A Kinter

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands
    Audrey L Kinter
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:6738-46. 2008
  2. ncbi request reprint CD25+ regulatory T cells isolated from HIV-infected individuals suppress the cytolytic and nonlytic antiviral activity of HIV-specific CD8+ T cells in vitro
    Audrey L Kinter
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    AIDS Res Hum Retroviruses 23:438-50. 2007
  3. pmc Suppression of HIV-specific T cell activity by lymph node CD25+ regulatory T cells from HIV-infected individuals
    Audrey Kinter
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:3390-5. 2007
  4. pmc CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status
    Audrey L Kinter
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, 10 Center Dr, Bethesda, MD 20892, USA
    J Exp Med 200:331-43. 2004
  5. ncbi request reprint Chemokines, cytokines and HIV: a complex network of interactions that influence HIV pathogenesis
    A Kinter
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Immunol Rev 177:88-98. 2000
  6. ncbi request reprint Host factors in the pathogenesis of HIV disease
    O J Cohen
    National Institute of Allergy and Infectious Diseases, Laboratory of Immunoregulation, Bethesda, Maryland, USA
    Immunol Rev 159:31-48. 1997
  7. ncbi request reprint Peripheral blood-derived CD34+ progenitor cells: CXC chemokine receptor 4 and CC chemokine receptor 5 expression and infection by HIV
    M E Ruiz
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1576, USA
    J Immunol 161:4169-76. 1998
  8. ncbi request reprint Interactions of CCR5 and CXCR4 with CD4 and gp120 in human blood monocyte-derived dendritic cells
    X Xiao
    Laboratory of Experimental and Computational Biology, NCI FCRDC, NIH, Frederick, Maryland, 21702 1201, USA
    Exp Mol Pathol 68:133-8. 2000
  9. ncbi request reprint Productive HIV infection of resting CD4+ T cells: role of lymphoid tissue microenvironment and effect of immunomodulating agents
    Audrey Kinter
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases NIH, MSC 1576, Building 10, Room 6A33, 10 Center Drive, Bethesda, MD 20892 1576, USA
    AIDS Res Hum Retroviruses 19:847-56. 2003
  10. pmc Characterization of the defective interaction between a subset of natural killer cells and dendritic cells in HIV-1 infection
    Domenico Mavilio
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:2339-50. 2006

