Chand Khanna

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Guiding the optimal translation of new cancer treatments from canine to human cancer patients
    Chand Khanna
    School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin, USA
    Clin Cancer Res 15:5671-7. 2009
  2. ncbi request reprint Biologically relevant orthotopic neuroblastoma xenograft models: primary adrenal tumor growth and spontaneous distant metastasis
    Chand Khanna
    Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    In Vivo 16:77-85. 2002
  3. ncbi request reprint A randomized controlled trial of octreotide pamoate long-acting release and carboplatin versus carboplatin alone in dogs with naturally occurring osteosarcoma: evaluation of insulin-like growth factor suppression and chemotherapy
    Chand Khanna
    Pediatric Oncology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 8:2406-12. 2002
  4. doi request reprint Catching cancer by the tail: new perspectives on the use of kinase inhibitors
    Chand Khanna
    Center for Cancer Research, Comparative Oncology Program, and Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA
    Clin Cancer Res 15:3645-7. 2009
  5. ncbi request reprint Novel targets with potential therapeutic applications in osteosarcoma
    Chand Khanna
    National Institutes of Health, National Cancer Institute, Pediatric Oncology Branch, Tumor Metastasis Biology Section, 37 Convent Drive, Bethesda, MD 20892, USA
    Curr Oncol Rep 10:350-8. 2008
  6. ncbi request reprint Targeting the lung: preclinical and comparative evaluation of anticancer aerosols in dogs with naturally occurring cancers
    Chand Khanna
    Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Cancer Drug Targets 3:265-73. 2003
  7. ncbi request reprint Molecular approaches in pediatric oncology
    Chand Khanna
    Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Rockville and Bethesda, Maryland, USA
    Annu Rev Med 57:83-97. 2006
  8. ncbi request reprint Modeling metastasis in vivo
    Chand Khanna
    Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 26:513-23. 2005
  9. ncbi request reprint The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis
    Chand Khanna
    Pediatric Oncology Branch and Tissue Array Project Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 10:182-6. 2004
  10. doi request reprint Murine osteosarcoma primary tumour growth and metastatic progression is maintained after marked suppression of serum insulin-like growth factor I
    Sung Hyeok Hong
    Pediatric Oncology Branch, Centre for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Cancer 124:2042-9. 2009

Detail Information

Publications63

  1. pmc Guiding the optimal translation of new cancer treatments from canine to human cancer patients
    Chand Khanna
    School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin, USA
    Clin Cancer Res 15:5671-7. 2009
    ..A summary of this meeting and subsequent discussion are provided here to afford clarity on the conduct of these studies so as to optimize the opportunities provided by this novel drug development and modeling strategy...
  2. ncbi request reprint Biologically relevant orthotopic neuroblastoma xenograft models: primary adrenal tumor growth and spontaneous distant metastasis
    Chand Khanna
    Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    In Vivo 16:77-85. 2002
    ..These well characterized, relevant, highly angiogenic, and metastatic orthotopic models of NB will be a valuable resource to improve our understanding of the biology and treatment of NB...
  3. ncbi request reprint A randomized controlled trial of octreotide pamoate long-acting release and carboplatin versus carboplatin alone in dogs with naturally occurring osteosarcoma: evaluation of insulin-like growth factor suppression and chemotherapy
    Chand Khanna
    Pediatric Oncology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 8:2406-12. 2002
    ..The study compared primary tumor necrosis and apoptosis, and survival of pet dogs receiving OncoLAR and carboplatin chemotherapy compared with dogs receiving placebo and carboplatin...
  4. doi request reprint Catching cancer by the tail: new perspectives on the use of kinase inhibitors
    Chand Khanna
    Center for Cancer Research, Comparative Oncology Program, and Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA
    Clin Cancer Res 15:3645-7. 2009
    ..The study represents another example of opportunities to include pet dogs in studies that improve our understanding of human cancer biology and therapy...
