Research Topics
Genomes and Genes
| Chand KhannaSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Guiding the optimal translation of new cancer treatments from canine to human cancer patientsChand Khanna
School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin, USA
Clin Cancer Res 15:5671-7. 2009..A summary of this meeting and subsequent discussion are provided here to afford clarity on the conduct of these studies so as to optimize the opportunities provided by this novel drug development and modeling strategy...
Catching cancer by the tail: new perspectives on the use of kinase inhibitorsChand Khanna
Center for Cancer Research, Comparative Oncology Program, and Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA
Clin Cancer Res 15:3645-7. 2009..The study represents another example of opportunities to include pet dogs in studies that improve our understanding of human cancer biology and therapy...
Molecular approaches in pediatric oncologyChand Khanna
Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Rockville and Bethesda, Maryland, USA
Annu Rev Med 57:83-97. 2006..We present a model for understanding cancer biology, using specific examples taken from pediatric oncology, and then discuss the application of molecular techniques to the clinical management of pediatric cancer patients...- Novel targets with potential therapeutic applications in osteosarcomaChand Khanna
National Institutes of Health, National Cancer Institute, Pediatric Oncology Branch, Tumor Metastasis Biology Section, 37 Convent Drive, Bethesda, MD 20892, USA
Curr Oncol Rep 10:350-8. 2008..It is likely and potentially favorable for some targets to be relevant for more than one process. This review summarizes novel targets under evaluation for the treatment of osteosarcoma based on these three features of the disease... - Modeling metastasis in vivoChand Khanna
Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Carcinogenesis 26:513-23. 2005..No single metastasis model is sufficient to answer all questions. As such, the selection of the optimal model(s) for each biological or translational question is necessary... - The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasisChand Khanna
Pediatric Oncology Branch and Tissue Array Project Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Med 10:182-6. 2004..High ezrin expression in dog tumors was associated with early development of metastases. Consistent with this data, we found a significant association between high ezrin expression and poor outcome in pediatric osteosarcoma patients... - Biologically relevant orthotopic neuroblastoma xenograft models: primary adrenal tumor growth and spontaneous distant metastasisChand Khanna
Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
In Vivo 16:77-85. 2002..These well characterized, relevant, highly angiogenic, and metastatic orthotopic models of NB will be a valuable resource to improve our understanding of the biology and treatment of NB... - Targeting the lung: preclinical and comparative evaluation of anticancer aerosols in dogs with naturally occurring cancersChand Khanna
Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Curr Cancer Drug Targets 3:265-73. 2003..A summary of work involving pet dogs with primary and metastatic cancers to the lung and the investigation of therapeutic chemotherapy and cytokine immunotherapy aerosols will be presented... - A randomized controlled trial of octreotide pamoate long-acting release and carboplatin versus carboplatin alone in dogs with naturally occurring osteosarcoma: evaluation of insulin-like growth factor suppression and chemotherapyChand Khanna
Pediatric Oncology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Clin Cancer Res 8:2406-12. 2002..The study compared primary tumor necrosis and apoptosis, and survival of pet dogs receiving OncoLAR and carboplatin chemotherapy compared with dogs receiving placebo and carboplatin... - Murine osteosarcoma primary tumour growth and metastatic progression is maintained after marked suppression of serum insulin-like growth factor ISung Hyeok Hong
Pediatric Oncology Branch, Centre for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Int J Cancer 124:2042-9. 2009..Collectively, these data suggest that marked reduction in serum IGF-I is not sufficient to slow the progression of either primary or metastatic models of osteosarcoma... - Dysregulation of ezrin phosphorylation prevents metastasis and alters cellular metabolism in osteosarcomaLing Ren
Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
Cancer Res 72:1001-12. 2012.... - Cooperative activity of cytotoxic chemotherapy with antiangiogenic thrombospondin-I peptides, ABT-526 in pet dogs with relapsed lymphomaAnthony Rusk
Animal Clinical Investigation, LLC, Bethesda, Maryland, USA
Clin Cancer Res 12:7456-64. 2006..To further assist in the development of ABT-526, we report herein on its evaluation in combination with cytotoxic chemotherapy in pet dogs with relapsed non-Hodgkin's lymphoma (NHL)... - Inhibition of AP-1 transcriptional activity blocks the migration, invasion, and experimental metastasis of murine osteosarcomaVirna D Leaner
Cell and Cancer Biology Department, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Am J Pathol 174:265-75. 2009..This study shows that differences in metastatic activity can be due to AP-1 activation. The inhibition of AP-1 activity may serve as a therapeutic tool in the management of osteosarcoma... - CCI-779 inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism linked to the targeting of mTOR/Hif-1alpha/VEGF signalingXiaolin Wan
Molecular Oncology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1928, USA
Neoplasia 8:394-401. 2006..Together, these data suggest that CCI-779 inhibits human RMS xenograft growth by an antiangiogenic mechanism associated with the targeting of mTOR/Hif-1alpha/VEGF signaling... - Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screeningPatrick J Grohar
Molecular Oncology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Dr MSC 1104, 10 CRC 1W 3816, Bethesda, MD 20892 1104, USA
J Natl Cancer Inst 103:962-78. 2011..quot;.. - Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastasesSu Young Kim
Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Clin Exp Metastasis 25:201-11. 2008..Our findings show that inhibition of the CXCR4/CXCL12 pathway decreases metastatic disease in two murine tumor models and expands on previous reports to describe potential mechanisms of action... - The ezrin metastatic phenotype is associated with the initiation of protein translationJoseph W Briggs
Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
Neoplasia 14:297-310. 2012..Taken together, these results provide a novel mechanistic basis by which Ezrin may contribute to metastasis... - Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progressionMelissa Paoloni
Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
BMC Genomics 10:625. 2009.... - Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcomaXiaolin Wan
Molecular Oncology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-1106, USA
Cancer Res 65:2406-11. 2005..These results suggest that blocking the mTOR/S6K1/4E-BP1 pathway may be an appropriate target for strategies to reduce tumor cell metastasis... - Addiction to elevated insulin-like growth factor I receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibodyLiang Cao
Genetics Branch, Center for Cancer Research, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 4265, USA
Cancer Res 68:8039-48. 2008..Subsequent progression of tumors was associated with reactivation of p-AKT despite sustained suppression of IGF-IR. These results identified the first predictive biomarker for anti-IGF-IR therapies in cancer... - STEALTH liposome-encapsulated cisplatin (SPI-77) versus carboplatin as adjuvant therapy for spontaneously arising osteosarcoma (OSA) in the dog: a randomized multicenter clinical trialDavid M Vail
The Comprehensive Cancer Center, University of Wisconsin Madison, Madison, WI 53706, USA
Cancer Chemother Pharmacol 50:131-6. 2002..This trial was designed to compare the efficacy of adjuvant STEALH liposome-encapsulated cisplatin (SPI-77) to "standard-of-care" carboplatin therapy in dogs with osteosarcoma (OSA) in the context of a randomized study design... - A compendium of canine normal tissue gene expressionJoseph Briggs
Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS ONE 6:e17107. 2011..Accordingly, we now present the first genome-wide, canine normal tissue gene expression compendium with corresponding human cross-species analysis... - Modeling metastasis biology and therapy in real time in the mouse lungArnulfo Mendoza
Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
