B Kelsall

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Dendritic cells at the host-pathogen interface
    Brian L Kelsall
    Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Nat Immunol 3:699-702. 2002
  2. doi request reprint Recent progress in understanding the phenotype and function of intestinal dendritic cells and macrophages
    B Kelsall
    Mucosal Immunobiology Section, Laboratory of Molecular Immunology, NIAID NIH, Bethesda, Maryland, USA
    Mucosal Immunol 1:460-9. 2008
  3. pmc Cholera toxin inhibits IL-12 production and CD8alpha+ dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function
    Andrea la Sala
    Laboratory of Molecular and Cellular Immunology, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele, 00163 Rome, Italy
    J Exp Med 206:1227-35. 2009
  4. pmc Primary role for Gi protein signaling in the regulation of interleukin 12 production and the induction of T helper cell type 1 responses
    J He
    Immune Cell Interaction Unit, Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 191:1605-10. 2000
  5. ncbi request reprint Innate and adaptive mechanisms to control [corrected] pathological intestinal inflammation
    B L Kelsall
    Mucosal Immunobiology Section, Laboratory of Molecular Immunology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1886, USA
    J Pathol 214:242-59. 2008
  6. ncbi request reprint Involvement of intestinal dendritic cells in oral tolerance, immunity to pathogens, and inflammatory bowel disease
    Brian L Kelsall
    Mucosal Immunobiology Section, Laboratory of Molecular Immunology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Rev 206:132-48. 2005
  7. ncbi request reprint Mucosal dendritic cells in immunity and inflammation
    Brian L Kelsall
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 5:1091-5. 2004
  8. ncbi request reprint Interleukin-12 production by dendritic cells. The role of CD40-CD40L interactions in Th1 T-cell responses
    B L Kelsall
    Mucosal Immunity Section, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 795:116-26. 1996
  9. pmc Differences in time of virus appearance in the blood and virus-specific immune responses in intravenous and intrarectal primary SIVmac251 infection of rhesus macaques; a pilot study
    L Stevceva
    Basic Research Laboratory, National Cancer Institute, 41 D804, Bethesda, Maryland, 20892, USA
    BMC Infect Dis 1:9. 2001
  10. ncbi request reprint Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of macaques
    I M Belyakov
    Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, Bethesda, Maryland, USA
    Nat Med 7:1320-6. 2001

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Dendritic cells at the host-pathogen interface
    Brian L Kelsall
    Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Nat Immunol 3:699-702. 2002
  2. doi request reprint Recent progress in understanding the phenotype and function of intestinal dendritic cells and macrophages
    B Kelsall
    Mucosal Immunobiology Section, Laboratory of Molecular Immunology, NIAID NIH, Bethesda, Maryland, USA
    Mucosal Immunol 1:460-9. 2008
    ..It will also address the unique phenotype of intestinal macrophages and briefly what is known regarding the relationships between these cell types...
  3. pmc Cholera toxin inhibits IL-12 production and CD8alpha+ dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function
    Andrea la Sala
    Laboratory of Molecular and Cellular Immunology, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele, 00163 Rome, Italy
    J Exp Med 206:1227-35. 2009
    ....
  4. pmc Primary role for Gi protein signaling in the regulation of interleukin 12 production and the induction of T helper cell type 1 responses
    J He
    Immune Cell Interaction Unit, Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 191:1605-10. 2000
    ..Further, healing was prevented by coadministration of anti-IL-12 and PT. These data demonstrate that endogenous Gi protein signaling has a primary role in the regulation of IL-12 production and the induction of Th1 responses in vivo...
  5. ncbi request reprint Innate and adaptive mechanisms to control [corrected] pathological intestinal inflammation
    B L Kelsall
    Mucosal Immunobiology Section, Laboratory of Molecular Immunology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1886, USA
    J Pathol 214:242-59. 2008
    ....
  6. ncbi request reprint Involvement of intestinal dendritic cells in oral tolerance, immunity to pathogens, and inflammatory bowel disease
    Brian L Kelsall
    Mucosal Immunobiology Section, Laboratory of Molecular Immunology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Rev 206:132-48. 2005
    ..In this review, a brief discussion of general issues of DC biology that are pertinent to mucosal immunity is followed by a more in-depth discussion of the phenotype and function of DC populations in the intestine...
  7. ncbi request reprint Mucosal dendritic cells in immunity and inflammation
    Brian L Kelsall
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 5:1091-5. 2004
  8. ncbi request reprint Interleukin-12 production by dendritic cells. The role of CD40-CD40L interactions in Th1 T-cell responses
    B L Kelsall
    Mucosal Immunity Section, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 795:116-26. 1996
    ....
  9. pmc Differences in time of virus appearance in the blood and virus-specific immune responses in intravenous and intrarectal primary SIVmac251 infection of rhesus macaques; a pilot study
    L Stevceva
    Basic Research Laboratory, National Cancer Institute, 41 D804, Bethesda, Maryland, 20892, USA
    BMC Infect Dis 1:9. 2001
    ..Here we performed a pilot study in the SIVmac251 macaque model to address whether the route of viral entry influences the kinetics of the appearance and the size of virus-specific immune in different tissue compartments...
