Grace E Kissling

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Respiratory symptoms in relation to residential coal burning and environmental tobacco smoke among early adolescents in Wuhan, China: a cross-sectional study
    Päivi M Salo
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
    Environ Health 3:14. 2004
  2. pmc Sensitivity of the erythrocyte micronucleus assay: dependence on number of cells scored and inter-animal variability
    Grace E Kissling
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Mutat Res 634:235-40. 2007
  3. pmc Evaluation of dichloroacetic acid for carcinogenicity in genetically modified Tg.AC hemizygous and p53 haploinsufficient mice
    Grace E Kissling
    Environmental Diseases and Medicine Program, Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 107:19-26. 2009
  4. ncbi request reprint The utility of the guppy (Poecilia reticulata) and medaka (Oryzias latipes) in evaluation of chemicals for carcinogenicity
    Grace E Kissling
    Environmental Medicine and Diseases Program and Environmental Toxicology Program, National Institute of Environmental Health Sciences, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Toxicol Sci 92:143-56. 2006
  5. doi request reprint Mechanistic insights from the NTP studies of chromium
    Kristine L Witt
    Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 41:326-42. 2013
  6. pmc Summary of chemically induced pulmonary lesions in the National Toxicology Program (NTP) toxicology and carcinogenesis studies
    Darlene Dixon
    Cellular and Molecular Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 36:428-39. 2008
  7. pmc No increases in biomarkers of genetic damage or pathological changes in heart and brain tissues in male rats administered methylphenidate hydrochloride (Ritalin) for 28 days
    Kristine L Witt
    Biomolecular Screening Branch, NIEHS NTP, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Environ Mol Mutagen 51:80-8. 2010
  8. pmc Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene
    Sylvia C Hewitt
    Laboratory of Reproductive and Developmental Toxicology, National Institutes of Health, Research Triangle Park, North Carolina, USA
    FASEB J 24:4660-7. 2010
  9. pmc Hexavalent chromium is carcinogenic to F344/N rats and B6C3F1 mice after chronic oral exposure
    Matthew D Stout
    National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 117:716-22. 2009
  10. pmc Influence of Helicobacter hepaticus infection on the chronic toxicity and carcinogenicity of triethanolamine in B6C3F1 mice
    Matthew D Stout
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 36:783-94. 2008

Detail Information

Publications71

  1. pmc Respiratory symptoms in relation to residential coal burning and environmental tobacco smoke among early adolescents in Wuhan, China: a cross-sectional study
    Päivi M Salo
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
    Environ Health 3:14. 2004
    ..Cigarette smoking and coal burning are the primary sources of indoor air pollution in Chinese households. However, effects of these exposures on Chinese children's respiratory health are not well characterized...
  2. pmc Sensitivity of the erythrocyte micronucleus assay: dependence on number of cells scored and inter-animal variability
    Grace E Kissling
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Mutat Res 634:235-40. 2007
    ....
  3. pmc Evaluation of dichloroacetic acid for carcinogenicity in genetically modified Tg.AC hemizygous and p53 haploinsufficient mice
    Grace E Kissling
    Environmental Diseases and Medicine Program, Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 107:19-26. 2009
    ..AC mice appear less sensitive to hepatocarcinogenesis than standard rodent models. These results suggest caution for the use of Tg.AC and p53 mice to screen unknown chemicals in drinking water for potential carcinogenicity...
  4. ncbi request reprint The utility of the guppy (Poecilia reticulata) and medaka (Oryzias latipes) in evaluation of chemicals for carcinogenicity
    Grace E Kissling
    Environmental Medicine and Diseases Program and Environmental Toxicology Program, National Institute of Environmental Health Sciences, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Toxicol Sci 92:143-56. 2006
    ..These results suggest that fish models are of limited utility in screening unknown chemicals for potential carcinogenicity...
  5. doi request reprint Mechanistic insights from the NTP studies of chromium
    Kristine L Witt
    Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 41:326-42. 2013
    ..The multiple potential pathways of Cr-induced genotoxicity will be discussed...
