T Kino

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Peripheral CLOCK regulates target-tissue glucocorticoid receptor transcriptional activity in a circadian fashion in man
    Evangelia Charmandari
    First Department of Pediatrics, University of Athens Medical School, Aghia Sophia Children s Hospital, Athens, Greece
    PLoS ONE 6:e25612. 2011
  2. pmc Viral infection increases glucocorticoid-induced interleukin-10 production through ERK-mediated phosphorylation of the glucocorticoid receptor in dendritic cells: potential clinical implications
    Sinnie Sin Man Ng
    Unit on Molecular Hormone Action, Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 8:e63587. 2013
  3. pmc Circadian rhythms of glucocorticoid hormone actions in target tissues: potential clinical implications
    Tomoshige Kino
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD, NIH, Bethesda, MD 20892, USA
    Sci Signal 5:pt4. 2012
  4. pmc ZNF764 haploinsufficiency may explain partial glucocorticoid, androgen, and thyroid hormone resistance associated with 16p11.2 microdeletion
    Tomoshige Kino
    Unit on Molecular Hormone Actio, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1109, USA
    J Clin Endocrinol Metab 97:E1557-66. 2012
  5. ncbi request reprint Rho family Guanine nucleotide exchange factor Brx couples extracellular signals to the glucocorticoid signaling system
    Tomoshige Kino
    Pediatric Endocrinology Section, Reproductive Biology and Medicine Branch, NICHD, National Institutes of Health, Bethesda Maryland 20892, USA
    J Biol Chem 281:9118-26. 2006
  6. pmc Glucocorticoid receptor mutants demonstrate increased motility inside the nucleus of living cells: time of fluorescence recovery after photobleaching (FRAP) is an integrated measure of receptor function
    Tomoshige Kino
    Pediatric Endocrinology Section, Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development National Institutes of Health, Bethesda, MD 20892 1109, USA
    Mol Med 10:80-8. 2004
  7. ncbi request reprint Statin-induced blockade of prenylation alters nucleocytoplasmic shuttling of GTP-binding proteins gamma2 and beta2 and enhances their suppressive effect on glucocorticoid receptor transcriptional activity
    T Kino
    National Institutes of Health, Bethesda, MD 20892, USA
    Eur J Clin Invest 35:508-13. 2005
  8. pmc G protein beta interacts with the glucocorticoid receptor and suppresses its transcriptional activity in the nucleus
    Tomoshige Kino
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 169:885-96. 2005
  9. ncbi request reprint FLASH interacts with p160 coactivator subtypes and differentially suppresses transcriptional activity of steroid hormone receptors
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, Building 10, Clinical Research Center, Room 1 3140, 10 Center Drive, MSC 1109, Bethesda, MD 20892 1109, USA
    J Steroid Biochem Mol Biol 92:357-63. 2004
  10. ncbi request reprint HIV-1 accessory protein Vpr inhibits the effect of insulin on the Foxo subfamily of forkhead transcription factors by interfering with their binding to 14-3-3 proteins: potential clinical implications regarding the insulin resistance of HIV-1-infected pat
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, NIH, 10 Center Dr MSC 1109, Building 10, Clinical Research Center, Room 1 3140, Bethesda, MD 20892 1109, USA
    Diabetes 54:23-31. 2005

Detail Information

Publications84

  1. pmc Peripheral CLOCK regulates target-tissue glucocorticoid receptor transcriptional activity in a circadian fashion in man
    Evangelia Charmandari
    First Department of Pediatrics, University of Athens Medical School, Aghia Sophia Children s Hospital, Athens, Greece
    PLoS ONE 6:e25612. 2011
    ..In this manuscript, we studied the effect of CLOCK-mediated GR acetylation on the sensitivity of peripheral tissues to glucocorticoids in humans...
  2. pmc Viral infection increases glucocorticoid-induced interleukin-10 production through ERK-mediated phosphorylation of the glucocorticoid receptor in dendritic cells: potential clinical implications
    Sinnie Sin Man Ng
    Unit on Molecular Hormone Action, Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 8:e63587. 2013
    ..The results may further underlie in part known exacerbation of IL-10/T helper-2-related allergic disorders by stress and viral infection...
  3. pmc Circadian rhythms of glucocorticoid hormone actions in target tissues: potential clinical implications
    Tomoshige Kino
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD, NIH, Bethesda, MD 20892, USA
    Sci Signal 5:pt4. 2012
    ....
