier presentation of disease. We also describe a hitherto unknown association between SNPs at a chromosome 10 locus and the severity of NASH fibrosis... - Host response to translocated microbial products predicts outcomes of patients with HBV or HCV infectionNetanya G Sandler
Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Gastroenterology 141:1220-30, 1230.e1-3. 2011..We investigated whether the extent and progression of liver disease in patients with chronic HBV or HCV infection are associated with microbial translocation and subsequent activation of monocytes... - Results from a human renal allograft tolerance trial evaluating T-cell depletion with alemtuzumab combined with deoxyspergualinAllan D Kirk
Transplantation Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Transplantation 80:1051-9. 2005..CONCLUSIONS: We conclude that treatment with alemtuzumab and DSG does not induce tolerance in humans. Chemokine production may not be adequately suppressed using this approach... - A 25-year study of the clinical and histologic outcomes of hepatitis C virus infection and its modes of transmission in a cohort of initially asymptomatic blood donorsRobert D Allison
Department of Transfusion Medicine, National Institutes of Health, Bethesda, MD, USA
J Infect Dis 206:654-61. 2012..A total of 738 volunteer blood donors who were positive for anti-hepatitis C virus (HCV) were assessed for risk factors and outcomes for up to 15 years within the study and up to 54 years from the estimated onset of infection... - A pilot study of pioglitazone treatment for nonalcoholic steatohepatitisKittichai Promrat
Liver Diseases Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
Hepatology 39:188-96. 2004..The long-term safety and benefits of pioglitazone require further study... - Evaluation of tacrolimus abbreviated area-under-the-curve monitoring in renal transplant patients who are potentially at risk for adverse eventsYuen Yi Hon
Pharmacy Department, Clinical Center, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Clin Transplant 24:557-63. 2010..C0 correlated well with abbreviated AUCs. Lower C0 and AUC appeared to be associated with biopsy-proven AR>6 months post-transplant. Further prospective evaluation of TAC AUC and C0 monitoring in a larger cohort of patients is warranted... - Type 1 diabetes associated with acquired generalized lipodystrophy and insulin resistance: the effect of long-term leptin therapyJean Y Park
Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Clin Endocrinol Metab 93:26-31. 2008..Acquired generalized lipodystrophy (AGL) is marked by severe insulin resistance and hypertriglyceridemia. Rarely, AGL and type 1 diabetes (T1D) coexist... - Hepatic abnormalities in patients with chronic granulomatous diseaseNadeem Hussain
Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892 1800, USA
Hepatology 45:675-83. 2007..Vascular lesions such as venopathy and--to a lesser extent--NRH are common. The cause and clinical consequences of venopathy await prospective evaluation... - Reactivation of hepatitis B with reappearance of hepatitis B surface antigen after chemotherapy and immunosuppressionTara N Palmore
National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, MSC 1888, Bethesda, Maryland 20892 1888, USA
Clin Gastroenterol Hepatol 7:1130-7. 2009..We report 6 patients who experienced loss of serologic markers of hepatitis B immunity and reappearance of HBsAg in the serum as a result of a variety of acquired immune deficiencies... - Association of interleukin-15-induced peripheral immune activation with hepatic stellate cell activation in persons coinfected with hepatitis C virus and HIVRobert D Allison
Department of Transfusion Medicine, National Institutes of Health, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 1876, USA
J Infect Dis 200:619-23. 2009..Future strategies that reduce immune activation and HSC activation may delay progression of liver fibrosis... - Placebo in nonalcoholic steatohepatitis: insight into natural history and implications for future clinical trialsRohit Loomba
Liver Diseases Branch, National Institute of Diabetes and Digestive Diseases, National Institutes of Health, Bethesda, Maryland, USA
Clin Gastroenterol Hepatol 6:1243-8. 2008..The aim of our study was to assess the biochemical and histologic changes seen in the placebo arm of the randomized, placebo-controlled trials in adult patients with NASH... - Hepatic histologic response (HR) to combination therapy among HCV/HIV-coinfected individuals: interferon induces HR independent of sustained virologic response (SVR)Lynne Wu
Laboratory of Immunoregulation, NIAID, NIH, DHHS, Bethesda, Maryland, USA
AIDS Res Hum Retroviruses 22:1091-8. 2006..Combination therapy resulted in an HR for most of the patients, however, further follow-up of these patients will determine the durability of such an HR... - Increased caffeine consumption is associated with reduced hepatic fibrosisApurva A Modi