  6. pmc Summary of chemically induced pulmonary lesions in the National Toxicology Program (NTP) toxicology and carcinogenesis studies
    Darlene Dixon
    Cellular and Molecular Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 36:428-39. 2008
    ....
  7. pmc No increases in biomarkers of genetic damage or pathological changes in heart and brain tissues in male rats administered methylphenidate hydrochloride (Ritalin) for 28 days
    Kristine L Witt
    Biomolecular Screening Branch, NIEHS NTP, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Environ Mol Mutagen 51:80-8. 2010
    ..Additionally, no histopathological changes in brain or heart, or elevated serum biomarkers of cardiac injury were observed in these MPH-exposed rats...
  8. pmc Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene
    Sylvia C Hewitt
    Laboratory of Reproductive and Developmental Toxicology, National Institutes of Health, Research Triangle Park, North Carolina, USA
    FASEB J 24:4660-7. 2010
    ..Our Ex3α ERα model will be useful in studies of complete or selective ablation of ERα in target tissues...
  9. pmc Hexavalent chromium is carcinogenic to F344/N rats and B6C3F1 mice after chronic oral exposure
    Matthew D Stout
    National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 117:716-22. 2009
    ..Hexavalent chromium [Cr(VI)] is a human carcinogen after inhalation exposure. Humans also ingest Cr(VI) from contaminated drinking water and soil; however, limited data exist on the oral toxicity and carcinogenicity of Cr(VI)...
  10. pmc Influence of Helicobacter hepaticus infection on the chronic toxicity and carcinogenicity of triethanolamine in B6C3F1 mice
    Matthew D Stout
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 36:783-94. 2008
    ..These data suggest that in the initial study, H. hepaticusinfluenced the induction of hepatocellular neoplasms in males, but not in females...
  11. pmc The estrogenic content of rodent diets, bedding, cages, and water bottles and its effect on bisphenol A studies
    Julius E Thigpen
    Comparative Medicine Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    J Am Assoc Lab Anim Sci 52:130-41. 2013
    ..The oral route of BPA exposure should be used when results are to be extrapolated to humans...
  12. pmc Immunohistochemical investigation of F344/N rat islet cell tumors from national toxicology program studies
    Christopher Koivisto
    Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 40:751-63. 2012
    ..This is the first study to describe the immunophenotype of islet cell tumors in the F344 rat and to show that islet cell tumors in the F344 rat exhibit similarities in protein expression to the human counterpart...
  13. doi request reprint Comparison of Comet assay dose-response for ethyl methanesulfonate using freshly prepared versus cryopreserved tissues
    Leslie Recio
    Genetic and Molecular Toxicology Division, ILS, Research Triangle Park, NC, USA
    Environ Mol Mutagen 53:101-13. 2012
    ..We also demonstrated that for three tissues (blood, liver, stomach), air transport did not alter the sensitivity of the Comet assay for detecting DNA damage...
  14. doi request reprint Multisite carcinogenicity and respiratory toxicity of inhaled 1-bromopropane in rats and mice
    Daniel L Morgan
    National Institute of Environmental Health Sciences, National Toxicology Program, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 39:938-48. 2011
    ..Inflammatory lesions with Splendore Hoeppli (S-H) material were present primarily in the nose and skin of exposed male and female rats, indicating that 1-BP caused immunosuppression...
  15. pmc Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals
    Kristine L Witt
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Mutat Res 649:101-13. 2008
    ..No significant differences were observed between results obtained by the two methods in either species. These results support the use of FCM for determining MN-RET frequency in rodents after chemical exposure...
  16. pmc Effects of hormonally active agents on steroid hormone receptor expression and cell proliferation in the myometrium of ovariectomized macaques
    Georgette D Hill
    Integrated Laboratory Systems ILS, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 39:508-15. 2011
    ..These data suggest that ERα and PR expression in the myometrium is influenced by treatment with hormonally active agents...
  17. pmc Estrogen Regulates MAPK-Related Genes through Genomic and Nongenomic Interactions between IGF-I Receptor Tyrosine Kinase and Estrogen Receptor-Alpha Signaling Pathways in Human Uterine Leiomyoma Cells
    Linda Yu
    Molecular Pathogenesis Group, National Toxicology Program NTP Laboratory, NTP, Department of Health and Human Services DHHS, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Research Triangle Park, NC 27709, USA
    J Signal Transduct 2012:204236. 2012
    ....
