J L Katz

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint The validity of the reinstatement model of craving and relapse to drug use
    Jonathan L Katz
    Psychobiology Section, NIDA Addiction Research Center, NIH DHHS, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 168:21-30. 2003
  2. ncbi request reprint Behavioral effects of rimcazole analogues alone and in combination with cocaine
    Jonathan L Katz
    Department of Health and Human Services, Medications Discovery Research Branch, NIDA Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Eur J Pharmacol 468:109-19. 2003
  3. ncbi request reprint Cocaine-induced locomotor activity and cocaine discrimination in dopamine D4 receptor mutant mice
    Jonathan L Katz
    Medications Discovery Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA
    Psychopharmacology (Berl) 170:108-14. 2003
  4. ncbi request reprint Effects of N-substituted analogs of benztropine: diminished cocaine-like effects in dopamine transporter ligands
    Jonathan L Katz
    Psychobiology, Medications Discovery Research Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 309:650-60. 2004
  5. ncbi request reprint Discriminative stimulus effects of putative D3 dopamine receptor agonists in rats
    J L Katz
    Psychobiology Section, NIDA Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Behav Pharmacol 11:483-93. 2000
  6. ncbi request reprint Relationships among dopamine transporter affinities and cocaine-like discriminative-stimulus effects
    J L Katz
    Psychobiology Section, NIDA Intramural Research Program, National Institutes of Health, P O Box 5180, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 148:90-8. 2000
  7. ncbi request reprint Effects of dopamine D1-like receptor agonists on food-maintained operant behavior in rats
    Jonathan L Katz
    Psychobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    Behav Pharmacol 17:303-9. 2006
  8. ncbi request reprint Structure-activity relationships at monoamine transporters and muscarinic receptors for N-substituted-3alpha-(3'-chloro-, 4'-chloro-, and 4',4''-dichloro-substituted-diphenyl)methoxytropanes
    A H Newman
    Medicinal Chemistry and Psychobiology Sections, National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland 21224, USA
    J Med Chem 44:633-40. 2001
  9. ncbi request reprint Novel tropane-based irreversible ligands for the dopamine transporter
    M F Zou
    Medicinal Chemistry Section, National Institute on Drug Abuse-Intramural Research Program, Baltimore, Maryland 21131, USA
    J Med Chem 44:4453-61. 2001
  10. ncbi request reprint Dopamine transporter binding without cocaine-like behavioral effects: synthesis and evaluation of benztropine analogs alone and in combination with cocaine in rodents
    J L Katz
    Psychobiology Section, Medications Discovery Research Branch, NIDA Intramural Research Program, National Institutes of Health, P.O. Box 5180, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 154:362-74. 2001

Collaborators

Detail Information

Publications54

  1. ncbi request reprint The validity of the reinstatement model of craving and relapse to drug use
    Jonathan L Katz
    Psychobiology Section, NIDA Addiction Research Center, NIH DHHS, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 168:21-30. 2003
    ..The reinstatement procedure has been used increasingly as a laboratory model of craving and relapse to drug abuse. With the number of reports involving this procedure growing, its validity as a model of relapse merits discussion...
  2. ncbi request reprint Behavioral effects of rimcazole analogues alone and in combination with cocaine
    Jonathan L Katz
    Department of Health and Human Services, Medications Discovery Research Branch, NIDA Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Eur J Pharmacol 468:109-19. 2003
    ....
  3. ncbi request reprint Cocaine-induced locomotor activity and cocaine discrimination in dopamine D4 receptor mutant mice
    Jonathan L Katz
    Medications Discovery Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA
    Psychopharmacology (Berl) 170:108-14. 2003
    ..However, given the lack of selectivity of most of the available pharmacological tools among D(2), D(3) and D(4) dopamine receptors, the roles of these specific receptors remain unclear...
  4. ncbi request reprint Effects of N-substituted analogs of benztropine: diminished cocaine-like effects in dopamine transporter ligands
    Jonathan L Katz
    Psychobiology, Medications Discovery Research Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 309:650-60. 2004
    ..These compounds have reduced efficacy compared with cocaine, a long duration of action, and may serve as leads for the development of medications to treat cocaine abuse...