  5. ncbi request reprint Novel targets with potential therapeutic applications in osteosarcoma
    Chand Khanna
    National Institutes of Health, National Cancer Institute, Pediatric Oncology Branch, Tumor Metastasis Biology Section, 37 Convent Drive, Bethesda, MD 20892, USA
    Curr Oncol Rep 10:350-8. 2008
    ..It is likely and potentially favorable for some targets to be relevant for more than one process. This review summarizes novel targets under evaluation for the treatment of osteosarcoma based on these three features of the disease...
  6. ncbi request reprint Targeting the lung: preclinical and comparative evaluation of anticancer aerosols in dogs with naturally occurring cancers
    Chand Khanna
    Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Cancer Drug Targets 3:265-73. 2003
    ..A summary of work involving pet dogs with primary and metastatic cancers to the lung and the investigation of therapeutic chemotherapy and cytokine immunotherapy aerosols will be presented...
  7. ncbi request reprint Molecular approaches in pediatric oncology
    Chand Khanna
    Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Rockville and Bethesda, Maryland, USA
    Annu Rev Med 57:83-97. 2006
    ..We present a model for understanding cancer biology, using specific examples taken from pediatric oncology, and then discuss the application of molecular techniques to the clinical management of pediatric cancer patients...
  8. ncbi request reprint Modeling metastasis in vivo
    Chand Khanna
    Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 26:513-23. 2005
    ..No single metastasis model is sufficient to answer all questions. As such, the selection of the optimal model(s) for each biological or translational question is necessary...
  9. ncbi request reprint The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis
    Chand Khanna
    Pediatric Oncology Branch and Tissue Array Project Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 10:182-6. 2004
    ..High ezrin expression in dog tumors was associated with early development of metastases. Consistent with this data, we found a significant association between high ezrin expression and poor outcome in pediatric osteosarcoma patients...
  10. doi request reprint Murine osteosarcoma primary tumour growth and metastatic progression is maintained after marked suppression of serum insulin-like growth factor I
    Sung Hyeok Hong
    Pediatric Oncology Branch, Centre for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Cancer 124:2042-9. 2009
    ..Collectively, these data suggest that marked reduction in serum IGF-I is not sufficient to slow the progression of either primary or metastatic models of osteosarcoma...
  11. pmc Dysregulation of ezrin phosphorylation prevents metastasis and alters cellular metabolism in osteosarcoma
    Ling Ren
    Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Res 72:1001-12. 2012
    ....
  12. pmc Inhibition of AP-1 transcriptional activity blocks the migration, invasion, and experimental metastasis of murine osteosarcoma
    Virna D Leaner
    Cell and Cancer Biology Department, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Pathol 174:265-75. 2009
    ..This study shows that differences in metastatic activity can be due to AP-1 activation. The inhibition of AP-1 activity may serve as a therapeutic tool in the management of osteosarcoma...
  13. ncbi request reprint Cooperative activity of cytotoxic chemotherapy with antiangiogenic thrombospondin-I peptides, ABT-526 in pet dogs with relapsed lymphoma
    Anthony Rusk
    Animal Clinical Investigation, LLC, Bethesda, Maryland, USA
    Clin Cancer Res 12:7456-64. 2006
    ..To further assist in the development of ABT-526, we report herein on its evaluation in combination with cytotoxic chemotherapy in pet dogs with relapsed non-Hodgkin's lymphoma (NHL)...
  14. pmc Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening
    Patrick J Grohar
    Molecular Oncology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Dr MSC 1104, 10 CRC 1W 3816, Bethesda, MD 20892 1104, USA
    J Natl Cancer Inst 103:962-78. 2011
    ....
  15. pmc Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases
    Su Young Kim
    Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Exp Metastasis 25:201-11. 2008
    ..Our findings show that inhibition of the CXCR4/CXCL12 pathway decreases metastatic disease in two murine tumor models and expands on previous reports to describe potential mechanisms of action...
  16. pmc CCI-779 inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism linked to the targeting of mTOR/Hif-1alpha/VEGF signaling
    Xiaolin Wan
    Molecular Oncology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1928, USA
    Neoplasia 8:394-401. 2006
    ..Together, these data suggest that CCI-779 inhibits human RMS xenograft growth by an antiangiogenic mechanism associated with the targeting of mTOR/Hif-1alpha/VEGF signaling...