  4. pmc ZNF764 haploinsufficiency may explain partial glucocorticoid, androgen, and thyroid hormone resistance associated with 16p11.2 microdeletion
    Tomoshige Kino
    Unit on Molecular Hormone Actio, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1109, USA
    J Clin Endocrinol Metab 97:E1557-66. 2012
    ..Microdeletion of small chromosomal segments results in hereditary or sporadic diseases by affecting expression of residing genes...
  5. ncbi request reprint Rho family Guanine nucleotide exchange factor Brx couples extracellular signals to the glucocorticoid signaling system
    Tomoshige Kino
    Pediatric Endocrinology Section, Reproductive Biology and Medicine Branch, NICHD, National Institutes of Health, Bethesda Maryland 20892, USA
    J Biol Chem 281:9118-26. 2006
    ..Nuclear Brx might act as a local GRE-GR-transcriptosome activator by mediating the effect of small G-proteins on glucocorticoid-regulated genes...
  6. pmc Glucocorticoid receptor mutants demonstrate increased motility inside the nucleus of living cells: time of fluorescence recovery after photobleaching (FRAP) is an integrated measure of receptor function
    Tomoshige Kino
    Pediatric Endocrinology Section, Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development National Institutes of Health, Bethesda, MD 20892 1109, USA
    Mol Med 10:80-8. 2004
    ....
  7. ncbi request reprint Statin-induced blockade of prenylation alters nucleocytoplasmic shuttling of GTP-binding proteins gamma2 and beta2 and enhances their suppressive effect on glucocorticoid receptor transcriptional activity
    T Kino
    National Institutes of Health, Bethesda, MD 20892, USA
    Eur J Clin Invest 35:508-13. 2005
    ..These proteins, as a heterodimeric complex, suppress glucocorticoid response element-mediated transcriptional activity of the glucocorticoid receptor through direct physical interactions between Gbeta and the glucocorticoid receptor...
  8. pmc G protein beta interacts with the glucocorticoid receptor and suppresses its transcriptional activity in the nucleus
    Tomoshige Kino
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 169:885-96. 2005
    ..We conclude that the Gbetagamma complex interacts with the GR and suppresses its transcriptional activity by associating with the transcriptional complex formed on GR-responsive promoters...
  9. ncbi request reprint FLASH interacts with p160 coactivator subtypes and differentially suppresses transcriptional activity of steroid hormone receptors
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, Building 10, Clinical Research Center, Room 1 3140, 10 Center Drive, MSC 1109, Bethesda, MD 20892 1109, USA
    J Steroid Biochem Mol Biol 92:357-63. 2004
    ..Thus, FLASH differentially suppresses steroid hormone receptor-induced transcriptional activity by interfering with their association with SRC2/N-CoA2 and SRC3/N-CoA3 but not with SRC1/N-CoA1...
  10. ncbi request reprint HIV-1 accessory protein Vpr inhibits the effect of insulin on the Foxo subfamily of forkhead transcription factors by interfering with their binding to 14-3-3 proteins: potential clinical implications regarding the insulin resistance of HIV-1-infected pat
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, NIH, 10 Center Dr MSC 1109, Building 10, Clinical Research Center, Room 1 3140, Bethesda, MD 20892 1109, USA
    Diabetes 54:23-31. 2005
    ..Vpr thus may contribute to the tissue-selective insulin resistance often observed in HIV-1-infected individuals...
  11. ncbi request reprint Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1583, USA
    Ann N Y Acad Sci 1024:153-67. 2004
    ....
  12. ncbi request reprint Glucocorticoid and mineralocorticoid receptors and associated diseases
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1583, U S A
    Essays Biochem 40:137-55. 2004
    ..Here we discuss the actions of GR and MR and the molecular defects of naturally occuring mutations in these receptors with associated pathophysiological changes...
  13. ncbi request reprint Virus-mediated modulation of the host endocrine signaling systems: clinical implications
    Tomoshige Kino
    Pediatric Endocrinology Section, Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1109, USA
    Trends Endocrinol Metab 18:159-66. 2007
    ..We propose that virus-encoded molecules and the signaling systems they influence are potential therapeutic targets for the treatment of disorders that are associated with some viral infections...