Detail Information

Publications17

  1. ncbi request reprint The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands
    Audrey L Kinter
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:6738-46. 2008
    ....
  2. ncbi request reprint CD25+ regulatory T cells isolated from HIV-infected individuals suppress the cytolytic and nonlytic antiviral activity of HIV-specific CD8+ T cells in vitro
    Audrey L Kinter
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    AIDS Res Hum Retroviruses 23:438-50. 2007
    ..These data suggest that CD25(+) Treg-mediated suppression of the antiviral activity of HIV-specific CD8(+) T cells could impact the ability of HIV-infected individuals to control HIV replication in vivo...
  3. pmc Suppression of HIV-specific T cell activity by lymph node CD25+ regulatory T cells from HIV-infected individuals
    Audrey Kinter
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:3390-5. 2007
    ....
  4. pmc CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status
    Audrey L Kinter
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, 10 Center Dr, Bethesda, MD 20892, USA
    J Exp Med 200:331-43. 2004
    ..These in vitro data suggest that CD25(+)CD4(+) T reg cells may contribute to the diminution of HIV-specific T cell immune responses in vivo in the early stages of HIV disease...
  5. ncbi request reprint Chemokines, cytokines and HIV: a complex network of interactions that influence HIV pathogenesis
    A Kinter
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Immunol Rev 177:88-98. 2000
    ..Finally, the interaction between chemokine receptors and chemokines or HIV envelope has significant effects on cellular functions which likely play a role in HIV pathogenesis...
  6. ncbi request reprint Host factors in the pathogenesis of HIV disease
    O J Cohen
    National Institute of Allergy and Infectious Diseases, Laboratory of Immunoregulation, Bethesda, Maryland, USA
    Immunol Rev 159:31-48. 1997
    ..HIV-specific immune responses, including cytotoxic T-lymphocyte (CTL) responses and neutralizing antibody responses, also appear to play salutary roles in protecting against disease progression...
  7. ncbi request reprint Peripheral blood-derived CD34+ progenitor cells: CXC chemokine receptor 4 and CC chemokine receptor 5 expression and infection by HIV
    M E Ruiz
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1576, USA
    J Immunol 161:4169-76. 1998
    ....
  8. ncbi request reprint Interactions of CCR5 and CXCR4 with CD4 and gp120 in human blood monocyte-derived dendritic cells
    X Xiao
    Laboratory of Experimental and Computational Biology, NCI FCRDC, NIH, Frederick, Maryland, 21702 1201, USA
    Exp Mol Pathol 68:133-8. 2000
    ..Therefore, for most CD4+ target cells restraint(s) on productive HIV-1 infection appears to occur at stages of the virus life cycle subsequent to the gp120-CD4-coreceptor complex formation...
  9. ncbi request reprint Productive HIV infection of resting CD4+ T cells: role of lymphoid tissue microenvironment and effect of immunomodulating agents
    Audrey Kinter
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases NIH, MSC 1576, Building 10, Room 6A33, 10 Center Drive, Bethesda, MD 20892 1576, USA
    AIDS Res Hum Retroviruses 19:847-56. 2003
    ..The ability of resting CD4+ T cells to support HIV replication in the microenvironment of the lymphoid tissue has implications in the pathogenesis of HIV disease and may provide an additional avenue for therapeutic intervention...
  10. pmc Characterization of the defective interaction between a subset of natural killer cells and dendritic cells in HIV-1 infection
    Domenico Mavilio
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:2339-50. 2006
    ....
  11. pmc Identification of NKG2A and NKp80 as specific natural killer cell markers in rhesus and pigtailed monkeys
    Domenico Mavilio
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Dr, Bldg 10, Rm 6A08A, MSC 1576, Bethesda, MD 20814, USA
    Blood 106:1718-25. 2005
    ..This new phenotypic and functional characterization of NKG2A and NKp80 in rhesus and pigtailed macaque NK cells provides a new approach in the analysis of their innate immune system...
  12. pmc Characterization of CD56-/CD16+ natural killer (NK) cells: a highly dysfunctional NK subset expanded in HIV-infected viremic individuals
    Domenico Mavilio
    Laboratory of Immunoregulation and Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:2886-91. 2005
    ..These data suggest that the expansion of this highly dysfunctional CD56(-) NK cell subset in HIV-viremic individuals largely accounts for the impaired function of the total NK cell population...
  13. ncbi request reprint Contrasting effects of low-dose IL-2 on vaccine-boosted simian immunodeficiency virus (SIV)-specific CD4+ and CD8+ T cells in macaques chronically infected with SIVmac251
    Janos Nacsa
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA
    J Immunol 174:1913-21. 2005
    ..Thus, we conclude that the decrease in virus-specific CD4+ T cell response may be due to IL-2-promoted redistribution of cells from the circulation, or due to Ag-induced cell death, rather than suppression by a T regulatory population...
  14. ncbi request reprint HIV envelope induces virus expression from resting CD4+ T cells isolated from HIV-infected individuals in the absence of markers of cellular activation or apoptosis
    Audrey L Kinter
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 170:2449-55. 2003
    ....
  15. ncbi request reprint Neonatal natural killer cells produce chemokines and suppress HIV replication in vitro
    Helene B Bernstein
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20814, USA
    AIDS Res Hum Retroviruses 20:1189-95. 2004
    ..Our results show that nNK cells can inhibit HIV replication via a chemokine-mediated mechanism, and support a potential role for the innate immune system in preventing perinatal transmission of HIV in a noncytolytic manner...
  16. ncbi request reprint The effect of elective cesarean delivery and intrapartum infection on fetal lymphocyte activation and susceptibility to HIV infection
    Helene B Bernstein
    Department of Gynecology and Obstetrics, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Am J Obstet Gynecol 187:1283-9. 2002
    ..A second hypothesis was that intrapartum infection correlates with increased lymphocyte activation and susceptibility to human immunodeficiency virus infection...
  17. ncbi request reprint Interleukin (IL)-4 inhibits phorbol-ester induced HIV-1 expression in chronically infected U1 cells independently from the autocrine effect of endogenous tumour necrosis factor-alpha, IL-1beta, and IL-1 receptor antagonist
    Delia Goletti
    Italian National Institute of Infectious Diseases Lazzaro Spallanzani, Roma, Italy
    Cytokine 17:28-35. 2002
    ..Thus, IL-4 may favour a state of microbiological quiescence in infected monocytic cells bypassing the induction of HIV expression mediated by pro-inflammatory cytokines...