  17. pmc The ezrin metastatic phenotype is associated with the initiation of protein translation
    Joseph W Briggs
    Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Neoplasia 14:297-310. 2012
    ..Taken together, these results provide a novel mechanistic basis by which Ezrin may contribute to metastasis...
  18. pmc Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression
    Melissa Paoloni
    Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Genomics 10:625. 2009
    ....
  19. ncbi request reprint STEALTH liposome-encapsulated cisplatin (SPI-77) versus carboplatin as adjuvant therapy for spontaneously arising osteosarcoma (OSA) in the dog: a randomized multicenter clinical trial
    David M Vail
    The Comprehensive Cancer Center, University of Wisconsin Madison, Madison, WI 53706, USA
    Cancer Chemother Pharmacol 50:131-6. 2002
    ..This trial was designed to compare the efficacy of adjuvant STEALH liposome-encapsulated cisplatin (SPI-77) to "standard-of-care" carboplatin therapy in dogs with osteosarcoma (OSA) in the context of a randomized study design...
  20. pmc Addiction to elevated insulin-like growth factor I receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody
    Liang Cao
    Genetics Branch, Center for Cancer Research, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 4265, USA
    Cancer Res 68:8039-48. 2008
    ..Subsequent progression of tumors was associated with reactivation of p-AKT despite sustained suppression of IGF-IR. These results identified the first predictive biomarker for anti-IGF-IR therapies in cancer...
  21. ncbi request reprint Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma
    Xiaolin Wan
    Molecular Oncology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892 1106, USA
    Cancer Res 65:2406-11. 2005
    ..These results suggest that blocking the mTOR/S6K1/4E-BP1 pathway may be an appropriate target for strategies to reduce tumor cell metastasis...
  22. pmc A compendium of canine normal tissue gene expression
    Joseph Briggs
    Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e17107. 2011
    ..Accordingly, we now present the first genome-wide, canine normal tissue gene expression compendium with corresponding human cross-species analysis...
  23. pmc Modeling metastasis biology and therapy in real time in the mouse lung
    Arnulfo Mendoza
    Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 120:2979-88. 2010
    ..We believe that this assay system is uniquely capable of advancing our understanding of both metastasis biology and therapeutic strategies...
  24. pmc Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models
    James G Taylor
    Pulmonary and Vascular Medicine Branch, National Heart, Lung, and Blood Institute NHLBI, NIH, Bethesda, Maryland 20892 4605, USA
    J Clin Invest 119:3395-407. 2009
    ..These findings support the potential therapeutic targeting of FGFR4 in RMS...
  25. ncbi request reprint Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators
    Yanlin Yu
    Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 10:175-81. 2004
    ..The identification of ezrin and Six-1 as critical regulators of metastasis in RMS provides new mechanistic and therapeutic insights into this pediatric cancer...
  26. pmc Apoptosis resistance and PKC signaling: distinguishing features of high and low metastatic cells
    Sung Hyeok Hong
    Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Neoplasia 14:249-58. 2012
    ..The connection to PKC activation may provide a biologic rationale for the use of PKC inhibition in the prevention of metastatic progression...
  27. pmc Rapamycin pharmacokinetic and pharmacodynamic relationships in osteosarcoma: a comparative oncology study in dogs
    Melissa C Paoloni
    Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    PLoS ONE 5:e11013. 2010
    ....
  28. ncbi request reprint Nm23-H1 suppresses metastasis by inhibiting expression of the lysophosphatidic acid receptor EDG2
    Christine E Horak
    Women s Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Res 67:11751-9. 2007
    ..73; P = 0.004). The data indicate that Nm23-H1 down-regulation of EDG2 is functionally important to suppression of tumor metastasis...
  29. ncbi request reprint Immune reconstitution prevents metastatic recurrence of murine osteosarcoma
    Melinda S Merchant
    Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Cancer Immunol Immunother 56:1037-46. 2007
    ..The results further suggest that T cell depleting cancer therapies may eliminate beneficial immune responses and that immune reconstitution of lymphopenic cancer patients could prevent metastatic recurrence of solid tumors...