  14. ncbi request reprint Cyclin-dependent kinase 5 differentially regulates the transcriptional activity of the glucocorticoid receptor through phosphorylation: clinical implications for the nervous system response to glucocorticoids and stress
    Tomoshige Kino
    Reproductive Biology and Medicine Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892, USA
    Mol Endocrinol 21:1552-68. 2007
    ..Thus, CDK5 exerts some of its biological activities in neuronal cells through the GR, dynamically modulating GR transcriptional activity in a target promoter-dependent fashion...
  15. pmc Glucocorticoid receptor: implications for rheumatic diseases
    T Kino
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Exp Rheumatol 29:S32-41. 2011
    ....
  16. pmc Acetylation-mediated epigenetic regulation of glucocorticoid receptor activity: circadian rhythm-associated alterations of glucocorticoid actions in target tissues
    Tomoshige Kino
    Unit on Molecular Hormone Action, Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bldg 10, CRC, Rm 1 3140, 10 Center Drive MSC 1109, Bethesda, MD 20892 1109, USA
    Mol Cell Endocrinol 336:23-30. 2011
    ..Thus, acetylation-mediated epigenetic regulation of the glucocorticoid receptor may be essential for the maintenance of proper time-integrated glucocorticoid action, significantly influencing human well-being and longevity...
  17. pmc Cyclin-dependent kinase 5 modulates the transcriptional activity of the mineralocorticoid receptor and regulates expression of brain-derived neurotrophic factor
    Tomoshige Kino
    Unit on Molecular Hormone Action, Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1109, USA
    Mol Endocrinol 24:941-52. 2010
    ....
  18. pmc Noncoding RNA gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor
    Tomoshige Kino
    Unit on Molecular Hormone Action, Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1109, USA
    Sci Signal 3:ra8. 2010
    ..We conclude that Gas5 is a "riborepressor" of the GR, influencing cell survival and metabolic activities during starvation by modulating the transcriptional activity of the GR...
  19. pmc Human glucocorticoid receptor isoform beta: recent understanding of its potential implications in physiology and pathophysiology
    Tomoshige Kino
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bldg 10, Clinical Research Center, Rm 1E 3140, 10 Center Drive MSC 1109, Bethesda, MD 20892 1109, USA
    Cell Mol Life Sci 66:3435-48. 2009
    ..In this review, we discuss the functions of GRbeta, its mechanisms of action, and its pathologic implications...
  20. pmc Glucocorticoid receptor (GR) beta has intrinsic, GRalpha-independent transcriptional activity
    Tomoshige Kino
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892 1109, USA
    Biochem Biophys Res Commun 381:671-5. 2009
    ..Our results indicate that GRbeta has intrinsic, GRalpha-independent, gene-specific transcriptional activity, in addition to its previously reported dominant negative effect on GRalpha-induced transactivation of GRE-driven promoters...
  21. pmc Brx mediates the response of lymphocytes to osmotic stress through the activation of NFAT5
    Tomoshige Kino
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Sci Signal 2:ra5. 2009
    ..Our results indicate that Brx integrates the responses of immune cells to osmotic stress and inflammation by elevating intracellular osmolarity and stimulating the production of cytokines...
  22. ncbi request reprint 3-O-Formyl-20R,21-epoxyresibufogenin suppresses IL-6-type cytokine actions by targeting the glycoprotein 130 subunit: potential clinical implications
    Tomoshige Kino
    Pediatric Endocrinology Section, Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, Clinical Research Center, Bethesda, MD 20892 1109, USA
    J Allergy Clin Immunol 120:437-44. 2007
    ..The multifunctional inflammatory cytokine IL-6 regulates the acute phase reaction and plays central roles in the pathogenesis of chronic inflammatory disorders...
  23. ncbi request reprint Tissue glucocorticoid resistance/hypersensitivity syndromes
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1583, USA
    J Steroid Biochem Mol Biol 85:457-67. 2003
    ....
  24. ncbi request reprint AIDS-related insulin resistance and lipodystrophy syndrome
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1583, USA
    Curr Drug Targets Immune Endocr Metabol Disord 3:111-7. 2003
    ..In this article, we review our current understanding of the pathogenesis and therapeutic approach of this newly emerging AIDS-associated metabolic syndrome...
  25. ncbi request reprint Pathologic human GR mutant has a transdominant negative effect on the wild-type GR by inhibiting its translocation into the nucleus: importance of the ligand-binding domain for intracellular GR trafficking
    T Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1583, USA
    J Clin Endocrinol Metab 86:5600-8. 2001
    ..We conclude that the trans-dominant negative effect of the pathological mutant is exerted primarily at the translocation step, whereas that of the natural isoform beta is exerted at the level of transcription...