J Clin Invest 120:2979-88. 2010..We believe that this assay system is uniquely capable of advancing our understanding of both metastasis biology and therapeutic strategies... - Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted modelsJames G Taylor
Pulmonary and Vascular Medicine Branch, National Heart, Lung, and Blood Institute NHLBI, NIH, Bethesda, Maryland 20892 4605, USA
J Clin Invest 119:3395-407. 2009..These findings support the potential therapeutic targeting of FGFR4 in RMS... - Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulatorsYanlin Yu
Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Med 10:175-81. 2004..The identification of ezrin and Six-1 as critical regulators of metastasis in RMS provides new mechanistic and therapeutic insights into this pediatric cancer... - Apoptosis resistance and PKC signaling: distinguishing features of high and low metastatic cellsSung Hyeok Hong
Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Neoplasia 14:249-58. 2012..The connection to PKC activation may provide a biologic rationale for the use of PKC inhibition in the prevention of metastatic progression... - Rapamycin pharmacokinetic and pharmacodynamic relationships in osteosarcoma: a comparative oncology study in dogsMelissa C Paoloni
Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
PLoS ONE 5:e11013. 2010.... - Nm23-H1 suppresses metastasis by inhibiting expression of the lysophosphatidic acid receptor EDG2Christine E Horak
Women s Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
Cancer Res 67:11751-9. 2007..73; P = 0.004). The data indicate that Nm23-H1 down-regulation of EDG2 is functionally important to suppression of tumor metastasis... - The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradationYien Che Tsai
Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA
Nat Med 13:1504-9. 2007.... - Immune reconstitution prevents metastatic recurrence of murine osteosarcomaMelinda S Merchant
Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
Cancer Immunol Immunother 56:1037-46. 2007..The results further suggest that T cell depleting cancer therapies may eliminate beneficial immune responses and that immune reconstitution of lymphopenic cancer patients could prevent metastatic recurrence of solid tumors... - Ezrin mediates growth and survival in Ewing's sarcoma through the AKT/mTOR, but not the MAPK, signaling pathwayKartik Krishnan
Molecular Oncology Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 1 3816, 10 Center Drive, Bethesda, MD 20892, USA
Clin Exp Metastasis 23:227-36. 2006..These results, therefore, demonstrate that, in Ewing's sarcoma, the biology of ezrin is distinct from that described in other sarcomas. This study further validates ezrin as a potential therapeutic target... - Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeletonDalit Barkan
Laboratory of Cell Biology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Cancer Res 68:6241-50. 2008..Targeting this process may provide therapeutic strategies for inhibition of the dormant-to-proliferative metastatic switch... - Inhibition of tumor cell motility by the interferon-inducible GTPase MxAJ Frederic Mushinski
Laboratory of Cancer Biology and Genetics, Medical Oncology Branch, Pediatric Oncology Branch, and Urologic Oncology Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 284:15206-14. 2009..These data demonstrate that MxA inhibits tumor cell motility and invasion, and that MxA expression can be induced by small molecules, potentially offering a new approach to the prevention and treatment of metastasis... - Evaluation of eIF4E expression in an osteosarcoma-specific tissue microarrayTanasa S Osborne
Tumor and Metastasis Biology Section, Pediatric Oncology Branch, National Institutes of Health, Bethesda, MD 20892, USA
J Pediatr Hematol Oncol 33:524-8. 2011..We found that eIF4E was uniformly expressed in OS patient samples. No association was found between eIF4E and outcome in OS patients. This novel OS TMA provided a facile mechanism to assess the role of a relevant protein biomarker in OS... - Ecteinascidin 743 interferes with the activity of EWS-FLI1 in Ewing sarcoma cellsPatrick J Grohar
Molecular Oncology Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1928, USA
Neoplasia 13:145-53. 2011..In addition, the modulation of EWS-FLI1 makes it a novel targeting agent for ESFT and suggests that further development of this compound for the treatment of ESFT is warranted... - Launching a novel preclinical infrastructure: comparative oncology trials consortium directed therapeutic targeting of TNFalpha to cancer vasculatureMelissa C Paoloni
Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
PLoS ONE 4:e4972. 2009..Large animal spontaneous cancer models can be a valuable addition to successful studies of cancer biology and novel therapeutic drug, imaging and device development... - Alterations in Gemin5 expression contribute to alternative mRNA splicing patterns and tumor cell motilityJong Heun Lee
Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
Cancer Res 68:639-44. 2008..The data also show that changes in mRNA splicing patterns accompany metastatic progression, which may contribute to proteome instability... - Credentialing preclinical pediatric xenograft models using gene expression and tissue microarray analysisCraig C Whiteford
Oncogenomics Section, Comparative Oncology Program, and Cell and Molecular Biology Section, Pediatric Oncology Branch
Cancer Res 67:32-40. 2007..The database will facilitate the identification of tumor markers predictive of response to tested agents as well as the discovery of new molecular targets... - CD1d-restricted natural killer T cells can down-regulate tumor immunosurveillance independent of interleukin-4 receptor-signal transducer and activator of transcription 6 or transforming growth factor-betaMasaki Terabe
Vaccine Branch and Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH Bldg 10 Rm 6B12, 9000 Rockville Pike, Bethesda, MD 20892, USA
Cancer Res 66:3869-75. 2006..These data suggest that a novel CD1d-restricted NKT cell-mediated mechanism for tumor immunosuppression is active in the K7M2 osteosarcoma model and that NKT cells can regulate immunosurveillance through more than one pathway... - Preclinical evaluation of antiangiogenic thrombospondin-1 peptide mimetics, ABT-526 and ABT-510, in companion dogs with naturally occurring cancersAnthony Rusk
Animal Clinical Investigation, LLC, Columbia, Maryland, USA
Clin Cancer Res 12:7444-55. 2006..To guide the clinical development of these drugs, translational studies in dogs with naturally occurring cancers were initiated... - Translation of new cancer treatments from pet dogs to humansMelissa Paoloni
Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, 37 Convent Drive, Room 2144, Bethesda, Maryland 20892, USA
Nat Rev Cancer 8:147-56. 2008.... - MS-27-275, an inhibitor of histone deacetylase, has marked in vitro and in vivo antitumor activity against pediatric solid tumorsJerry Jaboin
Cell and Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
Cancer Res 62:6108-15. 2002..Using xenograft orthotopic models of US, EWS, and neuroblastoma, we find that the growth of established tumors is inhibited in mice treated with MS-275... - The molecular biology of pulmonary metastasisKartik Krishnan
Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10 CRC Room 1 3816, Bethesda, MD 20892, USA
Thorac Surg Clin 16:115-24. 2006..Clearly, therefore, a synthesis of different technologies and complimentary information will be required to target metastases and improve the outcome for patients affected by them... - Nitric oxide synthase and breast cancer: role of TIMP-1 in NO-mediated Akt activationLisa A Ridnour
Radiation Biology Branch, National Cancer Institute, Bethesda, Maryland, United States of America
PLoS ONE 7:e44081. 2012..In summary, our findings suggest that tumors with high TIMP-1 and NOS2 behave more aggressively by mechanisms that favor Akt pathway activation... - Core biopsies can be used to distinguish differences in expression profiling by cDNA microarraysChristos Sotiriou
Medicine Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Gaithersburg, Maryland, USA
J Mol Diagn 4:30-6. 2002..Pooling the core biopsies did not improve the concordance with excisional biopsies. In conclusion, our results suggest that core biopsies can be used as a suitable and reliable material for the determination of tumor genetic profiles... - Modeling opportunities in comparative oncology for drug developmentIra K Gordon
NCI Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA
ILAR J 51:214-20. 2010.... - Comparative oncology todayMelissa C Paoloni
Comparative Oncology Program, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 2144, Bethesda, MD 20892, USA
Vet Clin North Am Small Anim Pract 37:1023-32; v. 2007..The state of the comparative oncology field is outlined in this article, with an emphasis on cancer in dogs... - Expression of the cytoskeleton linker protein ezrin in human cancersBenjamin Bruce
