F J Kaye

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch
    F J Kaye
    Medicine Branch, Division of Clinical Sciences, National Cancer Institute and National Naval Medical Center, Bethesda, MD, USA
    FEBS Lett 467:348-55. 2000
  2. ncbi Mect1-Maml2 fusion oncogene linked to the aberrant activation of cyclic AMP/CREB regulated genes
    Amy Coxon
    Genetics Branch and Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute and the National Naval Medical Center, Bethesda, Maryland 20889, USA
    Cancer Res 65:7137-44. 2005
  3. pmc A study of MECT1-MAML2 in mucoepidermoid carcinoma and Warthin's tumor of salivary glands
    Carmo Martins
    Departamento de Patologia Morfologica, Instituto Portugues de Oncologia, Rua Prof Lima Basto, 1099 023 Lisboa, Portugal
    J Mol Diagn 6:205-10. 2004
  4. ncbi Emerging biology of malignant salivary gland tumors offers new insights into the classification and treatment of mucoepidermoid cancer
    Frederic J Kaye
    Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Clin Cancer Res 12:3878-81. 2006
  5. ncbi RB and cyclin dependent kinase pathways: defining a distinction between RB and p16 loss in lung cancer
    Frederic J Kaye
    Genetics Branch, Center for Cancer Research, NCI, NIH and National Naval Medical Center, Bethesda, Maryland 20889, USA
    Oncogene 21:6908-14. 2002
  6. doi Enhanced activity of the CREB co-activator Crtc1 in LKB1 null lung cancer
    T Komiya
    Genetics Branch, National Cancer Institute and National Naval Medical Center, Bethesda, MD, USA
    Oncogene 29:1672-80. 2010
  7. ncbi Partial inactivation of the RB product in a family with incomplete penetrance of familial retinoblastoma and benign retinal tumors
    R A Kratzke
    NCI Navy Medical Oncology Branch, Bethesda, Maryland
    Oncogene 9:1321-6. 1994
  8. ncbi RET cooperates with RB/p53 inactivation in a somatic multi-step model for murine thyroid cancer
    A B Coxon
    Department of Genetics, National Cancer Institute and National Naval Medical Center, Bethesda, Maryland 20889, USA
    Oncogene 17:1625-8. 1998
  9. ncbi Assignment of ubiquilin2 (UBQLN2) to human chromosome xp11. 23-->p11.1 by GeneBridge radiation hybrids
    F J Kaye
    Medicine Branch, National Cancer Institute and National Naval Medical Center, Bethesda, MD 20889, USA
    Cytogenet Cell Genet 89:116-7. 2000
  10. ncbi Alternative splicing of the RBP1 gene clusters in an internal exon that encodes potential phosphorylation sites
    G A Otterson
    NCI Navy Oncology Branch, Bethesda, Maryland 20889
    Oncogene 8:949-57. 1993