  5. ncbi request reprint Discriminative stimulus effects of putative D3 dopamine receptor agonists in rats
    J L Katz
    Psychobiology Section, NIDA Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Behav Pharmacol 11:483-93. 2000
    ..However, there were no data that clearly distinguished these training drugs from each other or from drugs acting through D2 dopaminergic mechanisms...
  6. ncbi request reprint Relationships among dopamine transporter affinities and cocaine-like discriminative-stimulus effects
    J L Katz
    Psychobiology Section, NIDA Intramural Research Program, National Institutes of Health, P O Box 5180, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 148:90-8. 2000
    ..The binding to the dopamine transporter by cocaine and many of its analogs has been reported to fit better using a two-site model than a one-site model...
  7. ncbi request reprint Effects of dopamine D1-like receptor agonists on food-maintained operant behavior in rats
    Jonathan L Katz
    Psychobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    Behav Pharmacol 17:303-9. 2006
    ....
  8. ncbi request reprint Structure-activity relationships at monoamine transporters and muscarinic receptors for N-substituted-3alpha-(3'-chloro-, 4'-chloro-, and 4',4''-dichloro-substituted-diphenyl)methoxytropanes
    A H Newman
    Medicinal Chemistry and Psychobiology Sections, National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland 21224, USA
    J Med Chem 44:633-40. 2001
    ....
  9. ncbi request reprint Novel tropane-based irreversible ligands for the dopamine transporter
    M F Zou
    Medicinal Chemistry Section, National Institute on Drug Abuse-Intramural Research Program, Baltimore, Maryland 21131, USA
    J Med Chem 44:4453-61. 2001
    ..These ligands will provide important tools for further characterizing the binding domains for tropane-based dopamine uptake inhibitors at the DAT...
  10. ncbi request reprint Dopamine transporter binding without cocaine-like behavioral effects: synthesis and evaluation of benztropine analogs alone and in combination with cocaine in rodents
    J L Katz
    Psychobiology Section, Medications Discovery Research Branch, NIDA Intramural Research Program, National Institutes of Health, P.O. Box 5180, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 154:362-74. 2001
    ..These compounds possess features such as reduced efficacy compared to cocaine and a long duration of action that may render them particularly useful leads for the development of therapeutics for cocaine abusers...
  11. ncbi request reprint Comparison of the discriminative-stimulus effects of SKF 38393 with those of other dopamine receptor agonists
    R I Desai
    Psychobiology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health DHHS, Baltimore, MD 21224, USA
    Behav Pharmacol 14:223-8. 2003
    ..The present results suggest that second messenger effects other than stimulation of adenylyl cyclase may play an important role in the behavioral effects of dopamine D(1)-like agonists...
  12. ncbi request reprint The role of D2-like dopamine receptors in the locomotor stimulant effects of cocaine in mice
    A L Chausmer
    Medications Discovery Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, P.O. Box 5180, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 155:69-77. 2001
    ..The present data suggest that D2-like receptors are involved in the mechanisms underlying the induction of locomotor activity by cocaine...
  13. ncbi request reprint [3-cis-3,5-Dimethyl-(1-piperazinyl)alkyl]-bis-(4'-fluorophenyl)amine analogues as novel probes for the dopamine transporter
    J Cao
    Medicinal Chemistry Section, National Institute on Drug Abuse - Intramural Research Program, Baltimore, MD 21224, USA
    Bioorg Med Chem Lett 11:3169-73. 2001
    ..Despite high-affinity binding at DAT, and structural similarity to GBR 12909, preliminary studies suggest 9b behaves more like rimcazole than GBR 12909 and does not demonstrate cocaine-like psychostimulant behavior in mice...