  18. pmc Oral exposure to genistin, the glycosylated form of genistein, during neonatal life adversely affects the female reproductive system
    Wendy N Jefferson
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 117:1883-9. 2009
    ..S. infants are fed soy formula. High circulating levels of GEN have been measured in the serum of these infants, indicating that GIN is readily absorbed, hydrolyzed, and circulated...
  19. pmc Exposure to hexavalent chromium resulted in significantly higher tissue chromium burden compared with trivalent chromium following similar oral doses to male F344/N rats and female B6C3F1 mice
    Bradley J Collins
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 118:368-79. 2010
    ..In vitro studies demonstrated that Cr(VI), but not Cr(III), is a substrate of the sodium/sulfate cotransporter, providing a partial explanation for the greater absorption of Cr(VI)...
  20. pmc Fourteen-week toxicity study of green tea extract in rats and mice
    Po C Chan
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 38:1070-84. 2010
    ..The nose and liver are organs with high metabolic enzyme activity. The increased susceptibility of the nose and liver suggests a role for GTE metabolites in toxicity induction...
  21. pmc Toxicity and carcinogenicity of methyl isobutyl ketone in F344N rats and B6C3F1 mice following 2-year inhalation exposure
    Matthew D Stout
    Toxicology Operations Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicology 244:209-19. 2008
    ..Hepatocellular adenomas, and adenoma or carcinoma (combined) were increased in male and female mice exposed to 1800ppm. There were also treatment-related increases in multiple adenomas in both sexes...
  22. pmc p38 mitogen-activated protein kinase interacts with vinculin at focal adhesions during fatty acid-stimulated cell adhesion
    Margaret D George
    National Institute of Environmental Health Sciences, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Biochem Cell Biol 91:404-18. 2013
    ....
  23. pmc Human uterine leiomyoma-derived fibroblasts stimulate uterine leiomyoma cell proliferation and collagen type I production, and activate RTKs and TGF beta receptor signaling in coculture
    Alicia B Moore
    Cellular and Molecular Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park RTP, NC 27709, USA
    Cell Commun Signal 8:10. 2010
    ..In the present study, we investigated the interactions between human uterine leiomyoma (UtLM) cells and uterine leiomyoma-derived fibroblasts (FB), and their importance in cell growth and ECM protein production using a coculture system...
  24. pmc Estrogen receptor alpha (ERalpha) phospho-serine-118 is highly expressed in human uterine leiomyomas compared to matched myometrium
    Tonia L Hermon
    Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences NIEHS, National Toxicology Program NTP, National Institutes of Health NIH, Department of Health and Human Services DHHS, NC 27709, USA
    Virchows Arch 453:557-69. 2008
    ..These data suggest that ERalpha-phospho-Ser118 may be important in leiomyoma growth and is possibly phosphorylated by phospho-p44/42 MAPK...
  25. doi request reprint Investigating the potential for toxicity from long-term use of the herbal products, goldenseal and milk thistle
    June K Dunnick
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 39:398-409. 2011
    ..The fate of the active constituents of goldenseal and milk thistle is similar in humans and rodents; therefore, the modes of action may translate across species. Further studies are needed to extrapolate the findings to humans...
  26. ncbi request reprint Two-year toxicity and carcinogenicity studies of Panax ginseng in Fischer 344 rats and B6C3F1 mice
    Po Chuen Chan
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Chin Med 39:779-88. 2011
    ..In this paper, we reported the results of NTP chronic toxicity and tumorigenicity bioassay. It shows that, under these experimental conditions, Panax ginseng is not toxic or tumorigenic...
  27. pmc Effects of buprenorphine, meloxicam, and flunixin meglumine as postoperative analgesia in mice
    Jacquelyn T Tubbs
    Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    J Am Assoc Lab Anim Sci 50:185-91. 2011
    ..Flunixin meglumine at the given dosage (2.5 mg/kg) may not provide adequate analgesia for partial hepatectomy...
