Research Topics
| Emily O KistnerSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Method for using complete and incomplete trios to identify genes related to a quantitative traitEmily O Kistner
Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Genet Epidemiol 27:33-42. 2004..In addition, missing parental genotype data can be accommodated through an expectation-maximization (EM) algorithm approach. The EM approach allows recovery of most of the lost power due to incomplete trios...
A method for identifying genes related to a quantitative trait, incorporating multiple siblings and missing parentsEmily O Kistner
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Genet Epidemiol 29:155-65. 2005..We use simulations based on a population with admixture to compare our method to a popular non-parametric family-based association test (FBAT), testing the null of no association in the presence of linkage...
Genetic polymorphisms in transforming growth factor beta-1 (TGFB1) and childhood asthma and atopyHuiling Li
Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Hum Genet 121:529-38. 2007..77, 95% CI=1.22-2.57 for two copies). These three SNPs were also related to the degree of atopy. This largest study to date of genetic variation in TGFB1 and asthma and atopy adds to increasing evidence for a role in these disorders...
A method for using incomplete triads to test maternally mediated genetic effects and parent-of-origin effects in relation to a quantitative traitEmily O Kistner
Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
Am J Epidemiol 163:255-61. 2006..Methods are illustrated with birth weight and gestational length, two quantitative outcomes for which data were collected in a Montreal, Canada, study of intrauterine growth restriction between May 1998 and June 2000...
Genetic polymorphisms in arginase I and II and childhood asthma and atopyHuiling Li
Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
J Allergy Clin Immunol 117:119-26. 2006..A recent microarray study implicated arginase I (ARG1) and arginase II (ARG2) in mouse allergic asthma models and human asthma...
A genome-wide association study identifies IL23R as an inflammatory bowel disease geneRichard H Duerr
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, School of Medicine, University of Pittsburgh, University of Pittsburgh Medical Center Presbyterian, Mezzanine Level, C Wing, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Science 314:1461-3. 2006..These results and previous studies on the proinflammatory role of IL-23 prioritize this signaling pathway as a therapeutic target in inflammatory bowel disease...
Identification of genetic variants contributing to cisplatin-induced cytotoxicity by use of a genomewide approachR Stephanie Huang
Department of Medicine, University of Chicago, Chicago, IL 60637, USA
Am J Hum Genet 81:427-37. 2007..Our whole-genome approach can be used to elucidate the expression of quantitative trait loci contributing to a wide range of cellular phenotypes...
Transmission disequilibrium testing of the chromosome 15q11-q13 region in autismSoo Jeong Kim
Department of Psychiatry, College of Medicine, University of Florida, Gainesville, Florida, USA
Am J Med Genet B Neuropsychiatr Genet 147:1116-25. 2008..Further investigation of the 15q11-q13 region with denser genotyping in a larger sample set may be necessary to determine whether this region confers risk to autism, indicated by association, or to specific autism phenotypes...
Genetic variants contributing to daunorubicin-induced cytotoxicityR Stephanie Huang
Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
Cancer Res 68:3161-8. 2008..005 and P = 0.0008, respectively), and rs1551315 trends toward significance (P = 0.089). This unbiased method can be used to elucidate genetic variants contributing to a wide range of cellular phenotypes...
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's diseaseJeffrey C Barrett
Bioinformatics and Statistical Genetics, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
Nat Genet 40:955-62. 2008..The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development...
Genetic variants associated with carboplatin-induced cytotoxicity in cell lines derived from AfricansR Stephanie Huang
Department of Medicine, University of Chicago, 5841 South Maryland Avenue, Box MC2115, Chicago, IL 60637, USA
Mol Cancer Ther 7:3038-46. 2008..The identification of concentration specific genetic signatures allows for potential integration of pharmacokinetics, pharmacodynamics, and pharmacogenetics in tailoring chemotherapy...