  30. ncbi request reprint Ezrin mediates growth and survival in Ewing's sarcoma through the AKT/mTOR, but not the MAPK, signaling pathway
    Kartik Krishnan
    Molecular Oncology Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 1 3816, 10 Center Drive, Bethesda, MD 20892, USA
    Clin Exp Metastasis 23:227-36. 2006
    ..These results, therefore, demonstrate that, in Ewing's sarcoma, the biology of ezrin is distinct from that described in other sarcomas. This study further validates ezrin as a potential therapeutic target...
  31. ncbi request reprint The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation
    Yien Che Tsai
    Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA
    Nat Med 13:1504-9. 2007
    ....
  32. pmc Inhibition of tumor cell motility by the interferon-inducible GTPase MxA
    J Frederic Mushinski
    Laboratory of Cancer Biology and Genetics, Medical Oncology Branch, Pediatric Oncology Branch, and Urologic Oncology Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 284:15206-14. 2009
    ..These data demonstrate that MxA inhibits tumor cell motility and invasion, and that MxA expression can be induced by small molecules, potentially offering a new approach to the prevention and treatment of metastasis...
  33. pmc Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton
    Dalit Barkan
    Laboratory of Cell Biology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 68:6241-50. 2008
    ..Targeting this process may provide therapeutic strategies for inhibition of the dormant-to-proliferative metastatic switch...
  34. pmc Evaluation of eIF4E expression in an osteosarcoma-specific tissue microarray
    Tanasa S Osborne
    Tumor and Metastasis Biology Section, Pediatric Oncology Branch, National Institutes of Health, Bethesda, MD 20892, USA
    J Pediatr Hematol Oncol 33:524-8. 2011
    ..We found that eIF4E was uniformly expressed in OS patient samples. No association was found between eIF4E and outcome in OS patients. This novel OS TMA provided a facile mechanism to assess the role of a relevant protein biomarker in OS...
  35. pmc Ecteinascidin 743 interferes with the activity of EWS-FLI1 in Ewing sarcoma cells
    Patrick J Grohar
    Molecular Oncology Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1928, USA
    Neoplasia 13:145-53. 2011
    ..In addition, the modulation of EWS-FLI1 makes it a novel targeting agent for ESFT and suggests that further development of this compound for the treatment of ESFT is warranted...
  36. pmc Launching a novel preclinical infrastructure: comparative oncology trials consortium directed therapeutic targeting of TNFalpha to cancer vasculature
    Melissa C Paoloni
    Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    PLoS ONE 4:e4972. 2009
    ..Large animal spontaneous cancer models can be a valuable addition to successful studies of cancer biology and novel therapeutic drug, imaging and device development...
  37. pmc Alterations in Gemin5 expression contribute to alternative mRNA splicing patterns and tumor cell motility
    Jong Heun Lee
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Cancer Res 68:639-44. 2008
    ..The data also show that changes in mRNA splicing patterns accompany metastatic progression, which may contribute to proteome instability...
  38. ncbi request reprint CD1d-restricted natural killer T cells can down-regulate tumor immunosurveillance independent of interleukin-4 receptor-signal transducer and activator of transcription 6 or transforming growth factor-beta
    Masaki Terabe
    Vaccine Branch and Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH Bldg 10 Rm 6B12, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Cancer Res 66:3869-75. 2006
    ..These data suggest that a novel CD1d-restricted NKT cell-mediated mechanism for tumor immunosuppression is active in the K7M2 osteosarcoma model and that NKT cells can regulate immunosurveillance through more than one pathway...
  39. ncbi request reprint Credentialing preclinical pediatric xenograft models using gene expression and tissue microarray analysis
    Craig C Whiteford
    Oncogenomics Section, Comparative Oncology Program, and Cell and Molecular Biology Section, Pediatric Oncology Branch
    Cancer Res 67:32-40. 2007
    ..The database will facilitate the identification of tumor markers predictive of response to tested agents as well as the discovery of new molecular targets...