Liver Diseases Branch, National Institutes of Diabetes and Digestive and Kidney Diseases NIDDK, National Institutes of Health NIH, Bethesda, MD 20892, USA
Hepatology 51:201-9. 2010.... - Early changes in hepatitis C virus (HCV) levels in response to peginterferon and ribavirin treatment in patients with chronic HCV genotype 1 infectionJay H Hoofnagle
Liver Disease Research Branch, Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda 20817, USA
J Infect Dis 199:1112-20. 2009..Trial registration. ClinicalTrials.gov identifier: NCT00038974 ... - Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophyEdward D Javor
Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Hepatology 41:753-60. 2005..These reductions were associated with significant reductions in steatosis and the hepatocellular ballooning injury seen in NASH... - Composite tissue allotransplantation: classification of clinical acute skin rejectionLinda C Cendales
Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health, Department of Health and Human Resources, Bethesda, MD 20892 1102, USA
Transplantation 80:1676-80. 2005..However, a systematic examination of this process has not been performed, and there are no standardized criteria for the description of severity or type of rejection.. - Prognostic value of Ishak fibrosis stage: findings from the hepatitis C antiviral long-term treatment against cirrhosis trialJames E Everhart
Division of Digestive Diseases and Nutrition, Department of Health and Human Services, National Institutes of Health, Bethesda, MD 20892 5450, USA
Hepatology 51:585-94. 2010..Patients with fragmented biopsy specimens with low Ishak stage may be understaged histologically... - Lung manifestations in an autopsy-based series of pulmonary or disseminated nontuberculous mycobacterial diseaseMeghan L O'Connell
Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1888, USA
Chest 141:1203-9. 2012..The clinical, histopathologic, and radiologic disease manifestations of primary pulmonary or disseminated nontuberculous mycobacterial disease were compared in an autopsy series... - Composite tissue allotransplantation: classification of clinical acute skin rejectionLinda C Cendales
Office of the Clinical Director, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Disease, NIH, Department of Health and Human Resources, Bethesda, MD 20892 1102, USA
Transplantation 81:418-22. 2006..However, a systematic examination of this process has not been performed, and there are no standardized criteria for the description of severity or type of rejection... - Hepatoportal venopathy due to disseminated Mycobacterium avium complex infection in a child with IFN-gamma receptor 2 deficiencyAmy V Rapkiewicz
Laboratory of Pathology, National Cancer Institute, National Institute of Health, Bethesda, MD, USA
Virchows Arch 451:95-100. 2007..We herein report a case of a child with autosomal recessive IFN-gamma receptor 2 (IFN-gammaR2) deficiency who developed hepatic venopathy secondary to disseminated Mycobacterium avium complex (MAC) infection... - Composite tissue allotransplantation: development of a preclinical model in nonhuman primatesLinda C Cendales
Orthopedic Section, Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1102, USA
Transplantation 80:1447-54. 2005..However, the optimal strategies to prevent CTA rejection remain undefined. Presently, no CTA model exists to evaluate human-specific immunosuppressants or the relative immunogenicity of all CTA tissues... - Associations of chemokine system polymorphisms with clinical outcomes and treatment responses of chronic hepatitis CKittichai Promrat
The Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Gastroenterology 124:352-60. 2003..The roles of other disease-associated chemokine system polymorphisms have not been evaluated in hepatitis C virus infection... - Histological classification of liver and intrahepatic bile duct cancers in SEER registriesSean F Altekruse
National Cancer Institute, Division of Cancer Control and Population Sciences, Rockville, MD, USA
J Registry Manag 38:201-5. 2011..Incomplete histological characterization of hepatocellular carcinomas was noted in this report. It is likely to be explained by guidelines affirming the use of non-invasive diagnostic and treatment procedures for this cancer... - Progression of fibrosis in chronic hepatitis CMarc G Ghany
Liver Diseases Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIH, Building 10, Room 9B 06, 10 Center Drive, MSC 1800, Bethesda, MD 20892 1800, USA
Gastroenterology 124:97-104. 2003..We evaluated a large cohort of patients with chronic hepatitis C (CHC) using liver histology to assess the rate and predictors of progression of fibrosis... - Nodular regenerative hyperplasia: not all nodules are created equalPreeti A Reshamwala