  26. ncbi request reprint Nuclear receptor coactivator p160 proteins enhance the HIV-1 long terminal repeat promoter by bridging promoter-bound factors and the Tat-P-TEFb complex
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:2396-405. 2002
    ..Tat may function as an adaptor molecule, efficiently stimulating the processes of transcription initiation and elongation through potentiation of the coupling of p160 coactivators and the P-TEFb complex...
  27. ncbi request reprint AIDS-related lipodystrophy/insulin resistance syndrome
    T Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Horm Metab Res 35:129-36. 2003
    ..In this article, we review our current understanding of the pathogenesis of this severe AIDS-associated metabolic disorder...
  28. ncbi request reprint Conditional modulation of glucocorticoid receptor activities by CREB-binding protein (CBP) and p300
    T Kino
    Section on Pediatric Endocrinology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1862, USA
    J Steroid Biochem Mol Biol 70:15-25. 1999
    ..These findings suggest that CBP and p300 may function additively or antagonistically to each other depending on their relative concentrations and type of target tissue, to influence the sensitivity of tissues to glucocorticoids...
  29. ncbi request reprint Familial/sporadic glucocorticoid resistance syndrome and hypertension
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development NIH, Building 10, Room 9D42, 10 Center Drive MSC 1583, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 970:101-11. 2002
    ..These results suggest that the pathologic mechanisms of glucocorticoid resistance is quite broad, and this is reflected in the wide variability of the clinical picture in patients with the syndrome...
  30. ncbi request reprint Tumor necrosis factor alpha receptor- and Fas-associated FLASH inhibit transcriptional activity of the glucocorticoid receptor by binding to and interfering with its interaction with p160 type nuclear receptor coactivators
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1583, USA
    J Biol Chem 278:3023-9. 2003
    ..These findings indicate that FLASH participates in TNF alpha-induced blockade of GR transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa B...
  31. ncbi request reprint Transcription factor TFIIH components enhance the GR coactivator activity but not the cell cycle-arresting activity of the human immunodeficiency virus type-1 protein Vpr
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 298:17-23. 2002
    ..These findings suggest that TFIIH participates in Vpr's GR coactivating activity, at a step beyond its interaction with p300/CBP...
  32. ncbi request reprint Protein 14-3-3sigma interacts with and favors cytoplasmic subcellular localization of the glucocorticoid receptor, acting as a negative regulator of the glucocorticoid signaling pathway
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:25651-6. 2003
    ..Conversely, through its 14-3-3 protein interactions, GRalpha may influence these processes...
  33. pmc Human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr induces transcription of the HIV-1 and glucocorticoid-responsive promoters by binding directly to p300/CBP coactivators
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1583, USA
    J Virol 76:9724-34. 2002
    ..These results indicate that Vpr activates transcription by acting as an adapter linking transcription components and coactivators...
  34. ncbi request reprint Glucocorticoids suppress human immunodeficiency virus type-1 long terminal repeat activity in a cell type-specific, glucocorticoid receptor-mediated fashion: direct protective effects at variance with clinical phenomenology
    T Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, Building 10, Room 9D42, National Institutes of Health, 10 Center Drive MSC 1583, Bethesda, MD 20892, USA
    J Steroid Biochem Mol Biol 75:283-90. 2000
    ..We conclude that glucocorticoids suppress, rather than stimulate, the HIV-1 promoter, thus acting, protectively for the host. Their apparent negative clinical association with AIDS is most likely due to immunosuppression of the host...
  35. pmc The HIV-1 virion-associated protein vpr is a coactivator of the human glucocorticoid receptor
    T Kino
    Section on Pediatric Endocrinology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    J Exp Med 189:51-62. 1999
    ..The glucocorticoid coactivator activity of Vpr may contribute to increased tissue glucocorticoid sensitivity in the absence of hypercortisolism and to the pathogenesis of AIDS...
  36. ncbi request reprint Natural glucocorticoid receptor mutants causing generalized glucocorticoid resistance: molecular genotype, genetic transmission, and clinical phenotype
    Evangelia Charmandari
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 89:1939-49. 2004
    ....