  40. ncbi request reprint Preclinical evaluation of antiangiogenic thrombospondin-1 peptide mimetics, ABT-526 and ABT-510, in companion dogs with naturally occurring cancers
    Anthony Rusk
    Animal Clinical Investigation, LLC, Columbia, Maryland, USA
    Clin Cancer Res 12:7444-55. 2006
    ..To guide the clinical development of these drugs, translational studies in dogs with naturally occurring cancers were initiated...
  41. doi request reprint Translation of new cancer treatments from pet dogs to humans
    Melissa Paoloni
    Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, 37 Convent Drive, Room 2144, Bethesda, Maryland 20892, USA
    Nat Rev Cancer 8:147-56. 2008
    ....
  42. ncbi request reprint MS-27-275, an inhibitor of histone deacetylase, has marked in vitro and in vivo antitumor activity against pediatric solid tumors
    Jerry Jaboin
    Cell and Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Res 62:6108-15. 2002
    ..Using xenograft orthotopic models of US, EWS, and neuroblastoma, we find that the growth of established tumors is inhibited in mice treated with MS-275...
  43. ncbi request reprint The molecular biology of pulmonary metastasis
    Kartik Krishnan
    Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10 CRC Room 1 3816, Bethesda, MD 20892, USA
    Thorac Surg Clin 16:115-24. 2006
    ..Clearly, therefore, a synthesis of different technologies and complimentary information will be required to target metastases and improve the outcome for patients affected by them...
  44. doi request reprint Genome-wide association study identifies two susceptibility loci for osteosarcoma
    Sharon A Savage
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, MD, USA
    Nat Genet 45:799-803. 2013
    ..2 (rs7591996 and rs10208273; P = 1.0 × 10⁻⁸ and 2.9 × 10⁻⁷, respectively). These two loci warrant further exploration to uncover the biological mechanisms underlying susceptibility to osteosarcoma...
  45. pmc Nitric oxide synthase and breast cancer: role of TIMP-1 in NO-mediated Akt activation
    Lisa A Ridnour
    Radiation Biology Branch, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 7:e44081. 2012
    ..In summary, our findings suggest that tumors with high TIMP-1 and NOS2 behave more aggressively by mechanisms that favor Akt pathway activation...
  46. pmc Core biopsies can be used to distinguish differences in expression profiling by cDNA microarrays
    Christos Sotiriou
    Medicine Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Gaithersburg, Maryland, USA
    J Mol Diagn 4:30-6. 2002
    ..Pooling the core biopsies did not improve the concordance with excisional biopsies. In conclusion, our results suggest that core biopsies can be used as a suitable and reliable material for the determination of tumor genetic profiles...
  47. ncbi request reprint Expression of the cytoskeleton linker protein ezrin in human cancers
    Benjamin Bruce
    Tumor and Metastasis Biology Section, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Clin Exp Metastasis 24:69-78. 2007
    ....
  48. ncbi request reprint Modeling opportunities in comparative oncology for drug development
    Ira K Gordon
    NCI Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA
    ILAR J 51:214-20. 2010
    ....
  49. pmc Comparative oncology today
    Melissa C Paoloni
    Comparative Oncology Program, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 2144, Bethesda, MD 20892, USA
    Vet Clin North Am Small Anim Pract 37:1023-32; v. 2007
    ..The state of the comparative oncology field is outlined in this article, with an emphasis on cancer in dogs...
  50. ncbi request reprint Cancers as wounds that do not heal: differences and similarities between renal regeneration/repair and renal cell carcinoma
    Joseph Riss
    Laboratory of Biosystems and Cancer, Comparative Oncology Program, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 66:7216-24. 2006
    ..The observations reported here provide a conceptual framework for further efforts to understand the biology and to develop more effective diagnostic biomarkers and therapeutic strategies for renal tumors and renal ischemia...
  51. ncbi request reprint The biology of metastases in pediatric sarcomas
    Kartik Krishnan
    Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer J 11:306-13. 2005
    ..Finally, we discuss progress being made in our ability to study metastases and expectations for the future...