Collaborators

Detail Information

Publications27

  1. ncbi A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch
    F J Kaye
    Medicine Branch, Division of Clinical Sciences, National Cancer Institute and National Naval Medical Center, Bethesda, MD, USA
    FEBS Lett 467:348-55. 2000
    ..These findings extend the association between Hsp70 members and genes encoding UbL sequences and suggest a broader role for the Hsp70-like ATPase family in regulating cell cycle and cell death events...
  2. ncbi Mect1-Maml2 fusion oncogene linked to the aberrant activation of cyclic AMP/CREB regulated genes
    Amy Coxon
    Genetics Branch and Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute and the National Naval Medical Center, Bethesda, Maryland 20889, USA
    Cancer Res 65:7137-44. 2005
    ....
  3. pmc A study of MECT1-MAML2 in mucoepidermoid carcinoma and Warthin's tumor of salivary glands
    Carmo Martins
    Departamento de Patologia Morfologica, Instituto Portugues de Oncologia, Rua Prof Lima Basto, 1099 023 Lisboa, Portugal
    J Mol Diagn 6:205-10. 2004
    ..We have demonstrated that ISH and RT-PCR are sensitive methods for detecting MECT1-MAML2 in MEC. In contrast, we did not detect the t(11;19) nor MECT1-MAML2 expression in seven cases of WT...
  4. ncbi Emerging biology of malignant salivary gland tumors offers new insights into the classification and treatment of mucoepidermoid cancer
    Frederic J Kaye
    Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Clin Cancer Res 12:3878-81. 2006
  5. ncbi RB and cyclin dependent kinase pathways: defining a distinction between RB and p16 loss in lung cancer
    Frederic J Kaye
    Genetics Branch, Center for Cancer Research, NCI, NIH and National Naval Medical Center, Bethesda, Maryland 20889, USA
    Oncogene 21:6908-14. 2002
    ....
  6. doi Enhanced activity of the CREB co-activator Crtc1 in LKB1 null lung cancer
    T Komiya
    Genetics Branch, National Cancer Institute and National Naval Medical Center, Bethesda, MD, USA
    Oncogene 29:1672-80. 2010
    ....
  7. ncbi Partial inactivation of the RB product in a family with incomplete penetrance of familial retinoblastoma and benign retinal tumors
    R A Kratzke
    NCI Navy Medical Oncology Branch, Bethesda, Maryland
    Oncogene 9:1321-6. 1994
    ....
  8. ncbi RET cooperates with RB/p53 inactivation in a somatic multi-step model for murine thyroid cancer
    A B Coxon
    Department of Genetics, National Cancer Institute and National Naval Medical Center, Bethesda, Maryland 20889, USA
    Oncogene 17:1625-8. 1998
    ....
  9. ncbi Assignment of ubiquilin2 (UBQLN2) to human chromosome xp11. 23-->p11.1 by GeneBridge radiation hybrids
    F J Kaye
    Medicine Branch, National Cancer Institute and National Naval Medical Center, Bethesda, MD 20889, USA
    Cytogenet Cell Genet 89:116-7. 2000
  10. ncbi Alternative splicing of the RBP1 gene clusters in an internal exon that encodes potential phosphorylation sites
    G A Otterson
    NCI Navy Oncology Branch, Bethesda, Maryland 20889
    Oncogene 8:949-57. 1993
    ..The RBP1 gene encodes a widely expressed 200-kDa nuclear protein and undergoes alternative splicing that predicts a family of RB-binding peptides...
  11. pmc Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity
    S N Khleif
    National Cancer Institute Navy Medical Oncology Branch, Bethesda, MD 20889, USA
    Proc Natl Acad Sci U S A 93:4350-4. 1996
    ....
  12. ncbi Sustained expression of Mect1-Maml2 is essential for tumor cell growth in salivary gland cancers carrying the t(11;19) translocation
    T Komiya
    Genetics Branch, Center for Cancer Research, National Cancer Institute and National Naval Medical Center, Bethesda, MD, USA
    Oncogene 25:6128-32. 2006
    ..Our data show that the 'gain-of-function' activity from aberrant Mect1-Maml2 expression is a candidate therapeutic target for this group of malignant salivary gland tumors...
  13. ncbi Transgenic expression of human thymidylate synthase accelerates the development of hyperplasia and tumors in the endocrine pancreas
    M Chen
    Molecular Therapeutics Program, Center for Cancer Research, Bethesda, MD, USA
    Oncogene 26:4817-24. 2007
    ....
  14. ncbi A 'core ATPase', Hsp70-like structure is conserved in human, rat, and C. elegans STCH proteins
    G A Otterson
    Genetics Department, NCI Navy Oncology, Naval Hospital, Bethesda, MD 20889, USA
    Gene 199:287-92. 1997