Tumor and Metastasis Biology Section, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
Clin Exp Metastasis 24:69-78. 2007.... - Cancers as wounds that do not heal: differences and similarities between renal regeneration/repair and renal cell carcinomaJoseph Riss
Laboratory of Biosystems and Cancer, Comparative Oncology Program, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Cancer Res 66:7216-24. 2006..The observations reported here provide a conceptual framework for further efforts to understand the biology and to develop more effective diagnostic biomarkers and therapeutic strategies for renal tumors and renal ischemia... - Fishing for the origins of cancerGlenn Merlino
Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Genes Dev 21:1275-9. 2007 - The biology of metastases in pediatric sarcomasKartik Krishnan
Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
Cancer J 11:306-13. 2005..Finally, we discuss progress being made in our ability to study metastases and expectations for the future... - Revisiting the seed and soil in cancer metastasisMartin Mendoza
Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892, USA
Int J Biochem Cell Biol 41:1452-62. 2009..e. seed) and its microenvironment (i.e. soil). We will provide background to suggest that a critical outcome of the seed-soil interaction is resistance of the stresses that would otherwise impede metastasis... - Immune synapse formation requires ZAP-70 recruitment by ezrin and CD43 removal by moesinTal Ilani
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
J Cell Biol 179:733-46. 2007..In contrast, moesin dephosphorylation and removal, along with CD43, are necessary to prepare a region of the cell cortex for IS. Thus, ezrin and moesin have distinct and critical functions in the T cell cortex during IS formation... - Fas-negative osteosarcoma tumor cells are selected during metastasis to the lungs: the role of the Fas pathway in the metastatic process of osteosarcomaNadezhda V Koshkina
Division of Pediatrics Research, Unit 853, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Mol Cancer Res 5:991-9. 2007..Therefore, Fas may be considered as a new therapeutic target for osteosarcoma treatment... - Tumor expression of 4-1BB ligand sustains tumor lytic T cellsHua Zhang
National Cancer Institute; Bethesda, Maryland USA
Cancer Biol Ther 2:579-86. 2003..They further demonstrate a potential new therapeutic role for 4-1BBL mediated costimulation in expanding tumor reactive CTLs for use in the adoptive immunotherapy of cancer... - The dog as a cancer modelChand Khanna
Nat Biotechnol 24:1065-6. 2006 - Biology of childhood osteogenic sarcoma and potential targets for therapeutic development: meeting summaryRichard Gorlick
Memorial Sloan-Kettering Cancer Center, New York, New York, USA
Clin Cancer Res 9:5442-53. 2003..This report summarizes the information presented and discussed by the meeting participants... - Corruption of the Fas pathway delays the pulmonary clearance of murine osteosarcoma cells, enhances their metastatic potential, and reduces the effect of aerosol gemcitabineNancy Gordon
Children s Cancer Hospital, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Clin Cancer Res 13:4503-10. 2007..The purpose of these studies was to evaluate Fas expression in osteosarcoma lung metastases and the effect of gemcitabine on Fas expression and tumor growth... - Results of a phase II clinical trial on the use of ifosfamide for treatment of cats with vaccine-associated sarcomasKenneth M Rassnick
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Am J Vet Res 67:517-23. 2006..CONCLUSIONS AND CLINICAL RELEVANCE: Ifosfamide has antitumor activity against VAS in cats and is tolerated well by most cats. Ifosfamide should be evaluated as an adjuvant treatment for cats with VAS... - Single agent gemcitabine chemotherapy in dogs with spontaneously occurring lymphomaAvenelle I Turner
Gulf Coast Veterinary Oncology, Houston, TX, USA
J Vet Intern Med 20:1384-8. 2006.... - Preclinical studies of treosulfan demonstrate potent activity in Ewing's sarcomaSebastian Werner
Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Albert Ludwigs University, Mathildenstr 1, 79106, Freiburg, Germany
Cancer Chemother Pharmacol 62:19-31. 2008..Furthermore, the anti-tumor effect of treosulfan was studied in an orthotopic Ewing's sarcoma mouse xenograft model...