  37. pmc Activated glucocorticoid receptor interacts with the INHAT component Set/TAF-Ibeta and releases it from a glucocorticoid-responsive gene promoter, relieving repression: implications for the pathogenesis of glucocorticoid resistance in acute undifferentiat
    Takamasa Ichijo
    Section on Pediatric Endocrinology, Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1109, USA
    Mol Cell Endocrinol 283:19-31. 2008
    ....
  38. ncbi request reprint HIV-1 protein Vpr suppresses IL-12 production from human monocytes by enhancing glucocorticoid action: potential implications of Vpr coactivator activity for the innate and cellular immunity deficits observed in HIV-1 infection
    Marco Mirani
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 169:6361-8. 2002
    ..Through this effect, Vpr may contribute to the suppression of innate and cellular immunities of HIV-1-infected individuals and AIDS patients...
  39. ncbi request reprint A novel, C-terminal dominant negative mutation of the GR causes familial glucocorticoid resistance through abnormal interactions with p160 steroid receptor coactivators
    Alessandra Vottero
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, MSC 1583, Bethesda, MD 20892, USA
    J Clin Endocrinol Metab 87:2658-67. 2002
    ..The mutant receptor has an ineffective AF-2 domain, which leads to an abnormal interaction with p160 coactivators and a distinct nuclear distribution of both...
  40. pmc The non-ligand binding beta-isoform of the human glucocorticoid receptor (hGR beta): tissue levels, mechanism of action, and potential physiologic role
    M de Castro
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Med 2:597-607. 1996
    ....
  41. pmc Human immunodeficiency virus (HIV)-1 viral protein R suppresses transcriptional activity of peroxisome proliferator-activated receptor {gamma} and inhibits adipocyte differentiation: implications for HIV-associated lipodystrophy
    Shashi Shrivastav
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Disease NIH, 10 Center Drive MSC 1268, Bethesda, MD 20892 1268, USA
    Mol Endocrinol 22:234-47. 2008
    ..Vpr may alter sensitivity to insulin and thereby contribute to the development of lipodystrophy and insulin resistance observed in HIV-1-infected patients...
  42. ncbi request reprint A novel point mutation in helix 11 of the ligand-binding domain of the human glucocorticoid receptor gene causing generalized glucocorticoid resistance
    Evangelia Charmandari
    Section on Endocrinology, Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 92:3986-90. 2007
    ....
  43. ncbi request reprint Endocrine and metabolic evaluation of human immunodeficiency virus-infected patients with evidence of protease inhibitor-associated lipodystrophy
    J A Yanovski
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 84:1925-31. 1999
    ..The cause remains to be elucidated...
  44. ncbi request reprint Glucocorticoid and mineralocorticoid resistance/hypersensitivity syndromes
    T Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1583, USA
    J Endocrinol 169:437-45. 2001
    ..The former may directly stimulate viral proliferation, while the latter may indirectly enhance viral propagation by suppressing the host immune system through glucocorticoid-mediated mechanisms...
  45. ncbi request reprint Modulatory effects of L-carnitine on glucocorticoid receptor activity
    Irini Manoli
    Endocrine Section, Laboratory of Clinical Investigation, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 1033:147-57. 2004
    ..The clinical and therapeutic implications of these findings, as well as a better understanding of their mechanisms, warrant further research...
  46. ncbi request reprint Pituitary homeobox factor 1, a novel transcription factor in the adrenal regulating steroid 11beta-hydroxylase
    N Hiroi
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Horm Metab Res 35:273-8. 2003
    ..In conclusion, this study represents the first demonstration for a role of Ptx1/Pitx1 in the regulation of transcription of enzymes involved in adrenal steroidogenesis...
  47. ncbi request reprint Cushing's disease preceded by generalized glucocorticoid resistance: clinical consequences of a novel, dominant-negative glucocorticoid receptor mutation
    M Karl
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1862, USA
    Proc Assoc Am Physicians 108:296-307. 1996
    ..The latter probably was due to the combined effects of chronic corticotroph hyperstimulation, decreased glucocorticoid negative feedback, and at least one subsequent somatic defect in the control of the cell cycle...
  48. ncbi request reprint The glucocorticoid receptor and the orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II interact with and mutually affect each other's transcriptional activities: implications for intermediary metabolism
    Massimo U De Martino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, Mail Stop Code 1583, Building 10, Room 9D42, Bethesda, MD 20892 1583, USA
    Mol Endocrinol 18:820-33. 2004
    ..These interactions influence the transcription of both COUP-TFII- and GRalpha-responsive target genes, seem to be promoter specific, and can be in either a positive or negative direction...