  28. pmc Clusters of mutations from transient hypermutability
    John W Drake
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 102:12849-54. 2005
    ..In the case of the rapidly mutating riboviruses, the viral population appears to be composed of a majority with a mutation frequency substantially lower than the average and a minority with a huge mutational load...
  29. ncbi request reprint Olfactory epithelial metaplasia and hyperplasia in female Harlan Sprague-Dawley rats following chronic treatment with polychlorinated biphenyls
    Abraham Nyska
    Laboratory of Experimental Pathology National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 9998, USA
    Toxicol Pathol 33:371-7. 2005
    ..Variable amounts of acute inflammatory exudate appeared within the lumen of the nasal cavity, overlying the affected epithelium. Occasionally, the inflammation eroded through the skull and into the adjacent olfactory bulbs...
  30. pmc A survival-adjusted quantal-response test for analysis of tumor incidence rates in animal carcinogenicity studies
    Shyamal D Peddada
    Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Environ Health Perspect 114:537-41. 2006
    ..The trend test and the multiple pairwise comparisons test are demonstrated using an example from a study conducted by the NTP...
  31. doi request reprint Chronic progressive nephropathy in male F344 rats in 90-day toxicity studies: its occurrence and association with renal tubule tumors in subsequent 2-year bioassays
    Greg S Travlos
    National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 39:381-9. 2011
    ....
  32. doi request reprint Analgesic effects of tramadol, carprofen or multimodal analgesia in rats undergoing ventral laparotomy
    Coralie Zegre Cannon
    Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Lab Anim (NY) 40:85-93. 2011
    ..The authors found that carprofen, tramadol and a combination of carprofen and tramadol were all acceptable analgesia regimens for a rat laparotomy model...
  33. pmc Diet-induced obesity in male mice is associated with reduced fertility and potentiation of acrylamide-induced reproductive toxicity
    Burhan I Ghanayem
    Laboratory of Pharmacology, Biostatistics Branch, and Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Biol Reprod 82:96-104. 2010
    ..This work demonstrated that diet-induced obesity in mice caused a significant reduction in male fertility and exacerbated AA-induced reproductive toxicity and germ cell mutagenicity...
  34. pmc A novel role for the T-box transcription factor Tbx1 as a negative regulator of tumor cell growth in mice
    Carol S Trempus
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Mol Carcinog 50:981-91. 2011
    ..2011 Wiley Periodicals, Inc...
  35. pmc Elevated frequencies of micronucleated erythrocytes in infants exposed to zidovudine in utero and postpartum to prevent mother-to-child transmission of HIV
    Kristine L Witt
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Environ Mol Mutagen 48:322-9. 2007
    ..These results demonstrate that transplacentalZDV exposure is genotoxic in humans. Long-term monitoring of HIV-uninfected ZDV-exposed infants is recommended to ensure their continued health...
  36. pmc Immunohistochemical analysis of expressions of hepatic cytochrome P450 in F344 rats following oral treatment with kava extract
    Natasha P Clayton
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Exp Toxicol Pathol 58:223-36. 2007
    ..Kava-induced hepatic functional changes in the F344 rat might be relevant to human clinical cases of hepatotoxicity following exposure...
  37. ncbi request reprint Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination
    Sherine S L Chan
    Laboratory of Molecular Genetics, National Institute of Environmental HealthSciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Environ Mol Mutagen 48:190-200. 2007
    ..Our data suggest that AZT/3TC combination treatment produces greater mtDNA damage than either agent individually, and that female mice are more sensitive than males to AZT/3TC-induced mtDNA damage...
  38. pmc Species and gender differences in the carcinogenic activity of trimethylolpropane triacrylate in rats and mice
    Inok Surh
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA Electronic address
    Food Chem Toxicol 66:254-61. 2014
    ..In conclusion, our studies show that TMPTA is a dermal irritant in both rats and mice of either sex. Increased incidences of tumor formation were observed in female mice and male rats. ..
