Pavel P Khil

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Crystal structure of the Escherichia coli YjiA protein suggests a GTP-dependent regulatory function
    Pavel P Khil
    Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    Proteins 54:371-4. 2004
  2. pmc Crystal structure of Escherichia coli protein ybgI, a toroidal structure with a dinuclear metal site
    Jane E Ladner
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and the National Institute of Standards and Technology, 9600 Gudelsky Drive, Rockville, MD 20850, USA
    BMC Struct Biol 3:7. 2003
  3. ncbi request reprint Gene expression profiles of Spo11-/- mouse testes with spermatocytes arrested in meiotic prophase I
    Natalya A Smirnova
    Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, 5 Memorial Drive, Bethesda, Maryland 20892, USA
    Reproduction 132:67-77. 2006
  4. pmc Detecting sequence polymorphisms associated with meiotic recombination hotspots in the human genome
    Jie Zheng
    Computational Biology Branch, NCBI, NLM, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, USA
    Genome Biol 11:R103. 2010
  5. pmc Genetic crossovers are predicted accurately by the computed human recombination map
    Pavel P Khil
    Genetics and Biochemistry Branch, The National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 6:e1000831. 2010
  6. ncbi request reprint Molecular features and functional constraints in the evolution of the mammalian X chromosome
    Pavel P Khil
    Genetics and Biochemistry Branch, National Institutes of Health, Bethesda, MD 20892, USA
    Crit Rev Biochem Mol Biol 40:313-30. 2005
  7. ncbi request reprint X for intersection: retrotransposition both on and off the X chromosome is more frequent
    Pavel P Khil
    Genetics and Biochemistry Branch and Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Genet 21:3-7. 2005
  8. pmc Sensitive mapping of recombination hotspots using sequencing-based detection of ssDNA
    Pavel P Khil
    Genetics and Biochemistry Branch, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA
    Genome Res 22:957-65. 2012
  9. ncbi request reprint Characterization of the DNA damage-inducible helicase DinG from Escherichia coli
    Oleg N Voloshin
    Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:28284-93. 2003
  10. ncbi request reprint Over 1000 genes are involved in the DNA damage response of Escherichia coli
    Pavel P Khil
    Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Mol Microbiol 44:89-105. 2002

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Crystal structure of the Escherichia coli YjiA protein suggests a GTP-dependent regulatory function
    Pavel P Khil
    Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    Proteins 54:371-4. 2004
  2. pmc Crystal structure of Escherichia coli protein ybgI, a toroidal structure with a dinuclear metal site
    Jane E Ladner
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and the National Institute of Standards and Technology, 9600 Gudelsky Drive, Rockville, MD 20850, USA
    BMC Struct Biol 3:7. 2003
    ..The protein encoded by the gene ybgI was chosen as a target for a structural genomics project emphasizing the relation of protein structure to function...
  3. ncbi request reprint Gene expression profiles of Spo11-/- mouse testes with spermatocytes arrested in meiotic prophase I
    Natalya A Smirnova
    Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, 5 Memorial Drive, Bethesda, Maryland 20892, USA
    Reproduction 132:67-77. 2006
    ..Finally, we discovered unknown genes that are affected by the disruption of the Spo11 gene and therefore may be specifically involved in meiosis and spermatogenesis...
  4. pmc Detecting sequence polymorphisms associated with meiotic recombination hotspots in the human genome
    Jie Zheng
    Computational Biology Branch, NCBI, NLM, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, USA
    Genome Biol 11:R103. 2010
    ..At the same time, recombination hotspots are heritable. Previous studies showed instances where differences in recombination rate could be associated with sequence polymorphisms...
  5. pmc Genetic crossovers are predicted accurately by the computed human recombination map
    Pavel P Khil
    Genetics and Biochemistry Branch, The National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 6:e1000831. 2010
    ..In summary, we find that by combining several computed population-specific maps we can capture the variation in individual hotspots to generate a hotspot map that can predict almost all present-day genetic crossovers...
  6. ncbi request reprint Molecular features and functional constraints in the evolution of the mammalian X chromosome
    Pavel P Khil
    Genetics and Biochemistry Branch, National Institutes of Health, Bethesda, MD 20892, USA
    Crit Rev Biochem Mol Biol 40:313-30. 2005
    ..Here we address multiple functional constraints that were encountered in the evolution of the X chromosome and the impact that this evolutionary history has had on its modern behavior...
  7. ncbi request reprint X for intersection: retrotransposition both on and off the X chromosome is more frequent
    Pavel P Khil
    Genetics and Biochemistry Branch and Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Genet 21:3-7. 2005
    ..A new study addresses the differential distribution of retroposed genes in human and mouse genomes. Surprisingly, chromosome X is a major source and a preferred target for retrotransposition...