  49. pmc AMPK regulates metabolic actions of glucocorticoids by phosphorylating the glucocorticoid receptor through p38 MAPK
    Nancy Nader
    Unit on Molecular Hormone Action, Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Clinical Research Center, Room 1 3140, 10 Center Drive MSC 1109, Bethesda, MD 20892 1109, USA
    Mol Endocrinol 24:1748-64. 2010
    ..Because increased action of glucocorticoids is associated with the development of metabolic disorders, activation of AMPK could be a promising target for developing pharmacological interventions to these pathologies...
  50. ncbi request reprint Steroidogenic factor 1 messenger ribonucleic acid expression in steroidogenic and nonsteroidogenic human tissues: Northern blot and in situ hybridization studies
    M S Ramayya
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 82:1799-806. 1997
    ..These findings suggest that hSF-1 may play a role in reticuloendothelial/immune cell maturation and/or function, as well as nervous system development and/or neurosteroid biosynthesis...
  51. ncbi request reprint Tissue glucocorticoid sensitivity: beyond stochastic regulation on the diverse actions of glucocorticoids
    T Kino
    Pediatric Endocrinology Section, Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1109, USA
    Horm Metab Res 39:420-4. 2007
    ....
  52. ncbi request reprint The Smad6-histone deacetylase 3 complex silences the transcriptional activity of the glucocorticoid receptor: potential clinical implications
    Takamasa Ichijo
    Pediatric Endocrinology Section, Reproductive Biology and Medicine Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:42067-77. 2005
    ....
  53. ncbi request reprint The human glucocorticoid receptor (GR) isoform {beta} differentially suppresses GR{alpha}-induced transactivation stimulated by synthetic glucocorticoids
    Oren Fruchter
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 90:3505-9. 2005
    ..These results may provide helpful information concerning the selection of synthetic glucocorticoids for treatment of pathological conditions in which hGRbeta modulates the sensitivity of tissues to glucocorticoids...
  54. ncbi request reprint Novel causes of generalized glucocorticoid resistance
    E Charmandari
    Section on Pediatric Endocrinology, Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Horm Metab Res 39:445-50. 2007
    ....
  55. ncbi request reprint The human glucocorticoid receptor (hGR) beta isoform suppresses the transcriptional activity of hGRalpha by interfering with formation of active coactivator complexes
    Evangelia Charmandari
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, Building 10, Room 9D42, Bethesda, Maryland 20892 1583, USA
    Mol Endocrinol 19:52-64. 2005
    ..These findings suggest that participation of hGRbeta in the formation of a coactivator complex renders this complex ineffective...
  56. ncbi request reprint Glucocorticoid action networks and complex psychiatric and/or somatic disorders
    George P Chrousos
    First Department of Pediatrics, Athens University Medical School, 11527 Athens, Greece
    Stress 10:213-9. 2007
    ....
  57. pmc A novel point mutation in helix 10 of the human glucocorticoid receptor causes generalized glucocorticoid resistance by disrupting the structure of the ligand-binding domain
    Nancy Nader
    Unit on Molecular Hormone Action, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Clinical Research Center, 10 Center Drive MSC 1109, Bethesda, Maryland 20892 1109, USA
    J Clin Endocrinol Metab 95:2281-5. 2010
    ..Most of the reported cases are adults, demonstrating symptoms associated with mineralocorticoid and/or adrenal androgen excess caused by compensatively increased secretion of the adrenocorticotropic hormone...
  58. ncbi request reprint L-carnitine: A nutritional modulator of glucocorticoid receptor functions
    Salvatore Alesci
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1583, USA
    FASEB J 17:1553-5. 2003
    ....
  59. ncbi request reprint Glucocorticoids and their actions: an introduction
    Evangelia Charmandari
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1583, USA
    Ann N Y Acad Sci 1024:1-8. 2004
  60. ncbi request reprint Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism
    Massimo U De Martino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1583, USA
    Ann N Y Acad Sci 1024:72-85. 2004
    ..It appears that glucocorticoids exert their intermediary effects partly via physical interaction with COUP-TFII...
  61. ncbi request reprint L-Carnitine is a modulator of the glucocorticoid receptor alpha
    Salvatore Alesci
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1284, USA
    Ann N Y Acad Sci 1024:147-52. 2004
    ..We conclude that pharmacologic doses of LC can activate GRalpha and, via this mechanism, regulate glucocorticoid-responsive genes, potentially sharing some of the biological and therapeutic properties of glucocorticoids...
