D C Klein

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi 14-3-3 proteins in pineal photoneuroendocrine transduction: how many roles?
    D C Klein
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development NIH 49 6A82, Bethesda, MD 20892 4480, USA
    J Neuroendocrinol 15:370-7. 2003
  2. ncbi 14-3-3 Proteins and photoneuroendocrine transduction: role in controlling the daily rhythm in melatonin
    D C Klein
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 4480, USA
    Biochem Soc Trans 30:365-73. 2002
  3. ncbi Characterization of the Saccharomyces cerevisiae homolog of the melatonin rhythm enzyme arylalkylamine N-acetyltransferase (EC 2.3.1.87)
    S Ganguly
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology NICHD, National Institutes of Health, 49 Convent Dr, Bethesda, MD 20892 4480, USA
    J Biol Chem 276:47239-47. 2001
  4. ncbi Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis
    S Ganguly
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 4480, USA
    Proc Natl Acad Sci U S A 98:8083-8. 2001
  5. ncbi Melatonin synthesis: analysis of the more than 150-fold nocturnal increase in serotonin N-acetyltransferase messenger ribonucleic acid in the rat pineal gland
    P H Roseboom
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institute of Health, Bethesda, Maryland 20892 4480
    Endocrinology 137:3033-45. 1996
  6. ncbi cAmp regulation of arylalkylamine N-acetyltransferase (AANAT, EC 2.3.1.87): a new cell line (1E7) provides evidence of intracellular AANAT activation
    S L Coon
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:24097-107. 2001
  7. ncbi Chick pineal melatonin synthesis: light and cyclic AMP control abundance of serotonin N-acetyltransferase protein
    M Zatz
    Section on Biochemical Pharmacology, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, Bethesda, MD 20892 4068, USA
    J Neurochem 74:2315-21. 2000
  8. ncbi Natural melatonin 'knockdown' in C57BL/6J mice: rare mechanism truncates serotonin N-acetyltransferase
    P H Roseboom
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Brain Res Mol Brain Res 63:189-97. 1998
  9. ncbi Orphan nuclear receptor RZRbeta: cyclic AMP regulates expression in the pineal gland
    R Baler
    Laboratory of Developmental Neurobiology, National Institute of Child and Human Development, National Institutes of Health, Bethesda, Maryland 20892 USA
    Biochem Biophys Res Commun 220:975-8. 1996
  10. ncbi Cloning and characterization of the epsilon and zeta isoforms of the 14-3-3 proteins
    P H Roseboom
    Section on Neuroendocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
    DNA Cell Biol 13:629-40. 1994

