J W Kinney

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Peripheral administration of urocortin suppresses operant responding for food reward
    J W Kinney
    Section on Behavioral Neuropharmacology, NIMH, Bethesda, MD 20892 1375, USA
    Peptides 22:583-7. 2001
  2. pmc Deficits in trace cued fear conditioning in galanin-treated rats and galanin-overexpressing transgenic mice
    Jefferson W Kinney
    Section on Behavioral Genomics, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Learn Mem 9:178-90. 2002
  3. ncbi request reprint Galanin peptide levels in hippocampus and cortex of galanin-overexpressing transgenic mice evaluated for cognitive performance
    C C Wrenn
    Section on Behavioral Genomics, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Neuropeptides 36:413-26. 2002
  4. ncbi request reprint Galanin GAL-R1 receptor null mutant mice display increased anxiety-like behavior specific to the elevated plus-maze
    Andrew Holmes
    Section on Behavioral Genomics, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 28:1031-44. 2003
  5. ncbi request reprint Central galanin administration blocks consolidation of spatial learning
    Jefferson W Kinney
    Section on Behavioral Genomics, National Institute of Mental Health, Galanin Inhibits Consolidation, Building 10 Room 4011, Bethesda, MD 20892 1375, USA
    Neurobiol Learn Mem 80:42-54. 2003
  6. ncbi request reprint Learning and memory performance in mice lacking the GAL-R1 subtype of galanin receptor
    Craige C Wrenn
    Laboratory of Behavioural Neuroscience, National Institute of Mental Health, Bethesda, MD 20892 1375, USA
    Eur J Neurosci 19:1384-96. 2004
  7. ncbi request reprint Galanin impairs performance on learning and memory tasks: findings from galanin transgenic and GAL-R1 knockout mice
    Nathan R Rustay
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA
    Neuropeptides 39:239-43. 2005
  8. pmc A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus
    Xiaoying Lu
    Department of Neuropharmacology and The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:874-9. 2005
  9. ncbi request reprint A novel, systemically active, selective galanin receptor type-3 ligand exhibits antidepressant-like activity in preclinical tests
    Alasdair M Barr
    Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, La Jolla, CA, United States
    Neurosci Lett 405:111-5. 2006

Detail Information

Publications9

  1. ncbi request reprint Peripheral administration of urocortin suppresses operant responding for food reward
    J W Kinney
    Section on Behavioral Neuropharmacology, NIMH, Bethesda, MD 20892 1375, USA
    Peptides 22:583-7. 2001
    ..These data indicated that the peripheral administration of urocortin reduced the motivation of food deprived subjects to respond...
  2. pmc Deficits in trace cued fear conditioning in galanin-treated rats and galanin-overexpressing transgenic mice
    Jefferson W Kinney
    Section on Behavioral Genomics, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Learn Mem 9:178-90. 2002
    ..These findings are the first demonstration that galanin impairs performance on an emotional memory task and support the hypothesis that galanin-induced deficits are specific to more difficult cognitive tasks...
  3. ncbi request reprint Galanin peptide levels in hippocampus and cortex of galanin-overexpressing transgenic mice evaluated for cognitive performance
    C C Wrenn
    Section on Behavioral Genomics, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Neuropeptides 36:413-26. 2002
    ..Several interpretations of these findings are discussed, including the possibility that a threshold level of galanin overexpression is sufficient to impair performance on learning and memory tasks in mice...
  4. ncbi request reprint Galanin GAL-R1 receptor null mutant mice display increased anxiety-like behavior specific to the elevated plus-maze
    Andrew Holmes
    Section on Behavioral Genomics, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 28:1031-44. 2003
    ..These behavioral findings in the first galanin receptor null mutant mouse are consistent with the hypothesis that galanin exerts anxiolytic actions via the GAL-R1 receptor under conditions of relatively high stress...
  5. ncbi request reprint Central galanin administration blocks consolidation of spatial learning
    Jefferson W Kinney
    Section on Behavioral Genomics, National Institute of Mental Health, Galanin Inhibits Consolidation, Building 10 Room 4011, Bethesda, MD 20892 1375, USA
    Neurobiol Learn Mem 80:42-54. 2003
    ..A potential mechanism by which galanin produces this impairment may involve the inhibition of adenylate cyclase activity, leading to inhibition of downstream molecular events that are necessary for consolidation of long-term memory...
  6. ncbi request reprint Learning and memory performance in mice lacking the GAL-R1 subtype of galanin receptor
    Craige C Wrenn
    Laboratory of Behavioural Neuroscience, National Institute of Mental Health, Bethesda, MD 20892 1375, USA
    Eur J Neurosci 19:1384-96. 2004
    ..The generally normal phenotype of GAL-R1 null mutants supports the use of this line for identification of the receptor subtypes that mediate the cognitive deficits produced by exogenous galanin...
  7. ncbi request reprint Galanin impairs performance on learning and memory tasks: findings from galanin transgenic and GAL-R1 knockout mice
    Nathan R Rustay
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA
    Neuropeptides 39:239-43. 2005
    ..The growing body of rodent literature implicating excess GAL in cognitive impairment is relevant to the overexpression of GAL in the basal forebrain during the progression of Alzheimer's disease...
  8. pmc A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus
    Xiaoying Lu
    Department of Neuropharmacology and The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:874-9. 2005
    ....
  9. ncbi request reprint A novel, systemically active, selective galanin receptor type-3 ligand exhibits antidepressant-like activity in preclinical tests
    Alasdair M Barr
    Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, La Jolla, CA, United States
    Neurosci Lett 405:111-5. 2006
    ..These combined data from two species indicate that GalR3 receptor antagonists may exhibit antidepressant-like effects...