A S Kimes

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Cerebral glucose metabolism during opioid withdrawal following methylnaloxonium injection into the locus coeruleus
    A S Kimes
    Brain Imaging Center, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Brain Res 814:1-12. 1998
  2. ncbi request reprint 2-[18F]F-A-85380: PET imaging of brain nicotinic acetylcholine receptors and whole body distribution in humans
    Alane S Kimes
    NIDA Intramural Research Program Baltimore, Maryland 21224, USA
    FASEB J 17:1331-3. 2003
  3. ncbi request reprint 2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: synthesis, affinity for nicotinic acetylcholine receptors, and molecular modeling
    A O Koren
    Brain Imaging Center, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    J Med Chem 41:3690-8. 1998
  4. ncbi request reprint Synthesis and evaluation of N-[11C]methylated analogues of epibatidine as tracers for positron emission tomographic studies of nicotinic acetylcholine receptors
    A G Horti
    Brain Imaging Center, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, Maryland 21224
    J Med Chem 41:4199-206. 1998
  5. ncbi request reprint Dose-dependent effects of D-N-allylnormetazocine on regional cerebral metabolic rates for glucose
    A Della Puppa
    Neuroimaging and Drug Action Section, National Institute on Drug Abuse, Baltimore, MD 21224
    Brain Res 603:38-46. 1993
  6. ncbi request reprint Effects of triazolam on brain activity during episodic memory encoding: a PET study
    M Z Mintzer
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuropsychopharmacology 25:744-56. 2001
  7. ncbi request reprint Radiosynthesis of 5-(2-(4-pyridinyl)vinyl)-6-chloro-3-(1-[(11)C]methyl-2-(S)-pyrrolidinylmethoxy)pyridine, a high affinity ligand for studying nicotinic acetylcholine receptors by positron emission tomography
    L L Brown
    Brain Imaging Center, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Bioorg Med Chem 9:3055-8. 2001
  8. pmc Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task
    K I Bolla
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neuroimage 19:1085-94. 2003

Detail Information

Publications8

  1. ncbi request reprint Cerebral glucose metabolism during opioid withdrawal following methylnaloxonium injection into the locus coeruleus
    A S Kimes
    Brain Imaging Center, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Brain Res 814:1-12. 1998
    ..The present data support the view that LC is a major substrate of opioid withdrawal in the brain, and they suggest that LC plays an important role in changing rCMRglc during opioid withdrawal induced by systemic naloxone administration...
  2. ncbi request reprint 2-[18F]F-A-85380: PET imaging of brain nicotinic acetylcholine receptors and whole body distribution in humans
    Alane S Kimes
    NIDA Intramural Research Program Baltimore, Maryland 21224, USA
    FASEB J 17:1331-3. 2003
    ..180 +/- 30 mSv/MBq or 0.7 rem/mCi with a 2.4 h void interval) suggests that multiple studies could be performed in a single subject. The results predict that quantitative PET imaging of nAChRs in human brain with 2-[18F]FA is feasible...
  3. ncbi request reprint 2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: synthesis, affinity for nicotinic acetylcholine receptors, and molecular modeling
    A O Koren
    Brain Imaging Center, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    J Med Chem 41:3690-8. 1998
    ..The new ligands with high affinity for nAChRs may be of interest as pharmacological probes, potential medications, and candidates for developing radiohalogenated tracers to study nAChRs...
  4. ncbi request reprint Synthesis and evaluation of N-[11C]methylated analogues of epibatidine as tracers for positron emission tomographic studies of nicotinic acetylcholine receptors
    A G Horti
    Brain Imaging Center, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, Maryland 21224
    J Med Chem 41:4199-206. 1998
    ..2.1]heptane ([18F]FPH), which are highly specific nAChR probes. The initial brain uptake of the 11C analogues and the acute toxicity of the corresponding authentic nonlabeled compounds appeared to be related to their lipophilicity...
  5. ncbi request reprint Dose-dependent effects of D-N-allylnormetazocine on regional cerebral metabolic rates for glucose
    A Della Puppa
    Neuroimaging and Drug Action Section, National Institute on Drug Abuse, Baltimore, MD 21224
    Brain Res 603:38-46. 1993
    ....
  6. ncbi request reprint Effects of triazolam on brain activity during episodic memory encoding: a PET study
    M Z Mintzer
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuropsychopharmacology 25:744-56. 2001
    ..Results are discussed in relation to triazolam's effects on mnemonic versus attentional processes...
  7. ncbi request reprint Radiosynthesis of 5-(2-(4-pyridinyl)vinyl)-6-chloro-3-(1-[(11)C]methyl-2-(S)-pyrrolidinylmethoxy)pyridine, a high affinity ligand for studying nicotinic acetylcholine receptors by positron emission tomography
    L L Brown
    Brain Imaging Center, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Bioorg Med Chem 9:3055-8. 2001
    ..An efficient radiochemical synthesis of 5-(2-(4-pyridinyl)vinyl)-6-chloro-3-(1-[(11)C]methyl-2-(S)-pyrrolidinylmethoxy)pyridine (1c), a potential tracer for the study of nAChR by positron emission tomography, has been developed...
  8. pmc Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task
    K I Bolla
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neuroimage 19:1085-94. 2003
    ..Compromised decision-making could contribute to the development of addiction and undermine attempts at abstinence...