  8. pmc Sensitive mapping of recombination hotspots using sequencing-based detection of ssDNA
    Pavel P Khil
    Genetics and Biochemistry Branch, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA
    Genome Res 22:957-65. 2012
    ..The use of our technique reduces the nonspecific double-stranded DNA (dsDNA) background >10-fold. Our method can be extended to other systems where the identification of ssDNA or DSBs is desired...
  9. ncbi request reprint Characterization of the DNA damage-inducible helicase DinG from Escherichia coli
    Oleg N Voloshin
    Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:28284-93. 2003
    ..We discuss the possible involvement of the DinG helicase in DNA replication and repair processes...
  10. ncbi request reprint Over 1000 genes are involved in the DNA damage response of Escherichia coli
    Pavel P Khil
    Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Mol Microbiol 44:89-105. 2002
    ..Analysis of the gene expression data highlighted the essential involvement of sigma(s)-regulated genes and the general stress response network in the response to DNA damage...
  11. ncbi request reprint The mouse X chromosome is enriched for sex-biased genes not subject to selection by meiotic sex chromosome inactivation
    Pavel P Khil
    Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, 5 Memorial Drive, Bethesda, Maryland 20892, USA
    Nat Genet 36:642-6. 2004
    ..Inactivation of the X chromosome in male meiosis may be a universal driving force for X-chromosome demasculinization...
  12. ncbi request reprint Crystal structure of the Escherichia coli YcdX protein reveals a trinuclear zinc active site
    Alexey Teplyakov
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and the National Institute of Standards and Technology, Rockville, Maryland 20850, USA
    Proteins 51:315-8. 2003
  13. pmc Crystal structure of the YchF protein reveals binding sites for GTP and nucleic acid
    Alexey Teplyakov
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and the National Institute of Standards and Technology, Rockville, Maryland 20850, USA
    J Bacteriol 185:4031-7. 2003
    ..Taken together with other experimental data and genomic analysis, these results suggest that YchF may be part of a nucleoprotein complex and may function as a GTP-dependent translation factor...
  14. pmc Crystal structure of the YgfZ protein from Escherichia coli suggests a folate-dependent regulatory role in one-carbon metabolism
    Alexey Teplyakov
    Center for Advanced Research in Biotechnology, 9600 Gudelsky Drive, Rockville, MD 20850, USA
    J Bacteriol 186:7134-40. 2004
    ....
  15. ncbi request reprint Crystal structure of the Escherichia coli Tas protein, an NADP(H)-dependent aldo-keto reductase
    Galina Obmolova
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and the National Institute of Standards and Technology, Rockville, Maryland 20850, USA
    Proteins 53:323-5. 2003
  16. pmc Crystal structure of the YffB protein from Pseudomonas aeruginosa suggests a glutathione-dependent thiol reductase function
    Alexey Teplyakov
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville, MD 20850, USA
    BMC Struct Biol 4:5. 2004
    ..The crystal structure determination of YffB was undertaken as part of a structural genomics effort in order to assist with the functional assignment of the protein...
  17. ncbi request reprint Crystal structure of the YajQ protein from Haemophilus influenzae reveals a tandem of RNP-like domains
    Alexey Teplyakov
    Center for Advanced Research in Biotechnology of the University of Maryland Biotechnology Institute and the National Institute of Standards and Technology, 9600 Gudelsky Drive, Rockville, MD 20850, USA
    J Struct Funct Genomics 4:1-9. 2003
    ..This structural motif is a characteristic feature of many RNA-binding proteins. The tetrameric structure observed in the crystal suggests a possibility of binding two stretches of double-stranded nucleic acid...
  18. ncbi request reprint Assisting functional assignment for hypothetical Heamophilus influenzae gene products through structural genomics
    Gary L Gilliland
    Center for Advanced Research in Biotechnology of the University of Maryland Biotechnology Institute and the National Institute of Standards and Technology, 9600 Gudelsky Drive, Rockville, MD 20850, USA
    Curr Drug Targets Infect Disord 2:339-53. 2002
    ..In addition to aiding in functional assignment, this effort is identifying a number of possible new targets for drug development...
  19. ncbi request reprint Crystal structure of the YjeE protein from Haemophilus influenzae: a putative Atpase involved in cell wall synthesis
    Alexey Teplyakov
    Center for Advanced Research in Biotechnology of the University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA
    Proteins 48:220-6. 2002
    ..The distribution of conserved residues suggests that the protein may work as a "molecular switch" triggered by ATP hydrolysis. The phylogenetic pattern of YjeE suggests its involvement in cell wall biosynthesis...