  39. pmc The naturally occurring luteinizing hormone surge is diminished in mice lacking estrogen receptor Beta in the ovary
    Friederike L Jayes
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina
    Biol Reprod 90:24. 2014
    ..ESR2 is not necessary within the pituitary and hypothalamus for the generation of a normal LH surge and for normal fertility, but ESR2 is essential within the ovary to provide proper signals. ..
  40. pmc Mutagenesis dependent upon the combination of activation-induced deaminase expression and a double-strand break
    Vladimir Poltoratsky
    Laboratory of Structural Biology, National Institutes of Health, NIEHS, 111 T W Alexander Drive, PO Box 12233, MD F1 12, Research Triangle Park, NC 27709, USA
    Mol Immunol 48:164-70. 2010
    ..Implications of these findings for SHM of immunoglobulin genes in human B cells are discussed...
  41. pmc Endotoxin, coliform, and dust levels in various types of rodent bedding
    Tanya E Whiteside
    Comparative Medicine, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC, USA
    J Am Assoc Lab Anim Sci 49:184-9. 2010
    ..We conclude that paper bedding is the optimal bedding type for conducting LPS inhalation studies and that rodent bedding containing high levels of endotoxin may alter the results of respiratory and immunologic studies in rodents...
  42. pmc Methylphenidate and amphetamine do not induce cytogenetic damage in lymphocytes of children with ADHD
    Kristine L Witt
    National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Triangle Park, NC 27709, USA
    J Am Acad Child Adolesc Psychiatry 47:1375-83. 2008
    ....
  43. pmc Mismatch repair-independent tandem repeat sequence instability resulting from ribonucleotide incorporation by DNA polymerase ε
    Alan B Clark
    Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, United States
    DNA Repair (Amst) 10:476-82. 2011
    ..g., during the repair of nicks resulting from rNMPs in DNA. The results make interesting predictions that can be tested...
  44. ncbi request reprint Chemical-induced atrial thrombosis in NTP rodent studies
    Katsuhiko Yoshizawa
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences NIEHS, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 33:517-32. 2005
    ..A download option appears at the bottom of this abstract. In order to access the full article online, you must either have an individual subscription or a member subscription accessed through www.toxpath.org...
  45. pmc The fidelity of DNA synthesis by yeast DNA polymerase zeta alone and with accessory proteins
    Xuejun Zhong
    Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 34:4731-42. 2006
    ....
  46. pmc Analysis of chromatin dynamics during glucocorticoid receptor activation
    Craig J Burd
    Chromatin and Gene Expression Group, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Mol Cell Biol 32:1805-17. 2012
    ....
  47. pmc Differential correction of lagging-strand replication errors made by DNA polymerases {alpha} and {delta}
    Stephanie A Nick McElhinny
    Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 107:21070-5. 2010
    ....
  48. doi request reprint Evaluation of dosages and routes of administration of tramadol analgesia in rats using hot-plate and tail-flick tests
    Coralie Zegre Cannon
    Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Lab Anim (NY) 39:342-51. 2010
    ..Intraperitoneal administration of 12.5 mg tramadol per kg body weight had no notable side effects, and the authors plan to further study this dosage and route of administration in a rodent surgical model of pain...
  49. pmc Toxicity and carcinogenicity of the water disinfection byproduct, dibromoacetic acid, in rats and mice
    Ronald L Melnick
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, NC 27709, USA
    Toxicology 230:126-36. 2007
    ..These studies provide critical information for future re-evaluations of health-based drinking water standards for haloacetic acids...
  50. pmc Selective disruption of ER{alpha} DNA-binding activity alters uterine responsiveness to estradiol
    Sylvia C Hewitt
    National Institute of Environment Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 23:2111-6. 2009
    ..In summary, this study provides a comprehensive analysis of uterine genes regulated by E(2) via ERE and non-ERE pathways...
  51. ncbi request reprint Association of race, age and body mass index with gross pathology of uterine fibroids
    Alicia B Moore
    Laboratory of Experimental Pathology and Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    J Reprod Med 53:90-6. 2008
    ..To determine the associations of race, age and body mass index (BMI) with the gross pathology parameters of uterine leiomyomas in premenopausal women undergoing hysterectomy or myomectomy...