Collaborators

Detail Information

Publications31

  1. ncbi 14-3-3 proteins in pineal photoneuroendocrine transduction: how many roles?
    D C Klein
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development NIH 49 6A82, Bethesda, MD 20892 4480, USA
    J Neuroendocrinol 15:370-7. 2003
    ..We review general aspects of 14-3-3 proteins and their biological function as binding partners, and also focus on their roles in pineal photoneuroendocrine transduction...
  2. ncbi 14-3-3 Proteins and photoneuroendocrine transduction: role in controlling the daily rhythm in melatonin
    D C Klein
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 4480, USA
    Biochem Soc Trans 30:365-73. 2002
    ..This enhances melatonin production >10-fold. Light exposure results in dephosphorylation of the enzyme and disassociation from 14-3-3, leading to destruction and a rapid drop in melatonin production and release and circulating levels...
  3. ncbi Characterization of the Saccharomyces cerevisiae homolog of the melatonin rhythm enzyme arylalkylamine N-acetyltransferase (EC 2.3.1.87)
    S Ganguly
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology NICHD, National Institutes of Health, 49 Convent Dr, Bethesda, MD 20892 4480, USA
    J Biol Chem 276:47239-47. 2001
    ..Perhaps the most striking difference is that fungal AANATs lack the regulatory domains of the vertebrate enzyme, which appear to be essential for the regulatory role the enzyme plays in photochemical transduction...
  4. ncbi Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis
    S Ganguly
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 4480, USA
    Proc Natl Acad Sci U S A 98:8083-8. 2001
    ..Similar switches could play a role in cAMP signal transduction in other biological systems...
  5. ncbi Melatonin synthesis: analysis of the more than 150-fold nocturnal increase in serotonin N-acetyltransferase messenger ribonucleic acid in the rat pineal gland
    P H Roseboom
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institute of Health, Bethesda, Maryland 20892 4480
    Endocrinology 137:3033-45. 1996
    ..A approximately 10-fold night/day rhythm in AA-NAT messenger RNA occurs in the retina, and AA-NAT messenger RNA is also detected at low levels in the brain...
  6. ncbi cAmp regulation of arylalkylamine N-acetyltransferase (AANAT, EC 2.3.1.87): a new cell line (1E7) provides evidence of intracellular AANAT activation
    S L Coon
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:24097-107. 2001
    ..This previously unrecognized switching mechanism could function physiologically to control melatonin production without changing AANAT protein levels...
  7. ncbi Chick pineal melatonin synthesis: light and cyclic AMP control abundance of serotonin N-acetyltransferase protein
    M Zatz
    Section on Biochemical Pharmacology, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, Bethesda, MD 20892 4068, USA
    J Neurochem 74:2315-21. 2000
    ..Our results indicate that light can rapidly regulate the abundance of a specific protein (AA-NAT) within a photoreceptive cell...
  8. ncbi Natural melatonin 'knockdown' in C57BL/6J mice: rare mechanism truncates serotonin N-acetyltransferase
    P H Roseboom
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Brain Res Mol Brain Res 63:189-97. 1998
    ..The decrease in melatonin signaling may have been a selective factor in the development of laboratory strains of mice because melatonin can inhibit reproduction and modify circadian rhythmicity...
  9. ncbi Orphan nuclear receptor RZRbeta: cyclic AMP regulates expression in the pineal gland
    R Baler
    Laboratory of Developmental Neurobiology, National Institute of Child and Human Development, National Institutes of Health, Bethesda, Maryland 20892 USA
    Biochem Biophys Res Commun 220:975-8. 1996
    ..Here we confirm high expression of this receptor in the pineal gland, and report that pineal RZRbeta expression exhibits a strong daily rhythm. Expression is under photoneural regulation and involves an adrenergic --> cAMP mechanism...
  10. ncbi Cloning and characterization of the epsilon and zeta isoforms of the 14-3-3 proteins
    P H Roseboom
    Section on Neuroendocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
    DNA Cell Biol 13:629-40. 1994
    ..This investigation also revealed the epsilon isoform was present at high levels in the rat pineal gland early in development and decreased steadily thereafter and that 30-kD isoforms exhibited the inverse developmental pattern...
  11. ncbi Two arylalkylamine N-acetyltransferase genes mediate melatonin synthesis in fish
    S L Coon
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, NICHD, National Institutes of Health, Bethesda, Maryland 20892 4480, USA
    J Biol Chem 274:9076-82. 1999
    ..The evolution of two AANATs may represent a strategy to optimally meet tissue-related requirements for synthesis of melatonin: pineal melatonin serves an endocrine role and retinal melatonin plays a paracrine role...
  12. ncbi Avian melatonin synthesis: photic and circadian regulation of serotonin N-acetyltransferase mRNA in the chicken pineal gland and retina
    M Bernard
    Section on Neuroendocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurochem 68:213-24. 1997
    ..In contrast, changes in mRNA content are not involved in the rapid light-induced decrease in AA-NAT activity...
  13. ncbi Regulation of arylalkylamine N-acetyltransferase-2 (AANAT2, EC 2.3.1.87) in the fish pineal organ: evidence for a role of proteasomal proteolysis
    J Falcon
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 4480, USA
    Endocrinology 142:1804-13. 2001
    ....
  14. ncbi Characterization of the chicken serotonin N-acetyltransferase gene. Activation via clock gene heterodimer/E box interaction
    N W Chong
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 275:32991-8. 2000
    ..These observations suggest that binding of clock gene heterodimers to the cAANAT E box is a critical element in the expression of the cAANAT gene in vitro...
  15. ncbi The human serotonin N-acetyltransferase (EC 2.3.1.87) gene (AANAT): structure, chromosomal localization, and tissue expression
    S L Coon
    Section on Neuroendocrinology, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Genomics 34:76-84. 1996