  14. ncbi request reprint Two types of bias in psychophysical detection and recognition procedures: nonparametric indices and effects of drugs
    J L Katz
    Preclinical Pharmacology Branch, NIDA Addiction Research Center, Baltimore, MD 21224
    Psychopharmacology (Berl) 97:202-5. 1989
    ..Finally, some representative drug effects are shown indicating that certain drugs may selectively affect the two types of bias...
  15. ncbi request reprint Effects of adenosine analogs alone and in combination with caffeine in the squirrel monkey
    J L Katz
    Preclinical Pharmacology Branch, NIDA Addiction Research Center, Baltimore, MD 21224
    Pharmacol Biochem Behav 29:429-32. 1988
    ..These results do not support the notion that increases in rates of behavior, e.g., psychomotor-stimulant effects, produced by caffeine are due to its antagonist actions at adenosine receptors...
  16. ncbi request reprint Transcriptional responses to reinforcing effects of cocaine in the rat hippocampus and cortex
    I N Krasnova
    Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, NIH DHHS, Baltimore, MD 21224, USA
    Genes Brain Behav 7:193-202. 2008
    ..Differences in the transcriptional responses in the hippocampus and cortex suggest the primary importance of the hippocampus for recent memory processing associated with cocaine-induced CPP...
  17. pmc Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors
    Takato Hiranita
    Psychobiology Section, Medications Discovery Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Suite 200, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 339:662-77. 2011
    ..These findings suggest that the unique effects of rimcazole analogs are due to dual actions at the DAT and σRs and that a combined target approach may have utility in development of medical treatments for cocaine abuse...
  18. pmc N-substituted benztropine analogs: selective dopamine transporter ligands with a fast onset of action and minimal cocaine-like behavioral effects
    Su min Li
    Sections, Medications Discovery Research Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Pharmacol Exp Ther 336:575-85. 2011
    ....
  19. ncbi request reprint N-8-Substituted benztropinamine analogs as selective dopamine transporter ligands
    Peter Grundt
    Medicinal Chemistry Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Bioorg Med Chem Lett 15:5419-23. 2005
    ..However, for certain N-8 substituted derivatives, selectivity over muscarinic M1 receptor affinity was reduced...
  20. pmc Comparative structure-activity relationships of benztropine analogues at the dopamine transporter and histamine H(1) receptors
    Santosh S Kulkarni
    Medicinal Chemistry Section, Intramural Research Program, National Institute on Drug Abuse, NIH, 5500, Nathan Shock Drive, Baltimore, MD 21224, USA
    Bioorg Med Chem 14:3625-34. 2006
    ..Molecular models at the DAT and the histamine H(1) receptor provide further insight into the structural requirements for binding affinity and selectivity that can be implemented in future drug design...
  21. ncbi request reprint Interactions of cocaine with dopamine uptake inhibitors or dopamine releasers in rats discriminating cocaine
    Su min Li
    Psychobiology Section, National Institute on Drug Abuse, Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 317:1088-96. 2006
    ....
  22. ncbi request reprint Assessment of the influence of histaminergic actions on cocaine-like effects of 3alpha-diphenylmethoxytropane analogs
    Vera C Campbell
    Psychobiology, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 315:631-40. 2005
    ....
  23. ncbi request reprint Relationship between in vivo occupancy at the dopamine transporter and behavioral effects of cocaine, GBR 12909 [1-{2-[bis-(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine], and benztropine analogs
    Rajeev I Desai
    Medication Discovery Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 315:397-404. 2005
    ..The present results suggest that among drugs that act at the DA transporter, the slower apparent rates of occupancy with the DA transporter by the BZT analogs may contribute in an important way to differences in their effectiveness...
  24. ncbi request reprint A comparison of the locomotor stimulant effects of D1-like receptor agonists in mice
    Rajeev I Desai
    Psychobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, P O Box 5180, Baltimore MD 21224, USA
    Pharmacol Biochem Behav 81:843-8. 2005
    ..The current classification of D1-like agonists according to their intrinsic efficacies as defined by AC stimulation needs further scrutiny...
  25. doi request reprint Cocaine-like neurochemical effects of antihistaminic medications
    Gianluigi Tanda
    Psychobiology Section, Medications Discovery Research Branch, Department of Health and Human Services, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurochem 106:147-57. 2008
    ....