  52. pmc An interlaboratory study of perfluorinated alkyl compound levels in human plasma
    Matthew P Longnecker
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P O Box 12233, MD A3 05, Research Triangle Park, NC 27709, USA
    Environ Res 107:152-9. 2008
    ..Considering the degree of between-subject variation in levels among people in background-exposed populations, the results indicate that biomarker-based epidemiologic studies of associations with health could have reasonable precision...
  53. pmc Determination of the di-(2-ethylhexyl) phthalate NOAEL for reproductive development in the rat: importance of the retention of extra animals to adulthood
    Chad R Blystone
    Department of Health andHuman Services, National Institute of Environmental Health, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 116:640-6. 2010
    ....
  54. pmc Variations in phytoestrogen content between different mill dates of the same diet produces significant differences in the time of vaginal opening in CD-1 mice and F344 rats but not in CD Sprague-Dawley rats
    Julius E Thigpen
    Comparative Medicine Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Environ Health Perspect 115:1717-26. 2007
    ..The optimum test diet and rodent species/strain for evaluating endocrine-disrupting compounds (EDCs) are critical...
  55. pmc Low-fidelity DNA synthesis by the L979F mutator derivative of Saccharomyces cerevisiae DNA polymerase zeta
    Jana E Stone
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences Research, NIH, DHHS, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 37:3774-87. 2009
    ..This may explain the origin of some multiple clustered mutations observed in vivo...
  56. ncbi request reprint In vitro growth and ovulation of follicles from ovaries of estrogen receptor (ER){alpha} and ER{beta} null mice indicate a role for ER{beta} in follicular maturation
    Judith M A Emmen
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences National Institutes of Health, MD B3 02, P O Box 12233, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 146:2817-26. 2005
    ..Collectively, these data indicate that ERbeta, but not ERalpha, plays a direct role in folliculogenesis. ERbeta appears to facilitate follicle maturation from the early antral to the preovulatory stage...
  57. pmc Detection of human CYP2C8, CYP2C9, and CYP2J2 in cardiovascular tissues
    Tracy C DeLozier
    National Institute of Environmental Health Sciences, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Drug Metab Dispos 35:682-8. 2007
    ..The expression of CYP2J2 and CYP2C8 in human heart, and CYPC9 and CYP2J2 in aorta and coronary artery is consistent with a physiological role for these enzymes in these tissues...
  58. pmc RPA and PCNA suppress formation of large deletion errors by yeast DNA polymerase delta
    John M Fortune
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 34:4335-41. 2006
    ..Strong suppression of deletions by PCNA and RPA suggests that they may contribute to the high replication fidelity needed to stably maintain eukaryotic genomes that contain abundant repetitive sequences...
  59. pmc Hepatocyte nuclear factor 4{alpha} regulates rifampicin-mediated induction of CYP2C genes in primary cultures of human hepatocytes
    Ritu Rana
    Human Metabolism Section, Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Drug Metab Dispos 38:591-9. 2010
    ..5-fold), and CYP2C19 (1.8- versus 1.1-fold). These results provide clear evidence that HNF4alpha contributes to the constitutive expression of the human CYP2C genes and is also important for up-regulation by the PXR agonist rifampicin...
  60. pmc Volatile organic compounds and pulmonary function in the Third National Health and Nutrition Examination Survey, 1988-1994
    Leslie Elliott
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709 2233, USA
    Environ Health Perspect 114:1210-4. 2006
    ..Blood levels of VOCs may be more indicative of personal exposures than are air concentrations; no studies have addressed their relationship with respiratory outcomes...
  61. ncbi request reprint Evaluation of glycosaminoglycans content and 5-hydroxytryptamine 2B receptor in the heart valves of Sprague-Dawley rats with spontaneous mitral valvulopathy--a possible exacerbation by dl-amphetamine sulfate in Fischer 344 rats?
    Chandikumar S Elangbam
    Safety Assessment, GlaxoSmithKline, Research Triangle Park, NC 27709, USA
    Exp Toxicol Pathol 58:89-99. 2006
    ..However, additional research is needed to confirm a role for 5HT2BR in the pathogenesis of SMV in SD rats, and to further characterize the relationship between dl-amphetamine treatment and exacerbation of SMV in F344 rats...