Liver Diseases Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892-1800, USA
Hepatology 44:7-14. 2006 - Results from a human renal allograft tolerance trial evaluating the humanized CD52-specific monoclonal antibody alemtuzumab (CAMPATH-1H)Allan D Kirk
Transplantation and Autoimmunity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
Transplantation 76:120-9. 2003..We therefore performed a study to determine if pretransplant T-cell depletion with alemtuzumab would induce tolerance in human renal allografts and to evaluate the nature of the alloimmune response in the setting of T-cell depletion... - Molecular and immunohistochemical characterization of the onset and resolution of human renal allograft ischemia-reperfusion injurySteven C Hoffmann
National Institute of Diabetes and Digestive and Kidney Diseases and Navy Transplantation and Autoimmunity Branch, Bethesda, MD 20892, USA
Transplantation 74:916-23. 2002..This gives way to a T-cell dominant milieu even in grafts selected for their stable function and absence of rejection. These data have implications for understanding the fundamental link between I/R injury and alloimmunity... - Discordance among transient elastography, aspartate aminotransferase to platelet ratio index, and histologic assessments of liver fibrosis in patients with chronic hepatitis CNaveen Gara
Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Clin Gastroenterol Hepatol 11:303-8.e1. 2013..We evaluated discordance among TE, APRI, and histology diagnoses of cirrhosis... - Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaquesThomas A Waldmann
Center for Cancer Research, National Cancer Institute, Frederick, MD, USA
Blood 117:4787-95. 2011.... - Nodular regenerative hyperplasia and severe portal hypertension in cystinosisNadeem Hussain
Section on Human Biochemical Genetics, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892-1851, USA
Clin Gastroenterol Hepatol 4:387-94. 2006..NRH may represent a rare, late complication of cystinosis, although the mechanism remains undefined... - Late-onset gastrointestinal pain in juvenile dermatomyositis as a manifestation of ischemic ulceration from chronic endarteropathyGulnara Mamyrova
Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, Bethesda, Maryland 20892-1301, USA
Arthritis Rheum 57:881-4. 2007 - Cigarette smoking, body mass index, gastro-esophageal reflux disease, and non-steroidal anti-inflammatory drug use and risk of subtypes of esophageal and gastric cancers by P53 overexpressionJonine D Figueroa
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Cancer Causes Control 20:361-8. 2009..Further research on these tumors is needed to identify molecular markers associated with variations in the risk factor profiles... - Compartmental analysis of plasma and liver n-3 essential fatty acids in alcohol-dependent men during withdrawalRobert J Pawlosky
Laboratory of Metabolic Control, National Cancer Institute NIH, Bethesda, MD, USA
J Lipid Res 50:154-61. 2009.... - Cellular and tissue localization of globotriaosylceramide in Fabry diseaseHasan Askari
Developmental and Metabolic Neurology Branch, NINDS, National Institutes of Health, Building 10, Room 3D03, 9000 Rockville Pike, Bethesda, MD 20892 1260, USA
Virchows Arch 451:823-34. 2007..These findings are crucial for the understanding of the disease mechanism and suggest the usefulness of immunostaining for globotriaosylceramide as a means to assess response to novel, specific therapies... - Malignant insulinoma: spectrum of unusual clinical featuresBoaz Hirshberg
Division of Intramural Research, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Cancer 104:264-72. 2005..The aims of the current study were to summarize the National Institutes of Health experience during the last two decades and to conduct a critical review of the current literature... - Salivary gland involvement in chronic graft-versus-host disease: prevalence, clinical significance, and recommendations for evaluationMatin M Imanguli
Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Biol Blood Marrow Transplant 16:1362-9. 2010..Formal evaluation of salivary function using standardized criteria is needed, and this could be incorporated as an outcome measure in clinical trials of cGVHD... - A spectrum of severe familial liver disorders associate with telomerase mutationsRodrigo T Calado
Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS ONE 4:e7926. 2009..Here, we sought to determine the spectrum of clinical manifestations associated with telomerase loss-of-function mutations... - Hepatocellular carcinoma confirmation, treatment, and survival in surveillance, epidemiology, and end results registries, 1992-2008Sean F Altekruse
Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, MD 20852, USA