  26. ncbi request reprint Structure-activity relationship studies on a novel series of (S)-2beta-substituted 3alpha-[bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane analogues for in vivo investigation
    Mu Fa Zou
    Medicinal Chemistry and Psychobiology Sections, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, DHHS, Baltimore, Maryland 21224, USA
    J Med Chem 49:6391-9. 2006
    ....
  27. ncbi request reprint Design and synthesis of a novel photoaffinity ligand for the dopamine and serotonin transporters based on 2beta-carbomethoxy-3beta-biphenyltropane
    Amy Hauck Newman
    Medicinal Chemistry and Psychobiology Sections, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health DHHS, Baltimore, MD, USA
    J Med Chem 49:6621-5. 2006
    ..Moreover, this compound showed moderate binding affinity for the serotonin transporter (SERT, K(i) = 109 +/- 14 nM), suggesting the potential utility of [(125)I]11 in both DAT and SERT protein structure studies...
  28. ncbi request reprint Investigation of the potential pharmacokinetic and pharmaco-dynamic drug interaction between AHN 1-055, a potent benztropine analog used for cocaine abuse, and cocaine after dosing in rats using intracerebral microdialysis
    Sangeeta Raje
    Pharmacokinetics Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, 21201 6808, USA
    Biopharm Drug Dispos 27:229-40. 2006
    ..Accordingly, the objectives of this study were to evaluate the pharmacokinetics and dopamine release of AHN 1-055, in the presence of cocaine...
  29. ncbi request reprint c-Fos facilitates the acquisition and extinction of cocaine-induced persistent changes
    Jianhua Zhang
    Division of Neuropathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Neurosci 26:13287-96. 2006
    ..Our findings indicate that c-Fos produced in D1 receptor-expressing neurons integrates mechanisms to facilitate both the acquisition and extinction of cocaine-induced persistent changes...
  30. pmc Dual DAT/sigma1 receptor ligands based on 3-(4-(3-(bis(4-fluorophenyl)amino)propyl)piperazin-1-yl)-1-phenylpropan-1-ol
    Jianjing Cao
    Medicinal Chemistry Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USA
    Bioorg Med Chem Lett 18:5238-41. 2008
    ....
  31. ncbi request reprint Effects of muscarinic M1 receptor blockade on cocaine-induced elevations of brain dopamine levels and locomotor behavior in rats
    Gianluigi Tanda
    Psychobiology, Department of Health and Human Services, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 321:334-44. 2007
    ....
  32. pmc Muscarinic preferential M(1) receptor antagonists enhance the discriminative-stimulus effects of cocaine in rats
    Gianluigi Tanda
    Psychobiology Section, Medications Discovery Research Branch, National Institute on Drug Abuse, Intramural Research Program, NIH, DHHS, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Pharmacol Biochem Behav 87:400-4. 2007
    ....
  33. ncbi request reprint Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors
    Claus J Loland
    Molecular Neuropharmacology Group, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Mol Pharmacol 73:813-23. 2008
    ..Our data suggest that chemically different DAT inhibitors stabilize distinct transporter conformations and that this in turn affects the cocaine-like subjective effects of these compounds in vivo...
  34. ncbi request reprint Pharmacodynamic assessment of the benztropine analogues AHN-1055 and AHN-2005 using intracerebral microdialysis to evaluate brain dopamine levels and pharmacokinetic/pharmacodynamic modeling
    Sangeeta Raje
    Pharmacokinetics Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201, USA
    Pharm Res 22:603-12. 2005
    ..Hence, the objective of this study was to mathematically characterize the PD of BZT analogues and cocaine, using appropriate PK/PD models...
  35. ncbi request reprint Place conditioning and locomotor effects of N-substituted, 4',4''-difluorobenztropine analogs in rats
    Su min Li
    Psychobiology Section, Medications Discovery Research Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 313:1223-30. 2005
    ....