  62. ncbi request reprint Familial/sporadic glucocorticoid resistance: clinical phenotype and molecular mechanisms
    Evangelia Charmandari
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1583, USA
    Ann N Y Acad Sci 1024:168-81. 2004
    ..The present review focuses on the mechanisms of GR action and the clinical manifestations and molecular mechanisms of familial/sporadic glucocorticoid resistance...
  63. ncbi request reprint Pediatric stress: hormonal mediators and human development
    Evangelia Charmandari
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Horm Res 59:161-79. 2003
    ....
  64. ncbi request reprint A novel point mutation in the ligand-binding domain (LBD) of the human glucocorticoid receptor (hGR) causing generalized glucocorticoid resistance: the importance of the C terminus of hGR LBD in conferring transactivational activity
    Evangelia Charmandari
    Department of Pediatric Endocrinology, Great Ormond Street Hospital for Children, 9th Floor, Southwood Building, Great Ormond Street, London, United Kingdom WC1N 3JH
    J Clin Endocrinol Metab 90:3696-705. 2005
    ..We conclude that the carboxyl terminus of the ligand-binding domain of hGRalpha is extremely important in conferring transactivational activity by altering multiple functions of this composite transcription factor...
  65. ncbi request reprint Monoamine oxidase-A is a major target gene for glucocorticoids in human skeletal muscle cells
    Irini Manoli
    Endocrine Section, Laboratory of Clinical Investigation, NCCAM, NIH, Bethesda, Maryland 20892, USA
    FASEB J 19:1359-61. 2005
    ..We suggest that MAO-A-mediated oxidative stress can lead to cell damage, representing a novel pathogenetic mechanism for glucocorticoid-induced myopathy and a potential target for therapeutic intervention...
  66. ncbi request reprint Functional characterization of the natural human glucocorticoid receptor (hGR) mutants hGRalphaR477H and hGRalphaG679S associated with generalized glucocorticoid resistance
    Evangelia Charmandari
    Pediatric Endocrinology Section, Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20895, USA
    J Clin Endocrinol Metab 91:1535-43. 2006
    ....
  67. ncbi request reprint Low glucocorticoid receptor alpha/beta ratio in T-cell lymphoblastic leukemia
    C A Longui
    Section on Pediatric Endocrinology, DEB, NICHD, NIH, Bethesda, USA
    Horm Metab Res 32:401-6. 2000
    ....
  68. pmc The Rho guanine nucleotide exchange factor AKAP13 (BRX) is essential for cardiac development in mice
    Chantal M Mayers
    Program in Reproductive and Adult Endocrinology, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:12344-54. 2010
    ..The results suggest that AKAP13 coordinates Galpha(12) and Rho signaling to an essential transcription program in developing cardiomyocytes...
  69. pmc Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications
    Nancy Nader
    Section on Pediatric Endocrinology, Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1109, USA
    FASEB J 23:1572-83. 2009
    ..Further, these results suggest that a peripheral target tissue circadian rhythm indirectly influences the functions of every organ and tissue inside the body through modulation of the ubiquitous and diverse actions of glucocorticoids...
  70. pmc Interactions of the circadian CLOCK system and the HPA axis
    Nancy Nader
    Unit on Molecular Hormone Action, Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Endocrinol Metab 21:277-86. 2010
    ..In this review, we summarize the mutual physiologic interactions between the circadian CLOCK system and the HPA axis, and discuss their clinical implications...
  71. ncbi request reprint The PPARdelta agonist GW501516 suppresses interleukin-6-mediated hepatocyte acute phase reaction via STAT3 inhibition
    T Kino
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1109, USA
    Eur J Clin Invest 37:425-33. 2007
    ..Peroxisome proliferator-activated receptor delta (PPARdelta), which binds to and is activated by a variety of fatty acids, was recently shown to have anti-inflammatory actions...
  72. ncbi request reprint Glucocorticoids and inflammation revisited: the state of the art. NIH clinical staff conference
    Denis Franchimont
    Pediatric and Reproductive Endocrinology Branch, NICHD, NIH, Bethesda, MD 20892 1583, USA
    Neuroimmunomodulation 10:247-60. 2002
    ..Designer' glucocorticoids promise to be a great new advance in the therapy of inflammatory diseases...
