Akiko Kimura

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc The gene encoding the hematopoietic stem cell regulator CCN3/NOV is under direct cytokine control through the transcription factors STAT5A/B
    Akiko Kimura
    Laboratory of Genetics and Physiology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:32704-9. 2010
  2. pmc The transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesis
    Akiko Kimura
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases NIDDK, National Institutes of Health NIH, Bethesda, MD, USA
    Blood 114:4721-8. 2009
  3. pmc Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-{beta} and STAT3 activation
    Atsushi Hosui
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 206:819-31. 2009
  4. pmc Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression
    Bing Mei Zhu
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases NIDDKD, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Blood 112:2071-80. 2008

Collaborators

Detail Information

Publications4

  1. pmc The gene encoding the hematopoietic stem cell regulator CCN3/NOV is under direct cytokine control through the transcription factors STAT5A/B
    Akiko Kimura
    Laboratory of Genetics and Physiology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:32704-9. 2010
    ..ChIP assays using 32D cells revealed IL-3-induced binding of STAT5A/B to a γ-interferon-activated sequences site in the Ccn3/Nov gene promoter. This is the first report that Ccn3/Nov is directly induced by cytokines through STAT5A/B...
  2. pmc The transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesis
    Akiko Kimura
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases NIDDK, National Institutes of Health NIH, Bethesda, MD, USA
    Blood 114:4721-8. 2009
    ..Finally, transcriptome analysis indicated that STAT5A/B directs GM-CSF signaling through the regulation of proliferation and survival genes...
  3. pmc Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-{beta} and STAT3 activation
    Atsushi Hosui
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 206:819-31. 2009
    ..In conclusion, loss of STAT5 results in elevated TGF-beta levels and enhanced growth hormone-induced STAT3 activity. We propose that a deregulated STAT5-TGF-beta-STAT3 network contributes to the development of chronic liver disease...
  4. pmc Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression
    Bing Mei Zhu
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases NIDDKD, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Blood 112:2071-80. 2008
    ..Chromatin immunoprecipitation experiments confirmed the binding of STAT5A/B to these sites. We conclude that STAT5A/B is an important regulator of iron update in erythroid progenitor cells via its control of Tfr1 transcription...