    ..The recognition that the truncated 'core ATPase' structure of the STCH molecule is conserved in human, rat, and C. elegans tissues suggests an important role for this unique member of the membrane-bound Hsp70 family...
  15. pmc Induction of Myc-intron-binding polypeptides MIBP1 and RFX1 during retinoic acid-mediated differentiation of haemopoietic cells
    M Zajac-Kaye
    Department of Developmental Therapeutics, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20889, USA
    Biochem J 345:535-41. 2000
    ..We also show that the time course of MIBP1 and RFX1 induction is inversely correlated with the down-regulation of c-myc levels during the treatment of HL60 cells with retinoic acid...
  16. ncbi Molecular biology of lung cancer
    F J Kaye
    Genetics Branch, Center for Cancer Research, National Cancer Institute Navy Oncology and National Naval Medical Center, Naval Hospital, Building 8 Room 5105, Bethesda, MD 20889, USA
    Lung Cancer 34:S35-41. 2001
    ..This review will briefly outline some of the tumor suppressor gene pathways that are known or suspected to play an important role in the development of this deadly malignancy...
  17. pmc Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein
    Y W Kim
    NCI Navy Medical Oncology Branch, National Cancer Institute, Bethesda, Maryland
    Mol Cell Biol 14:7256-64. 1994
    ....
  18. ncbi New leads suggest a clinically relevant genotype-phenotype relationship for the p53 gene
    Frederic J Kaye
    J Natl Cancer Inst 95:926-7. 2003
  19. ncbi t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway
    Giovanni Tonon
    Genetics Branch, Center for Cancer Research, National Cancer Institute and the National Naval Medical Center, Bethesda, Maryland 20889, USA
    Nat Genet 33:208-13. 2003
    ..These data suggest a new mechanism to disrupt the function of a Notch co-activator in a common type of malignant salivary gland tumor...
  20. ncbi Ritterazine B, a new cytotoxic natural compound, induces apoptosis in cancer cells
    Takefumi Komiya
    Division of Medical Oncology, Kinki University School of Medicine, 377 2 Ohnohigashi, 589 8511, Osakasayama City, Osaka, Japan
    Cancer Chemother Pharmacol 51:202-8. 2003
    ..The objective of this study was to determine the cytotoxicity of ritterazine B to non-small-cell lung cancer (NSCLC) cells in vitro and its effects on the cell cycle and apoptosis...
  21. ncbi A curious link between epidermal growth factor receptor amplification and survival: effect of "allele dilution" on gefitinib sensitivity?
    Frederic J Kaye
    J Natl Cancer Inst 97:621-3. 2005
  22. ncbi Multiple reciprocal translocations in salivary gland mucoepidermoid carcinomas
    Giovanni Tonon
    Genetics Branch, National Cancer Institute, NNMC, 8901 Wisconsin Avenue, Bldg 8, Room 5101, Bethesda, MD 20889 5105, USA
    Cancer Genet Cytogenet 152:15-22. 2004
    ..The presence of multiple reciprocal translocations in both benign and malignant salivary gland tumors may also suggest a particular mechanism within mucous or serous glands mediating chromosomal rearrangements...
  23. ncbi EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy
    J Guillermo Paez
    Departments of Medical Oncology and Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Science 304:1497-500. 2004
    ..These results suggest that EGFR mutations may predict sensitivity to gefitinib...
  24. ncbi For whom the bell tolls: susceptibility to common adult cancers in retinoblastoma survivors
    Frederic J Kaye
    J Natl Cancer Inst 96:342-3. 2004
  25. ncbi CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: implications for histogenesis and biologic behavior
    Yamilet Tirado
    Department of Pathology, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Genes Chromosomes Cancer 46:708-15. 2007
    ....
  26. doi CRTC1/MAML2 fusion transcript in Warthin's tumor and mucoepidermoid carcinoma: evidence for a common genetic association
    Diana Bell
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Genes Chromosomes Cancer 47:309-14. 2008
    ..This article contains Supplementary Material available at http://www.interscience.wiley.com/jpages/1045-2257/suppmat...
  27. ncbi Evolutionary conservation of a 2-kb intronic sequence flanking a tissue-specific alternative exon in the PTBP2 gene
    Lambratu Rahman
    Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Genomics 83:76-84. 2004
    ..The striking conservation of this large segment of flanking intronic sequence suggests an important role in tissue-specific splice site selection and may function in regulating the production of functional nPTB...