Hepatology 55:476-82. 2012..Additional progress may be possible with continued use of clinical surveillance to follow individuals at risk for HCC, enabling early intervention... - Causes of death in hyper-IgE syndromeAlexandra F Freeman
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1684, USA
J Allergy Clin Immunol 119:1234-40. 2007..Little has been published regarding the causes of death in these patients or pathologic findings... - Update on fatty liver disease and steatohepatitisFatima Zahra Aly
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Adv Anat Pathol 18:294-300. 2011.... - MKS3-related ciliopathy with features of autosomal recessive polycystic kidney disease, nephronophthisis, and Joubert SyndromeMeral Gunay-Aygun
Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
J Pediatr 155:386-92.e1. 2009..To describe 3 children with mutations in a Meckel syndrome gene (MKS3), with features of autosomal recessive polycystic kidney disease (ARPKD), nephronophthisis, and Joubert syndrome (JS)... - Cancers as wounds that do not heal: differences and similarities between renal regeneration/repair and renal cell carcinomaJoseph Riss
Laboratory of Biosystems and Cancer, Comparative Oncology Program, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Cancer Res 66:7216-24. 2006..The observations reported here provide a conceptual framework for further efforts to understand the biology and to develop more effective diagnostic biomarkers and therapeutic strategies for renal tumors and renal ischemia... - Liver biopsy findings in chronic hepatitis BHaresh Mani
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Hepatology 49:S61-71. 2009..Thus, liver biopsy can play an important role in staging and grading chronic hepatitis B and should be more widely used in assessing the need for therapy... - Nodular regenerative hyperplasia in common variable immunodeficiencyIvan J Fuss
Mucosal Immunity Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
J Clin Immunol 33:748-58. 2013..The purpose of this study was to define the characteristics and course of this complication of CVID... - Host-dependent patterns of tissue injury in invasive pulmonary aspergillosisTheodouli Stergiopoulou
Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA
Am J Clin Pathol 127:349-55. 2007..Thus, the status of innate host defenses contributes significantly to the histologic patterns observed in IPA... - Analysis of factors associated with outcome in patients with malignant peritoneal mesothelioma undergoing surgical debulking and intraperitoneal chemotherapyAndrew L Feldman
Surgical Metabolism Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Clin Oncol 21:4560-7. 2003..Favorable outcome is associated with age, tumor biology (selection of patients with a history of previous debulking), lack of invasive tumor growth, and minimal residual disease after tumor resection... - Peripheral CD4(+)CD8(+) T cells are differentiated effector memory cells with antiviral functionsMichelina Nascimbeni
Liver Diseases Section, DDB, NIDDK, National Institutes of Health, DHHS 10 Center Drive, Bldg 10, Room 9B16, Bethesda, MD 20892-1800, USA
Blood 104:478-86. 2004.... - Cyclical Cushing syndrome presenting in infancy: an early form of primary pigmented nodular adrenocortical disease, or a new entity?Daniel F Gunther
Section on Endocrinology and Genetics, Developmental Endocrinology Branch, National Institute of Child Health and Human Development NIH, Building 10, Room 10N262, 10 Center Drive MSC 1862, Bethesda, MD 20892 1862, USA
J Clin Endocrinol Metab 89:3173-82. 2004.... - Functionally significant renal allograft rejection is defined by transcriptional criteriaSteven C Hoffmann
Transplantation Branch, NIDDK, NIH, DHHS, Bethesda, Maryland 20892, USA
Am J Transplant 5:573-81. 2005..Quantitative analysis of selected gene transcripts may enhance the clinical assessment of allografts... - A novel bacterium associated with lymphadenitis in a patient with chronic granulomatous diseaseDavid E Greenberg
Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
PLoS Pathog 2:e28. 2006..This is the first reported case of invasive human disease caused by any of the Acetobacteraceae. Polyphasic taxonomic analysis shows this organism to be a new genus and species for which we propose the name Granulobacter bethesdensis... - Semiquantitation of polycyclic aromatic hydrocarbon-DNA adducts in human esophagus by immunohistochemistry and the automated cellular imaging systemHilde E van Gijssel
Laboratory of Cellular Carcinogenesis and Tumor Promotion, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Cancer Epidemiol Biomarkers Prev 11:1622-9. 2002..These results appear to support the hypothesis that high PAH exposure levels may be etiologically associated with the development of esophageal cancer in Linxian... - Antitumor effects in mice of the intravenous injection of attenuated Salmonella typhimuriumSteven A Rosenberg