  52. ncbi request reprint Fishing for the origins of cancer
    Glenn Merlino
    Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 21:1275-9. 2007
  53. pmc A novel noninvasive method for evaluating experimental lung metastasis in mice
    Arnulfo Mendoza
    Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Am Assoc Lab Anim Sci 52:584-9. 2013
    ..PAAM is a simple, reproducible, and efficient method to assist in the detection of advanced pulmonary metastasis in mice and contributes to their humane care during longitudinal studies. ..
  54. doi request reprint Revisiting the seed and soil in cancer metastasis
    Martin Mendoza
    Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892, USA
    Int J Biochem Cell Biol 41:1452-62. 2009
    ..e. seed) and its microenvironment (i.e. soil). We will provide background to suggest that a critical outcome of the seed-soil interaction is resistance of the stresses that would otherwise impede metastasis...
  55. ncbi request reprint Tumor expression of 4-1BB ligand sustains tumor lytic T cells
    Hua Zhang
    National Cancer Institute Bethesda, Maryland USA
    Cancer Biol Ther 2:579-86. 2003
    ..They further demonstrate a potential new therapeutic role for 4-1BBL mediated costimulation in expanding tumor reactive CTLs for use in the adoptive immunotherapy of cancer...
  56. ncbi request reprint Biology of childhood osteogenic sarcoma and potential targets for therapeutic development: meeting summary
    Richard Gorlick
    Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Clin Cancer Res 9:5442-53. 2003
    ..This report summarizes the information presented and discussed by the meeting participants...
  57. ncbi request reprint The dog as a cancer model
    Chand Khanna
    Nat Biotechnol 24:1065-6. 2006
  58. ncbi request reprint Corruption of the Fas pathway delays the pulmonary clearance of murine osteosarcoma cells, enhances their metastatic potential, and reduces the effect of aerosol gemcitabine
    Nancy Gordon
    Children s Cancer Hospital, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 13:4503-10. 2007
    ..The purpose of these studies was to evaluate Fas expression in osteosarcoma lung metastases and the effect of gemcitabine on Fas expression and tumor growth...
  59. ncbi request reprint Fas-negative osteosarcoma tumor cells are selected during metastasis to the lungs: the role of the Fas pathway in the metastatic process of osteosarcoma
    Nadezhda V Koshkina
    Division of Pediatrics Research, Unit 853, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Res 5:991-9. 2007
    ..Therefore, Fas may be considered as a new therapeutic target for osteosarcoma treatment...
  60. pmc Immune synapse formation requires ZAP-70 recruitment by ezrin and CD43 removal by moesin
    Tal Ilani
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    J Cell Biol 179:733-46. 2007
    ..In contrast, moesin dephosphorylation and removal, along with CD43, are necessary to prepare a region of the cell cortex for IS. Thus, ezrin and moesin have distinct and critical functions in the T cell cortex during IS formation...
  61. ncbi request reprint Results of a phase II clinical trial on the use of ifosfamide for treatment of cats with vaccine-associated sarcomas
    Kenneth M Rassnick
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Am J Vet Res 67:517-23. 2006
    ..To determine clinical activity and toxic effects of ifosfamide when used to treat cats with vaccine-associated sarcoma (VAS)...
  62. ncbi request reprint Single agent gemcitabine chemotherapy in dogs with spontaneously occurring lymphoma
    Avenelle I Turner
    Gulf Coast Veterinary Oncology, Houston, TX, USA
    J Vet Intern Med 20:1384-8. 2006
    ..Its use in veterinary medicine has been limited and to date this drug has not been used as a first-line therapy in dogs with lymphoma...
  63. ncbi request reprint Preclinical studies of treosulfan demonstrate potent activity in Ewing's sarcoma
    Sebastian Werner
    Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Albert Ludwigs University, Mathildenstr 1, 79106, Freiburg, Germany
    Cancer Chemother Pharmacol 62:19-31. 2008
    ..Furthermore, the anti-tumor effect of treosulfan was studied in an orthotopic Ewing's sarcoma mouse xenograft model...