  62. pmc Processivity clamp gp45 and ssDNA-binding-protein gp32 modulate the fidelity of bacteriophage RB69 DNA polymerase in a sequence-specific manner, sometimes enhancing and sometimes compromising accuracy
    Anna Bebenek
    Institute of Biochemistry and Biophysics, Polish Academy of Science, Warsaw
    Genetics 169:1815-24. 2005
    ..Thus, accessory proteins contribute to the site-specific variability in mutation rates characteristically seen in mutational spectra...
  63. pmc Spontaneous occurrence of a distinctive renal tubule tumor phenotype in rat carcinogenicity studies conducted by the national toxicology program
    Gordon C Hard
    Private Consultant, Tairua, New Zealand
    Toxicol Pathol 36:388-96. 2008
    ..Accordingly, it is suggested that this distinctive renal tumor phenotype be recorded as a separate category from conventional RTT when assessing the carcinogenic potential of a test compound...
  64. pmc MtBE and cancer in animals: statistical issues with poly-3 survival adjustments for lifetime studies
    Grace E Kissling
    Regul Toxicol Pharmacol 50:428-9. 2008
  65. pmc Participation of mouse DNA polymerase iota in strand-biased mutagenic bypass of UV photoproducts and suppression of skin cancer
    Chad A Dumstorf
    Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202 1786, USA
    Proc Natl Acad Sci U S A 103:18083-8. 2006
    ..Collectively, these data reveal functions for pol iota in bypassing UV photoproducts and in delaying the onset of UV-induced skin cancer...
  66. ncbi request reprint Efficacy of sucrose to reduce pain in premature infants during eye examinations for retinopathy of prematurity
    Peter Gal
    Pharmacy Division, Greensboro Area Health Education Center, Greensboro, NC 27401 1020, USA
    Ann Pharmacother 39:1029-33. 2005
    ..Sweet solutions have been shown to reduce procedural pain in newborns...
  67. pmc Mutator alleles of yeast DNA polymerase zeta
    Ayako N Sakamoto
    Research Group for Gene Resources, Department of Ion Beam Applied Biology, Japan Atomic Energy Agency, Watanuki machi 1233, Takasaki, Gunma 370 1292, Japan
    DNA Repair (Amst) 6:1829-38. 2007
    ..Reduced fidelity with retention of robust polymerase activity suggests that the homologous rev3-L979F allele may be useful for analyzing pol zeta functions in mammals, where REV3 deletion is lethal...
  68. pmc Acute pulmonary function response to ozone in young adults as a function of body mass index
    William D Bennett
    Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Inhal Toxicol 19:1147-54. 2007
    ..022). Although our population studied was predominantly normal weight, we found that higher body mass index may be a modest risk factor for adverse pulmonary effects associated with ozone exposure, especially for women...
  69. pmc Genetic variation in cytochrome P450 2J2 and soluble epoxide hydrolase and risk of ischemic stroke in a Chinese population
    Laxi Zhang
    Department of Internal Medicine, The Institute of Hypertension, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Pharmacogenet Genomics 18:45-51. 2008
    ....
  70. pmc N-ethyl-N-nitrosourea (ENU)-induced meningiomatosis and meningioma in p16(INK4a)/p19(ARF) tumor suppressor gene-deficient mice
    James P Morrison
    Charles River Laboratories, Pathology Associates, Durham, North Carolina 27703, USA
    Toxicol Pathol 35:780-7. 2007
    ..This ENU inducible meningeal lesion in p16(+/-)/p19(+/-) mice may provide additional insight into the pathogenesis of meningeal neoplasia and aid the development of therapeutics...
  71. pmc The rate and character of spontaneous mutation in Thermus thermophilus
    Reena R Mackwan
    Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221 0006, USA
    Genetics 180:17-25. 2008
    ..thermophilus resembled those of the thermoacidophilic archaeon Sulfolobus acidocaldarius, despite important molecular differences between these two thermophiles and their genomes...