  36. ncbi request reprint Synthesis and biological evaluation of 2-substituted 3beta-tolyltropane derivatives at dopamine, serotonin, and norepinephrine transporters
    Lifen Xu
    Department of Chemistry, University of New Orleans, New Orleans, Louisiana 70148, USA
    J Med Chem 45:1203-10. 2002
    ..These data indicate that a behavioral characterization of compounds is a critical feature of efforts to discover pharmacological treatments for cocaine abuse...
  37. ncbi request reprint Enantioselective synthesis of S-(+)-2beta-carboalkoxy-3alpha-[bis(4-fluorophenyl)methoxy]tropanes as novel probes for the dopamine transporter
    Mu Fa Zou
    Medicinal Chemistry Section, National Institute on Drug Abuse Intramural Research Program, NIH, Baltimore, MD 21224, USA
    Bioorg Med Chem Lett 12:1249-52. 2002
    ....
  38. ncbi request reprint Cocaine-induced locomotor activity and cocaine discrimination in dopamine D2 receptor mutant mice
    Allison L Chausmer
    Psychobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institute of Health, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 163:54-61. 2002
    ..Because these compounds generally lack selectivity among the D2-like DA receptors, the specific roles of the subtypes remain unclear...
  39. ncbi request reprint Intravenous cocaine induced-activity and behavioural sensitization in norepinephrine-, but not dopamine-transporter knockout mice
    Andy N Mead
    Behavioural Neuroscience Branch, National Institute of Drug Abuse Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Eur J Neurosci 16:514-20. 2002
    ..In addition to existing data concerning the reinforcing effects of cocaine in DAT-KO mice, these data suggest a dissociation between the reinforcing and locomotor stimulant effects of cocaine...
  40. ncbi request reprint Variability of drug self-administration in rats
    Leigh V Panlilio
    Preclinical Pharmacology Section, Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 167:9-19. 2003
    ..Although temporal patterns of drug self-administration in animals are known to be highly regular, this regularity has rarely been quantified or systematically compared across reinforcers...
  41. ncbi request reprint Locomotor and discriminative-stimulus effects of cocaine in dopamine D5 receptor knockout mice
    Elizabeth E Elliot
    Department of Public Health, Adelaide University, 5005 South Australia, Australia
    Psychopharmacology (Berl) 169:161-8. 2003
    ..Because these compounds generally lack selectivity among the dopamine D1 and D5 receptors, the specific roles of the subtypes have not been determined...
  42. ncbi request reprint Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents
    Jianjing Cao
    Medicinal Chemistry, NIDA IRP, Baltimore, Maryland 21224, USA
    J Med Chem 46:2589-98. 2003
    ..Behavioral evaluation of analogues with varying affinities for both DAT and sigma(1) receptors may provide a novel approach toward designing medications for cocaine abuse...
  43. ncbi request reprint Structure-activity relationship comparison of (S)-2beta-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes and (R)-2beta-substituted 3beta-(3,4-dichlorophenyl)tropanes at the dopamine transporter
    Mu Fa Zou
    Medicinal Chemistry and Psychobiology Sections, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    J Med Chem 46:2908-16. 2003
    ..Together, the binding profiles across these systems demonstrated significant differences between these two classes of tropane-based ligands, which may be exploited toward the discovery of a cocaine-abuse pharmacotherapeutic...
  44. ncbi request reprint Synthesis and monoamine transporter binding of 2-(diarylmethoxymethyl)-3 beta-aryltropane derivatives
    Lifen Xu
    Department of Chemistry, University of New Orleans, New Orleans, Louisiana 70148, USA
    J Med Chem 47:1676-82. 2004
    ....
  45. ncbi request reprint Synthesis and biological evaluation of meperidine analogues at monoamine transporters
    Stacey A Lomenzo
    Department of Chemistry, University of New Orleans, New Orleans, LA 70148, USA
    J Med Chem 48:1336-43. 2005
    ..However, none of the analogues tested produced locomotor effects or substituted for cocaine in drug discrimination studies, suggesting that the mu-opioid effects of these analogues may contribute to the poor efficacy observed in vivo...