    ..Brain and pituitary AA-NAT could modulate serotonin-dependent aspects of human behavior and pituitary function...
  16. ncbi GCN5-related N-acetyltransferases: a structural overview
    F Dyda
    Laboratory of Molecular Biology, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Biophys Biomol Struct 29:81-103. 2000
    ..Despite the diversity of substrate specificities, members of the GNAT superfamily demonstrate remarkable similarity in protein topology and mode of acetyl coenzyme A binding, likely reflecting a conserved catalytic mechanism...
  17. ncbi The melatonin rhythm-generating enzyme: molecular regulation of serotonin N-acetyltransferase in the pineal gland
    D C Klein
    Section on Neuroendocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 4480, USA
    Recent Prog Horm Res 52:307-57; discussion 357-8. 1997
    ..The variety of mechanisms that have evolved among vertebrates to achieve the same goal-a rhythm in melatonin-underlines the important role melatonin plays as the hormonal signal of environmental lighting in vertebrates...
  18. ncbi Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation
    T Obsil
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 105:257-67. 2001
    ....
  19. ncbi The structural basis of ordered substrate binding by serotonin N-acetyltransferase: enzyme complex at 1.8 A resolution with a bisubstrate analog
    A B Hickman
    Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 0560, USA
    Cell 97:361-9. 1999
    ..A water-filled channel leading from the active site to the surface provides a pathway for proton removal following amine deprotonation. Furthermore, structural and mutagenesis results indicate an important role for Tyr-168 in catalysis...
  20. ncbi The rat arylalkylamine N-acetyltransferase gene promoter. cAMP activation via a cAMP-responsive element-CCAAT complex
    R Baler
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 272:6979-85. 1997
    ..The results of deletion analysis and site-directed mutagenesis indicate that cAMP activation requires a CRE.CCAAT complex consisting of a near-perfect CRE and an inverted CCAAT box located within two helical turns...
  21. ncbi Circadian expression of transcription factor Fra-2 in the rat pineal gland
    R Baler
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 270:27319-25. 1995
    ..AP-1 binding activity changes in parallel to changes in the level of Fra-2 protein...
  22. ncbi Pineal serotonin N-acetyltransferase: expression cloning and molecular analysis
    S L Coon
    Section on Neuroendocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Science 270:1681-3. 1995
    ..The night-to-day ratio of ovine pineal AA-NAT mRNA is less than 2. In contrast, the ratio exceeds 150 in rats. AA-NAT represents a family within a large superfamily of acetyltransferases...
  23. ncbi Localization of the hydroxyindole-O-methyltransferase gene to the pseudoautosomal region: implications for mapping of psychiatric disorders
    H Yi
    Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Hum Mol Genet 2:127-31. 1993
    ..It will be possible to readily identify or exclude the involvement of this gene in genetic diseases by linkage analysis of the disease locus with the high frequency multiallelic polymorphisms at this locus...
  24. ncbi Recoverin in pineal organs and retinae of various vertebrate species including man
    H W Korf
    Section on Neuroendocrinology, National Institutes of Health, Bethesda, MD 20892
    Brain Res 595:57-66. 1992
    ..However, the functional role of recoverin in the mammalian pineal organ, which is not photosensitive, remains unknown...
  25. ncbi Genetic, temporal and developmental differences between melatonin rhythm generating systems in the teleost fish pineal organ and retina
    J Falcon
    Laboratoire Arago, UMR 7628, CNRS and University Pierre and Marie Curie, BP 44, F 66651 Banyuls sur Mer, France
    J Neuroendocrinol 15:378-82. 2003
    ..We review the fish pineal and retinal melatonin rhythm generating systems and consider the evolutional pressures and other factors which led to these differences...
  26. ncbi Transcripts encoding two melatonin synthesis enzymes in the teleost pineal organ: circadian regulation in pike and zebrafish, but not in trout
    V Begay
    Departement des Neurosciences, CNRS UMR 6558, Faculte des Sciences, Poitiers, France
    Endocrinology 139:905-12. 1998
    ....
  27. ncbi Development and regulation of rhodopsin kinase in rat pineal and retina
    A K Ho
    J Neurochem 46:1176-9. 1986
    ..The finding of neural control of pineal rhodopsin kinase in the pineal gland of adult rats is consistent with a function of the enzyme in the neural regulation of pineal function...
  28. ncbi Human hydroxyindole-O-methyltransferase: presence of LINE-1 fragment in a cDNA clone and pineal mRNA
    S J Donohue
    Toxicology Branch, National Cancer Institute, National Institutes of Health, Rockville, MD 20892
    DNA Cell Biol 12:715-27. 1993
    ..The human HIOMT sequence should be useful in further studies of this enzyme and will also be of special importance in evaluating the functional significance of the inclusion of a fragment of the LINE-1 in an mRNA...
  29. ncbi Rat pineal S-antigen: sequence analysis reveals presence of alpha-transducin homologous sequence
    T Abe
    Molecular Biology Section, National Eye Institute, Bethesda, MD 20892
    FEBS Lett 247:307-11. 1989
    ..These sequences may play a role in the action of pineal S-Ag in transmembrane signal transduction...
  30. ncbi Immunocytochemical demonstration of rod-opsin, S-antigen, and neuron-specific proteins in the human pineal gland
    S K Huang
    Institut für Anatomie und Zytobiologie, Justus Liebig Universitat, Giessen, Federal Republic of Germany
    Cell Tissue Res 267:493-8. 1992
    ....
  31. ncbi Transcriptional regulation of arylalkylamine-N-acetyltransferase-2 gene in the pineal gland of the gilthead seabream
    B Zilberman Peled
    Department of Zoology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    J Neuroendocrinol 19:46-53. 2007
    ..These results suggest that seabream aanat2 is a clock-controlled gene that is regulated by conserved mechanisms...