  73. ncbi request reprint Combating atherosclerosis with LXR alpha and PPAR alpha agonists: is rational multitargeted polypharmacy the future of therapeutics in complex diseases?
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Interv 4:254-7. 2004
  74. ncbi request reprint Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1
    Tomoshige Kino
    Human Retrovirus Section, Center for Basic Research, National Cancer Institute Frederick, Frederick, Maryland 21702 1201, USA
    DNA Cell Biol 23:193-205. 2004
    ..Further studies on Vpr function are needed to fully assess the function of this important early regulatory molecule of HIV and other lentiviruses...
  75. ncbi request reprint Tissue-specific glucocorticoid resistance-hypersensitivity syndromes: multifactorial states of clinical importance
    Tomoshige Kino
    J Allergy Clin Immunol 109:609-13. 2002
  76. ncbi request reprint Ski-interacting protein, a bifunctional nuclear receptor coregulator that interacts with N-CoR/SMRT and p300
    Gary M Leong
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, NSW, Australia
    Biochem Biophys Res Commun 315:1070-6. 2004
    ..Overall these results suggest that transcriptional action of SKIP may depend on distinct functional domains and cell line-specific interactions with both corepressors and coactivators...
  77. ncbi request reprint Glucocorticoid action networks--an introduction to systems biology
    George P Chrousos
    J Clin Endocrinol Metab 89:563-4. 2004
  78. ncbi request reprint Female pseudohermaphroditism caused by a novel homozygous missense mutation of the GR gene
    Berenice B Mendonca
    Unidade de Endocrinologia do Desenvolvimento e Laboratorio de Hormonios e Genetica Molecular, Disciplina de Endocrinologia, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Brazil
    J Clin Endocrinol Metab 87:1805-9. 2002
    ..This phenotype indicates that pre- and postnatal virilization can occur in females with the glucocorticoid resistance syndrome...
  79. pmc Ikaros transcription factors: flying between stress and inflammation
    George P Chrousos
    First Department of Pediatrics, University of Athens, Athens, Greece
    J Clin Invest 115:844-8. 2005
    ..These results indicate that Ikaros is an ontogenetic and phylogenetic integrator of the stress and immune systems and that abnormalities in its function may produce endocrine and/or immune pathologies...
  80. ncbi request reprint Intracellular glucocorticoid signaling: a formerly simple system turns stochastic
    George P Chrousos
    Department of Pediatrics, University of Athens, Athens 115 27, Greece
    Sci STKE 2005:pe48. 2005
    ..The presence of multiple GR monomers and dimers in different quantities with quantitatively and qualitatively different transcriptional activities suggests that the glucocorticoid signaling system is highly stochastic...
  81. pmc Vpr protein of human immunodeficiency virus type 1 binds to 14-3-3 proteins and facilitates complex formation with Cdc25C: implications for cell cycle arrest
    Tomoshige Kino
    Human Retrovirus Section, Center for Cancer Research, National Cancer Institute Frederick, Bldg 535, Rm 210, Frederick, MD 21702 1201, USA
    J Virol 79:2780-7. 2005
    ..These results indicate that Vpr promotes cell cycle arrest at the G(2)/M phase by facilitating association of 14-3-3 and Cdc25C independently of the latter's phosphorylation status...
  82. pmc Generalized glucocorticoid resistance: clinical aspects, molecular mechanisms, and implications of a rare genetic disorder
    Evangelia Charmandari
    Division of Endocrinology and Metabolism, Clinical Research Center, Biomedical Research Foundation of the Academy of Athens, 4 Soranou tou Efessiou Street, Athens, Greece
    J Clin Endocrinol Metab 93:1563-72. 2008
    ..We review the clinical aspects, molecular mechanisms, and implications of this disorder...
  83. ncbi request reprint Effects of transgenic expression of HIV-1 Vpr on lipid and energy metabolism in mice
    Ashok Balasubramanyam
    Translational Metabolism Unit, Division of Diabetes, Endocrinology and Metabolism, BCM 700B, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Am J Physiol Endocrinol Metab 292:E40-8. 2007
    ....
  84. ncbi request reprint Human renal mesangial cells produce aldosterone in response to low-density lipoprotein (LDL)
    Tetsuo Nishikawa
    Department of Medicine, Yokohama Rosai Hospital, 3211 Kozukue cho, Kohoku Ku, Yokohama City, Kanagawa 222 0036, Japan
    J Steroid Biochem Mol Biol 96:309-16. 2005
    ....