  46. ncbi request reprint Identification of a dopamine transporter ligand that blocks the stimulant effects of cocaine
    Rajeev I Desai
    Psychobiology, Medications Discovery Research Branch, National Institute on Drug Abuse, Intramural Research Program, Department of Health and Human Services, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci 25:1889-93. 2005
    ..The antagonism of cocaine suggests that DAT ligands with reduced cocaine-like activity can function as cocaine antagonists and suggests JHW007 as a lead for discovery of cocaine-abuse pharmacotherapeutics...
  47. ncbi request reprint Effects of 4'-chloro-3 alpha-(diphenylmethoxy)-tropane on mesostriatal, mesocortical, and mesolimbic dopamine transmission: comparison with effects of cocaine
    Gianluigi Tanda
    Psychobiology, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 313:613-20. 2005
    ..Nonetheless, the present results suggest that the differences in behavioral effects between cocaine and 4-Cl-BZT are related to differences in their patterns of activation of DA transmission...
  48. ncbi request reprint Novel azido and isothiocyanato analogues of [3-(4-phenylalkylpiperazin-1-yl)propyl]bis(4-fluorophenyl)amines as potential irreversible ligands for the dopamine transporter
    Jianjing Cao
    Medicinal Chemistry and Psychobiology Sections, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    J Med Chem 47:6128-36. 2004
    ....
  49. ncbi request reprint Structure-activity relationships at monoamine transporters for a series of N-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes: comparative molecular field analysis, synthesis, and pharmacological evaluation
    Santosh S Kulkarni
    Medicinal Chemistry Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    J Med Chem 47:3388-98. 2004
    ..Most of the analogues showed high DAT affinity (12-50 nM), selectivity (10- to 120-fold), potent inhibition of dopamine uptake, and lower lipophilicities as predicted by cLogD values...
  50. ncbi request reprint The effect of 6-substituted-4',4"-difluorobenztropines on monoamine transporters and the muscarinic M1 receptor
    Peter Grundt
    Medicinal Chemistry, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Bioorg Med Chem Lett 14:3295-8. 2004
    ..81 to 175 nM and [(3)H]pirenzepine (M1), with a range of affinities ( K(i)= -8430 nM). Binding affinities at the SERT and the NET were generally low...
  51. ncbi request reprint Comparison of interactions of D1-like agonists, SKF 81297, SKF 82958 and A-77636, with cocaine: locomotor activity and drug discrimination studies in rodents
    Allison L Chausmer
    Medications Discovery Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 159:145-53. 2002
    ..The structurally novel isochroman D1-like agonist, A-77636, has not been well characterized and may prove to be useful as such an agent...
  52. ncbi request reprint Continuing implications of the early evidence against the drive-reduction hypothesis of the behavioral effects of drugs
    Donald E McMillan
    Department of Pharmacology, University of Arkansas for Medical Science, 4301 W Markham Street, Little Rock, AR 72205 7101, USA
    Psychopharmacology (Berl) 163:251-64. 2002
    ..The work of Dews, Morse, and Kelleher offered an alternative explanation that the scheduling of reinforcers, and the patterns and rates of responding maintained, were more important determinants of drug effects...
  53. ncbi request reprint Human cocaine-seeking behavior and its control by drug-associated stimuli in the laboratory
    Leigh V Panlilio
    Preclinical Pharmacology Section, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA
    Neuropsychopharmacology 30:433-43. 2005
    ..The similarity of the response patterns in humans and animals also supports the use of second-order schedules in animals as a valid model of human drug seeking...
  54. ncbi request reprint Intravenous cocaine-induced activity in A/J and C57BL/6J mice: behavioral sensitization and conditioned activity
    Andy N Mead
    Behavioral Neuroscience Branch, National Institute of Drug Abuse Intramural Research Program, Baltimore, MD 21222, USA
    Neuropharmacology 42:976-86. 2002
    ..In summary, these data extend to the i.v. route of administration previous observations on cocaine-induced activity and conditioned activity...