  10. ncbi request reprint Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of macaques
    I M Belyakov
    Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, Bethesda, Maryland, USA
    Nat Med 7:1320-6. 2001
    ..Moreover, CD4+ T cells were better preserved. Thus, induction of CTLs in the intestinal mucosa, a key site of virus replication, with a mucosal AIDS vaccine ameliorates infection by SHIV in non-human primates...
  11. ncbi request reprint Reciprocal IFN-gamma and TGF-beta responses regulate the occurrence of mucosal inflammation
    W Strober
    Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Immunol Today 18:61-4. 1997
    ..Interventions that artificially bring the excessive Th1-cell response back into balance, such as administration of IL-12 antagonists, should therefore find a central place in the treatment of the disease...
  12. ncbi request reprint Phenotype and function of intestinal dendritic cells
    Cecilia Johansson
    Laboratory of Molecular Immunology, NIAID, NIH, 10 Center Drive, 10 11N214, Bethesda, 20892 MD, USA
    Semin Immunol 17:284-94. 2005
    ..While early in our understanding, knowledge about the involvement of DC subpopulations in the regulation of mucosal immunity may well provide a basis for the development of novel vaccines and therapeutics...
  13. ncbi request reprint Factors involved in the differentiation of TGF-beta-producing cells from naive CD4+ T cells: IL-4 and IFN-gamma have opposing effects, while TGF-beta positively regulates its own production
    R A Seder
    Lymphokine Regulation Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 160:5719-28. 1998
    ..Finally, the addition of exogenous TGF-beta to priming cultures significantly enhanced the production of TGF-beta upon restimulation, demonstrating that TGF-beta has a role in self-regulating its own production...
  14. pmc Peyer's patch dendritic cells process viral antigen from apoptotic epithelial cells in the intestine of reovirus-infected mice
    Marina N Fleeton
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N228, Bethesda, MD 20892, USA
    J Exp Med 200:235-45. 2004
    ....
  15. pmc Impairment of Gag-specific CD8(+) T-cell function in mucosal and systemic compartments of simian immunodeficiency virus mac251- and simian-human immunodeficiency virus KU2-infected macaques
    Z Hel
    Basic Research Laboratory, Bethesda, Maryland 20892, USA
    J Virol 75:11483-95. 2001
    ..The data obtained in this pilot study lead to the hypothesis that disease progression may be associated with loss of virus-specific CD8(+) T-cell function...
  16. pmc Successful granulocyte-colony stimulating factor treatment of Crohn's disease is associated with the appearance of circulating interleukin-10-producing T cells and increased lamina propria plasmacytoid dendritic cells
    P J Mannon
    Mucosal Immunity Section, Laboratory of Host Defense, NIAID, NIH, Bethesda, MD, USA
    Clin Exp Immunol 155:447-56. 2009
    ....
  17. ncbi request reprint Cutting edge: Peyer's patch plasmacytoid dendritic cells (pDCs) produce low levels of type I interferons: possible role for IL-10, TGFbeta, and prostaglandin E2 in conditioning a unique mucosal pDC phenotype
    Nikhat Contractor
    Mucosal Immunobiology Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 179:2690-4. 2007
    ..In the intestine, this may be beneficial in preventing harmful innate and adaptive immune responses to commensal microorganisms...
  18. pmc Type I interferons produced by hematopoietic cells protect mice against lethal infection by mammalian reovirus
    Cecilia Johansson
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:1349-58. 2007
    ..Therefore, innate immunity in PPs is an essential component of host defense that limits systemic spread of pathogens that infect the intestinal mucosa...
  19. doi request reprint CCR6 marks regulatory T cells as a colon-tropic, IL-10-producing phenotype
    Kazuya Kitamura
    Mucosal Immunobiology Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 185:3295-304. 2010
    ..CCR6 may contribute to the regulation of colitis by directing its function in Ag-specific, IL-10-producing iTreg cells to the inflamed colon...
  20. ncbi request reprint Dendritic cells in germ-free and specific pathogen-free mice have similar phenotypes and in vitro antigen presenting function
    Kristen L W Walton
    Department of Medicine, CB 7032, 7317 MBRB, University of North Carolina, Chapel Hill, NC 27599 7032, USA
    Immunol Lett 102:16-24. 2006
    ..In addition, splenic APC from GF mice are fully competent to stimulate naïve T-cell proliferation in vitro...
  21. pmc Cholera toxin induces migration of dendritic cells from the subepithelial dome region to T- and B-cell areas of Peyer's patches
    Vijay K Shreedhar
    GI Cell Biology Laboratory, Children s Hospital, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 71:504-9. 2003
    ..Our data provide the first demonstration that DCs move in response to enterotoxin adjuvants and live bacteria that enter the mucosa via M cells...
  22. ncbi request reprint Affecting the effectors: a kick in the gut?
    Cecilia Johansson
    Nat Immunol 6:644-6. 2005