Surgery Branch and Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Building 10, Room 2B42, 9000 Rockville Pike, Bethesda, MD 20892, USA
J Immunother (1997) 25:218-25. 2002.... - Hepatic abscess in patients with chronic granulomatous diseaseMatthew Lublin
Surgery Branch, National Cancer Institute, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Ann Surg 235:383-91. 2002..Early excision and treatment with antibiotics directed against S. aureus is necessary. General surgeons should be aware of this rare immunodeficiency and should aggressively manage hepatic abscesses in these patients... - Prevalence and clinical significance of lymphocytic foci in minor salivary glands of healthy volunteersLida Radfar
National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
Arthritis Rheum 47:520-4. 2002..To determine the prevalence and severity of focal lymphocytic sialadenitis in minor salivary glands of healthy, asymptomatic individuals, in whom Sjögren's syndrome (SS) has been excluded... - Kidney transplantation with rabbit antithymocyte globulin induction and sirolimus monotherapyS John Swanson
Organ Transplant Service, Walter Reed Army Medical Center, Washington, DC, USA
Lancet 360:1662-4. 2002..Rejection was typically correlated with low concentrations of sirolimus, indicating continued dependence on maintenance immunosuppression... - Pathologic assessment of non-alcoholic fatty liver diseaseSilvia Bondini
Center for Liver Diseases at Inova Fairfax Hospital, 3300 Gallows Road, Falls Church, VA 22042, USA
Clin Liver Dis 11:17-23, vii. 2007..This article reviews some of the studies dealing with the histopathology of NAFLD, with attempts to develop a standardized pathologic scoring system for NASH... - Peginterferon and ribavirin treatment in African American and Caucasian American patients with hepatitis C genotype 1Hari S Conjeevaram
Division of Gastroenterology, The University of Michigan, Ann Arbor, Michigan 48109 0362, USA
Gastroenterology 131:470-7. 2006..Compared with Caucasian Americans (CA), African Americans (AA) with chronic hepatitis C are less likely to respond to interferon-based antiviral therapy... - Clinical spectrum and histopathologic features of chronic hepatitis C infection in childrenParvathi Mohan
Department of Gastroenterology and Nutrition, Children s National Medical Center, Washington, DC 20010, USA
J Pediatr 150:168-74, 174.e1. 2007..To define the natural history and outcomes of children infected with hepatitis C virus (HCV) at birth or in early childhood... - Pathologic features associated with fibrosis in nonalcoholic fatty liver diseaseTerry Gramlich
Cleveland Clinic Foundation, OH, USA
Hum Pathol 35:196-9. 2004..We conclude that the presence of hepatocyte injury in NAFLD is associated with fibrosis. These pathological features can be used to establish the pathological criteria for diagnosis of the progressive form of NAFLD or NASH... - Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver diseaseNaga Chalasani
Indiana University School of Medicine, 1050 Wishard Boulevard, Indianapolis, IN 46202, USA
J Hepatol 48:829-34. 2008..The relationship between severity and zonal location of steatosis and the presence of steatohepatitis and various histological features that define NASH has not been formally studied... - Race, insulin resistance and hepatic steatosis in chronic hepatitis CHari S Conjeevaram
Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109 0362, USA
Hepatology 45:80-7. 2007..Insulin resistance but not steatosis was independently associated with lower sustained virological response... - Modeling hepatic fibrosis in African American and Caucasian American patients with chronic hepatitis C virus infectionRobert J Fontana
Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
Hepatology 44:925-35. 2006..The excellent performance of the Virahep-C model in an external validation cohort suggests the findings are replicable and potentially generalizable... - Myxovirus-1 and protein kinase haplotypes and fibrosis in chronic hepatitis C virusLeland J Yee
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
Hepatology 46:74-83. 2007..CONCLUSION: In addition to other factors, polymorphisms in cytokine genes may play a role in the progression of HCV-related fibrosis; however, further studies are needed... - E1 therapeutic vaccination for chronic hepatitis C: all that glitters is not goldMarc G Ghany
Hepatology 38:1092-4. 2003 - Cutaneous sarcoidosis and primary biliary cirrhosis: A chance association or related diseases?Sowmya Kishor
Department of Dermatology, Eastern Virginia Medical School, Norfolk, Virginia, USA
J Am Acad Dermatol 58:326-35. 2008..Although the pathogenesis of both sarcoidosis and PBC remains elusive, the simultaneous occurrence of these uncommon diseases suggests a common pathway may contribute to granuloma formation in both disorders...