C Khanna

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint An orthotopic model of murine osteosarcoma with clonally related variants differing in pulmonary metastatic potential
    C Khanna
    Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Clin Exp Metastasis 18:261-71. 2000
  2. doi request reprint Protein kinase C regulates ezrin-radixin-moesin phosphorylation in canine osteosarcoma cells
    S H Hong
    Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Vet Comp Oncol 9:207-18. 2011
  3. doi request reprint The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC
    L Ren
    Tumor and Metastasis Biology Section, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Oncogene 28:792-802. 2009
  4. ncbi request reprint Metastasis-associated differences in gene expression in a murine model of osteosarcoma
    C Khanna
    Pediatric Oncology, National Cancer Institute, and Cancer Genetics Branch, Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 61:3750-9. 2001
  5. pmc Beta4 integrin promotes osteosarcoma metastasis and interacts with ezrin
    X Wan
    Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 1928, USA
    Oncogene 28:3401-11. 2009
  6. pmc A review of the association between osteosarcoma metastasis and protein translation
    T S Osborne
    Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    J Comp Pathol 146:132-42. 2012
  7. ncbi request reprint Hypomagnesemia in 188 dogs: a hospital population-based prevalence study
    C Khanna
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, USA
    J Vet Intern Med 12:304-9. 1998
  8. doi request reprint Loss-of-function screen in rhabdomyosarcoma identifies CRKL-YES as a critical signal for tumor growth
    C L Yeung
    Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Oncogene 32:5429-38. 2013
  9. ncbi request reprint Spontaneous and genetically engineered animal models; use in preclinical cancer drug development
    K Hansen
    Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA
    Eur J Cancer 40:858-80. 2004

Collaborators

Detail Information

Publications9

  1. ncbi request reprint An orthotopic model of murine osteosarcoma with clonally related variants differing in pulmonary metastatic potential
    C Khanna
    Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Clin Exp Metastasis 18:261-71. 2000
    ..This well characterized and relevant model of OSA will be a valuable resource to improve our understanding of the biology and treatment of metastasis in OSA...
  2. doi request reprint Protein kinase C regulates ezrin-radixin-moesin phosphorylation in canine osteosarcoma cells
    S H Hong
    Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Vet Comp Oncol 9:207-18. 2011
    ..Finally, both ezrin phosphorylation and cell migration were inhibited using a PKC inhibitor. These data suggest that an association between PKC-mediated activation of ezrin and the metastatic phenotype in canine OS cells...
  3. doi request reprint The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC
    L Ren
    Tumor and Metastasis Biology Section, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Oncogene 28:792-802. 2009
    ..These data are the first to suggest a dynamic regulation of ezrin phosphorylation during metastasis and to connect the PKC family members with this regulation...
  4. ncbi request reprint Metastasis-associated differences in gene expression in a murine model of osteosarcoma
    C Khanna
    Pediatric Oncology, National Cancer Institute, and Cancer Genetics Branch, Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 61:3750-9. 2001
    ..This work represents a rationale approach to the evaluation of microarray data and will be useful to identify genes that may be causally associated with metastasis...
  5. pmc Beta4 integrin promotes osteosarcoma metastasis and interacts with ezrin
    X Wan
    Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 1928, USA
    Oncogene 28:3401-11. 2009
    ..These data begin to integrate ezrin and beta4 integrin expression into a model of action for the mechanism of osteosarcoma metastases...
  6. pmc A review of the association between osteosarcoma metastasis and protein translation
    T S Osborne
    Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    J Comp Pathol 146:132-42. 2012
    ..A comparative perspective on the problem of OS metastasis that utilizes a cross-species approach may offer unique opportunities to assist in this prioritization and generate new hypotheses related to this important clinical problem...
  7. ncbi request reprint Hypomagnesemia in 188 dogs: a hospital population-based prevalence study
    C Khanna
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, USA
    J Vet Intern Med 12:304-9. 1998
    ..9), a diagnosis of cardiovascular disease (P < .02; OR = 1.9); and being a Collie (P < .02; OR = 3.9) or German Shepherd Dog (P < .002; OR = 2.2). These results can be used to better understand and predict hypomagnesemia in dogs...
  8. doi request reprint Loss-of-function screen in rhabdomyosarcoma identifies CRKL-YES as a critical signal for tumor growth
    C L Yeung
    Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Oncogene 32:5429-38. 2013
    ..This study also demonstrates the use of functional screening to identify a potentially novel therapeutic target and treatment approach for these highly aggressive pediatric cancers. ..
  9. ncbi request reprint Spontaneous and genetically engineered animal models; use in preclinical cancer drug development
    K Hansen
    Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA
    Eur J Cancer 40:858-80. 2004
    ..Examples of their successful use and an outline of their relative strengths and weaknesses will be provided...